paving the way to individualized therapy

... with the inner mitochondrial membrane [10–13] In the steroidogenic cells, the step that determines the rate of steroid synthesis (the rate-limiting step) is the transport of cholesterol to the ... AACoA to AA within the mitochondria may constitute a mechanism to deliver AA into specific compartment of the cells, the next experiment was carried out to determine the effect of AA-CoA, the substrate ... through the CPT1dependent pathway The specificity of this mechanism to release AA inside the mitochondria is shown by the fact that the content of labeled AA in another organelle such as the nucleus...

Ngày tải lên: 16/03/2014, 12:20

Ngày tải lên: 13/11/2014, 10:36

... the point of the current supply electrode and 12 mm of the point of the voltage measurement electrode while insulating the other parts, and measures the electric conductivity of the soil in the ... China The outflow of salts according to the amount of moisture infiltrated to the soil was obtained from the column experiment Therefore, if the amount of moisture that infiltrates downward in the ... indicator of the total salt concentration in the soil column, to observe the runoff rate of salts The four-electrode sensor consisted of four stainless steel rods inserted in parallel into an...

Ngày tải lên: 05/09/2013, 09:38

... (28) QC is the diffusion flux of the colloids from the fracture into the rock-matrix and QC = −εθ ∂CP ∂z z = b (29) ε is the percentage of matrix flux diffusion into the rock-matrix since the diffusion ... to the rock-matrix satisfying the boundary condition n +1 The colloid concentration at the second node of the rock-matrix CP is the fourth unknown in the (n+1)th time level in equation (27) The ... along the fracture The lower order spatial moments have been obtained using a similar approach to Guven et al [28] The zeroth moment (M0) is proportional to the total mass of the fluid in the high...

Ngày tải lên: 05/09/2013, 17:03

... consulted on the times they run, as well as the route and number of stops Here again there is the potential for women to be empowered to not only be the users but to be the operators of these initiatives ... village to the town it should be on the day that women generally go and sell their crops in the town The point to be made is that transport planners need to consult the women who are often the frequent ... by how dirty the non-school-going children and babies were Women did not have the energy to always take them to the streams to bathe, nor did they have enough water at home to keep them clean This...

Ngày tải lên: 15/02/2014, 01:20

... pedestrian/cycleway exists along a significant portion of the motorway route, allowing a convenient alternative for cyclists and runners/walkers The transverse distance between the edge of the motorway and the ... pedestrian/cycleways along part of their journey While these are effective for the portions of the commute where they exist, in the city where pedestrians and cyclists merge with the motorised traffic, the ... 19] The monitor has a resolution of 0.05 ppm and a range of 0-200 ppm In each case, the monitor was placed as close as practical to the commuter’s face The participants were asked to log the...

Ngày tải lên: 18/02/2014, 04:20

... uptake from the blood into the liver [30], as well as from the gastric lumen into the blood [31] The ability of bilitranslocase to interact with anthocyanins led us to consider the hypothesis that ... vesicles, the latter has been shown to be due to the entry of BSP into vesicles and has been referred to as electrogenic BSP uptake [28] Preliminary tests were carried out to examine the dependence ... K+ in the assay) If the disappearance of BSP from the assay medium represents an uptake into the vesicular compartment, it is expected that the former parameter be directly related to the vesicular...

Ngày tải lên: 20/02/2014, 01:20

... of the GLUT1 and the insulin-responsive GLUT4 glucose transporter The effect of arsenite on early events in insulin receptor signalling To elucidate the signalling-pathways that contribute to ... (*P < 0.05) as is the case for insulin The identity of the tyrosinekinase activity activated in response to arsenite remains to be resolved The pharmacological p38 MAPK inhibitor, SB203580, affects ... statistically significant compared to the uninhibited samples (*P < 0.05) the amount of GLUT1 Indeed, treatment of the adipocytes with the protein synthesis inhibitors cycloheximide or emetine had...

Ngày tải lên: 21/02/2014, 00:20

... paralogs each of Toc159 (atToc159, atToc132, atToc120 and atToc90) [17–20] and Toc75 (atToc75-III, atToc75-IV, atToc75-I and atToc75V ⁄ atOep80) [21] There is evidence that the different Toc GTPases ... accumulation of photosynthetic protein [18] These data suggest that atToc90 may contribute to the import of photosynthetic proteins into chloroplasts Similar to atToc132 and atToc120, atToc34 is more ... discussed, the ‘motor’ and the ‘targeting’ hypotheses [68,76] The main difference between those models is the nature of the primary receptor, namely Toc34 or Toc159 in the ‘motor’ and ‘targeting’ hypotheses,...

Ngày tải lên: 07/03/2014, 03:20

... because the demand of the chloroplast is ‘sensed’ inside the organelle, the IEM is closest to the origin of the signal, and thus regulation at the Tic complex could be one of the fastest ways to react ... of transported proteins from the cytosol to their final destination in the chloroplast The Tic and Toc translocons are therefore perfectly situated to impose a regulatory control over incoming preproteins ... which anchor the protein in the membrane The position and function of the long C-terminal tail on the other hand remains a matter of controversy [10,11,13–15] According to one hypothesis, the hydrophilic...

Ngày tải lên: 07/03/2014, 03:20

... different to E coli SecA [20] These differences suggest that cpSecA has evolved to be specifically suited to the chloroplast thylakoid environment The Tat pathway Unlike the Sec pathway, the Tat pathway ... destined to be transported by the Tat pathway contain a characteristic pair of arginine residues in the N-terminal region of the signal peptide, which gives the pathway its name The Sec pathway The ... allowing the transportation of proteins that fold too quickly or tightly for the Sec pathway, or proteins that require the insertion of co-factors in the stroma before transport into the thylakoid...

Ngày tải lên: 07/03/2014, 03:20

... and Toc159 system used by proteins involved in photosynthesis [36] The Toc159 family in Arabidopsis consists of four proteins: Toc159, Toc132, Toc120 and Toc 90 [37] It is possible that one of these ... utilize a different receptor compared to several mitochondrial proteins imported via the general and carrier import pathways The same study also assessed the role of other outer membrane proteins ... did not appear to play any specific role in the import of GR compared to mitochondrial precursor proteins One protein that was identified to play a role in the import of GR into mitochondria was...

Ngày tải lên: 07/03/2014, 03:20

... it, the other sensor nodes may also sense the event and attempt to assign an ID to the same event However, since the medium is not idle due to the local broadcast of the sensor node which was the ... from (1), the distortion observed in the estimation of the signal being tracked depends on the reporting frequency rate used by the sensor nodes sending their readings to the sink in the decision ... pending on the current state , and the values of ESRT then calculates the updated reporting frequency to be broadcast to the source nodes At the end of the next decision interval, the sink derives...

Ngày tải lên: 16/03/2014, 19:20

... conservation laws, then the model can be used to understand the behavior of the system even under the situations where we not have the data On the other hand, the models based purely on the probabilistic ... integrate the variability of the system along with the scientific knowledge pertaining to the system In relation to the above-mentioned diffusion problem of the liquid within the rock material, the ... measure of the degree of tortuous paths present within the porous medium The term "tz that arises from the mathematical averaging is in fact the total surface area perpendicular to the flow presented...

Ngày tải lên: 22/03/2014, 15:20

... by the soluble domain of the receptor protein Toc34 (A) Increasing concentrations (0–10 lM) of overexpressed soluble receptor Toc34DTM, mM ATP and mM GTP, were added to the import mix prior to ... in the presence of the competitor pOE33 but not in the presence of mOE33 Taken together, we conclude that the intermembrane space constituents pTic22 and pMGD1 are bona fide substrates of the Toc ... Taken together, our experiments indicate that pTic22 and pMGD1 use the general import pathway to traverse the outer envelope and diverge at the level of the intermembrane space ⁄ inner envelope The...

Ngày tải lên: 23/03/2014, 07:20

... determining the accessibility of the ectoenzyme acetylcholinesterase, and the endoenzyme glyceraldehyde-3-phosphate dehydrogenase to their substrates Triton X-100 was used to disrupt the permeability ... inhibition of the inhibitable component, U0 is the uptake in the absence of the inhibitor, Unoninh is the uptake which cannot be inhibited and ni is the Hill coefficient for the inhibitor For simple ... column except the first the variance ratio (see Eqn 5) has been calculated relative to the column immediately to the left The fit obtained with the constraints n1 ¼ and n2 ¼ is not shown as the fitted...

Ngày tải lên: 23/03/2014, 21:20

... spread around the STO peak confirms that the LMO peak overlaps with the STO peak; this overlap along with the intense LSMO peak confirms the pseudomorphic nature of the superlattice on STO substrates ... that the temperature gradient across the ferromagnetic conductor (LSMO) generates spin current These spin currents may be injected into the ferromagnetic semiconductor (LMO) due to lowering of the ... cross-plane thermal conductivity in the temperature range of 300 K–380 K is shown in Figure The cross-plane thermal conductivity indicates that the suppression of thermal conductivity due to the interfaces...

Ngày tải lên: 06/05/2014, 08:53

... exponentially until they reach the center of the barrier, and then they grow until they reach the metallic interface on the other side Since the wavefunction connects the two metallic leads, the electrons ... spin to pair together (due to the so-called superconducting correlations) The physical picture is similar to two marbles on a rubber sheet—each feels the depression of the other marble, and they ... interaction with the phonons, which allows them to pair electrons together that are not located at the same position at the same time The pairing leads to an energy gap, so the superconductor has no...

Ngày tải lên: 04/06/2014, 14:33

Ngày tải lên: 04/06/2014, 14:41