patient concerns choices and clinical judgment in evidence based practice

... SQ participated in acquiring clinical samples and follow-up clinical information MSC participated in study design and coordination, data analysis and interpretation and final writing of the manuscript ... analysis and interpretation, and drafted the manuscript PP and LG participated in acquiring clinical and laboratory data, data analysis and data interpretation and drafted the manuscript LG, JV, and ... cell lines Six NSCLC cell lines consisting of three adenocarcinoma cell lines (A549, H522 and H358), two large carcinoma cell lines (H460, H661), and one squamous cell carcinoma cell line (H226),...

Ngày tải lên: 18/06/2014, 16:20

... Whereas colistin is mainly administered i.v in critically ill patients, it can be safely be administered by inhalation in patients with pneumonia/VAP or intrathecally in patients with meningitis due ... Optimizing colistin dose based on PK/PD properties The optimal dose of colistin has not been determined in the ICU setting, because since there is a lack of relative clinical studies In addition, ... samples containing colistin < μg/ml resulted in complete bacterial killing Based on these findings, the currently used colistin dosing regimens might not provide the most effective therapy and therefore...

Ngày tải lên: 21/06/2014, 01:20

... others (having warm, satisfying, trusting relationships with others), (3) autonomy (self-determination and independence), (4) environmental mastery (a sense of mastery and competence in handling one's ... scores decreased with increasing participant age The above findings were virtually the same even after controlling for age and gender (one and two cases were missing for age and gender, respectively) ... the IPO in clinical and non -clinical populations If future studies agree with our findings, the Japanese version of the IPO will prove an excellent tool to screen for personality pathology in busy...

Ngày tải lên: 08/08/2014, 23:21

... production in RP patients [15,16] Surprisingly, a more prominent response was seen for CIX and CXI in a patient presenting a fatal tracheomalacia, indicating CIX and CXI rather than CII as being involved ... dominating symptom is inflammation in the peripheral joints characterized by redness, swelling and pain, which mimic the symptoms of arthritis in RP patients In the majority of the rodent strains, ... have not yet been investigated in RP patients Adjuvants and oils can induce arthritis in many rat strains [33–36] and auricular chondritis in Wistar rats [21] Finally, in FH and Wistar rats, chondritis...

Ngày tải lên: 09/08/2014, 06:22

... 3b) practice than others (Figure 6) Following the joint review, discussion of (i) idiosyncratic cases encountered in clinical practice, and (ii) problems with evaluating types of necrosis in both ... 8a-d) Association between outcome and clinical variables For each trial, outcome analyses were undertaken using clinical and pathological data The following clinical variables were considered: ... resection; black line = CR-Gd II; red line = STR-Gd II; blue line = CR-Gd III; green line = STR-Gd III grade and outcome in an extensive study of children of all ages, including infants, that were...

Ngày tải lên: 11/08/2014, 07:21

... of RSV infection, recruited patients and collected clinical samples, isolated and performed the initial characterization of the clinical RSV strains ST recruited patients and collected clinical ... no evidence of syncytium formation in these cells Interestingly, RSV BT4a-infected PBECs and mock-infected controls were indistinguishable in terms of CPE Similar data were obtained following infection ... not affect growth kinetics Differential chemokine/cytokine secretion following RSV A2 and clinical isolate infection Chemokines/cytokines are important mediators of innate and adaptive immune...

Ngày tải lên: 11/08/2014, 21:22

... for setting up and coordinating the study, and drafted the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests ... Sequencing and analysis of viral genomes All positive samples (environmental and clinical) were confirmed by sequencing of the PCR product The purified PCR products of the clinical HAV strains were ... strains in Barcelona, from both environmental and clinical samples, revealed a 95% prevalence of genotype I, with nearly 50% being either subgenotype IA or subgenotype IB Interestingly, in the...

Ngày tải lên: 12/08/2014, 01:21

... clusters in a) the extracellular domain (exons 2-4) and b) the serine/threonine protein kinase domain (exons 9-11) Four mutations occurred in more than one independent patient/ family: p.R491W and ... gene (promoter and coding regions including flanking intronic regions) and the coding regions of the ACVRL1, ENDOGLIN, and the SMAD8 genes did not reveal any defect Especially, no point mutations ... Since occurrence of BMPR2 mutations obviously influences the clinical phenotype genetic testing may become of increasing clinical relevance Patients with BMPR2 mutation tend to a more severe clinical...

Ngày tải lên: 12/08/2014, 13:22

... to an increasing demand for the development of commercial assays in order to allow the screening of patients in the routine clinical setting The recent development and validation of a line blot ... provide insight into the pathogenesis of CADM and ILD and into the reported association between viral infections and myositis The clinical utility and identity of this autoantigen have since been ... identified these proteins as small ubiquitin-like modifier activating enzyme and (SAE) that are involved in the post-translational modification of numerous targets, including protein kinases and transcription...

Ngày tải lên: 12/08/2014, 15:22

... cough The causes of chronic cough in 110 patients were shown in Table Beside the single cause, cough symptoms in 10 patients could be explained by two causes, including cases of cough variant asthma ... explanation since we recruited the patients consecutively It is likely that in previous studies reporting gender differences in HRQOL, female patients were coughing more frequently than men, and in this ... effects on HRQOL of patients in many aspects including physical, psychological and social domains, among which the adverse impact on the psychosocial domain is the most notable and possibly related...

Ngày tải lên: 13/08/2014, 08:20

... Cytokines, prostaglandin (PG) E2 and leukotriene (LT) B4 were measured in plasma and cytokines and PGE2 in whole blood culture supernatants Cytokines and eicosanoids were measured using enzyme-linked ... only limited, and contradictory, information on the influence of fish oil containing parenteral nutrition in septic ICU patients on markers of inflammation and on clinical endpoints However, ... Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial Critical...

Ngày tải lên: 13/08/2014, 20:21

... obtained that enabled drilling down into accumulated data without identifying individual patients Data collection and processing The following patient visit-specific data were extracted: Patient ... [14,15] includes individual patient data but not include all EDs and are only published every second year None of the mentioned databases include information regarding mortality and morbidity during ... patterns in EDs C and F are unclear, but according to the leadership in ED C, the pattern in ED C may be related to hospital crowding with admitted patients waiting in the ED for an in- hospital...

Ngày tải lên: 13/08/2014, 23:20

... of each patient, maintaining sensitivity to cultural beliefs and practices 2.2.6 Evaluation of clinical practice guidelines Although many asthma practical guidelines have been published in the ... of patients managed in the usual manner before our intervention and following the intervention program which was instituted in January 2001 2.2 Description of intervention program An evidence- based ... magnesium sulfate and aminophylline in acute asthma These articles were searched out in the literature for clinical evidence on the management of acute asthma by using MEDLINE (PUBMED) and COCHRANE...

Ngày tải lên: 26/09/2015, 11:07

... steps in evidence- based practice These steps include the following: asking answerable questions, investigating the evidence, appraising the evidence, adapting and applying the evidence, and evaluating ... http://www.umass.edu/schoolcounseling/ 24 Evidence- Based Practice in School Mental Health ■■■ Evidence- Based Practice: Definition and Process Preview The last chapter identified five reasons for evidence- based practice and ... use clinical 22 Evidence- Based Practice in School Mental Health wisdom or personal experience as the basis for their interventions Clinical reasons included standards of care, avoiding harm, and...

Ngày tải lên: 06/03/2014, 02:20

... salivary cystatin activity and output of cystatin C during gingival inflammation [72] Cystatins are thought to contribute to maintaining oral health by inhibiting certain proteolytic enzymes In addition ... of the evidence- based approach Guidance is available for the searching, selecting, abstracting and appraising, synthesis and decision-making on clinical trial evidence While these guidelines are ... tissue, skin, bone and intestinal epithelium In addition, stem cells must be present in tissues which regenerate after injury such as liver and muscle Interestingly, recent evidence indicates...

Ngày tải lên: 06/03/2014, 12:21

... role in 20S PT activities We next analyzed Grx2 fragmentation using mass spectrometry, by incubating Grx2 in standard buffer for 30 or h in the presence of n-PT After incubation, standard Grx2 and ... after simultaneous incubation of proteasome preparations with cardiolipin and Grx2 The results obtained showed 25% and 65% increased chymotrypsin-like activity and 61% and 100% increased postacidic ... Grx2 is ubiquitinated in vivo Discussion Sulfhydryl groups play a critical role in the function of many proteins, including enzymes, transcription factors and membrane proteins [35] In a previous...

Ngày tải lên: 23/03/2014, 07:20

... (Chapters and 2), evaluates what is known about CAM focusing on definitional, usage, and research (clinical and preclinical) strategies; positioning of evidence- based medicine; and education/training ... School Alternative Medicine: Implications for Clinical Practice Clinical Training in Mind/Body Medicine University of Arizona School of Medicine Program in Integrative Medicine University of California ... the Chinese Ministry of Public Health and is used in approximately 1000 hospitals.85 PRECLINICAL ISSUES Although EChT is already prevalent in clinical practice in China, and a number of clinical...

Ngày tải lên: 29/03/2014, 07:20

... explore some of the exciting and challenging directions presented in this book References Adelson, E.H and Niyogi, S A Analyzing and recognizing walking gures in XYT In IEEE CVPR-94, pages 469{474, ... human hand tracking In ECCV, pages 35{46, May 1994 R Jain and K Wakimoto Multiple perspective interactive video In Proceedings of the International Conference on Multimedia Computing and Systems, ... names using audio only, and combined audio and video The best recognition rate of about 55% is obtained with combined audio and video input in the presence of crosstalk Goldschen et al, in chapter...

Ngày tải lên: 24/04/2014, 13:40

... for clinical improvements in developing settings In addition to adequate knowledge and resources, the health care staff needs to have a certain level of clinical activity to be able to maintain ... competence and skills For example, it is assumed that having too few deliveries in a health care institution results in difficulties in maintaining high standard delivery care [17] Yet, in the current ... Community -based interventions for improving perinatal and neonatal health outcomes in developing countries: a review of the evidence Pediatrics 2005, 115:519-617 Haladyna T: Developing and validating...

Ngày tải lên: 18/06/2014, 17:20

... those involved in creating and carrying out policy and procedures and those involved in direct practice Previous research has indicated a need to include multiple perspectives when implementing ... implementing innovations such as new guidelines and EBPs in medical settings should consider multiple levels and contexts including the innovation itself, the individual professional, the patient, ... contracts and requirements for EBPs Finally, the ‘Costs of EBP’ cluster contains nine items relating to concerns regarding the costs of training, equipment, supplies, administrative demands, and Page...

Ngày tải lên: 10/08/2014, 11:20