pathways of biotransformation phase i reactions
Báo cáo khoa học: "Toxicity report of once weekly radiation therapy for low-risk prostate adenocarcinoma: preliminary results of a phase I/II trial" pdf
Ngày tải lên :
09/08/2014, 09:21
... Arcangeli G, Saracino B, Gomellini S, et al: A Prospective Phase III Randomized Trial of Hypofractionation Versus Conventional Fractionation in Patients With High-Risk Prostate Cancer International ... toxicity of various hypofractionated RT regimens compared with standard RT fractionation Our findings show that a hypofractionated RT regimen consisting of 45 Gy in nine weekly fractions of five ... late toxicity, tumour control and survival In addition to the radiobiological advantages of this treatment on tumour control, hypofractionation offers important logistical and financial benefits,...
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Ab initio kinetic modeling of gas phase radical reactions
Ngày tải lên :
11/09/2015, 09:15
... unimolecular dissociation/recombination reactions 34 II 2.6 Ab initio calculations of kinetic parameters 38 2.6.1 Ab initio rate coefficients for radical-radical recombination reactions ... operation 163 conditions I, II, and III in Table 5.1 I- hp, II-hp, and III-hp are modeled using high-pressure-limit rate coefficients I- pdep, IIpdep, and III-pdep are modeled using pressure-dependent ... lifetime of the radical intermediates To test the predicting capabilities of ab initio calculations for such gas phase radical reactions, we modeled the low temperature atmospheric oxidation of...
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REVIEW OF DOE’S VISION 21 RESEARCH AND DEVELOPMENT PROGRAM—PHASE I potx
Ngày tải lên :
29/03/2014, 13:20
... their individual efforts in gathering information and writing sections of the report vii viii ACKNOWLEDGMENTS This report has been reviewed in draft form by individuals chosen for their diverse ... University, Pittsburgh, Pennsylvania RAMON L ESPINO, University of Virginia, Charlottesville ENRIQUE IGLESIA, University of California, Berkeley EDWARD S RUBIN, Carnegie Mellon University, Pittsburgh, ... technology-related findings and recommendations identified by the committee They pertain to gasification, gas purification, turbines, and fuel cells Gasification Finding Under current conditions in the United...
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báo cáo hóa học:" Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma" docx
Ngày tải lên :
18/06/2014, 15:20
... http://www.translational-medicine.com/content/7/1/68 administration of equivalent mixtures of antibody and IL2 [6] EMD 273063 was tested in a phase I clinical trial aimed at evaluating its safety, toxicity and in vivo immunological ... were clinical anti-tumor activity, safety, toxicity and pharmacokinetics (PK) of EMD 273063 Toxicity grades were classified according to the NCI Common Toxicity Criteria Version Objective tumor ... conducted in accordance with both the provisions of the Declaration of Helsinki and Good Clinical Practice Site monitoring included review of the accuracy of the data in the case report forms Page of...
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Báo cáo hóa học: " Phase I clinical trial of the vaccination for the patients with metastatic melanoma using gp100derived epitope peptide " pot
Ngày tải lên :
18/06/2014, 16:20
... specific lysis of inhibition by isotype control) - (% specific lysis of inhibition by MAb)]/(% specific lysis of inhibition by isotype control) × 100 All mAb was purchased from Dako Japan Inc Immuno-histochemical ... patient P3 (B) Figure Immunohistochemical analysis of vitiligo Biopsy specimens of the area with vitiligo in P2 were stained with H&E to identify infiltrating cells This focus was a match for vitiligo ... the vitiligo of P2 and examined with H&E and immunohistochemical staining (Fig 2) The infiltration of CD3+ T-cells was observed at the epidermis with de-pigmentation (Fig 2A and 2B) These infiltrating...
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Báo cáo sinh học: "Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety" ppt
Ngày tải lên :
18/06/2014, 19:20
... Registration of Pharmaceuticals for Human Use (ICH)-Good Clinical Practice (GCP)-registered phase I/ II clinical trial of rh-HGF As this application is the first clinical trial to administer rh-HGF ... proteinuria Therefore, we established a stepwise infusion method to avoid a rapid reduction of BP, and confirmed reversibility of renal toxicity through additional preclinical studies In this clinical ... efficacy Therefore, it will be desirable to examine the clinical efficacy of rh-HGF in additional clinical trials involving patients with less severe conditions Systemic administration of potent growth...
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Báo cáo sinh học: "Safety and feasibility of third-party multipotent adult progenitor cells for immunomodulation therapy after liver transplantation–a phase I study (MISOT-I)" doc
Ngày tải lên :
18/06/2014, 22:20
... is still associated with a significant intrinsic risk Side effects include opportunistic (mainly biliary) infections in the short-term and drug-specific side effects or malignancies in the intermediate ... ejection fraction ≤50% HIV seropositive, HTLV seropositive, varicella virus active infection, or syphilis active infection History of any malignancy (including lymphoproliferative disease and hepatocellular ... regeneration in models of limb ischemia [23], improving cardiac function after myocardial infarction [24], and contributing to the regeneration of injured livers through their ability to differentiate...
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báo cáo hóa học:" Safety and feasibility of third-party multipotent adult progenitor cells for immunomodulation therapy after liver transplantation–a phase I study (MISOT-I)" pptx
Ngày tải lên :
20/06/2014, 04:20
... is still associated with a significant intrinsic risk Side effects include opportunistic (mainly biliary) infections in the short-term and drug-specific side effects or malignancies in the intermediate ... ejection fraction ≤50% HIV seropositive, HTLV seropositive, varicella virus active infection, or syphilis active infection History of any malignancy (including lymphoproliferative disease and hepatocellular ... regeneration in models of limb ischemia [23], improving cardiac function after myocardial infarction [24], and contributing to the regeneration of injured livers through their ability to differentiate...
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Báo cáo y học: "A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy" pps
Ngày tải lên :
08/08/2014, 17:20
... given every to hours in this study During the 12 week course of the study, PSADT was the primary endpoint Using this criterion, thirteen of 17 patients had significant increases in PSA doubling ... following washout of the chemotherapeutic agent In addition, pharmacokinetic studies indicated serum vitamin C levels returned to steady-state values within to hours of oral administration.15 ... In this study, Apatone was administered daily in a single oral dose which was 2.5 to times higher than the dose employed during the initial 12 weeks of our study This dose resulted in a significant...
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Báo cáo y học: "Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase" potx
Ngày tải lên :
09/08/2014, 07:20
... recombinant uricase did not inhibit the ELISA, indicating that the protein moiety of PEG-uricase did not react with anti-PEG-uricase antibody By contrast, PEG-uricase itself completely inhibited ... treatment with PEG-uricase Lack of inhibition of uricase activity by antibody against PEG-uricase Aliquots of plasma from a subject in the 'long-circulating' group, in which there was uricase activity ... uricase activity The expected level of uricase activity was observed, indicating that antibody against PEG- Efficacy of PEG-uricase In this first phase I trial, single subcutaneous injections of to...
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Báo cáo khoa học: "Phase i study of ‘dose-dense’ pemetrexed plus carboplatin/radiotherapy for locally advanced non-small cell lung carcinoma" pps
Ngày tải lên :
09/08/2014, 09:20
... Patients/Eligibility This study was available to patients with locally advanced NSCLC who required definitive full dose radiotherapy as part of their treatment plan This included stage IIIA, IIIB ... Most patients had stage III disease (6 stage IIIA; stage IIIB) and patients had oligometastatic (3 brain, bone) stage IV disease Histology was squamous in patients, adenocarcinoma in patients, ... outside of the radiotherapy fields With improving local control, the ability to control micrometastatic disease has increasing importance in improving overall survival It is possible that higher...
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Báo cáo khoa học: "A phase I radiation dose-escalation study to determine the maximal dose of radiotherapy in combination with weekly gemcitabine in patients with locally advanced pancreatic adenocarcinoma" doc
Ngày tải lên :
09/08/2014, 09:22
... late toxicity As in our study, the acute toxicity consisted of dose-limiting GI toxicity Application of the linear quadratic model indicates that 42 Gy in 2.8 Gy-fractions is biologically equivalent ... nelfinavir [24] or erlotinib, gefitinib and bevacizumab [25-27] with a CRT regimen, although further confirmation of initial positive results in phase I studies is warranted by randomised trials ... indication of anti-tumour activity [13,15,16] In a phase I study by McGinn et al to find the MTD of gemcitabine in association with RT to 50.4 Gy in 1.8 Gy daily fractions in patients with locally...
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Báo cáo khoa học: " Combination of celecoxib with percutaneous radiotherapy in patients with localised prostate cancer – a phase I study" ppt
Ngày tải lên :
09/08/2014, 10:20
... cancer is not increased Further phase II and III testing is required for efficacy testing IGF-R Insulin-like growth factor receptor mg Milligram MRI Magnetic resonance imaging Abbreviations AP ... encouraging preliminary outcome results An additional phase I/ II trial concerning 27 patients with brain metastases treated with radiation and celecoxib [77] confirmed the feasibility and safety Govindan ... (gastrointestinal and genitourinary) This finding may simply reflect a certain lack of precision for the definition of grade effects using the RTOG criteria, allowing inaccuracies when comparing patient...
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Báo cáo y học: "Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus" potx
Ngày tải lên :
09/08/2014, 13:21
... belimumab was biologically active in vivo and was safely administered to patients with SLE These findings supported the initiation of phase II studies investigating the safety and clinical activity ... urticaria with chest pain was reported in one patient with a prior history of drug-induced urticaria during the administration of a 20 mg/kg single dose The infusion was discontinued approximately ... binds to soluble BLyS with high affinity The antibody exerts its biologic activity by preventing the binding of BLyS to its receptors [19] Belimumab potently inhibits BLyS-induced proliferation...
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Báo cáo y học: "Phase I safety study of 0.5% PRO 2000 vaginal Gel among HIV un-infected women in Pune, India" potx
Ngày tải lên :
10/08/2014, 05:20
... study participants This study was sponsored by the HIV Prevention Trials Network of the Division of AIDS, US National Institute of Allergy and Infectious Diseases, US National Institute of Child Health ... mild, transient and well tolerated None of the participants reported prior history of IMB episode IMB was reported in previous Phase I clinical trials of the same product[9,10] Since microbicides ... risk as well as the high-risk women from Pune, India All AEs were mild to moderate and transient PRO 2000 Gel is one of the five candidate microbicides currently entering the Phase II/IIb efficacy...
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báo cáo khoa học: "First-in-class, first-in-human phase I results of targeted agents: Highlights of the 2008 American Society of Clinical Oncology meeting" pot
Ngày tải lên :
10/08/2014, 22:20
... targets are intra-cytoplasmic Survivin inhibitors Survivin is a member of the inhibitor of apoptosis protein (IAP) family, and has generated interest because of its increased expression in many human ... dose in most phase I trials Finally, although evaluation of clinical efficacy is not the purpose of phase I trials, the clinical outcomes for patients enrolled in these trials is of major interest ... study drug, occurring within a specified time period after drug delivery, although variations of DLT definitions may exist based on anticipated toxicity from preclinical data Maximum tolerated dose...
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Báo cáo y học: " Assessment of pulmonary antibodies with induced sputum and bronchoalveolar lavage induced by nasal vaccination against Pseudomonas aeruginosa: a clinical phase I/II study" pot
Ngày tải lên :
12/08/2014, 15:21
... propria [21] The weak correlation of IgG antibodies in IS to serum IgG is consistent with this dual origin of bronchial IgG antibodies IgA antibody levels in IS showed no correlation to systemic ... vaccifractions ofnasal primary and lavage fluidsystemicA and C) vaccinationline) and IgA antibodies of n = circles, dotted line) in single Sequential Sequential analysis of OprF-OprI-specific IgG and IgA ... this technique may be usefully applied in the process of optimization of the vaccination strategy The use of IS for detection of vaccine induced antibodies has limitations A major drawback of...
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History of Modern Biotechnology I - Springer
Ngày tải lên :
08/08/2012, 09:52
... lovastatin) and agriculture (polyoxins, phosphinothricins) Clavulanic acid is a penicillinase inhibitor which is used in combination with penicillinase-sensitive penicillins.Lovastatin (mevinolin) is ... protection against damping off: (i) zwittermycin A, a linear aminopolyol and (ii) antibiotic B, an aminoglycoside antibiotic containing a disaccharide Zwittermycin A inhibits elongation of the ... penicillin N in that it consisted of a b-lactam ring attached to a side chain of d-a-aminoadipic acid It differed, however, from the penicillins in containing a six-membered dihydrothiazine ring...
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The Great Ideas of Psychology Part I - Daniel N. Robinson
Ngày tải lên :
07/11/2012, 14:21
... provide the response indefinitely Nothing in the acquisition of the conditioning provides a cue about which response will yield a reinforcer Similarly, after relatively few avoidance conditioning ... Brain” and the subsequent ninepart series, “The Mind.” He is past president of two divisions of the American Psychological Association: the division of the history of psychology and the division ... knowing what is inside the organism, even if there isn’t anything inside the organism at all II A purely descriptive science of behavior must be lean in its terminology, avoiding the use of private,...
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