pathways and crossroads to colorectal cancer

... of apoptosis [12] Caspase is one of the executioner caspases involved in both, the extrinsic and intrinsic pathways of apoptosis Colorectal cancer is the third most common cancer in males and second ... include long duration of actions and feasibility of oral administration It has shown to inhibit cell proliferation and invasion and to induce apoptosis in colorectal cancer cell lines [13,14] In ... reported to have cytotoxic and anti-proliferative actions on various cancer cells [3,4,14-18]; however, the exact mechanisms of apoptosis are not well understood Doxycycline has also been reported to...

Ngày tải lên: 09/08/2014, 04:20

... 66 colorectal cancer patients and 50 controls were used to generate high-resolution MALDI-TOF protein profiles Thirty-four patients out of thirty-seven with early stage disease (stage and 2) and ... found to be too low This makes data comparison and verification between laboratories difficult [66] SELDI-TOF technology is has recently been applied to the identification of responders and non-responders ... primary and metastatic colorectal cancer Cancer Control 2006, 13:27-31 Gal R, Sadikov E, Sulkes J, Klein B, Koren R: Deleted in colorectal cancer protein expression as a possible predictor of...

Ngày tải lên: 09/08/2014, 04:21

... of Colorectal Cancer ic is colorectal cancer incidence rate, rc is colorectal cancer remission rate, m is background mortality rate, fx is colorectal cancer mortality rate Costs of Colorectal cancer ... relation to the null of interventions to reduce Colorectal Cancer in selected WHO subregions Additional file 4: Average Cost per DALY in relation to the null of interventions to reduce Colorectal Cancer ... consumption and colorectal cancer risk: dose-response meta-analysis of epidemiological studies Int J Cancer 2002, 98:241-56 28 IARC Handbooks of Cancer Prevention: Weight Control and Physical...

Ngày tải lên: 13/08/2014, 11:22

... minimizing toxic effects, are critically important The molecular mechanisms of 5-FU cytotoxicity have been characterized, especially its ability to incorporate into RNA and DNA and to inhibit ... molecular signalling pathways modulated by miRNAs, which play a role in colorectal cancer, as well as cancer in general, are only partially characterized miRNA-143 and miRNA-145 (miR-143 and miR-145) ... normal mucosa, both at the adenomatous and cancer stages of colorectal neoplasia, as well as in colon cancer cell lines [3,5] Furthermore, miR-143 is a putative cancer biomarker that is also down-regulated...

Ngày tải lên: 07/03/2014, 00:20

... University of Toronto, Toronto, Ont., Canada 14 Regional Cancer Prevention and Early Detection Network Hamilton, Niagara, Haldimand, Brant., Canada 15 Systemic, Supportive and Regional Cancer Programs, ... Medicine, McMaster University, Hamilton, Ont., Canada Primary Care, Cancer Care Ontario, Toronto, Ont., Canada 10 Prevention and Screening, Cancer Care Ontario, Toronto, Ont., Canada 11 Population ... University, Hamilton, Ont., Canada Hamilton Urban Core Community Centre, Hamilton, Ont., Canada Department of Family and Community Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ont.,...

Ngày tải lên: 10/08/2014, 11:20

... pancreatojejunostomy and a new ileotransversostomy Figure Resection and reconstruction of the superior mesenteric vein with superficial vein segment (A) Distal anastomosis (B) Proximal anastomosis ... pancreatoduodenectomy favors the autogenous conduits Apart from the commonly used saphenous vein (SV) and SMV, autologous reconstructions with the internal jugular vein, left renal vein, and gonadal ... head Hepatobiliary Pancreat Dis Int 2004, 3:612-615 O’Sullivan AW, Heaton N, Rela M: Cancer of the uncinate process of the pancreas: surgical anatomy and clinicopathological features Hepatobiliary...

Ngày tải lên: 10/08/2014, 23:20

... study are: to explore patients' and physicians' attitudes towards the use of shared decision making in the setting of colorectal cancer; to identify and explore the enablers and barriers to the use ... making in the setting of colorectal cancer; and identify and explore strategies to promote shared decision making in the setting of colorectal cancer Methods Overview Prior to the start of this project, ... will be obtained Standard principles of qualitative research methods will be used to conduct interviews with colorectal cancer patients and their physicians to learn whether and how shared decision...

Ngày tải lên: 11/08/2014, 05:21

... study are: to explore patients' and physicians' attitudes towards the use of shared decision making in the setting of colorectal cancer; to identify and explore the enablers and barriers to the use ... making in the setting of colorectal cancer; and identify and explore strategies to promote shared decision making in the setting of colorectal cancer Methods Overview Prior to the start of this project, ... will be obtained Standard principles of qualitative research methods will be used to conduct interviews with colorectal cancer patients and their physicians to learn whether and how shared decision...

Ngày tải lên: 11/08/2014, 16:20

... http://www .cancer. gov/cancertopics/types/colon -and- rectal American Cancer Society Detailed Guide: Colon and Rectum Cancer, How is Colorectal Cancer Staged Accessed 1-11-7 http://www .cancer. org/docroot/CRI/content/CRI_2_4_3X_How_is_colon _and_ rectu ... 5-FU and Irinotecan efficacy and toxicity is important for the development of more efficient and less toxic treatment strategies for patients with colorectal cancer The goal of this study was to ... (American Cancer Society Detailed Guide: Colon and Rectum Cancer, How is Colorectal Cancer Staged) Stage I: T1 N0 M0; T2 N0 M0 Cancer is contained to inner lining Stage II: T3 N0 M0; T4 N0 M0 Cancer...

Ngày tải lên: 24/08/2014, 10:58

... patients by MALDI-TOF MS We used WCX magnetic beads to screen potential serum biomarkers for colorectal cancer detection A total of 264 serum samples from colorectal cancer patients and healthy volunteers ... Ramacciato G, de Angelis R, et al The role of CEA, TPA and CA 19-9 in the early detection of recurrent colorectal cancer Int J Colorectal Dis 1989; 4:230-233 20 Rodland KD Proteomics and cancer ... models of colorectal cancer, breast cancer, and chronic myelogenous and acute lymphoblastic leukaemia J Exp Clin Cancer Res.2005; 24(4):505-14 O'Connell JB, Maggard MA, Ko CY Colon cancer survival...

Ngày tải lên: 25/10/2012, 11:18

... cetuximab should have the option to continue therapy until they and their consultants consider it appropriate to stop Clinical need and practice 2.1 Colorectal cancer is a malignant neoplasm arising ... (colon and rectum) Colorectal cancer is the third most common cancer in the UK, with approximately 30,000 new cases registered in England and Wales in 2002 This represents 12% of all new cancer ... Bowel Cancer Cancer Voices Cancerbackup Bowel Cancer UK (Colon Cancer Concern) CORE (Digestive Disorders Foundation) Long-term Medical Conditions Alliance Lynn’s Bowel Cancer Campaign Macmillan Cancer...

Ngày tải lên: 14/02/2014, 22:20

... hypothesized to lead to HPV incidence, persistence, and progression to cervical precancer and cancer (Castle and Giuliano 2003) Studies that directly evaluate womens immune response to HPV infection ... ability to produce and secrete the inflammatory cytokine TNF- (Sakuishi, Apetoh et al 2010) At later time points of the persistent infection, the cells also fail to produce IFN- and lose their cytotoxic ... into viral persistence and failed to produce effector cytokines such as IL-2 and TNF- Recently, IL-21 was identified as an essential component of CD4+ T cell help to sustain CD8+ T cell effector...

Ngày tải lên: 07/03/2014, 20:20

... JA, and methyl viologen (MV) The ectopic expression of GhMPK2 in transgenic tobacco plants led to enhanced resistance to fungi and viruses This resistance was most probably attributable to elevated ... of MV (0, and 10 lm) for 72 h, and then immersed in 80% acetone for 48 h to extract the chlorophyll; the disks were then subjected to spectrophotometric measurement of chlorophylls a and b The ... signaling pathways Results Expression of GhMPK2 was upregulated by oxidative stress and phytohormones To study the effect of oxidative stress and signaling molecules on the expression of GhMPK2, total...

Ngày tải lên: 14/03/2014, 23:20

... history and tend to present at a more advanced stage of the disease Long and short-term incidence of colorectal cancer is also affected by aspirin intake and this effect may be Colorectal Cancer ... Instability in colorectal cancer Cancer Res 1998;58:5248-57 Breivik J, Ragnhild AL, Gunn IM et al ; Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors ... of family history and the risk of colorectal cancer New England J Of Medicine 1994; 331: 1669-74 Goh KL, Quek KF, Yeo GTS et al Colorectal cancer in Asians: a demographic and anatomic survey...

Ngày tải lên: 17/03/2014, 02:20

... J et al Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer Cancer Res 2003; 63; 4805–4808 96 Vandrovcova J, Lagerstedt-Robinsson ... immunohistochemistry for Methylguanine DNA Methyltransferase (MGMT); f, immunohistochemistry for MLH1] The glands to the left are normal and show nuclear expression of both MGMT and MLH1 The gland ... integral to CRC research References Iacopetta B Are there two sides to colorectal cancer? Int J Cancer 2002; 101; 403–408 Vogelstein B, Fearon ER, Hamilton SR et al Genetic alterations during colorectal- tumor...

Ngày tải lên: 22/03/2014, 17:20

... necrosis factor-α (TNF-α) or the TNF-related apoptosis-inducing ligand (TRAIL), and cellular mediators in the apoptotic pathway such as the pro-apoptotic members of Bcl-2 family and adaptors that ... New Pathways and Cell Death in Breast Cancer and results from intracellular signaling thereafter, which ultimately leads to the degradation of functional proteins, destroy of cytoskeletons and ... activation and ultimately the cleavage of various protein substrates and apoptosis of the cell (Houston & O’Connell, 2004; Wajant, 2002) In addition to FasL/Fas, other death receptors and ligands have...

Ngày tải lên: 23/03/2014, 17:20

... response to the disproportionate incidence of advanced-stage breast cancer and high fatality rates is to stress the importance of educating women to recognize the early signs of breast cancer and to ... Access to Care • S25 Toronto Sunnybrook Regional Cancer Center, and Cancer Care Ontario, Toronto, Ontario, Canada; Martin Yaffe, PhD, Ontario Breast Screening Program, Toronto, Ontario, Canada; Shahla ... Detection and Access to Care • S19 goal of detecting a greater proportion of breast cancers when they are asymptomatic, but also downsizing symptomatic breast cancers as well In the United Kingdom, Stockton...

Ngày tải lên: 29/03/2014, 01:20

... Molecular Medicine, vol 50: Colorectal Cancer: Methods and Protocols Edited by: S M Powell © Humana Press Inc., Totowa, NJ 25 26 El-Rifai and Knuutila Fig CGH karyotype (upper) and profile of DNA copy ... PACs, BACs, and YACs while generFrom: Methods in Molecular Medicine, vol 50: Colorectal Cancer: Methods and Protocols Edited by: S M Powell © Humana Press Inc., Totowa, NJ 35 36 Pack and Zhuang ... Hence, histologic analysis of tumors will remain an From: Methods in Molecular Medicine, vol 50: Colorectal Cancer: Methods and Protocols Edited by: S M Powell © Humana Press Inc., Totowa, NJ...

Ngày tải lên: 10/04/2014, 22:22

... acid-free paper To yesterday's, today's, and tomorrow's cancer and pain patients, who deserve the best And to my mother and father, who always did their level best: her passing humbled me and opened ... characteristics together and define a tumor's stage and site: TO to T4 to rate the size of a primary tumor, NO to N3 to distinguish whether nearby lymph nodes are affected, and MO to indicates an ... understanding the strategies doctors use in treating cancer pain Chapter covers how to identify doctors who use modern approaches to treating pain and how to be assertive in ensuring that pain and...

Ngày tải lên: 11/06/2014, 09:59

... of progenitor and stem cells: molecular analysis of cytotoxic T cell clones Folia Histochem Cytobiol 2007, 45:5-14 Long SA, Khalili J, Ashe J, Berenson R, Ferrand C, Bonyhadi M: Standardized ... colorectal cancer J Pathol 1997, 182:318-24 Naito Y, Saito K, Shiiba K, Ohuchi A, Saigenji K, Nagura H, Ohtani H: CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal ... cell and macrophage peritumoral infiltration in colorectal cancer Oncol Rep 2003, 10:309-13 Chiba T, Ohtani H, Mizoi T, Naito Y, Sato E, Nagura H, Ohuchi A, Ohuchi K, Shiiba K, Kurokawa Y, Satomi...

Ngày tải lên: 18/06/2014, 16:20