pathophysiology of dupuytren s disease

... neurodegenerative diseases: Parkinson s disease, PD, Alzheimer disease, AD, Multiple sclerosis, MS, Amiotrofic Lateral Sclerosis, ALS 38 Etiology and Pathophysiology of Parkinson 's Disease PD LINGO1 ... Pathophysiology of Parkinson 's Disease Genetics of Parkinson Disease 19 The classic approaches of linkage analysis and positional cloning have been very successful strategies to identify genes causing the ... molecular pathways involved in the pathological process responsible for causation of Parkinson s disease A great focus has been given to pathophysiology of Parkinson s disease, role of basal ganglia...

Ngày tải lên: 27/06/2014, 19:20

... robust model of parkinsonism Proceedings of the National Academy of Sciences, of the United States of America, 102, 2174 2179 1: THE ETIOPATHOGENESIS OF PARKINSON S DISEASE: BASIC MECHANISMS OF ... which slows or stops disease progression ACKNOWLEDGEMENT This study was supported by grants from the NIH/NINDS (1 RO1 NS045999-01), the Bendheim Parkinson s Disease Center, and the Morris and ... these positive symptoms of PD ANIMAL MODELS OF PARKINSON S DISEASE AND PARKINSONISM Early animal models of PD were based on lesions of midbrain areas in monkeys (Poirier et al., 1975) These anatomical...

Ngày tải lên: 14/02/2014, 17:20

... a-syn, proteins that displayed increased (›) or decreased (fl) expression as a consequence of a-synuclein overexpression; complex, proteins that displayed altered levels as a result of the association ... silver-stained gel images revealed 28 spots whose intensity was significantly different in at least one of the four groups considered (Fig 2) Two groups of spots showing remarkable changes in the isoform ... present study could represent a valuable starting-point for focused investigations aiming to better understand the key issues of PD pathogenesis Materials and methods Cells Human neuroblastoma SH-SY5Y...

Ngày tải lên: 15/02/2014, 01:20

... of their parents.[1] Scrofula, which is another disease closely allied to consumption, is hereditary also; and hip disease, disease of the spine, abscesses, and enlarged glands in any members ... Afterwards may be studied the diseases of the head, the chest, and the bowels; next constitutional diseases, such as consumption and scrofula; and lastly, the various fevers, as typhoid, or, as it is ... great causes of mortality in infancy, and of sickliness in later life The statistics of Foundling Hospitals bear sad testimony to the fact of its dangers, and the researches of physicians show that...

Ngày tải lên: 17/02/2014, 23:20

... as AD progresses Behavioral and personality changes, including agitation, aggression, and psychosis, often emerge as the disease progresses Depressed mood often occurs with AD Brain autopsies ... Parkinson s disease than in DLB The diagnosis is supported by a history of syncope, falls, confusion, extreme sensitivity to the movement side effects of neuroleptics, delusions, and other types of ... Cognitive screening includes using validated screening instruments, such as the MMSE, and brief bedside assessments Cognitive screenings are usually sensitive to significant cognitive impairment associated...

Ngày tải lên: 05/03/2014, 23:20

... development of a variety of movement disorders These diseases are conventionally categorized into either hypokinetic disorders, such as Parkinson s disease, or hyperkinetic disorders such as hemiballism ... existence of movement disorders such as Huntington s disease (HD) or dystonia, which seem to cross the boundary between these diseases Another common misconception is that movement disorders are ... humans with such disorders The most serious shortcoming of the aforementioned scheme of parkinsonian pathophysiology is, perhaps, that changes in the spontaneous discharge patterns, and the responses...

Ngày tải lên: 05/03/2014, 23:20

... development is the result of an aberrant shift in activity of tau kinases and phosphatases [3] Thus, although targeting plaques and NFTs may ameliorate some of the consequences of AD and no doubt lessen ... enzymes because activity of the enzymes is dependent on optimal metal loading Cu deficiency is central to the recessive Menkes and Wilson diseases, and has been implicated in AD Just as excess Cu ... inhibition of synaptic transmission is dependent on the presence of Ab oligomers, and that Ab monomers are relatively nontoxic in these assays [56,57] As described above, synaptically released Zn is required...

Ngày tải lên: 07/03/2014, 10:20

... Alzheimer s disease and dementia will find this book of interest, including physicians, medical students, psychologists, scientists, graduate students, and allied health professionals including nurses, social ... lipofuscinosis Multiple infarct dementia “Binswanger s disease “Small vessel ischemic disease CADASIL Schizophrenia Dementia syndrome of depression Bipolar disorder Malingering Obsessive compulsive disorder ... what Alzheimer s Disease 31 neuropathologists are now confirming as “Alzheimer s disease (Consensus recommendations for the postmortem diagnosis of Alzheimer s disease The National Institute on Aging,...

Ngày tải lên: 14/03/2014, 21:20

... index ISBN 1-85070-943-2 Extrapyramidal disorders Atlases Parkinsonism Atlases Movement disorders Atlases I Title II Series [DNLM: Parkinson Disease atlases Basal Ganglia Diseases atlases Movement ... characteristics of Parkinson 's disease must take into account the inaccuracies of clinical diagnosis In a successive series of 100 patients with a clinical diagnosis of Parkinson 's disease, only ... Parkinson s disease ©2004 CRC Press LLC Figure 11 Posture in later-stage Parkinson s disease Figure 12 Parkinson s disease: Impaired fist clenching Figure 13 Parkinson s disease: Tremor illustrated...

Ngày tải lên: 14/03/2014, 22:20

... ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 11 Posture in later-stage Parkinson s disease AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 12 Parkinson s disease: impaired fist ... hippocampus 4 AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure Parkinson s disease: horizontal sections of midbrain (upper) and pons (lower) Courtesy of S. E.Daniel, The Parkinson s Disease Society ... RD, Bakay RA Neurosurgical horizons in Parkinson s disease Neurology 1993;43:l–7 Parkinson 's disease Any discussion of the clinical characteristics of Parkinson s disease must take into account...

Ngày tải lên: 14/03/2014, 22:20

... localization of these isoforms in the brain In order to try to understand how these isoforms may differ, we examined the expression of the isoforms known to be transcribed in brain tissue, isoforms RCAN1-1 ... Alzheimer s Disease Research Center at the University of Southern California s Keck School of Medicine, Los Angeles, CA Brain tissues, with a postmortem interval of less than h, were fresh frozen ... Importantly, this complements data from rat tissues showing that calcineurin is also expressed in neurons [14,15] RCAN1 gene expression is significant in several tissues, particularly human brain, spinal...

Ngày tải lên: 16/03/2014, 11:20

... disorders, is representative of a number of inherited diseases The initiation of the disease process depends on the size of polyglutamine tails [32] The cognitive and psychiatric decline is caused ... basis of the changes in Vmax We examined the possibility that not only the expression levels of the same isoenzymes was altered in HD, but also different isoenzymes had been brought to expression, ... impairment suggested for HD [7] is not understood in detail Data from post mortem tissues (caudate and putamen of the striatum) of HD patients [8,9] suggest decreased activities of mitochondrial respiratory...

Ngày tải lên: 23/03/2014, 10:20

... caspases The striking similarity between the substrates for caspases and calpains raises the possibility that both protease families contribute to structural dysregulation and functional loss of ... apoptosis the hyperphosphorylation of neurofilaments and tau seen at early stages of AD Besides the alteration of the structure and properties of tau [the most studied member of the microtubuleassociated ... a-secretase substrate in the regulated APP a-processing [37,38] These results support the hypothesis of a decrease in calpain activity during aging leading to selective accumulation of its substrates...

Ngày tải lên: 23/03/2014, 10:21

... ~8 weeks, ~10 weeks, ~12 weeks, and ~13 weeks Discussion Gait disturbances are characteristic of Parkinson 's disease, Huntington 's disease, and amyotrophic lateral sclerosis Gait reflects several ... image analyses The treadmill belt was wiped clean between studies if necessary Statistics Data are presented as means ± SE ANOVA was used to test for statistical differences among saline-treated, ... aspects of pathogenesis and pathology of motor dysfunction, we also studied gait dynamics in the SOD1 G93A transgenic mouse model of ALS [39] to compare gait variability in mouse models of basal...

Ngày tải lên: 19/06/2014, 10:20

... actions of NSAIDs whereas inhibition of the constitutively expressed form (COX-1) is responsible for the gastrointestinal side effects [25] In this study we used the intrastriatal administration of ... section series was performed using an optical fractionator probe The precision of the serial section analyses was assessed by the coefficient of error (p < 0.05) TH positive cell bodies were counted ... These results show that celecoxib produced a selective reduction of local microglial reaction in response to the neurotoxin Discussion Regular intake of nonaspirin NSAIDs (and high dose of aspirin)...

Ngày tải lên: 19/06/2014, 22:20

... increased levels of cytokines in the brains of Alzheimer 's disease patients, and in transgenic mouse models of Alzheimer 's disease [10-12] However, all these reports have focused on a small number ... expressed in picograms per milligram of protein P < 0.05 was considered statistically significant Table 1: Quantification of Aβ levels in TgAPPsw and PS1/APPsw mouse brain slices Data expressed as ... review see [62]) Future studies will assess the relative proportions of monomers/dimers, oligomers or fibrils occurring in these mice brains and their relationship with the cytokine increases observed...

Ngày tải lên: 19/06/2014, 22:20

... performed on sections processed at the same time Single ANOVA statistical analysis was used to assess the significance of the differences in plaque area, glial and C3 activation products reactivity ... of the numbers of Aβ-positive objects (or the sum of the areas of the Aβ positive objects) for the entire section and dividing by the sum of the areas of all ROIs This analysis was performed blinded ... traditional image analysis approach Thus, this method is shown to accurately assess amyloid burden in transgenic mouse models of AD In addition, the use of object-based analysis provides data not obtainable...

Ngày tải lên: 19/06/2014, 22:20

... loss instead of a loss of TH expression To determine whether valdecoxib could prevent not only MPTP-induced loss of SNpc dopaminergic neurons but also the loss of striatal dopaminergic fibers, ... counts were performed by using a computer-assisted image analysis system consisting of a Zeiss Axioskop2Plus photomicroscope equipped with a MS-2000 (Applied Scientific Instrumentation, Eugene, ... ANOVA showed significant differences, pairwise comparisons between means were tested by Bonferroni post hoc testing Statistical significance was set at p < 0.05 for all analyses Results Valdecoxib...

Ngày tải lên: 19/06/2014, 22:20

... Presence No 280 (57.9%) Yes 204 (42.1%) - statistical mean Statistics Statistical analyses were performed with an SPSS program (version 14.0) Analyses for CRP SNPs and haplotypes used the most ... drugs; SNPs: single nucleotide polymorphisms; SP: senile plaques; TASTY: Tampere autopsy study; TMAs: tissue microarrays Acknowledgements Many thanks to Heini Huhtala and Ilkka Seppälä (for assistance ... development of lesions, which then leads to other processes and damage to neurons, thus setting off a chain of events leading to AD The absence of statistically significant associations between...

Ngày tải lên: 19/06/2014, 22:20