pathology of ovarian tumors in mutation carriers

... have pointed to ovarian endometrioid adenocarcinoma occupying the second position in EOC incidence rank [24,25] In contrast, our analysis has indicated equal proportions of both ovarian mucinous ... impacts of age-related diseases, as cancer, on individuals quality of life In developing countries, as Brazil, the referred increased lifespan of the population is a milestone event in determining ... benign epithelial ovarian tumors (adenomas), tumors of low malignant potential (borderline tumors) , or malignant epithelial tumors (adenocarcinomas); being the latest the focus of the present article...

Ngày tải lên: 20/06/2014, 08:20

... University of Washington and Virginia Mason Medical Center, both in Seattle Women visiting either of primary care clinics (Family Medicine and Women’s Clinic) at the University of Washington were ... Severity of or Higher* No (%) of Women Symptom Ovarian Cancer (n = 44) Benign Ovarian Mass (n = 84) IBS (n = 109) Clinic (n = 1600) P Value Type of pain Pelvic Abdominal Indigestion Bloating Increased ... with ovarian cancer were significantly more likely to have pelvic pain, abdominal pain, difficulty eating, bloating, increased abdominal size, and urinary urgency compared with women seeking care...

Ngày tải lên: 29/03/2014, 01:20

... described in the preceding section suggest that initiating oncogenes strongly influence gene expression in the tumors arising in these two Genome Biology 2005, 6:R84 information MMTV-Wnt-1-induced tumors ... signaling [27] Consistent with these reports, we found higher level of Stra6 (P < 0.001, 9.0-fold) in MMTV-Wnt-1-induced tumors than in MMTV-Neu-induced tumors In addition, cellular retinol binding ... phenotype in tumors In addition, using proteins as markers of cell phenotypes, we showed that initiating oncogenes determine the developmental status of mammary tumor cells [8] Members of the Wnt...

Ngày tải lên: 14/08/2014, 14:22

... Mono-aspertyl chlorin e6 N Number of species n Number of binding sites per PVP monomer N0 Number of Ce6 binding sites per PVP molecule NIR Near infrared OSC Oral Squamous carcinoma P Number of PVP monomers ... agencies of other countries [22] However, Photofrin® posed several deficiencies, including poor tumour selectivity, weak absorption in the near infrared region and induction of long-lasting retinal ... thereby diminishing the fluorescence intensity [56] Fluorescence quenching has been utilized mainly for the determination of protein folding sequence, conformational changes of amino acid residues...

Ngày tải lên: 08/09/2015, 19:22

... result in good classification using a small training set, and the result depends on the training set To address this problem, the SVM training is iteratively refined as the level set grows • Defining ... consists of all training points), sensitivity to noise in the training data, and the undesirable behavior that occurs when a class is under-represented in the training data [8] One of the recent ... degrees of user involvement In the second approach, one-class SVM (support vector machine) algorithm is integrated into the level set method Knowing the advantage of one-class SVM in handling the...

Ngày tải lên: 08/11/2015, 17:33

... analysis of cell lines, the ~47 and ~51 kD forms of LRG1 protein were present in both ovarian cancer and NOSE cell lines (Figure 3B); the predominant form detected in all cases was 47 kD Interestingly, ... 11 of 14 benign, including toxic-shock syndrome [13], and during inflammatory responses of cystic fibrosis [33] LRG1 is also increased in serum of patients with hepatocellular carcinoma following ... Gillott DJ, Remorgida V, Anserini P, Ragni N, Grudzinskas JG: Increased expression of one isoform of leucine-rich alpha-2-glycoprotein in peritoneal fluid of women with uterine leiomyomas Arch Gynecol...

Ngày tải lên: 20/06/2014, 07:20

... apoptosis in various cell types including ovary [12-17] In ovarian cancer the expression of the retinol binding proteins involved in RA metabolism is reduced [18] Also it was shown that in the intestine ... 3A) and contained areas of intense staining adjacent to areas of no staining (Figure 4D - 4F) In malignant serous ovarian tumors ALDH1 staining varied (strong to weak or no staining; Figure 5) ... 37°C), deparaffinized in xylene, rehydrated in graded alcohols and rinsed with tap water Sections were examined for histopathology following routine staining with hematoxylin and eosin (H&E; Sigma-Aldrich,...

Ngày tải lên: 20/06/2014, 07:20

... with genotype B being more predominant We had indeed observed that genotypes B and C were the main strains infecting HBV carriers in Malaysia with the former being more predominant However region-wise, ... synthesis of HBV genome The occurrence of cytosine at nucleotide 1858 (C1858 variant) prevents the stable formation of precore stop codon mutation (TGG→TAG) due to the weak binding force with adenine ... Therefore, it is our interest to examine these correlations in HBV originated from Malaysian carriers Materials and Methods Samples A total of 77 sera samples infected with HBV were used in this study...

Ngày tải lên: 02/11/2012, 10:14

... disease-associated mutation found in EGF domains involves cysteine (48%) followed by arginine (11%) and glycine (10%) Although R fi X and G fi X mutations are also involved in polymorphism, C fi X mutations ... (K) The resulting amino acid and the number of occurrences for each mutation (in parenthesis) are shown above each bar Mutations involving cysteines are shown in bold Mutations (%) Amino acid sequence ... substantially increasing the binding [38] Although the structural determinants of the Notch ⁄ ligands interactions are not yet known in detail, the X-ray structure of a receptor binding module comprising...

Ngày tải lên: 16/03/2014, 00:20

... respectively) (D) Immunoblotting of increasing amounts of recombinant citrin and aralar1 Known amounts (as indicated) of bacterially expressed aralar1 and citrin N-terminal regions were loaded on ... antibody directed against its N-terminus, or against Aralar1 amino acids 507– 520 (results not shown) Citrin antibodies were against its N-terminus (upper panels) or against citrin amino acids 305–319 ... distribution becomes predominant in brain, heart and skeletal muscle, whereas citrin expression only predominates in kidney Distribution of AGC isoforms in tissues from the adult rat In adult rat tissues,...

Ngày tải lên: 24/03/2014, 04:21

... diameter[10,13,14] In contrast, the pore size of inter-endothelial cell gaps within the BTB of both brain tumors and peripheral tumors is much larger In the case of brain tumors, inter-endothelial cell gaps have ... limit of pore size within the BTB of peripheral tumors ranges between 200 nm and 1200 nm[15] In the case of malignant brain tumors, we recently probed the upper limit of pore size within the BTB of ... pores in BTB of peripheral tumors are the primary reason for the higher permeability of the BTB of malignant peripheral tumors compared to that of malignant brain tumors Furthermore, such findings...

Ngày tải lên: 18/06/2014, 15:20

... (heavy chain or TAP2) is missing in most tumor samples To determine whether expression of the components of MHC class I processing machinery could be ascribed to infiltrating leukocytes, we stained ... activation of ERK1/2 in medulloblastoma remains to be determined Dysregulation of ERK1/2 has been implicated in tumorigenesis of various cell types Mitogen-activated protein kinases are involved in the ... enabling full blown signaling indicated by increased phosphorylation (P) of intracellular portion of the receptor in metastatic medulloblastoma [35] Excess of β2m protein produced and secreted into...

Ngày tải lên: 18/06/2014, 15:20

... In borderline tumors, TP53 mutation and over-expression may occur, but are not common [46-48] In malignant tumors, the prevalence of TP53 gene mutations increases with increasing stage [44] In ... better investigate the nature of the gene(s) present here that may be involved in the genesis or progression of ovarian borderline tumors Much interest has focused on the loss of genetic information ... 6q27 found so consistently by Tibiletti et al [2] in borderline ovarian tumors was a feature also of the tumors of our series In none of nine informative cases (five with a normal karyotype, four...

Ngày tải lên: 18/06/2014, 16:20

... = negative or faint staining in 10% of cancer cells; = moderate staining; = strong staining A score of was considered negative, a score of was considered ... 21 mutation Discussion EGFR is a member of the ErbB family of receptor tyrosine kinases, which also includes HER2/neu, HER3, and HER4 [15] Activating mutations in the tyrosine kinase domain, involving ... specificity of 100% for the 15-bp deletion antibody Table summarizes the clinicopathological characteristics of patients and the findings of seven studies examining EGFR mutations by IHC, including the...

Ngày tải lên: 18/06/2014, 16:20

... Of 1000 GIST, a PDGFRA exon 18 mutation was found in 122 of the 346 gastric tumors and only two of the 75 small intestinal tumors Ten of the 170 gastric tumors and one of the 54 small intestinal ... out of nine patients, and in three out of nine patients two mutations were found in one or more tumor samples Five recurrent points of mutation were located in the KIT tyrosine kinase domain and ... and/or 558 codons of KIT exon 11 was found in 13 of 15 metastatic tumors and in only two of the nine mutated and not metastatic tumors These results suggested that mutations involving 557 and/or...

Ngày tải lên: 18/06/2014, 19:20

... positive carriers and p

Ngày tải lên: 20/06/2014, 01:20

... Of 1000 GIST, a PDGFRA exon 18 mutation was found in 122 of the 346 gastric tumors and only two of the 75 small intestinal tumors Ten of the 170 gastric tumors and one of the 54 small intestinal ... out of nine patients, and in three out of nine patients two mutations were found in one or more tumor samples Five recurrent points of mutation were located in the KIT tyrosine kinase domain and ... and/or 558 codons of KIT exon 11 was found in 13 of 15 metastatic tumors and in only two of the nine mutated and not metastatic tumors These results suggested that mutations involving 557 and/or...

Ngày tải lên: 20/06/2014, 03:20

... Effects of active immunization of sheep against an amino terminal peptide of the inhibin αC subunit on intrafollicular levels of activin A, inhibin A and follistatin Journal of Endocrinology ... Relationships among concentrations of steroids, insulin-like growth factor-I, and insulin-like growth factor binding proteins in ovarian follicular fluid of beef cattle Biology of Reproduction 1994, 51:971-981 ... important in mediating the effects of FSH on inhibin-A, activin-A, oestradiol and progesterone secretion and also important in mediating IGF-I stimulated inhibin-A, activin-A, follistatin, oestradiol...

Ngày tải lên: 20/06/2014, 07:20

... find out more about the causes that have contributed to this increase The second findings of our study showed that the cohort of endometriosis women had an increased risk of ovarian cancer of ... remains poor, despite significant improvements in surgical treatment and chemotherapy The first interesting results in our study were the constant increase of the number ovarian cancer since ... studies highlighting the increased risk of ovarian cancer in endometriosis patients [6,7,18] Since endometriosis is a common benign gynecological disorder affecting 10% of women during their reproductive...

Ngày tải lên: 20/06/2014, 07:20

... Canevari S, Ferrini S: Expression of interleukin-18 in human ovarian carcinoma and normal ovarian epithelium: Evidence for defective processing in tumor cells International Journal of Cancer 2002, ... are found in both normal ovarian epithelium and human ovarian carcinoma [40,41] Interleukin-18 (IL-18) is a proinflammatory cytokine that stimulates interferon-g production Ovarian carcinoma expresses ... Corning Inc., Corning NY) Cells used for experiments were low passage and maintained in culture for one to three months The doubling time of the cell line was measured by plating 104 cells into...

Ngày tải lên: 20/06/2014, 07:20