pathogenesis of blastic transformation in mpns
Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
Ngày tải lên :
14/02/2014, 18:20
... shown that interactions between KCs and endotoxin comprise the initiating event leading to hepatotoxicity in liver injury, including endotoxemia and ischemia ⁄ reperfusion injury [14] In our studies, ... receptor signaling is independent of Toll-interleukin receptor domain-containing adaptor protein Drug Metab Dispos 36, 95–101 10 Ghose R, Guo T & Haque N (2009) Regulation of gene expression of hepatic ... MA, USA) Binding of all of the antibodies was detected using an ECL detection system (iNtRON Biotechnology, Seoul, Korea) in accordance with the manufacturer’s instructions The intensity of the...
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Mystic Microsoft - A Journey of Transformation in the Halls of High Technology pptx
Ngày tải lên :
14/03/2014, 20:20
... maintain an expansive outlook in their work, seeing it in terms of offering something of real value to the world rather than merely making money In this way, corrosive office politics and interpersonal ... Microsoft was scheduled for the following morning I actually thought about giving it a miss since Boeing’s pending offer would downgrade my interest in the small software firm from “slimly marginal” ... contained in these pages involves one of the most successful business ventures in recent decades and the very heart of hightech, corporate multinationalism: Microsoft I was employed by Microsoft in...
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Báo cáo khoa học: FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis pdf
Ngày tải lên :
23/03/2014, 07:20
... regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid ... post-translational control in RA FLSs As a next step, we investigated the control mechanism underlying the expression of MLN51 following α-amanitin A – + – B + β-actin + + MLN51 β-actin MLN51 β-actin MG-132 MLN51 ... critical role in the proliferation of MH7A cells In order to determine whether MLN51 is involved in the anti-apoptosis as well as cell proliferation of MH7A in response to GM-CSF, we examined the...
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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" pptx
Ngày tải lên :
20/06/2014, 04:20
... examine the pY-Flt-1 and pY-FAK levels in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; less than 10% of cells were positive), (intermediate staining; ... and the clinical stage of GCTs at presentation To determine the status of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; less ... expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone-resorbing OCs (data not shown) To determine the immunolocalization of VEGF...
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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" potx
Ngày tải lên :
20/06/2014, 07:20
... examine the pY-Flt-1 and pY-FAK levels in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; less than 10% of cells were positive), (intermediate staining; ... and the clinical stage of GCTs at presentation To determine the status of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; less ... expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone-resorbing OCs (data not shown) To determine the immunolocalization of VEGF...
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Báo cáo hóa học: " Molecular Dynamics Simulation of Nanoindentation-induced Mechanical Deformation and Phase Transformation in Monocrystalline Silicon" potx
Ngày tải lên :
21/06/2014, 22:20
... spherical indenter was first adopted to interpret phase transformation features in monocrystalline Si We then adopted a Berkovich indenter in the simulations to compare the difference of phases induced ... shown in Fig 3, are in general similar to the ones induced by a spherical indenter, while the phase transformation region of the former is smaller than the latter A ring surrounding Si-II of a ... region in [001] single-crystal silicon Acta Mater 47(80), 2431–2436 (1999) V Domnich, Y Gogotsi, S Dub, Effect of phase transformations on the shape of the unloading curve in the nanoindentation of...
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Báo cáo lâm nghiệp: " Humus conditions and stand characteristics of artificially established young stands in the process of the transformation of spruce monocultures" pdf
Ngày tải lên :
07/08/2014, 03:22
... of a forest ecosystem from the point of view of the element cycle preservation in forest ecosystems and maintaining their ecological stability The condition and form of humus in forest ... (Waring, Running 1998) Forest floor is very important for forest soils affecting a number of their properties It is the regulator of runoff of rainfall water in watersheds, decreases the hazard of ... borderline of the buffer zone of the cation exchangeable capacity where the increased input of hydrogen ions is compensated for by basic cations Thus, compensation of the increased input of hydrogen...
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Báo cáo lâm nghiệp: "Transformation of solar radiation in Norway spruce stands into produced biomass – the effect of stand density" doc
Ngày tải lên :
07/08/2014, 10:21
... years after the thinning similarly like in previous years Positive effects of the high-type thinning in 2001 were reflected in the 17% increase of LAI in 2002 The realized thinning exhibited positive ... very often explained by latitudinal variation in intercepted PAR The values of e obtained for the investigated spruce stand are in the range of published reports The differences in e values obtained ... 233–241 Positive effects of thinning in 2001 were reflected in the 17% increase of LAI in 2002 Reaching or exceeding of the critical LAI value was responsible for a decrease in the radiation use...
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Báo cáo khoa học: "Effects of cyclosporin A treatment on the pathogenesis of avian leukosis virus subgroup J infection in broiler chickens with Marek’s disease virus exposure" ppt
Ngày tải lên :
07/08/2014, 17:22
... likely due to toxic principle of cyclosporin A on Tcell function Cyclosporin A prevents synthesis of cytokines by T cells by blocking a late stage of the signaling pathway initiated by the T-cell ... presence of antibody determined by AGID ALV-J and cyclosporin A Histologic changes within the bursa of Fabricius and thymus in Oil treated chickens were minimal in our experiment, indicating that ... resulted in different levels of expression of viral antigen in tissues [34] In our experiment, CSP treated chickens had higher intensity of viral antigen staining compared to that present in the...
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Báo cáo khoa học: "The effects of cyclophosphamide treatment on the pathogenesis of subgroup J avian leukosis virus (ALV-J) infection in broiler chickens with Marek''''s disease virus exposure" potx
Ngày tải lên :
07/08/2014, 17:22
... hatching [7,11] However, induced moulting or raised circulating corticosterone in adult hens did not influence of ALV infection or shedding Similarly, actively acquired antibody induced by inoculation ... Lucy Lee, ADOL, East Lansing, MI) After IHC staining, sections were counter-stained with hematoxylin, air dried, cover slipped, and examined using light microscopy Staining intensity and extent were ... post-infection, the frequency and intensity of the staining was significantly higher in the CY treated group than in the PBS treated group In our experiment CY treatment increased the rate of viremia,...
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Báo cáo y học: "Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis" doc
Ngày tải lên :
08/08/2014, 21:20
... CCR3 (in order of highest to lowest extent of increased transcript expression) Interestingly, upon examination of transcript expression of signaling pathway proteins and apoptosis-related proteins ... interferon-inducible protein 10 (IP10); leptin; monocyte chemotactic protein-3 (MCP3); monokine induced by gamma interferon (MIG); macrophage inflammatory protein alpha (MIP-1a); macrophage inflammatory ... upregulated in EoE subjects Along with bFGF upregulation, an increase in eotaxin was also seen in EoE subjects Interestingly, IL-5 was increased in the plasma of EoE subjects compared to that of GERD...
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Báo cáo y học: "Implication of granulocyte-macrophage colony-stimulating factor induced neutrophil gelatinase-associated lipocalin in pathogenesis of rheumatoid arthritis revealed by proteome analysis" doc
Ngày tải lên :
09/08/2014, 01:22
... cytokines such as interleukin (IL)1 and IL8 [5] and proteases [6], leading to the inflammation and destruction of the joints in RA Development of neutrophils from haematopoietic stem cells involves ... [15] The intensities of the detected peptides were normalised using that of the bradykinin fragment Western blotting The cultured neutrophils were solubilised in lysis buffer containing 30 mM ... cell line, was cultured in DMEM containing 10% FBS, 100 U/ml penicillin, 100 g/ml streptomycin, and mM glutamine under 5% CO2 at 37°C A total of × 103 cells were seeded into each well of the...
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Báo cáo y học: "Hypoxia in the pathogenesis of systemic sclerosis" ppt
Ngày tải lên :
09/08/2014, 01:22
... and HIF-1α is not ubiquitinated Thus, degradation of HIF-1α in the proteasome is inhibited and HIF-1α protein accumulates Binding of HIF-1 to HIF binding sites, formation of the transcriptional ... be involved in the pathogenesis of profibrotic disorders such as SSc We could demonstrate that hypoxia induced several extracellular matrix proteins, including fibronectin-1, thrombospondin-1, ... modifications of HIF-1α involved in the regulation of HIF-1α transactivation have been identified: hydroxylation of the carboxyl-terminal transactivation domain and protein phosphorylation by tyrosine kinase...
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báo cáo khoa học: "Littoral cell angioma of the spleen in a patient with previous pulmonary sarcoidosis: a TNF-α related pathogenesis?" pot
Ngày tải lên :
09/08/2014, 02:21
... metastatic diseases or disseminated infections [2] Since Figure Neoplastic sinuses lined by a single cell layer (20× obj, HE-staining) Cordesmeyer et al World Journal of Surgical Oncology 2011, ... microscopic examination reveals anastomosing vascular Figure Combined expression of endothelial (CD31) and histiocytic (CD68) markers in immunohistochemical staining Page of channels lined with tall ... increased production of TNF-a, eventually contributing to the pathogenesis of LCA, since inflammatory cells including TNF-a are known to have powerful effects on tumor development, producing an attractive...
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Báo cáo y học: "The role of structural genes in the pathogenesis of osteoarthritic disorder" potx
Ngày tải lên :
09/08/2014, 06:22
... layer protein) Fibronectin PRELP (proline/arginine-rich and leucine-rich repeat protein) Chondroadherin Fibrillin Tenascin-C Elastin MGP (matrix Gla protein) Chondromodulin-I Chondromodulin-II CD-RAP ... [23], linkage analysis of 14 candidate genes in OA kindreds resulted in the exclusion of 10 important cartilage genes, including COL2A1 [40] Analysis of 47 families with the phenotype of earlyonset ... The protein contains several repeat domains, including eight calcium-binding, calmodulin-like repeats Most COMP mutations identified in patients with MED or pseudoachondroplasia are amino acid...
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Báo cáo y học: "Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis" potx
Ngày tải lên :
09/08/2014, 06:22
... arthritis dylarginine deiminase of involvement of hyaluronic of rheumatoid Proposed mechanism (PADI4) in the pathogenesis acid (HA) and peptidylarginine deiminase (PADI4) in the pathogenesis of rheumatoid ... heparin-binding region of antithrombin However, such binding did not stimulate the activity of antithrombin as did heparin and heparan; in fact, it blocked the ability of antithrombin to inhibit ... the interleukin-1 induced synthesis of both nitric oxide and prostaglandin E2 in chondrocytes How Ca2+ and Fe3+ are involved in inhibiting antithrombin by HA is also poorly understood Some investigators...
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Báo cáo y học: "Direct interaction of immunoglobulins with synovial fibroblasts: a missing link in the pathogenesis of rheumatoid arthritis" potx
Ngày tải lên :
09/08/2014, 06:22
... chemoattractants in their fibroblasts J Immunol 2002,168:942-950 Kaufmann J, Franke S, Kientsch-Engel R, Oelzner P, Hein G, Stein G: Correlation of circulating interleukin 16 with proinflammatory cytokines in ... determines the disease specific immune response Given the variety of signaling pathways initiated by IGF-1 in fibroblasts, it may be speculated, as the authors mention briefly, that binding of antibodies ... Bahn RS: Graves’ immunoglobulins and cytokines stimulate the expression of intercellular adhesion molecule-1 (ICAM-1) in cultured Graves’ orbital fibroblasts Eur J Clin Invest 1992, 22:529-537 Rotella...
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Báo cáo y học: "The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration" pdf
Ngày tải lên :
09/08/2014, 06:22
... Treatment of tissue specimens A block of tissue incorporating AF and NP in continuity was fixed and processed into paraffin wax As some specimens contained bone, all the samples were decalcified in ... result in an increase in the gene expression of the aggrecanase ADAMTS4 in cells derived from degenerate NP In vivo, the NP contains the highest concentration of aggrecan in the IVD The response of ... BV: An interleukin-1 loop is induced in human skin fibroblasts upon stress relaxation in a three-dimensional collagen gel but is not involved in the upregulation of matrix metalloproteinase J...
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Báo cáo y học: "γ The role of the complement and the FcγR system in the pathogenesis of arthritis" pdf
Ngày tải lên :
09/08/2014, 06:23
... owing to the absence of its modulatory role in inhibiting FcγR activation [39] Similarly, in RA several lines of evidence have implicated FcRs, in particular IgG-binding receptors (FcγRs), in ... suggesting a more general mechanism of these receptors in inflammatory diseases Maintaining autoantibody titers through FcRn-mediated recycling One of the most striking characteristics of the ... C5a anaphylatoxin is a major regulaγ tor of activating versus inhibitory FcγRs in immune complexinduced lung disease J Clin Invest 2002, 110:1823-1830 Fearon DT: Seeking wisdom in innate immunity...
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