parkinson s disease with dementia pd d

... correlated to clinical measures Some clinical instruments are specific for individuals with IPD and are used to characterize these individuals: Unified Parkinson s Disease Rating Scale (UPDRS)9 and ... the UPDRS Development Committee Unified Parkinson s disease Rating Scale In: Fahn S, Marsden CD, Calne D, Goldstein M (eds) Recent developments in Parkinson s disease Florham Park NJ, USA: Macmillan ... or stand unassisted) and stage (wheelchair bound or bedridden unless aided) The second was the motor section III of the UPDRS9, composed of 14 items (speech, facial expression, tremor at rest,...

Ngày tải lên: 22/03/2014, 14:20

... non-enzymatic condensation of dopamine (DA) with aldehydes or pyruvic acid Increased concentrations of these TIQs are found in the cerebrospinal fluid (CSF) of patients with Parkinson s disease (PD) [1–3] ... Oxidative stress in Parkinson s disease Ann Neurol 53(Suppl 3), S2 6 S3 6 35 Mastore M, Kohler L & Nappi AJ (2005) Production and utilization of hydrogen peroxide associated with melanogenesis and ... Bezard E, Gross CE & Brotchie JM (2003) Presymptomatic compensation in Parkinson s disease is not dopamine-mediated Trends Neurosci 26, 215–221 56 Smissman EE, Reid JR, Walsh DA & Borchardt RT...

Ngày tải lên: 07/03/2014, 05:20

... tolerance and endurance, with total net training time of 30-45 minutes in each session Assessments Assessments included standardized tests of balance and, postural control as well as ADL s to evaluate ... trials was taken; 3) the chair rise (5CR) test was used to assess the ability to perform sit-to-stand and stand-to-sit transfers Patients were instructed to stand up and sit down five times as fast ... Geriatric Depression Scale short form (GDS-15) was used for the assessment of emotional wellbeing and depressive mood [31] Data analysis Descriptive statistics were used to evaluate the effects of...

Ngày tải lên: 19/06/2014, 08:20

... Time is registered in seconds, and gaitspeed is calculated as meters per second (m /s) A digital stopwatch is used In the study by Smithson et al One leg stance (OLS) was performed with the opposite ... FES (S) , n = 10 Admission day With anti -PD medication DBS ON Timed Up & Go (s) One leg stance (s) Sharpened Romberg (s) (eyes open) Sharpened Romberg (s) (eyes closed) BBS FES (S) Total score DBS ... assessment of postural stability in subjects with Parkinson' s disease J Neurol Neurosurg Psychiatry 2006, 77:322-326 Dibble LE, Lange M: Predicting falls in individuals with Parkinson disease: ...

Ngày tải lên: 19/06/2014, 08:20

... Controls PD Figure Gait parameters under different conditions in controls and subjects with Parkinson' s Disease Gait parameters under different conditions in controls and subjects with Parkinson' s Disease ... Progression of Parkinson s Disease Figure stimuli Schematization of responsiveness of PD subjects to visual Schematization of responsiveness of PD subjects to visual stimuli The diagram represents ... and Rehabilitation 2008, 5:3 Background Gait in Parkinson' s disease (PD) is characterized by short shuffling steps, reduced walking speed and increased stride variability, which increased as...

Ngày tải lên: 19/06/2014, 10:20

... Parkinson' s disease (Hoehn and Yahr, 1967) UPDRS is the unified Parkinson' s disease rating scale IPD patients' brains [6-8] and utilization of mouse models of parkinsonism [9-12] Specifically, roles for ... interactions and their possible implications are discussed Methods Sera and IPD patients During a routine office visit, IPD patients were asked if they would consider participation in a research ... unified Parkinson' s disease rating scale (UPDRS) scores (Table 1) The UPDRS is a combined score from the physician 's evaluation of motor activity including temors, rigidity, posture, gait, and bradykinesia...

Ngày tải lên: 19/06/2014, 22:20

... PDQ-39: 39-item Parkinson' s disease questionnaire; PDQUALIF: Parkinson' s disease quality of life scale; PFS16: 16-item Parkinson fatigue scale; SD: Standard deviation; SF-36: Medical Outcomes ... Parkinson' s disease: translation is not enough Parkinsonism Relat Disord 2003, 10:89-92 15 Hagell P, Nilsson MH: The 39-item Parkinson' s Disease Questionnaire (PDQ-39): is it a unidimensional construct? ... Figure Selected response categories Selected response categories for three-, four-, five-, and six-category response scales as determined from observed visual analog scales (VAS) values See Methods...

Ngày tải lên: 20/06/2014, 16:20

... with Lewy bodies and Parkinson' s disease are two disorders Moving Along 2003, 5:5 Aarsland D, Ballard CG, Halliday G: Are Parkinson' s disease with dementia and dementia with Lewy bodies the same ... "has not yet obtained a place in the classification of nosologists Some have regarded its characteristic symptoms as distinct and different diseases, and others have given its name to diseases differing ... of Parkinson' s disease J Neural Transm Suppl General Section 2002, 109:329-339 Hardy J: Dementia with Lewy bodies and Parkinson' s disease are one disorder Moving Along 2003, 5:4 Lees AJ: Dementia...

Ngày tải lên: 08/08/2014, 21:20

... in Parkinson' s disease: a case-control study Neurology 2006, 67:1225-29 Camp GV, Flamez A, Cosyns B, Goldstein J, Perdaens C, Schoors D: Heart valvular disease in patients with Parkinson' s disease ... patients with Parkinson' s disease and non-parkinsonian controls suggests that the risk of substantial valve regurgitation is 5-6 times higher in patients with Parkinson' s disease treated with cabergoline, ... cusps were thickened and had dense, diffuse fibrosis and some calcification The histopathologic examination revealed diffuse excessive fibrosis, local hyelinosis and dystrophic calcifications...

Ngày tải lên: 10/08/2014, 10:20

... domains A second limitation was that the measure of professional contacts was crude and not validated against a gold standard However, it was straightforward and easy to understand Third, the distinction ... the difference was also significant but lower in professionals with ≥10 PD patients No statistical difference was found for three measures: density, incloseness centrality, and outcloseness centrality ... is highest in health professionals who treat ≥10 PD patients and in those affiliated with a specialized hospital department Thus, connectedness with those two types of health professionals is...

Ngày tải lên: 10/08/2014, 11:20

... 11.3 Parkinson s Disease Parkinson s disease (also known as Parkinson disease or PD) is a degenerative disorder of the central nervous system that often impairs the sufferer s motor skills and speech ... John s wort with controls, including placebo or antidepressant drugs; and (4) if they measured outcomes with questionnaires assessing depressive symptoms, such as the Hamilton Depression Scale ... stimulants” (Japanese studies show it stimulates feeding of silkworm larvae; studies with neurological disorders (Parkinson s, ALS, MS) show mixed results) 11 Use of Selected Medicinal Herbs for Chemoprevention...

Ngày tải lên: 25/10/2013, 05:20

... oligomerizes and aggregates, is resistant to UPS-mediated degradation and PARKINSON S DISEASE AND PARKINSONISM PARKINSON S DISESASE Sporadic Autosomal Dominant SYN LRRK2 UCH-L1 GENES TOXIN Autosomal ... THERAPEUTICS of PARKINSON S DISEASE and OTHER MOVEMENT DISORDERS Therapeutics of Parkinson s Disease and Other Movement Disorders Edited by Mark Hallett and Werner Poewe © 2008 John Wiley & Sons, Ltd ISBN: ... which slows or stops disease progression ACKNOWLEDGEMENT This study was supported by grants from the NIH/NINDS (1 RO1 NS045999-01), the Bendheim Parkinson s Disease Center, and the Morris and Alma...

Ngày tải lên: 14/02/2014, 17:20

... has been generally confirmed in animal models of Parkinson s disease, and is also supported by recording studies in humans undergoing functional neurosurgery as treatment for Parkinson s disease ... Huntington s disease, and Parkinson brains Of the 14 cases with basal ganglia disease, only the PD cases had a severe loss of DA in the caudate and putamen (Ehringer and Hornykiewicz, 1960) Ehringer and ... introduced L-dopa therapy Hoehn and Yahr reported on 802 subjects derived from a retrospective clinical sample of 856 patients diagnosed with paralysis agitans, Parkinson s Disease and Parkinsonism seen...

Ngày tải lên: 14/02/2014, 17:20

... Identified from SWISS 2D- PAGE database dehydrogenase and to mitochondrial ATP synthase a subunit by comparison with 2D electrophoresis (2-DE) maps available in the SWISS 2D- PAGE database (http://www.expasy.org) ... cells also was not significantly affected by a-synuclein overexpression (Fig S2 ) Discussion Proteins differentially expressed in this model are individually linked to PD Most of the identified proteins ... a-syn, proteins that displayed increased (›) or decreased (fl) expression as a consequence of a-synuclein overexpression; complex, proteins that displayed altered levels as a result of the association...

Ngày tải lên: 15/02/2014, 01:20

... vesicles J Neurochem 78, 42–54 Autosomal recessive genes in Parkinson s disease 10 Wood-Kaczmar A, Gandhi S & Wood NW (2006) Understanding the molecular causes of Parkinson s disease Trends Mol ... of sporadic cases with disease onset before the age of 20 [2] Clinically, PD patients with mutations in PARK2 suffer a slow progression of the disease commonly associated with early-onset dystonia ... that DJ-1 specifically interacts with Parkin under stress conditions Specifically, this association is mediated by pathogenic DJ-1 mutations and oxidative stress [76] These data suggest a link DJ-1...

Ngày tải lên: 18/02/2014, 14:20

... UDP glycosyltransferase; CK, ceramide kinase; CS, ceramide synthase; DES, desaturase; GALC, galactosylceramidase; GBA, glucosylceramidase; GCS, glucosylceramide synthase; SMS, sphingomyelin synthase; ... pathology was used as a basis to understand the disease, pathways involved became evident This would be most unlikely to happen if, instead, clinical data was used These data are incomplete and there ... G201 9S dardarin substitution is a common cause Ceramide metabolism and Lewy body disease 52 53 54 55 56 of Parkinson s disease in a Portuguese cohort Mov Disord 20, 1653–1655 Gilks WP, Abou-Sleiman...

Ngày tải lên: 18/02/2014, 14:20

... Gets Parkinson s Disease? 25 PART II Signs and Symptoms of Parkinson s Disease Early Symptoms 43 Moderate Parkinson s Disease 59 Advanced Parkinson s Disease 82 Behavioral Changes and Psychiatric ... Whenever a diagnosis of Parkinson s disease is made, patients and families naturally ask, “What is Parkinson s disease? ” As doctors treating people with Parkinson s, of course, we discuss this question ... GETS PARKINSON S DISEASE? / 31 Studies with identical twins seem to indicate that heredity alone does not cause Parkinson s The medical profession considers such studies the best possible test—the...

Ngày tải lên: 19/02/2014, 04:20

... PARKINSON' S DISEASE AND MOVEMENT DISORDERS: DIAGNOSIS AND TREATMENT GUIDELINES FOR THE PRACTICING PHYSICIAN CURRENT CLINICAL PRACTICE Parkinson s Disease and Movement Disorders: Diagnosis and ... AND JOHN A ANDERSON, 1997 Osteoporosis: Diagnostic and Therapeutic Principles, edited by CLIFFORD J ROSEN, 1996 PARKINSON' S DISEASE AND MOVEMENT DISORDERS DIAGNOSIS AND TREATMENT GUIDELINES FOR ... Eric Ahlskog, PhD, MD Motor Speech Disorders: Clues to Neurologic Diagnosis 35 Joseph R Duffy, PhD B PARKINSON S DISEASE 55 What Is Parkinson s Disease? Neuropathology, Neurochemistry, and Pathophysiology...

Ngày tải lên: 05/03/2014, 23:20

... Reports of movement disorders secondary to extrastriatal pathology should therefore come as no surprise 3.1 Parkinson s Disease Early idiopathic Parkinson s disease (PD) is a well-circumscribed pathologic ... movement disorders such as Parkinson s and Huntington s diseases (PD/ HD) These structures classically include: 1) the striatum, which comprises the caudate nucleus (CD), putamen (PUT), and nucleus accumbens ... segments of the globus pallidus (Gpe and Gpi, respectively) for normal (NL) and parkinsonian (PD) monkeys, and for human patients with Parkinson' s disease (PD) , Hemiballismus (HB), and dystonia (DYS)...

Ngày tải lên: 05/03/2014, 23:20