parkinson s disease and alzheimer s disease

... 11.3 Parkinson s Disease Parkinson s disease (also known as Parkinson disease or PD) is a degenerative disorder of the central nervous system that often impairs the sufferer s motor skills and speech ... functions, neurotransmitter levels, emotional stress, and progression of neurodegenerative conditions such as Parkinson s and Alzheimer s diseases (Rahman et al., 2008) 11.4 Heart Disease 11.4.1 Case ... flesh, including essential fatty acids from seeds and seed oils, and fibers, such as microcrystalline cellulose, pectins, lignins, cutin-like polymers, and condensed tannins, have been suggested...

Ngày tải lên: 25/10/2013, 05:20

... degradation and PARKINSON S DISEASE AND PARKINSONISM PARKINSON S DISESASE Sporadic Autosomal Dominant SYN LRRK2 UCH-L1 GENES TOXIN Autosomal Recessive AGING PARKIN DJ-1 Protein O abnormal autophagy UPS ... THERAPEUTICS of PARKINSON S DISEASE and OTHER MOVEMENT DISORDERS Therapeutics of Parkinson s Disease and Other Movement Disorders Edited by Mark Hallett and Werner Poewe © 2008 John Wiley & Sons, Ltd ISBN: ... McNaught, K .S and Jenner, P (2001) Proteasomal function is impaired in substantia nigra in Parkinson s disease Neuroscience Letters, 297 (3), 191 194 20 PARKINSON S DISEASE AND PARKINSONISM McNaught,...

Ngày tải lên: 14/02/2014, 17:20

... L.: Sleep disturbances and excessive daytime sleepiness in Parkinson disease: an overview Arnulf, I.: Sleep and wakefulness disturbances in Parkinson s disease ... Disease and Parkinsonism seen at the Columbia-Presbyterian Medical Center from 1949 to 1964 Nearly 85% had classic Parkinson s Disease and 13% had post-encephalitic associated Parkinsonism This ... congress site and was often seen discussing topics of mutual interest with congress participant s There was an interesting new study presented by Professor Deuschl, Kiel, in which he demonstrates...

Ngày tải lên: 14/02/2014, 17:20

... biology and oxidative stress in Parkinson disease pathogenesis Nat Clin Pract Neurol 4, 600–609 Lesage S & Brice A (2009) Parkinson s disease: from monogenic forms to genetic susceptibility factors ... represent a valuable starting-point for focused investigations aiming to better understand the key issues of PD pathogenesis Materials and methods Cells Human neuroblastoma SH-SY5Y cells were cultured ... network, as well as statistically significant functional association with GO classifications [16] Western blotting Expression of a-synuclein and HSP70 was determined by western blotting Proteins (80...

Ngày tải lên: 15/02/2014, 01:20

... PARKINSON' S DISEASE AND MOVEMENT DISORDERS: DIAGNOSIS AND TREATMENT GUIDELINES FOR THE PRACTICING PHYSICIAN CURRENT CLINICAL PRACTICE Parkinson s Disease and Movement Disorders: Diagnosis and ... disorders On the island of Guam, amyotrophic lateral sclerosis, parkinsonism, and dementia occur in various combinations, perhaps as manifestations of the same disease process Outside Guam, the association ... paresis, however, has sinister implications; it is typical of certain multisystem cerebral disorders, such as progressive supranuclear palsy, variants of Niemann-Pick disease, and, sometimes,...

Ngày tải lên: 05/03/2014, 23:20

... disorders These diseases are conventionally categorized into either hypokinetic disorders, such as Parkinson s disease, or hyperkinetic disorders such as hemiballism or drug-induced dyskinesias ... disorders such as Huntington s disease (HD) or dystonia, which seem to cross the boundary between these diseases Another common misconception is that movement disorders are basal ganglia diseases ... pathophysiology of common human movement disorders such as Parkinson s and Huntington s diseases (PD/HD) These structures classically include: 1) the striatum, which comprises the caudate nucleus (CD),...

Ngày tải lên: 05/03/2014, 23:20

... index ISBN 1-85070-943-2 Extrapyramidal disorders Atlases Parkinsonism Atlases Movement disorders Atlases I Title II Series [DNLM: Parkinson Disease atlases Basal Ganglia Diseases atlases Movement ... Parkinson s disease ©2004 CRC Press LLC Figure 11 Posture in later-stage Parkinson s disease Figure 12 Parkinson s disease: Impaired fist clenching Figure 13 Parkinson s disease: Tremor illustrated ... characteristics of Parkinson' s disease must take into account the inaccuracies of clinical diagnosis In a successive series of 100 patients with a clinical diagnosis of Parkinson' s disease, only...

Ngày tải lên: 14/03/2014, 22:20

... PARKINSON S DISEASE Figure 16 Parkinson s disease: dystonic posturing of the big toe secondary to dopa therapy 15 16 AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 17 Parkinson s disease: ... findings in 100 successive Parkinsonian patients Idiopathic Parkinson s disease Progressive supranuclear palsy Multiple system atrophy Alzheimer s disease Alzheimer- type pathology with striatal ... Posture in later-stage Parkinson s disease AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 12 Parkinson s disease: impaired fist clenching 11 12 AN ILLUSTRATED POCKETBOOK OF PARKINSON S...

Ngày tải lên: 14/03/2014, 22:20

... nervous system neurons A recent study analyzed the enteric nervous system in PD and found that both Meissner s and Auerbach s plexuses were affected already in early stages of disease and terminal ... components Signal intensities were scored using a semiquantitative scale with five steps (–,+),+,++ and +++) Scores were based on several sections ⁄ animal and several animals ⁄ observation and confirmed ... large intestines Adh3 shows low and ubiquitous expression in all tissues and Aldh1 is observed at low to moderate levels in esophagus, stomach and jejunum, but not in rectum The apparent signal...

Ngày tải lên: 16/03/2014, 11:20

... a fellowship from the American Parkinson s Disease Association A.B.W is supported by the Michael J Fox Foundation for Parkinson s Disease Research, the American Parkinson s Disease Association, ... kinase associates with lipid rafts Hum Mol Genet 16, 678–690 15 West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, Ross CA, Dawson VL & Dawson TM (2005) Parkinson s disease- associated mutations ... morphogenesis, with the caveat that successful LRRK2 knockdown and even verification of endogenous expression is difficult to assess in most cell lines as a result of the presumed low levels of protein and...

Ngày tải lên: 23/03/2014, 04:20

... kinase (LRRK2) ⁄ PARK8 possesses GTPase activity that is altered in familial Parkinson s disease R1441C ⁄ G mutants J Neurochem 103, 238–247 Guo L, Gandhi PN, Wang W, Petersen RB, WilsonDelfosse ... dopamine transmission) and likely pre-symptomatic (or early) events of the disease process They should also be useful in testing the ‘two-hit’ or ‘multiple-hit’ hypothesis proposing that LRRK2 and other ... processes and will continue to impact our understanding of disease pathogenesis This minireview will examine the previous studies of genes for ROCO or LRRK2 homologs in slime mold Dictyostelium...

Ngày tải lên: 23/03/2014, 04:20

... Kawarai T, Sato C, SalehiRad S, Fisman GK, Al-Khairallah T, St George-Hyslop P, Singleton A & Rogaeva E (2005) LRRK2 gene in Parkinson disease: mutation analysis and case control association study ... and Di Fonzo et al [38] subsequently found that the G2385R variant is a common polymorphism and increases the risk of PD in Singaporean and Taiwan populations This association has been consistently ... Duke-NUS Graduate Medical School and SingHealth Services References Gandhi PN, Chen SG & Wilson-Delfosse AL (2009) Leucine-rich repeat kinase (LRRK2): a key player in the pathogenesis of Parkinson s...

Ngày tải lên: 23/03/2014, 04:20

... aspects of Parkinson s disease Parkinsonism and Parkinson s disease 34 Cognitive deficits in Parkinson s disease 55 Depression in Parkinson s disease 88 Anxiety, phobias, apathy, and premorbid personality ... guidelines, case studies and rating scales will meet the needs of all clinicians working with Parkinson s disease patients Sergio E Starkstein was Assistant Professor of Psychiatry at Johns Hopkins ... Pyramidal signs Rapid disease progression Sensory or visual neglect/cortical sensory distribution Snoring/restless sleep Supranuclear gaze palsy/slowing of saccades Very sparse blink rate Visual hallucinations...

Ngày tải lên: 28/03/2014, 22:21

... diagnosis at regular intervals (6–12 months) Throughout disease Diagnosis and early disease Disease progression Parkinson s disease algorithm Figure 3.1 Parkinson s disease algorithm: interventions ... or organisations: all healthcare professionals people with the disease and carers of these people patient support groups commissioning organisations service providers Parkinson s disease 2.4 Involvement ... Diagnosis is particularly highlighted This can be difficult, and while swift assessment by someone with appropriate expertise is important when suspicion of Parkinson s disease first arises, so...

Ngày tải lên: 31/03/2014, 13:20

... expression, 15 mg wet tissues with microcarriersRPE cells and tissues with microcarriers were lysed for ELISA assay The lysis buffer was prepared according to the manual in a ratio of mg tissue ... Independent ttest followed by post hoc Bonferroni tests were used for the analysis of other data via the SPSS 10.0 soft packages (SPSS Inc., USA) The criterion for statistical significance was set at ... tissues were dissected from embryonic brain and trypsinized into single-cell suspension using sterilized micropipette tips The cells were resuspended in DMEM and Ham 's F12 at 1:1 (D-F12), supplemented...

Ngày tải lên: 18/06/2014, 15:20

... Statistically significant differences were examined using a t-test or analysis of variance (ANOVA) and Tukey s multiple comparisons post-test (a P value of less than 0.05 was considered significant) Results ... Hunter Z, Peabody DS: Virus and virus-like particle-based immunogens for Alzheimer s disease induce antibody responses against amyloid-beta without concomitant T cell responses Vaccine 2006, 24:6321-6331 ... alone Statistical Analysis Statistical parameters (mean, standard deviation (SD), significant difference, etc.) were calculated using Prism 3.03 software (GraphPad Software, Inc., CA) Statistically...

Ngày tải lên: 18/06/2014, 22:20

... minutes in each session Assessments Assessments included standardized tests of balance and, postural control as well as ADL s to evaluate the effects of training Balance tests that were used included: ... perform sit-to-stand and stand-to-sit transfers Patients were instructed to stand up and sit down five times as fast as possible Page of starting in the sitting position and stopping after sitting ... task was trained during the sessions and reflects a training specific change Patients scored less (better) on the GDS (p = 0.05) and PDQ-39 scales, which suggests less depressive symptoms and...

Ngày tải lên: 19/06/2014, 08:20

... improves certain aspects of postural control in Parkinson' s disease, whereas medication does not Mov Disord 2006, 21:1088-1097 Magnusson M, Johansson K, Johansson BB: Sensory stimulation promotes ... periods This was conducted for anteroposterior and lateral sway, respectively, and both with eyes open and closed SPSS 12.0 (Chicago, Illinois, USA) was used for the calculations Results Clinical ... The Berg Balance Scale, best possible score is 56 points [30-32] FES (S) : Falls -Efficacy Scale, Swedish version Best possible total score is 130 points [38] (n = 8) Two patients were unable to...

Ngày tải lên: 19/06/2014, 08:20

... SOD1 G93A and wild-type control mice at age ~8 weeks, ~10 weeks, ~12 weeks, and ~13 weeks Discussion Gait disturbances are characteristic of Parkinson' s disease, Huntington 's disease, and amyotrophic ... image analyses The treadmill belt was wiped clean between studies if necessary Statistics Data are presented as means ± SE ANOVA was used to test for statistical differences among saline-treated, ... in Parkinson' s disease and Huntington 's disease Mov Disord 1998, 13:428-437 Blin O, Ferrandez AM, Serratrice G: Quantitative analysis of gait in Parkinson patients: increased variability of stride...

Ngày tải lên: 19/06/2014, 10:20