... than other endothelial cells inthe body In keeping with the theory of endothelial cell activation having a role in ANFH, coagulation-related gene expression in particular serine (or cysteine) ... development of early steroid-induced ANFH Determination of whether A2M over-expression in our study is either the result or the cause ofthe apoptosis found in our rats developing early ANFH following ... placed inthe pocket and the incision was sutured Based on the manufacturer's instructions the pellet releases a constant dose ofthe drug subcutaneously To maintain a constant dosage during the...
... economic standing and social class.29 Also inthe USA, the Bulletin ofthe History of Medicine in 1984 marked the changing position inthe history of nursing by including a review article by the historian ... concept of nursing practice focused on caring through the processes of ʻbeing-for -the- otherʼ is the focus of analysis inthe following section NURSING KNOWLEDGE, SKILLS AND CARING Analysing the ethics ... and the glorification of sacrifice are all enmeshed in an account that juxtaposes traditional masculine values with a disturbing incursion ofthe feminine In Britain since the Crimean war and in the...
... increment inthe protein level of GM-CSF-induced MLN51 (Fig 2E) These data indicate that GM-CSF not only induces the expression of MLN51, but also blocks the proteasome-mediated degradation of ... blocking ofthe proteasome degradation pathway GM-CSF-induced MLN51 is involved inthe hyperproliferation and anti-apoptosis of MH7A cells via the upregulation of FLIP Next, we investigated the ... of RA FLSs, thus indicating that other factors must be involved in this proliferation In our previous studies, we have determined that GM-CSF inthe synovial fluid plays an important role in the...
... chains, and branching ofthe chain at the carbon atom adjacent to the oxygen appears to confer higher toxicity than branching at the end ofthe chain (b) Replacement ofthe fluorine atom by another ... gases The large amount of work carried out on the preparation of these compounds led to the discovery of many interesting substances and to the development of several new methods of synthesis In ... obtained, the cis-form predominating inthe case of N-methyl-2 ,2’-dichlorodiethylamine Comparative studies ofthe rate of dimerization show that this rate falls off very markedly as the length of...
... meanings as: - pertaining to the first age ofthe world, or of anything ancient; - pertaining to or existing from the earliest beginnings;- constituting the earliest beginning or starting point;- ... turns in their circular ascent The fish swimming inthe middle were pressed so closely together that their fins stuck out ofthe water There it was again? The dark shadow ofthe eagle and the miniature ... rhythm-destroying movement is astonishing For a moment the seat ofthe swing motionless inthe air almost a whole metre below the culmination point before swinging downwards once more Inthe same instant the...
... each ofthe diVerent ‘traditions’ by its own standards and then to bring the best in all of them into dialogue with one another The analytic ambition of going to the sources and working out a single ... sense of this doctrine) As I have already indicated, there is nothing novel inthe idea that theologians might make use ofthe latest in philosophical thinking to help them express the great things ... understanding of them The theologians don’t seem to be doing the work in question I therefore hope I will not be accused of interdisciplinary chauvinism if I point out that the best work in philosophical...
... VEGF activates the VEGF-Flt-1-FAK pathway The activation of this signaling pathway might be involved inthe migration of these cells into the lesion at the site of bone destruction in GCTs We recently ... expression and the clinical stage of GCTs at presentation To determine the status of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; less ... Immunolocalization of VEGF, Flt-1 and Flk-1 in GCT samples We initially analyzed the expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone-resorbing...
... VEGF activates the VEGF-Flt-1-FAK pathway The activation of this signaling pathway might be involved inthe migration of these cells into the lesion at the site of bone destruction in GCTs We recently ... expression and the clinical stage of GCTs at presentation To determine the status of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; less ... Immunolocalization of VEGF, Flt-1 and Flk-1 in GCT samples We initially analyzed the expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone-resorbing...
... completes our proof since the manipulations at the beginning ofthe section prove that the two quotients in (5.42) have the same Hilbert series References [1] Yu Berest, P Etingof and V Ginzburg, Cherednik ... gives that the rational function in (5.43) gives the Hilbert series of Q[u, v, y]/ (Bm , Cm , v 2m ) The extra factor of (1 − t) inthe denominator accounting for the presence ofthe extra variable ... from a more elementary point of view In this vein we find particularly intriguing in (1.4) the degree shift of each isotypic component of QI m expressed by the presence ofthe factor n q m ( )−cλ...
... zones of sympatry (codes are listed in Tab II) Crosses are plotted at the coordinates ofthe four phenotypes inthe first two dimension ofthe SCA (the first number inthe brackets represent the ... Seed characteristics The percentages of germination obtained for populations ofthe two species and from the zone of sympatry (Tab II) reinforced the results obtained by Raquin et al [19] with ... microsatellite-derived marker Then we assessed the utility of two of them, together with germination tests of intact untreated seeds and embryo/seed length ratios measurements, for distinguishing between these two...
... thepathogenesisof EoE by enhancing activation of eosinophils through synergy with eotaxin via the ERK signaling pathway The data may be used inthe possible diagnosis and prognosis of EoE In ... together with eotaxin, FGF enhances activation of eosinophils in EoE specifically Page ofThe increased global expression of bFGF led to the investigation ofthe local expression bFGF ofthe esophageal ... this increase is also reflected systemically In addition, the extent of increase in FGF and ERK pathways was closely associated with the severity ofthe disease and endoscopic findings in the...
... binds directly to the ODDD of HIF-1α inthe cytoplasm and acetylates a single lysine residue at position 532 Acetylation of this specific lysine residue favours the interaction of HIF-1α and the ... part ofthe E3 ubiquitin ligase complex Interaction of prolinehydroxylated HIF-1α with pVHL/E3 ubiquitin ligase complex activates the ubiquitination machinery, thereby promoting degradation of ... HIF-1α is not ubiquitinated Thus, degradation of HIF-1α inthe proteasome is inhibited and HIF-1α protein accumulates Binding of HIF-1 to HIF binding sites, formation ofthe transcriptional complex...
... during infection in light ofthe short half-life (the drug could be discontinued during infection, allowing inflammatory cells to migrate to the site of infection), and the potential of inhibiting ... on the available in vivo data, which may provide more insight into the chances that disrupting one single factor ofthe complicated chemokine network could be clinically effective in chronic inflammatory ... inhibiting the migration of cells that are able to produce an array of proinflammatory cytokines at the site of inflammation The identification ofthe best targets will be the subject of future...
... protein; matrilin-1) Matrilin-3 CILP (cartilage intermediate layer protein) Fibronectin PRELP (proline/arginine-rich and leucine-rich repeat protein) Chondroadherin Fibrillin Tenascin-C Elastin MGP (matrix ... cartilage of all joints, this joint selectivity is quite puzzling We suggest that the answer may be found in a more careful examination ofthe interactions between intrinsic and extrinsic factors ... epiphyseal dysplasia of several joints during childhood, and OA ofthe knees in adulthood A complex splicing defect of exon and/or exon 10 inthe COL9A1 gene has been identified in other families [59]...
... arthritis dylarginine deiminase of involvement of hyaluronic of rheumatoid Proposed mechanism (PADI4) inthepathogenesis acid (HA) and peptidylarginine deiminase (PADI4) inthepathogenesisof rheumatoid ... antithrombin However, such binding did not stimulate the activity of antithrombin as did heparin and heparan; in fact, it blocked the ability of antithrombin to inhibit thrombin Inthe present study, the ... proteinase binding loop on the protein surface [19,20] Because the molecular structure of HA is analogous to that of heparin, HA might exert its effect by binding to the heparin-binding region of...
... passages in vitro before being exposed to the immunoglobulins Consequently, the data suggest that the local stromal environment inthe joint (and based on previous data from the group other organs ... determines the disease specific immune response Given the variety of signaling pathways initiated by IGF-1 in fibroblasts, it may be speculated, as the authors mention briefly, that binding of antibodies ... trigger the release of IL-16 in RASFs, the present research from Smith and Cruikshank extends the panel of signals involved inthe regulation of IL-16 at least under pathologic conditions Although the...
... result in an increase inthe gene expression ofthe aggrecanase ADAMTS4 in cells derived from degenerate NP In vivo, the NP contains the highest concentration of aggrecan inthe IVD The response of ... observed on the other cell types (Fig 6d) Discussion In this study, we investigated whether in IVD degeneration there is local production ofthe cytokine IL-1 and whether IL-1 could induce the cellular ... immunopositivity was observed inthe matrix ofthe IVDs or in blood vessels, with the exception of immunopositivity for ICE, which showed some staining inthe matrix and blood vessels ofthe most degenerate...
... suggesting a more general mechanism of these receptors in inflammatory diseases Maintaining autoantibody titers through FcRn-mediated recycling One ofthe most striking characteristics ofthe K/B ... through the regulation of FcRs much like the instructive role ofthe innate immune system for the adaptive response [56] The production of autoantibodies as a result ofthe failure ofthe immune ... anaphylatoxin, acting through the C5aR, is a major regulator ofthe transcription of activating and inhibitory FcγRs in IC-induced lung disease C5a increased the expression of activating FcγRIII and...
... maintain chondrocyte viability inthe face of catabolic changes in articular cartilage Many molecular aspects of HIF-1 signaling should be also studied to further clarify the role of HIF-1 inthe ... degeneration, and they provide new insights into pathogenesisof OA 14 15 16 17 Competing interests The authors declare that they have no competing interests 18 Authors' contributions KY carried out in vitro ... Germany) was used The assay is based on the light-emitting oxidation of luciferin by luciferase inthe presence of extremely low levels of ATP After collecting the chondrocytes by scraping, cells were...