... 1.18Abbreviations: RR ẳ relative risk (of stomach cancer) .Table 3 Stomachcancer cases in the UK in 2010 due to intake of salt 46 g dailyAge (years) Stomachcancer All cancer aAt exposure At outcome ... the findings with respect to lung cancer and exposure to tobacco smoke. In total, 34 599 cases of lung cancer inthe UK (86% of the total) were due to exposure to tobacco smokein 2010, the great ... per day for oesophagus andstomach cancer; X120 g perday for upper aero-digestive cancers; X57.1 g fruit per day for stomach cancer; and X160 g fruit per day for lung cancer. Giventhe estimates...
... history, 17 and the genetic and environmental 18factors that contribute to its develop-19ment. 20‘‘(II) Research on more precise 21diagnostic methods and screening to 22detect pancreaticcancer ... IHcurrent state of the science and the Federal Govern-1ment’s efforts on pancreaticcancer research and 2prepared ‘‘The National Plan to Advance Pancreatic 3 Cancer Research’’ to identify the highest ... doctorate de-7grees and clinician-scientists specializing in 8 pancreatic cancer research; and 9‘‘(v) guidelines for information gath-10ered by pancreaticcancer patient registries 11and...
... hypotheses linking breast cancer risk and exposures likely to includecarcinogens and endocrine disruptors, and demonstrate the value of detailed work histories in environmental and occupational epidemiology.Keywords: ... Operators 3336360 9422 Motor Vehicle Seating and Interior Trim Mfr Plastics Processing Machine Operators 3Minor sectors: Plastics manufacturing (nonauto) and Plastics manufacturing (auto).Exposure ... high-exposed jobs and 1 year in priorhigh-exposed farm work.Table 9 Breast cancer odds ratios (matched analysis) and menopausal status with BMI and selected risk factors and major sectors, by conditional...
... 11:4681-4688. [39] Ahuia N and Issa JP. 2000. Aging, methylation and cancer. Histol Histopathol 15(3):835-842. [40] Liu L, Wylie RC, Andrews LG, Tolloefsboi TO, 2003. Aging, cancerand nutrition: the ... (HDACs) and histone demethylases (HDMs) which remove acetyl and methyl groups from histone protiens. Histone methylation is maintained by histone methyltransferases and histone demethylases. Histone ... receptor overexpression, activating mutations, overexpression of receptor ligands, and/ or the loss of negative regulatory pathways. The overexpression of EGFR and its ligands (EGF and others) and/ or...
... to lend greater under-standing to the complexities surrounding the relationship between quality of life and psychosocial issues for women with breast cancer. Psychosocial Issues and Breast Cancer Researchers ... developed.This transition to a more integrative and systemic approach to health is a critical shifttoward providing more humane and holistic care for breast cancer patients, and ulti-mately for ... on-going studyfunded by the National Cancer Institute (NCI). This is a pilot study intended to explorepsychosocial factors and quality of life, preparatory to embarking on a larger scale, long-term...
... organizations to expand and coordinate their efforts to provide educational opportunities to healthcare providers to equip them to address the health and quality-of-life issues facing cancer survivors. ... work.Recommendation nine calls on federal and state policymakers to act to ensure that all cancer survivors have access to adequate and affordable 6 FROM CANCER PATIENT TOCANCER SURVIVORcommittee members ... need to be high on theagenda of cancer research. And I say that as a customer of cancer research and cancer care. I have not recently examined the figures, although I did atone point, and the...
... understanding of regulation of c-junexpression in quiescent rat liver. We have identified a positiveregulatory factor from normal rat liver that binds to theregion )148 to )124 of c-jun and stimulates ... innormal rat liver. The positive regulatory factor interactingwith this region was purified to homogeneity and the cDNAcloning of the gene encoding this factor is in progress to helpin understanding ... indi-cated the factor to be 40 kDa andto bind to its recognitionsequence as a dimer.Keywords:c-jun; DNA–protein interaction; in vitro tran-scription; rat liver positive regulatory factor; transcriptionalregulation.Elucidation...
... follow-up(0 to 14, 15 to 29, 30 to 34, 35 to 39, 40 to 44, 45 to 49,50 to 54, 55 to 59, 60 to 64, 65 to 69 and 70+) and calendar period of follow-up (1961 to 1965, , 2001 to 2005, 2006 to 2007.Case ... respect to inci-dence rate (1961 to 1985, 1986 to 1995, 1996 to 2000, and 2001 to 2007) and calendar period of diagnosis withrespect to case fatality (1961 to 1985, 1986 to 1 995, 1996 to 2000, and ... diagnosis1961 to 1985 444 0.98 (0.87 to 1.10) 49 0.84 (0.59 to 1.19)1986 to 1995 615 0.94 (0.86 to 1.04) 192 0.96 (0.82 to 1.13)1996 to 2000 282 1.10 (0.95 to 1.27) 129 0.90 (0.73 to 1.10)2001 to 2007...
... chemotherapeuticdrugs and tumor necrosis factor-related apoptosis-inducing ligand ⁄ Apo-2 ligand on apoptosis and onregression of breast carcinoma in vivo. Cancer Res 63,5390–5400.21 Tomlinson GE, ... nonmalignant,cells [16]. TRAIL binds to death receptors, DR4 and DR5, and recruits Fas-associated death domain pro-tein to the receptors. Caspase-8 is activated and subse-quently activates downstream ... inhibi-tion of apoptosis.Hypoxia has been reported to inhibit apoptosisinduced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) [14,15], which selectivelyinduces apoptosis in malignant,...
... divided into 2 groups (grade 1 and 2 versus 3 and 4) according to Forssell’s protocol [ 36]. Therefore,cases were regrouped into CD68TFHotspothigh (3 and 4)versus CD68TFHotspotlow (1 and 2) ... immunohistochemical staining; and PRQ and ZXanalyzed the results. ZXS and ZYX conceived the study, participated in thedesign, and coordinated and helped draft the manuscript. All authors read and ... breast, bladder,rectum, and endometrium, but the prognosis is favorablein nasopharyngeal, gastric, and ovarian cancers [17-28].Additionally, in liver, lung, and prostate cancers, the roleof TAMs...
... cells.Immunohistochemical analysis of ezrin expression in pancreatic ductal carcinoma samples To study the role of ezrin in pancreatic cancer, we ana-lyzed its expression pattern in 70 PDAC patients and ... related to the alteration of cell morphology and invasion.Immunohistochemical analysis showed that ezrin was overexpressed in pancreatic ductal adenocarcinoma (PDAC)(91.4%) and precancerous ... (CP) and pancreatic intraepithelial neoplasm (PanIN) (85.7% and 97.1%, respectively), compared to normal pancreatic tissues (0%). Ezrinwas also expressed in intercalated ducts adjacent to the...
... [197], and hepatoma [198], have demonstratedcytotoxic effects at pharmacologically-achievable con-centrations. Enhancement of cytotoxicity of docetaxel,epirubicin, irinotecan, and 5-FU to a ... activation and cytochrome c release. To extendtheir study into the clinical realm, th e investigators pro-spectively r andomized 34 patients wit h NYHA class III and IV heart failure to receive ... 23:99-109.76. Edgington TS, Mackman N, Fan ST, Ruf W: Cellular immune and cytokinepathways resulting in tissue factor expression and relevance to septicshock. Nouv Rev Fr Hematol 1992, 34(Suppl):S15-27.77....