... background pain and for pain intensity exacerbations; one evaluation was performed using a 6-point VRS and patients were asked to rate their pain intensity choosing from the following descriptors: ... defined as "consistent" if background pain intensity was lower than peak intensity, otherwise it was defined as "inconsistent" (background pain intensity higher than or equal to peak pain intensity) ... N (%) Pain duration (weeks) Mean (SD) 17.7 (21.8) Type of paina Somatic pain 162 (67.5) Visceral pain 82 (34.2) Neuropathic pain Primary cancer site or type 97 (40.4) Pain exacerbations in the...
... Ablation is indicated inpatientswith bundle-branch reentrant VT Ablation is indicated as adjunctive therapy inpatientswith an ICD who are receiving multiple shocks as a result of sustained VT ... associated with an in QTc (average ~5 msec) • However, experimental data suggest suppression of pro-arrhythmic markers • Indication inchronic angina: “Because ranolazine prolongs the QT interval, ... arrhythmias; reduce incidence of SCD • ♥ Amiodarone: No definite survival benefit; some studies have shown reduction in SCD inpatientswith LV dysfunction especially when given in conjunction with BB Has...
... and mortality in CKD 3-5 patientsin Spain (31) Our study extends this finding to patientswith more preserved renal function in American population Our hypothesis that serum albumin is a significant ... like chronic inflammation and malnutrition as predictors of the CVD inchronic kidney disease This multifactorial disease introduces new challenges in predicting and treating patients early in ... Inflammation and dietary protein intake exert competing effects on serum albumin and creatinine in hemodialysis patients Kidney Int 2001; 60: 333-340 46 Himmelfarb J, Stenvinkel P, Ikizler TA, and...
... biomarkers found in heart failure include BNP, NT pro-BNP, C-reactive protein, tumor necrosis factor a, interleukins and 6, TNF-a, matrix metalloproteinases, neuroepinephrine, renin, galectin-3 [16-18], ... plasma levels in both ICM and NIDCM groups vs controls Interestingly, IL-5 plasma levels inversely correlated with disease duration in NYHA III/IV ICM patientsIn fact, patientswith longer disease ... that IL-9 levels inversely correlated with ejection fraction in ICM patients, but not in NIDCM patients This would suggest that increased levels of this cytokine are associated with left ventricular...
... analysis showed that the minimal important difference of the HADS is approximately 1.5 points in COPD patients Investigators and those interpreting clinical research can use this minimal important difference ... range commonly encountered inpatientswithchronic disease.[26,27] A change of 1.5 points corresponds approximately to a 20% change from these baseline scores Inpatientswith substantially lower ... differ from patients included in the analyses The mean age of included patients was 68.7 (SD 8.9) years, 59 (67.0%) were males, patients had moderate to very severe COPD with a mean FEV1 in % predicted...
... deteriorated inpatientswith underweight COPD Respir Med 2005, 99:624-630 Hynninen KMJ, Pallesen P, Nordhus IH: Factors affecting health status in COPD patientswith co-morbid anxiety and depression Int ... 100, the lower scores indicating better health status [19-21] The SGRQ has been translated into different languages and used in several studies of COPD patients, including in Norway [22,23] The ... associated with a lower mental health, with symptoms explaining the greatest variance These findings highlight the importance of rehabilitation programmes that focus on the management of symptoms in...
... biomarkers found in heart failure include BNP, NT pro-BNP, C-reactive protein, tumor necrosis factor a, interleukins and 6, TNF-a, matrix metalloproteinases, neuroepinephrine, renin, galectin-3 [16-18], ... plasma levels in both ICM and NIDCM groups vs controls Interestingly, IL-5 plasma levels inversely correlated with disease duration in NYHA III/IV ICM patientsIn fact, patientswith longer disease ... that IL-9 levels inversely correlated with ejection fraction in ICM patients, but not in NIDCM patients This would suggest that increased levels of this cytokine are associated with left ventricular...
... terminally ill cancer patients [14-19] One study found that physician estimates had an independent effect beyond models incorporating other risk factors in predicting survival inpatientswith ... patient actually having an infarction [37] Other investigators found that in predicting return to work inpatientswith coronary disease, both physicians' and patients' estimates had independent prognostic ... prognosis in seriously ill patients admitted to intensive care units or survival inpatientswith terminal illness, usually cancer [14-19] A better understanding of physicians' prognostic estimates in...
... using the actuarial method with multiple-failure per patient Survival curves in figures are presented withpatients starting each time interval, but not with failures, data which are included in ... however, in the reasons for discontinuing etanercept and infliximab Etanercept was discontinued in 82% of the cases because of inefficacy, and infliximab was discontinued due to adverse events in 54% ... Finally, improvement in inflammation parameters was seen in 12 of 14 patients switching from infliximab to etanercept in another recent study [16] Information regarding switching to or from adalimumab...
... after months of treatment with pentoxifylline and vitamin E [14] No improvement was observed inpatients taking either medication alone While several receptor tyrosine kinase inhibitors have been ... reporting on side effects associated with the use of Pirfenidone, gastrointestinal complaints were common [15,37], photosensitivity occurred in several patients [37,38] and in one study a single ... ongoing for patientswith scleroderma, sclerosing peritonitis, proliferative vitreoretinopathy, myelofibrosis with myeloid metaplasia, renal focal segmental glomerulosclerosis and patients with...
... approach disseminating research findings into routine care The CAS framework suggests that local contexts and local interactions between individuals are critical considerations in designing interventions, ... pattern of interactions, including non-verbal communication, among agents • Introducing new agents into the system • Letters to patients • Nurse-led heart failure group clinic • Clinical reminders ... systematic review of interventions to improve outcomes of patientswith CHF through changing care delivery processes in clinical settings is consistent with literature reporting that interventions that...
... quasi-experimental study using a hospital level intervention to implement electronic clinical reminders with the goal of improving hyperlipidemia managementin VA IHD patients Intervention hospitals included three ... multi-faceted intervention In the planned intervention, we would have tested, in part, the effectiveness of implementing clinical reminders with and without the type of facilitation we describe in this ... for treating patientswith IHD and called for lowering LDL-c to 100 mg/dL or less inpatientswith known IHD [8-10] However, research has indicated that veterans receiving primary care in VHA may...
... quasi-experimental study using a hospital level intervention to implement electronic clinical reminders with the goal of improving hyperlipidemia managementin VA IHD patients Intervention hospitals included three ... multi-faceted intervention In the planned intervention, we would have tested, in part, the effectiveness of implementing clinical reminders with and without the type of facilitation we describe in this ... for treating patientswith IHD and called for lowering LDL-c to 100 mg/dL or less inpatientswith known IHD [8-10] However, research has indicated that veterans receiving primary care in VHA may...
... contains 36 items on functioning and disability with a recall period of 30 days[8] covering domains: Understanding and Communicating (6 items), Getting around (5 items), Self-care (4 items), Getting ... each domain by adding the item responses (the score computation allows for up to 30% of missing items per domain) and transforming them into a range from to 100, with higher scores indicating higher ... and the clinical specialist responsible of the patients'management Criteria used for classifying patients as being mild, moderate or severe are defined in Table The sample sizes of the final groups...
... HCV-positive patients included less individuals with resolutive HBV infection and more patientswith ongoing HBV infection (p < 0.01 and p = < 0.05, respectively) Thus, HBV ongoing infection was found in ... against the two viruses, are represented in Figure HBV viremia rates were lower in HCV/HBV co-infected patients as compared to the rates in individuals with single HBV infection (Figure 1A) In ... between individuals with single HBV infection and HCV/HBV co-infected patients revealed significantly lower viremia levels in the second group than in the first one (Figure 1A) These findings indicate...
... months This definition covers adequately the clinical course and findings in our patients from a clinical point of view The following two main types of CSOM were differentiated: chronic suppurative ... before starting data collection Patients were included in the study from April 2006 through July 2007 Data collection was completed in July, 2008 PatientsIn this study, patientswithchronic suppurative ... use in clinical studies Therefore, inclusion in the study was determined according to Nadol [1]: disease of the middle ear and/or mastoid with irreversible mucosal damage or infection lasting...
... IFN-induced pathways inpatientswith CHC than in healthy controls [20-23] As far as the influence of baseline expression of these miRNAs on the clinical outcome of IFN therapy inpatientswith ... reported to be involved in IFN-mediated antiviral activity against HCV, are expressed in PBMCs Table Baseline and IFN-induced expression of microRNAs and MxA-mRNA inpatientswithchronic hepatitis ... recorded in IFN alpha-treated PBMCs This is in agreement with Pedersen and co-authors, who observed a high-fold increase in miR-1 and a low-fold increase in miR-30 in experiments performed in vitro with...
... supporting the potential involvement of IL-17A in the phenotypic manifestations of COPD In addition, transgenic over expression of Il-17 in the alveoli of murine lung induces lung inflammation with ... gene polymorphism and chronic inflammatory lung diseases, including bronchial asthma and COPD, suggesting that IL-17F may be critically involved in the pathogenesis of chronic inflammatory lung diseases ... and visualized with DAB/hydrogen peroxide After counterstaining with haematoxyline, sections were dehydrated in increasing ethanol gradient and 100% xylene immediately before performing LCM The...
... that included assessment of trough FEV1 and had a duration of at least 14 days Indacaterol was compared with formoterol in two studies, with salmeterol in four studies and with tiotropium in one ... arm of each study, for both indacaterol (lefthand panel) and comparators (right-hand panel) Visual inspection of the indacaterol data points indicated that with increasing dose the response asymptotically ... response changed with baseline FEV As baseline FEV increased, both the steepness and the maximum of the dose response increased In particular, the lowest quartile, with a baseline FEV of less...
... contributions 15 RS was involved in the concept and planning of the meta analysis and in writing and editing the manuscript; PW and MW were involved in the writing and editing of the manuscript ... from the earliest assessment point (3 months) and maintained at months and 12 months, indicating that there was no decline in efficacy over this period There is increasing recognition that patient-centred ... treatment with oral and/or inhaled corticosteroids was permitted in six of the trials (67%), while anticholinergic therapy could be continued in four trials (44%) and methylxanthines in seven...