paget s disease of the breast

... nuclei [1,2] The pathogenesis of Paget s disease is still a subject of debate with two main hypotheses The epidermotropic hypothesis proposes that Paget s cells originate from ductal epithelium, ... where they migrate towards the epidermis This hypothesis is supported by the association between Paget s and an underlying breast carcinoma in the majority of patients The second hypothesis, the ... confirmed Paget s disease of the right nipple with no evidence of underlying invasive ductal carcinoma, ductal carcinoma in situ of the breast tissue or lymph node invasion Discussion Paget s disease...

Ngày tải lên: 11/08/2014, 00:22

... techniques of internal fixation This unusual case of delayed union of the femur fracture associated with Paget' s disease of the bone for which functional bracing was ultimately successful illustrates ... Ankrom MA, Shapiro JR: Paget' s disease of bone (osteitis deformans) J Am Geriatr Soc 1998, 46:1025-1033 Thomas DW, Shepherd JP: Paget' s disease of bone: current concepts in pathogenesis and treatment ... involving the entire femur of the fracture (Figure 5), the patient is able to walk unaided with a single T-cane Discussion Although Paget' s disease of the bone is a relatively common disease in Australia,...

Ngày tải lên: 20/06/2014, 04:20

... alendronate seemed to be more suitable for the treatment of Japanese patients since the dose of alendronate used for the treatment of osteoporosis in Japanese patients (5 mg per day) was half of that used ... other sclerosing bone dysplasia [2,3] To monitor disease activity and the effects of treatment, we measured T-ALP and uNTX levels of our patients every three to six months and assessed their ... months has afforded an effective treatment for PDB over the five-year follow-up in two Japanese patients with Paget' s disease of the bone To the best of our knowledge, this is the first report of...

Ngày tải lên: 11/08/2014, 12:20

... CKs, have consistently been proven to be the most useful diagnostic markers [2] This observation was confirmed in our case A recent classification based on the origin of the Paget' s cells has ... planus, psoriasis and seborrheic dermatitis This can result in delayed presentation as was the case with our patient In order to make the correct diagnosis, a high index of suspicion is required The ... Photograph of the penile lesion Photograph of the penile lesion Figure H&E stain of the resected specimen showing a clear margin H&E stain of the resected specimen showing a clear margin Discussion...

Ngày tải lên: 11/08/2014, 19:21

... treatment for Paget' s disease is to control disease activity with bisphosphonates This is the first reported case of Paget' s disease affecting pituitary gland function by involvement of the sphenoid ... function Discussion Erectile dysfunction is a common disorder and is an important health-care issue as it acts as a surrogate marker of other diseases of more concern, such as diabetes mellitus and ... fossa The hypothesis was that the hyperprolactinaemia may have been consequent upon the increased vascularity and blood flow through the sphenoid secondary to the activity of the Paget' s disease...

Ngày tải lên: 11/08/2014, 21:22

... though the presence of the M404V mutation could not be assessed in patient III-6, these hypotheses strongly support the need for further investigation into the possible role of the p62 protein in the ... was not performed on this subject; the skeletal extent of PDB is on the basis of X-ray evaluations bone biopsy showed the presence of an osteogenic sarcoma on the Pagetic bone already metastasized ... cases with a mis-sense mutation in the p62/SQSTM1 gene These results should be confirmed in other PDB patients of Italian and other ancestries Moreover, the value of a pre-symptomatic gene test...

Ngày tải lên: 09/08/2014, 07:20

... DA in the absence of neuronal degeneration [6] The CSF levels of TIQs increase in early PD and decrease as the disease progresses [12] TH inhibition by endogenous TIQs may therefore be most prominent ... kinases, which phosphorylate TH at serine residues of the N-terminal domain [22,23,28] Phosphorylation by protein kinase A (PKA) at Ser40, the most prominent of these regulatory sites, increases ... [10,27,39,45], leading to loss of TH activity [46,47] Second, thermal stability of the enzyme increases and its resistance to proteolysis improves [33] TH preparations from animal tissues are inevitably...

Ngày tải lên: 07/03/2014, 05:20

... Benign disorders and diseases of the breast Lymphatics of the breast The lymphatic drainage of the breast is of great importance in the spread of malignant disease of the breast but of lesser importance ... Fibrocystic disease Fibroadenosis Cystic hyperplasia Hyperplastic cystic disease Schimmelbusch s disease Chronic cystic mastitis Cystic mastopathy DUCT ECTASIA/PERIDUCTAL MASTITIS Plasma cell mastitis ... portion of the breast almost amounts to a surgico-pathological reflex’.2 What is surprising is that pathologists are still the most insistent  Benign disorders and diseases of the breast single...

Ngày tải lên: 28/03/2014, 22:20

... breast screening - http://thomsonlifestylecentre.com /breast- cancer-screening-package The American Cancer Society recently launched new cancer of the breast screening recommendations The brand ... new recommendations stand to find the best ideas in cancer of the breast tests rooted in the newest understanding The recommendations are targeted at women by having an average risk for cancer and ... Women within their 2 0s and 3 0s needs to include a breast examination every years with a medical expert in their healthcare - Breast self-exams aren't obligatory for ladies Request your personal doctor...

Ngày tải lên: 27/01/2014, 08:52

... COMPASS, COMPASS English as a Second Language (ESL), ASSET, and “Combined English Language Skills Assessment” (CELSA).4 The COMPASS ESL and CELSA tests were used only for ESL students The CELSA ... under this subpart of (1) The test taken by the student; (2) The date of the test; and (3) The student 's scores as reported by the test publisher, assessment center, or State Students Ineligible ... 16 students, the assessment center manually scored the tests For five of those eight students, the assessment center did not ensure that the tests were administered by certified test administrators...

Ngày tải lên: 18/02/2014, 04:20

... required the USMS to ask permission each day the USMS needed to use the system Ultimately, the FBI disabled five USMS radios because it said there was too much traffic The USMS Chief Inspector for the ... status of these components' LMRs follows 19 For purposes of this audit, obsolete systems are systems that are no longer supported by the manufacturer or the manufacturer is unable to supply spare ... that they can be received by the other systems This allows the agencies to continue using their existing systems but requires twice as much spectrum because each system occupies separate channels...

Ngày tải lên: 18/02/2014, 04:20

... instant the canoe glided into the obscurity of the shadows cast by the overhanging trees With the disappearance of Darius there came upon me the full sense of my responsibility, for I was the ... Yankees, an' the other is sneakin' in some corner!" There came the sound of hurried footsteps, and then the light of the lantern so far illumined the head of the stairway that I could see Darius, ... it as tough as is deserved These others are prisoners of war; but you two are traitors and spies, therefore must expect to fare according to your deserts." "That 's about the size of it, Amos,"...

Ngày tải lên: 21/02/2014, 08:20

... Eosonophilia was non-specific and was present in less than half of our patients The Casoni test and IHA were the only tests available to us The IHA was positive in 91% of patients tested The Casoni test ... trial version http://www.fineprint.com DISCUSSION: Hydatid disease is a parasitic infection caused by the larval form of echinococcus (1,2,3) granulosus The commonest sites of infestation are the ... form of primary closure of the cyst cavity without drainage, seems to offer the best therapeutic option in these patients Key words: Liver cysts, hydatid disease, echinoccocosis PDF created with...

Ngày tải lên: 05/03/2014, 12:20

Ngày tải lên: 07/03/2014, 15:20

... Blatty s adaptation of his novel THE EXORCIST (1973) is the scariest movie made on the subject of demonic possession It has had the most psychological impact on its a ­ udience since its release ... think of ourselves as masters of our universe: we’ve landed on the Moon, split the atom, and tamed the beasts of nature Seeing ourselves as anything less than perfect or at the bottom of the food ... imprison us and frustrate our curiosity about the infinite ­ osmic spaces beyond the radius of c our sight and analysis These stories frequently emphasise the element of horror because fear is our...

Ngày tải lên: 15/03/2014, 17:30

... The disease of respiratory system is one of the most frequent reasons for hospitalization of infants and children Basic knowledge of the development and functions of respiratory system are essential ... system are essential to understand many of these respiratory tract diseases 1.Anatomical characteristics of respiratory system (1) The upper airway nose; paranasal sinuses; pharynx; Eustachian tube ... nasal obstruction →dyspnea paranasal sinuses Maxillary sinuses appear at 2yrs, develop fully after 12yrs Frontal sinuses appear at 2-3yrs, enlarge at 6yrs →Paranasal sinusitis rarely occurs in...

Ngày tải lên: 22/03/2014, 09:20

... on the universality of the amyloid hypothesis in those diseases as well In Alzheimer s disease, genetic mutations in familial Alzheimer s disease reveal that Alzheimer s disease in those cases ... polyglutamine diseases, and is a common theme with other amyloid diseases, including transmitted spongiform encephalopathies, Parkinson s Revisiting the aggregation hypothesis disease, and Alzheimer s disease ... the human disease, with the exception of specific striatal cell loss These models caused a rethinking of aggregates in polyglutamine disease, raising the possibility that whereas they can be seen...

Ngày tải lên: 23/03/2014, 07:20

... types: linguistic awareness, psycholinguistic awareness, discourse awareness, communicative awareness, sociolinguistic awareness and strategic awareness • Linguistic awareness where the aim is ... approach and the steps it entails are important in diminishing or preventing students’ problems in writing? On the basis of these questions, the following hypothesis is put forward: If learners are ... randomization process later on) to be given the questionnaire The aim of the learners’ questionnaire is to gauge the students’ level of awareness of the writing process and the writing techniques underlying...

Ngày tải lên: 24/03/2014, 19:20

... Obesity: Vol 26, Suppl -4; 12/2002 Medline: 2000 - 2004 WHO (2/2000): Asia Pacific perspective (redefining obesity and treatment) WHO ; Geneva; - 5/6/1997 Report of WHO consultation on obesity ... (SHBG) nữ, tăng độ lọc testosteron tự oestradiol, gây rối loạn cân hormon sinh dục Với vỏ thợng thận: béo bụng làm tăng tiết cortisol làm tăng hoạt tính trục dới đồi - tuyến yên (HPA) cortisol ... glucocorticoid mỡ bụng, kéo theo hậu ức chế tác dụng chống tiêu mỡ insulin tế bào mỡ, chế tham gia vào biểu đề kháng insulin Nếu lại bồi thêm yếu tố nguy khác (nh stress, nghiện rợu, thuốc lá) hoạt...

Ngày tải lên: 25/03/2014, 05:20

... Descriptions Task Task Description Propulsion The MSL propulsion subsystem comprises two independently operated subsystems: cruise stage (CS) propulsion and the descent stage (DS) The CS propulsion subsystem ... incurring the resultant costs, NASA s Associate Administrator for the Science Mission Directorate should reassess the sufficiency of the Project s funding based on our calculations In addition, the MSL ... Project s history of cost estimation, reassess the sufficiency of available reserves, and adjust funding accordingly Management s Response The Associate Administrator for the Science Mission Directorate...

Ngày tải lên: 29/03/2014, 22:20