p15 methylation as a prognostic factor

... p53-mutated invasive carcinomas Immunohistochemical analysis of MIB-1, as a proliferative marker is a good approach for evaluation of the growth fraction [4,13] MIB-1 is a monoclonal antibody against ... score Proliferative activity was examined by staining with an anti-Ki-67 specific antibody, MIB-1, and was evaluated separately in each case after counting at least 500 nuclei in 3-5 randomly selected ... IV, stage II, stage I) and mammary gland adenoma (1 stage II, stage I) dogs with malignant tumors and with benign tumors had palpably enlarged lymph nodes in axillary and inguinal region It was...

Ngày tải lên: 07/08/2014, 17:22

... significant association of age, grade, lymph node spread and vascular invasion with distant metastases free survival (MFS) in all invasive carcinomas and the subgroup of IDC in an univariate analysis ... and cyclin E statistical associations p27 Cyclin E All invasive carcinomas Infiltrating duct carcinomas only All invasive carcinomas Infiltrating duct carcinomas only Distant metastases 0.85 0.54 ... years younger than patients without distant metastases (54 years) [p = 0.02] in the IDC group For all invasive carcinomas, the average age of patients with distant metastases was 46 years compared...

Ngày tải lên: 09/08/2014, 01:24

... 2005), he also makes a distinction between task-based teaching and tasksupported teaching The task-based teaching occurs when the teaching is based exclusively on meaning-focus tasks, and the task-supported ... functions and language notions are taught to learners at the same time with the assumption that language learning relates to learning formulaic expressions of language as well as learning rules of language ... II.1 A review of language teaching approaches Teaching language has received much focus for the past few decades So many approaches and methods such as Audiolingual Method, Total Physical Response,...

Ngày tải lên: 07/11/2012, 14:44

... higher pay based on language ability, reading technical material, translation work or achieving higher social status Instrumental motivation is often characteristic of second language acquisition, ... motivation has only been acknowledged as a significant factor in some research, whereas integrative motivation is continually linked to successful second language acquisition It has been found that ... instrumental forms of motivation For this reason he constructed a third group labelled as "personal" This category included motivational reasons such as, "pleasure at being able to read English, and...

Ngày tải lên: 06/09/2013, 10:10

... This has been related to an increased number of abnormal aspartate residues, spontaneously arising from L-asparaginyl deamidation and/or L-aspartyl isomerization reactions [7] In addition it has ... most abundant age-density fractions were used for the enzyme assays, and referred to as Ôbuoyant fractionÕ and Ôdense fractionÕ Pyruvate kinase (PK) activity was measured, as a cell-age marker, ... [7], are cytoskeletal components, such as ankyrin and bands 4.1 and 4.2, as well as the integral membrane protein band (AE1; the anion transporter) [6] In this respect, asparaginyl deamidation has...

Ngày tải lên: 08/03/2014, 22:20

... signaling through a novel mechanism involving nuclear accumulation of interferon regulatory factor J Virol 83, 2178–2187 Nakao K, Nakata K, Yamashita M, Tamada Y, Hamasaki K, Ishikawa H, Kato ... concentrations result in earlier maximal pathway activation and an increase in signal amplitude [3,4] Furthermore, alterations in the activity of a kinase or phosphatase may affect the speed of signalling ... using an RNeasy Plus Mini Kit (Qiagen, Hilden, Germany) The RNA was used for the quantitative real-time PCR and microarray analysis To generate cDNA, lg of total RNA was transcribed using a QuantiTect...

Ngày tải lên: 23/03/2014, 03:20

... which was much significant than the other variables and factors available Thus overall, the damage factor had both a statistical and a causal value, i.e functional and more precisely morphogenetic ... that an individual with a frost-nipped shoot was twice as likely to show a fork as an undamaged individual This value which was already high, should be considered to be a minimum value because ... general impression of severe damage Conversely, this experimental method has the advantage of allowing one to bypass the frost itself in a way, as its characteristics are always difficult to define accurately...

Ngày tải lên: 07/08/2014, 16:20

... plasma HIV viral loads of < 500 copies/ml In these analyses Aboriginal status was not associated with HIV plasma viral load response The multivariate analysis shows that only baseline HIV plasma ... plasma viral load, age, education, adherence, and history of IDU were associated with HIV plasma viral load response The univariate and multivariate associations of aboriginal status, clinical and ... deaths were smaller among racial minorities (black, Hispanic, Asian/Pacific Islanders, American Indian/Alaskan Native) compared with whites [45] These studies indicate that race/ethnicity has an...

Ngày tải lên: 10/08/2014, 05:20

... blood accumulating around the liver, causing upper abdominal pain The rupture may have increased, causing fetal heart rate pattern abnormalities Kurdoglu et al [5] reported a uterine rupture case: ... References Gupta A, Nanda S: Uterine rupture in pregnancy: a five-year study Arch Gynecol Obstet 2011, 283(3):437-441 Morimatsu Y, Matsubara S, Higashiyama N, Kuwata T, Ohkuchi A, Izumi A, Shibhara H, ... Cite this article as: Kuwata et al.: Intestinal adhesion due to previous uterine surgery as a risk factor for delayed diagnosis of uterine rupture: a case report Journal of Medical Case Reports...

Ngày tải lên: 10/08/2014, 23:20

... beginning with half a gram once a week; six months later his dose had increased to a gram a day By then he was shooting up daily He had never had any physical illness Once he was http://www.harmreductionjournal.com/content/2/1/11 ... http://www.harmreductionjournal.com/content/2/1/11 Figure withoutconcentration levels in a case A after conditioning in an accustomed place (A1 ) and in a new place (A2 ), and in a case B Heroin ... Heroin concentration levels in a case A after conditioning in an accustomed place (A1 ) and in a new place (A2 ), and in a case B without conditioning have the opportunity for secondary conditioning...

Ngày tải lên: 11/08/2014, 20:20

... blinded manner as a batch analysis MR-proADM was detected in EDTA plasma of all patients using a new sandwich immunoassay (B.R .A. H.M.S Sevadil® LIA; B.R .A. H.M.S., AG, Hennigsdorf/Berlin, Germany), ... analyte had no impact on recovery of the analyte Stability of the analyte (

Ngày tải lên: 12/08/2014, 23:20

... Furusho S, Kita T, Katayama N, Abo M, Ohkura N, Herai Y, Hori A, Ishiura Y, Nobata K, Ogawa H, Yasui M, Kasahara K, Nakao S: Comparison of cough reflex sensitivity after an inhaled antigen challenge ... respiratory diseases such as adult and pediatric asthma Also a series of epidemiological analyses on parental smoking and respiratory health in children have been performed [60,64,65,4,66-71] Overall ... study assessed the correlation of ETS exposure with the expression of inflammatory mediators in airway secretions of children with asthma IFN-gamma and IL-12, as well as IL-5 and IL-13 Table 1: Association...

Ngày tải lên: 13/08/2014, 08:20

... investigator All NSAIDs and aspirin were considered However, when aspirin was taken as an antiplatelet aggregant for the prevention of cardiovascular diseases (

Ngày tải lên: 13/08/2014, 16:20

... PART I: INTRODUCTION Rationale For centuries foreign language teaching approaches, methods and techniques have been changing because of different factors Learning a foreign language is a challenging ... in learning process? iii.Are students and teachers aware of technology application in teaching and learning English? iv What suggestions students and teachers have for organization and language ... on the motivation of EFL learners in language classes and to put forward some practical ideas in order to make language learning more effective The aims of survey is to reveal how teachers use...

Ngày tải lên: 04/08/2015, 09:41

... Vietnam Another reason is that the author has been a part of the “natural setting” She has been working in CARE International in Vietnam for one year and a half This case study uses both qualitative ... second and more important reason was that sending the questionnaire via email was fast, cheap and easy to reach the target groups and get feed back from them Beside the survey questionnaire, semi-structured ... and learning is a life-long process and in any environment, even after graduation or not in an educational setting, learning is always taking place and motivation for learning always live Last...

Ngày tải lên: 04/08/2015, 09:42

... community mental health teams Graduates were hired throughout the mental health system at standard rates of pay As case manager aides they helped their clients with a variety of tasks, such as applying ... increased demand for inpatient psychiatric care (Abas et al., 2003), and, while poverty and substance abuse are not necessarily related, poverty often increases the degree of harm that occurs at any ... elements are effective and which standards are necessary for success 175 Social factors as a basis for treatment Conclusion Social factors can affect the course and outcome of mental illness Programmes...

Ngày tải lên: 01/11/2013, 09:20

... 5¢-GAAUUUCACAUCCUCAACCUU-3¢) matched bases 192–210; the second siRNAZF5 (5¢-GAGGAAGCAUGA GAAACUCUU-3¢ and 5¢-GAGUUUCUCAUGCUUCCU CUU-3¢) matched bases 945–963; and the third siRNA ZF5 (5¢-GGUCCUGAACUACAUGUACUU-3¢ and 5¢-GUAC ... Luciferase activity was measured in a scintillation counter (Beckman Coulter, Fullerton, CA, USA) employing a Luciferase Assay System (Promega, catalog number E4030) in accordance with manufacturer’s ... assay RNA interference assay Three siRNAs for human ZF5 mRNA were selected based on general rules for siRNA selection [43] The first siRNAZF5 5¢-GGUUGAGGAUGUGAAAUUCUU-3¢ and 5¢-GAAUUUCACAUCCUCAACCUU-3¢)...

Ngày tải lên: 07/03/2014, 05:20

... dismutase NADPH oxidase activity was also assayed by polarographic measurement of the rate of O2 uptake at 20 °C with a Clark electrode at a voltage of 0.8 V All experiments were carried out at least ... GTPcS-loaded Rac2, MgSO4 and an optimal amount of arachidonic acid determined for each assay of oxidase activation [12] The rate of O2– production by the activated NADPH oxidase was calculated from ... contaminant [15] The identity of S10 0A8 was further ascertained by amino-acid sequencing, using Edman degradation As S10 0A9 has a blocked N-terminal amino acid, analysis of the protein was carried...

Ngày tải lên: 18/03/2014, 01:20

... were harvested, and the extracts were prepared for luciferase assay Luciferase activity was measured by the Luciferase Assay System (Promega, Madison, WI) as described previously [26] Transfection ... liposarcoma) in nuclear factorkappa B p65-mediated transcription as a coactivator J Biol Chem 276, 13395–13401 Takada, N., Sanda, T., Okamoto, H., Yang, J.P., Asamitsu, K., Sarol, L., Kimura, G., Uranishi, ... example, ATPase/helicase activity is found associated with TFIIH and chromatin remodeling complexes and plays crucial roles in transcriptional initiation and preinitiation The ATPase/helicase activity...

Ngày tải lên: 30/03/2014, 15:20

... tubular or tubulovillous adenomas with low (29 cases) to high (5 cases) grade dysplasia (AD), and 53 infiltrating adenocarcinomas classified using TNM (ajcc, american joint committee on cancer, ... relationship between TLR-4 expression and survival in adenocarcinomas, and the general tendency towards increased inflammatory markers as a function increasing tissue dysplasia up to malignancy, ... preneoplastic lesions are usually focal and mass forming There are also several differences in the sequences of molecular events leading from dysplasia to invasion in adenocarcinoma arising in IBD as...

Ngày tải lên: 18/06/2014, 16:20