oxidative stress signaling in alzheimer disease
Báo cáo y học: "BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease"
Ngày tải lên :
26/10/2012, 10:04
... in all
cases of Alzheimer disease. These findings not only further define the cell cycle reentry phenotype in Alzheimer
disease but also indicate that the neurofibrillary tangles which define ... P. Oxidative stress in mild cognitive impairment and
Alzheimer disease: a continuum. J Alzheimers Dis 2004; 6:
159-63.
34. Raina AK, Garrett MR, Previll LA, et al. Oncogenic parallels in
Alzheimer ... cardinal
intracellular lesion of Alzheimer disease (AD), and are
also found in normal aging, albeit to a lesser extent.
Highly phosphorylated tau protein is considered the
predominant proteinaceous...
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Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc
Ngày tải lên :
14/03/2014, 23:20
... oxidative stress. Thus, this study
suggests a role for GhMPK2 in the defense signaling
pathways in response to both pathogen infection and
oxidative stress.
Cotton GhMPK2 is involved in multiple signaling ... protein kinase and wound-
induced protein kinase, two MAPKs in group A, were
activated by inoculation with the tobacco mosaic virus
(TMV) [10]. Their orthologs in other plant species,
including ... species scavenging capability and
oxidative stress tolerance. These results increased our understanding of the
role of the group C GhMPK2 gene in multiple defense -signaling pathways,
including those...
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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
Ngày tải lên :
26/10/2012, 09:07
... synthase. The increased
activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased
and effective recycling of citrulline to arginine in anoxia, making nitric ... in brain in anoxia as observed by in-
crease in NOx concentration in this study support the
earlier findings of NO involvement in pathophysiol-
ogy of hypobaric hypoxia in brain (42-43). In this ... arginine at the site of synthesis.
Arginine is a semi essential amino acid and in CNS, its
availability depends upon: (a) uptake from the circu-
lating arginine and (b) recycling of citrulline...
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Tài liệu OXIDATIVE STRESS AND DISEASES pptx
Ngày tải lên :
12/02/2014, 16:20
... described the functioning of
blood-retinal barrier in detail, how it is impacted by ROS and retinal vein occlusion
induced by the inhibitor of a mitogen-activated protein kinase kinase.
The section ... main aim is to show examples which mirror our knowledge on the role of
oxidative stress in origin of diseases as well as its significance in disease complications. It
was it that oxidative stress ... researchers in the field of basic investigations
interested in the involvement of reactive oxygen species and oxidative stress in diverse
pathologies, medical scientists and practical physicians wishing...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
Ngày tải lên :
16/02/2014, 09:20
... the
pathogenic interaction between Ab and a-synuclein
was investigated by crossing PDGF–a-synuclein
and APP-SweInd, which led to a 1.6-fold increase in
a-synuclein inclusions in comparison with ... having sufficient power are therefore
extremely important in minimizing the in uence of
confounding factors arising from inherent problems
associated with breeding APP transgenic mice and
maintaining ... time-consuming and greatly
in uenced by individual handlers. IntelliCages are
automated learning cages where animals carrying
transponders are housed in groups and trained in
learning corners. Each individual...
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Tài liệu Báo cáo khoa học: Metabolic gene switching in the murine female heart parallels enhanced mitochondrial respiratory function in response to oxidative stress pdf
Ngày tải lên :
18/02/2014, 16:20
... Young
ME, Pham M, Zhang D, Cooksey RC, McClain DA,
Litwin SE et al. (2002) Insulin signaling coordinately
M. F. Essop et al. Metabolic gene switching in murine female heart
FEBS Journal 274 (2007) ... additional insights into this
interesting question.
Conclusions
In summary, we have identified a novel metabolic
gene switch (decrease in fatty acid utilization,
increase in glucose utilization) in the ... 2007)
doi:10.1111/j.1742-4658.2007.06051.x
The mechanisms underlying increased cardioprotection in younger female
mice are unclear. We hypothesized that serine-threonine protein kinase
(protein kinase B; Akt) triggers a metabolic...
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Tài liệu Báo cáo khoa học: Osmotic stress sensing and signaling in fishes doc
Ngày tải lên :
18/02/2014, 16:20
... of
MAPK cascades, mitogen-activated protein kinase
kinase kinase 7 interacting protein 2 (TAK 1 binding
protein 2 ẳ TAB 2), as an IEG during hyperosmotic
stress in tilapia gill epithelium [26]. This ... rapidly (within 2 h) induced by
hyperosmotic stress, indicating a role of this mitogen-
activated protein kinase kinase kinase 7 interacting
protein for osmosensory signal transduction in fish.
14-3-3 ... ele-
ment binding protein and osmotic stress transcription factor 1, which, in
turn, regulate the expression of genes involved in osmotic stress acclima-
tion. In addition to intracellular signaling...
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Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc
Ngày tải lên :
19/02/2014, 16:20
... oxidative stress.
Our findings show that pilocarpine induces SE,
which can produce alterations in superoxide dismutase
and catalase activities in different areas, thereby pro-
tecting the brain ... [2,19,20], immediately
after pilocarpine administration, animals persistently
show behavioral changes, including initial akinesia,
ataxic lurching, peripheral cholinergic signs (miosis,
piloerection, ... Interstrain differences in cognitive functions in
rats in relation to status epilepticus. Behav Brain Res
112, 77–83.
3 Treiman DM (1955) Electroclinical features of status
epilepticus. J Clin...
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Tài liệu Báo cáo khoa học: Enhancement of oxidative stress-induced apoptosis by Hsp105a in mouse embryonal F9 cells pptx
Ngày tải lên :
21/02/2014, 03:20
... treatment, cells were incubated in medium
containing 50 lgặmL
)1
neutral red at 37 C for 3 h, then
xed with 1% formaldehyde containing 1% CaCl
2
for
1 min. The dye incorporated into viable cells ... Hsp105a
plays an important role in protection of neuronal cells
against stress- induced apoptosis [26]. In accordance with
these findings, ischemia/reperfusion in the rat forebrain
induces the expression ... mitogen-activated protein kinase
(p38). Furthermore, oxidative stress- induced apoptosis was
suppressed by SB202190, a potent inhibitor of p38, in F9
cells. These findings indicated that the activation...
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Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues ppt
Ngày tải lên :
06/03/2014, 19:20
... PM
2.5
onWATandBATspecificgenesin
different adipose depots. There are several major find-
ings in this study. First, exposure to PM
2.5
resulted in
oxidative stress in BAT. Second, exposure to PM
2.5
induced changes ... 8 of 14
inflammatory response and IR development, were exam-
ined in mice. As shown in Figure 3, PM
2.5
exposure
induced a marked increase in macroph age (F4/80
+
cells)
infiltration in eWAT. ... reduced in both
eWAT and iBAT in response to PM
2.5
exposure.
Recent studies have implicated PM
2.5
in in creased adi-
pose inflammation and insulin resistance [11,12], and
epidemiological studies indicate...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
Ngày tải lên :
07/03/2014, 12:20
... neuron. The turning point upon which
the cell looses the ability to buffer the incoming calcium
resulting in an abrupt, sustained and irreversible
increase in [Ca
2+
]
c
, probably coincides with ... functions, in addition to
having supporting functions for oxidative defences [79],
involving the thioredoxin system [40]. Aconitase acts
also as an iron-responsive element binding protein, iso-
citrate ... by proteins resi-
ding in both the inner and outer mitochondrial
membrane, that is activated by mitochondrial Ca
2+
overloading and other factors including oxidative stress
[88,89]. In neurons...
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Báo cáo khoa học: Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress pdf
Ngày tải lên :
07/03/2014, 12:20
... enzymatic activity
involved in the oxidative stress in S. solfataricus.
To detect differences in the response to various
agents we induced oxidative stress with paraquat,
an O
2
ã
)
generating compound, ... stress conditions, are important in deter-
mining the level of Bcp2 protein. Similar results are
observed for genes and related proteins involved in
oxidative stress in other microrganisms [24]. ... S
p
peroxidatic cysteine;
X unidentified electron donor; S
R
resolving
cysteine; RSH protein or domain with CXXC
motif (e.g. thioredoxin). In typical 2-Cys, S
p
at the N terminus and S
R
at the C terminus
belong...
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Báo cáo khoa học: Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica pdf
Ngày tải lên :
15/03/2014, 23:20
... indicating the presence of two catalytically
independent domains, the N-terminal domain, display-
ing ALDH activity, and the C-terminal domain, con-
taining an iron-binding domain, which is involved ... against oxidative stress
damage, have not been reported.
In vivo effects on glucose-fermenting enzymes
and fluxes under oxidative stress
Recently, we reported that amebas incubated for
30 min in ... bind
close to the Fe–S clusters, blocking the access of ROS.
In this regard, a preliminary docking analysis with
coenzymes in the 3D model of EhPFOR suggested that
the CoA-binding site was, indeed,...
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Báo cáo khoa học: Exogenous oxidative stress induces Ca2+ release in the yeast Saccharomyces cerevisiae potx
Ngày tải lên :
15/03/2014, 23:20
... factors regulat-
ing the response to oxidative stress in yeast. Antioxid
Redox Signal 4, 123–140.
25 Ikner A & Shiozaki K (2005) Yeast signaling pathways
in the oxidative stress response. ... gene encoding
the regulatory subunit of calcineurin) under oxidative
stress was tested. It was noted that CNB1 deletion
resulted in an increase of tolerance to H
2
O
2
(Fig. 3B),
Oxidative stress ... Ca
2+
transport in
Saccharomyces cerevisiae. J Exp Biol 196, 157–166.
11 Cunningham KW & Fink GR (1996) Calcineurin inhib-
its VCX1-dependent H
+
⁄ Ca
2+
exchange and induces
Ca
2+
ATPases in Saccharomyces...
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