oxidative stress signaling in alzheimer disease

... in all cases of Alzheimer disease. These findings not only further define the cell cycle reentry phenotype in Alzheimer disease but also indicate that the neurofibrillary tangles which define ... P. Oxidative stress in mild cognitive impairment and Alzheimer disease: a continuum. J Alzheimers Dis 2004; 6: 159-63. 34. Raina AK, Garrett MR, Previll LA, et al. Oncogenic parallels in Alzheimer ... cardinal intracellular lesion of Alzheimer disease (AD), and are also found in normal aging, albeit to a lesser extent. Highly phosphorylated tau protein is considered the predominant proteinaceous...

Ngày tải lên: 26/10/2012, 10:04

Ngày tải lên: 16/03/2014, 14:20

Ngày tải lên: 23/03/2014, 15:21

Ngày tải lên: 11/08/2014, 11:21

Ngày tải lên: 19/06/2014, 22:20

... oxidative stress. Thus, this study suggests a role for GhMPK2 in the defense signaling pathways in response to both pathogen infection and oxidative stress. Cotton GhMPK2 is involved in multiple signaling ... protein kinase and wound- induced protein kinase, two MAPKs in group A, were activated by inoculation with the tobacco mosaic virus (TMV) [10]. Their orthologs in other plant species, including ... species scavenging capability and oxidative stress tolerance. These results increased our understanding of the role of the group C GhMPK2 gene in multiple defense -signaling pathways, including those...

Ngày tải lên: 14/03/2014, 23:20

Ngày tải lên: 19/06/2014, 22:20

... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... in brain in anoxia as observed by in- crease in NOx concentration in this study support the earlier findings of NO involvement in pathophysiol- ogy of hypobaric hypoxia in brain (42-43). In this ... arginine at the site of synthesis. Arginine is a semi essential amino acid and in CNS, its availability depends upon: (a) uptake from the circu- lating arginine and (b) recycling of citrulline...

Ngày tải lên: 26/10/2012, 09:07

... described the functioning of blood-retinal barrier in detail, how it is impacted by ROS and retinal vein occlusion induced by the inhibitor of a mitogen-activated protein kinase kinase. The section ... main aim is to show examples which mirror our knowledge on the role of oxidative stress in origin of diseases as well as its significance in disease complications. It was it that oxidative stress ... researchers in the field of basic investigations interested in the involvement of reactive oxygen species and oxidative stress in diverse pathologies, medical scientists and practical physicians wishing...

Ngày tải lên: 12/02/2014, 16:20

... the pathogenic interaction between Ab and a-synuclein was investigated by crossing PDGF–a-synuclein and APP-SweInd, which led to a 1.6-fold increase in a-synuclein inclusions in comparison with ... having sufficient power are therefore extremely important in minimizing the in uence of confounding factors arising from inherent problems associated with breeding APP transgenic mice and maintaining ... time-consuming and greatly in uenced by individual handlers. IntelliCages are automated learning cages where animals carrying transponders are housed in groups and trained in learning corners. Each individual...

Ngày tải lên: 16/02/2014, 09:20

... Young ME, Pham M, Zhang D, Cooksey RC, McClain DA, Litwin SE et al. (2002) Insulin signaling coordinately M. F. Essop et al. Metabolic gene switching in murine female heart FEBS Journal 274 (2007) ... additional insights into this interesting question. Conclusions In summary, we have identified a novel metabolic gene switch (decrease in fatty acid utilization, increase in glucose utilization) in the ... 2007) doi:10.1111/j.1742-4658.2007.06051.x The mechanisms underlying increased cardioprotection in younger female mice are unclear. We hypothesized that serine-threonine protein kinase (protein kinase B; Akt) triggers a metabolic...

Ngày tải lên: 18/02/2014, 16:20

... of MAPK cascades, mitogen-activated protein kinase kinase kinase 7 interacting protein 2 (TAK 1 binding protein 2 ẳ TAB 2), as an IEG during hyperosmotic stress in tilapia gill epithelium [26]. This ... rapidly (within 2 h) induced by hyperosmotic stress, indicating a role of this mitogen- activated protein kinase kinase kinase 7 interacting protein for osmosensory signal transduction in fish. 14-3-3 ... ele- ment binding protein and osmotic stress transcription factor 1, which, in turn, regulate the expression of genes involved in osmotic stress acclima- tion. In addition to intracellular signaling...

Ngày tải lên: 18/02/2014, 16:20

... oxidative stress. Our findings show that pilocarpine induces SE, which can produce alterations in superoxide dismutase and catalase activities in different areas, thereby pro- tecting the brain ... [2,19,20], immediately after pilocarpine administration, animals persistently show behavioral changes, including initial akinesia, ataxic lurching, peripheral cholinergic signs (miosis, piloerection, ... Interstrain differences in cognitive functions in rats in relation to status epilepticus. Behav Brain Res 112, 77–83. 3 Treiman DM (1955) Electroclinical features of status epilepticus. J Clin...

Ngày tải lên: 19/02/2014, 16:20

... treatment, cells were incubated in medium containing 50 lgặmL )1 neutral red at 37 C for 3 h, then xed with 1% formaldehyde containing 1% CaCl 2 for 1 min. The dye incorporated into viable cells ... Hsp105a plays an important role in protection of neuronal cells against stress- induced apoptosis [26]. In accordance with these findings, ischemia/reperfusion in the rat forebrain induces the expression ... mitogen-activated protein kinase (p38). Furthermore, oxidative stress- induced apoptosis was suppressed by SB202190, a potent inhibitor of p38, in F9 cells. These findings indicated that the activation...

Ngày tải lên: 21/02/2014, 03:20

... PM 2.5 onWATandBATspecificgenesin different adipose depots. There are several major find- ings in this study. First, exposure to PM 2.5 resulted in oxidative stress in BAT. Second, exposure to PM 2.5 induced changes ... 8 of 14 inflammatory response and IR development, were exam- ined in mice. As shown in Figure 3, PM 2.5 exposure induced a marked increase in macroph age (F4/80 + cells) infiltration in eWAT. ... reduced in both eWAT and iBAT in response to PM 2.5 exposure. Recent studies have implicated PM 2.5 in in creased adi- pose inflammation and insulin resistance [11,12], and epidemiological studies indicate...

Ngày tải lên: 06/03/2014, 19:20

... neuron. The turning point upon which the cell looses the ability to buffer the incoming calcium resulting in an abrupt, sustained and irreversible increase in [Ca 2+ ] c , probably coincides with ... functions, in addition to having supporting functions for oxidative defences [79], involving the thioredoxin system [40]. Aconitase acts also as an iron-responsive element binding protein, iso- citrate ... by proteins resi- ding in both the inner and outer mitochondrial membrane, that is activated by mitochondrial Ca 2+ overloading and other factors including oxidative stress [88,89]. In neurons...

Ngày tải lên: 07/03/2014, 12:20

... enzymatic activity involved in the oxidative stress in S. solfataricus. To detect differences in the response to various agents we induced oxidative stress with paraquat, an O 2 ã ) generating compound, ... stress conditions, are important in deter- mining the level of Bcp2 protein. Similar results are observed for genes and related proteins involved in oxidative stress in other microrganisms [24]. ... S p peroxidatic cysteine; X unidentified electron donor; S R resolving cysteine; RSH protein or domain with CXXC motif (e.g. thioredoxin). In typical 2-Cys, S p at the N terminus and S R at the C terminus belong...

Ngày tải lên: 07/03/2014, 12:20

... indicating the presence of two catalytically independent domains, the N-terminal domain, display- ing ALDH activity, and the C-terminal domain, con- taining an iron-binding domain, which is involved ... against oxidative stress damage, have not been reported. In vivo effects on glucose-fermenting enzymes and fluxes under oxidative stress Recently, we reported that amebas incubated for 30 min in ... bind close to the Fe–S clusters, blocking the access of ROS. In this regard, a preliminary docking analysis with coenzymes in the 3D model of EhPFOR suggested that the CoA-binding site was, indeed,...

Ngày tải lên: 15/03/2014, 23:20

... factors regulat- ing the response to oxidative stress in yeast. Antioxid Redox Signal 4, 123–140. 25 Ikner A & Shiozaki K (2005) Yeast signaling pathways in the oxidative stress response. ... gene encoding the regulatory subunit of calcineurin) under oxidative stress was tested. It was noted that CNB1 deletion resulted in an increase of tolerance to H 2 O 2 (Fig. 3B), Oxidative stress ... Ca 2+ transport in Saccharomyces cerevisiae. J Exp Biol 196, 157–166. 11 Cunningham KW & Fink GR (1996) Calcineurin inhib- its VCX1-dependent H + ⁄ Ca 2+ exchange and induces Ca 2+ ATPases in Saccharomyces...

Ngày tải lên: 15/03/2014, 23:20