oxidative stress in heart failure
Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... arginase in the study AS and AL activities increased in all the three brain regions significantly in anoxia suggesting an increased utilization of citrulline for the production of arginine in ... observed by increase in NOx concentration in this study support the earlier findings of NO involvement in pathophysiology of hypobaric hypoxia in brain (42-43) In this study the increased activity ... citrulline generated as a by-product can be recycled to arginine by successive actions of argininosuccinate synthetase (AS; EC 6.3.4.5) and argininosuccinate lyase (AL; EC 4.3.2.1) via the citrulline-NO...
- 8
- 622
- 0
Báo cáo y học: "Different effect of exercise on left ventricular diastolic time and interventricular dyssynchrony in heart failure patients with and without left bundle branch block"
... lack of increase in LV dyssynchrony during dobutamine stress in patients with wide QRS duration (20) In contrast, Kurita et al reported on an increased mechanical dyssynchrony during pacing–induced ... pacing–induced tachycardia in patients with normal QRS duration (21) A remarkable increase in intra-LV dyssynchrony was also demonstrated during pharmacological stress in systolic heart failure patients ... rest or during exercise or the exercise-related increase in EDVI and the corresponding LDT values were found in both IDCM subgroups Results Systolic and diastolic time intervals The clinical characteristics...
- 8
- 868
- 1
Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc
... characterize oxidative stress Our findings show that pilocarpine induces SE, which can produce alterations in superoxide dismutase and catalase activities in different areas, thereby protecting the brain ... [2,19,20], immediately after pilocarpine administration, animals persistently show behavioral changes, including initial akinesia, ataxic lurching, peripheral cholinergic signs (miosis, piloerection, ... Oxidative stress after status epilepticus in rats inefficiency of the electron-carrying components of the mitochondrial transport chain, monoamine degradation, xanthine oxidase reaction,...
- 6
- 480
- 0
Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... functions, in addition to having supporting functions for oxidative defences [79], involving the thioredoxin system [40] Aconitase acts also as an iron-responsive element binding protein, isocitrate ... Ca2+ overloading and other factors including oxidative stress [88,89] In neurons the presence of PTP in situ has not gained wide acceptance among investigators and results published in the literature ... alterations in [Na+]i That may explain our previous results in isolated nerve terminals showing that in the presence of an oxidative stress a concomitant elevation in [Na+]i acts deleteriously on in situ...
- 18
- 549
- 0
Báo cáo khoa học: Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica pdf
... activity, and the C-terminal domain, containing an iron-binding domain, which is involved in ADH activity The integrity of both domains and that of the iron-binding domain are required for ALDH ... 2010 FEBS 3383 Fermenting enzymes and oxidative stress in Entamoeba E Pineda et al Table Kinetic parameters of EhPFOR at 37 C Figures in parentheses indicate numbers of individual amebal extracts ... et al Fermenting enzymes and oxidative stress in Entamoeba samples was also applied where indicated The number of independent preparations assayed is indicated in parentheses Modeling the EhPFOR...
- 14
- 420
- 0
Báo cáo khoa học: Fasting-induced oxidative stress in very long chain acyl-CoA dehydrogenase-deficient mice pdf
... higher in VLCAD KO mice than in WT mice Fasting induced a significant increase in both genotypes; however, this was more evident in the VLCAD KO mice (Fig 3A) Interestingly, the MCT diet also induced ... observed in human VLCADD [5] In fact, in both mice and humans, clinical symptoms become mainly evident as a consequence of triggers such as fasting, resulting in the accumulation of long-chain acylcarnitines, ... protein utilizing the principle of protein-dye binding Anal Biochem 72, 248–254 FEBS Journal 277 (2010) 4699–4708 ª 2010 The Authors Journal compilation ª 2010 FEBS 4707 Oxidative stress in VLCAD...
- 10
- 381
- 0
Báo cáo khoa học: A nonribosomal peptide synthetase (Pes1) confers protection against oxidative stress in Aspergillus fumigatus ppt
... (2002) Invasive aspergillosis in 2002: an update Eur J Clin Microbiol Infect Dis 21, 161–172 Denning DW (1996) Therapeutic outcome in invasive aspergillosis Clin Infect Dis 23, 608–615 Denning DW ... Calmodulin forward Calmodulin reverse Aspergillus fumigatus actin forward Aspergillus fumigatus actin reverse 5¢ flanking forward 5¢ flanking reverse 3¢ flanking forward 3¢ flanking reverse zeocin–pyrG ... applied ROS Interestingly, upregulation of pes1 expression was not observed following H2O2-induced oxidative stress in cultures of A fumigatus 293.1 grown in either Sabouraud or 5% FBS in MEM (data...
- 16
- 361
- 0
Báo cáo hóa học: " Oxidative stress in NSC-741909-induced apoptosis of cancer cells" potx
... apoptosis In fact, ROS-induced oxidative stress and cell death play important roles in the efficacy of many antineoplastic agents [13,14] To investigate whether oxidative stress is involved in the ... several LOX inhibitors, including aesculetin (a nonselective LOX inhibitor), MK886 (an inhibitor of the 5-LOX-activating protein), zileuton (a 5-LOX inhibitor), baicalein (a 12/15-LOX inhibitor), ... decreased protein levels of MKP1, one of MAP kinase phosphatases that inactivate JNK and p38 MAP kinases [2] Interestingly, NSC-741909 induced an increase of MKP1 mRNA expression in both time-...
- 10
- 576
- 0
báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... that a full dose of indomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain oxidative stress in the Tg2576 mice [16] This finding suggests that ... brain oxidative stress E supplementation on Effect of indomethacin plus vitamin E supplementation on markers of brain oxidative stress Total cerebral cortex homogenates from Tg2576 receiving ... pH 7.0) containing protease inhibitor mixture (pepstatin A, leupeptin, N-tosyl-L-phenylalanine chloromethyl ketone, http://www.jneuroinflammation.com/content/1/1/21 soybean trypsin inhibitor, each...
- 9
- 490
- 0
báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... has been investigated with the use of specific protein kinase inhibitors revealing that protein kinase C (PKC) [37-39], p21-activated kinase-1 (PAK1) [40], mitogen-activated protein kinase (MAPK) ... src-family tyrosine kinases or inhibition of phosphatidylinositol-3 kinase (PI3K) attenuates ROS production These findings suggest that these kinases are involved in upstream signaling cascades responsible ... together, these findings provide compelling in vitro evidence that vitamin E could act to inhibit the Aβ-stimulated microglia inflammatory response Specifically, vitamin E could inhibit ROS and...
- 12
- 413
- 0
Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
... origin, was obtained from ATCC (Manassas, USA) and cultured Ham’s F-12 media (Gibco) containing mM L-glutamine supplemented with 0.01 mg/ml bovine pituitary extract (Gibco, USA), 0.005 mg/ml insulin ... PM10 to oxidative stress repair enzyme, we used RT-PCR analysis Figure shows the expression level of catalase mRNA induced by Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat ... PM2.5 induced more MDA formation than PM10 suggesting that PM2.5 induced more oxidative stress than PM10 In the single strand breakage assay using pBR322 DNA, the ratio of changed form II/total...
- 8
- 442
- 1
Báo cáo lâm nghiệp: "Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings" pot
... seedling, cut into ì mm pieces and incubated in mL of 100 mM phosphate buer (pH 7.5) containing 40 mM KNO3 and 1.5% 1-propanol Each sample was vortexed for to help tissue inltration by the incubation ... CO2 by PEPC increased in response to O3 in both groups of seedlings (Figs 5E5H) during the growing season The level of activity decreased in the neoformed ush of the episodic seedlings when the ... [14] GR is one of the enzymes of this cycle In the present study, GR activity increased two-fold in sugar maple seedlings in response to increasing O3 stress This enzyme ensures a high level of...
- 11
- 392
- 0
Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
... including hypoxic conditions and stimulation by transforming growth factor, CD40 ligand, interleukin 1, or interleukin [10] Oxidative stress also promotes angiogenesis [13] The link between oxidative ... 14 (7.4 ± 2) Ongoing angiotensin-converting enzyme inhibitors (no patients) Ongoing low-dose aspirin therapy (no patients) 25 Values are number (%) of patients unless otherwise indicated DLCO, ... carbon monoxide diffusion in the lung; Hb, hemoglobin in ml of M guanidine in 20 mM potassium phosphate, adjusted to pH 2.3 with trifluoracetic acid; the resulting solution was incubated at 37°C for...
- 6
- 518
- 0
Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
... Conclusion This study provides insight into the involvement of oxidative stress in the pathogenesis of OA from the viewpoint of oxidative stress induced genomic instability, especially telomere ... degeneration in cartilage The findings of the present study suggest that cumulative oxidative stress leads to a decrease in antioxidative capacity in articular cartilage, resulting in chondrocyte ... replication Oxidative stress increases the telomere shortening rate by up to one order of magnitude [46] From these findings, we postulated that oxidative stress directly induces chondrocyte telomere instability...
- 12
- 407
- 0
Báo cáo y học: " Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilag" pps
... lysosome in mediating high-glucose-induced downregulation of glucose transporter-1 protein Glucose transprotein porter-1 (GLUT-1) protein content normalized to the respective actin band in normal ... Nonproliferating monolayer cultures were established from each cartilage sample, allowed to recover in medium containing 5% fetal bovine serum for 24 hours, serum-starved overnight and maintained thereafter ... protein concentration Western blot analysis Whole cell lysates were prepared in RIPA buffer and the protein concentration was measured using the bicinchoninic acid/copper (II) sulphate protein...
- 11
- 431
- 0
Báo cáo y học: "Pu-Erh tea and GABA attenuates oxidative stress in kainic acid-induced status epilepticu" docx
... to investigate the protective mechanisms of GABA and Pu-erh tea leaf extract on KA-induced injury in neuronal cells in vivo and in vitro Methods Materials GABA and kainic acid (KA) were obtained ... factors, including members of the S100 protein family [45,46], act to sustain the inflammatory response or to determine direct effects on neurons and/or microglia, thus switching the inflammatory ... L, Hartley O, Dubois-Dauphin M, Krause KH: Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases Brain Res Brain Res Rev 2005, 48:16-42...
- 10
- 366
- 0
Báo cáo y học: "EGb761 protects motoneurons against avulsion-induced oxidative stress in rats Research article" ppsx
... removed[15,22,23] Inducible NOS (iNOS) activity and total NOS activity in spinal cord were measured with a NOS kit (Nanjing Jiancheng Institute of Biology and Engineering, Nanjing, China), which assessed ... by measuring the conversion of L-[14C]-arginine to L-[14C]citrulline [24] The total NOS activity was determined by incubating samples (50 μL) for 15 at 37°C in a reaction mixture containing buffer ... nicotinamide adenine dinucleotide phosphate(β-NADPH), mM CaCl2, 50 μM tetrahydrobiopterin (BH4) and μCi/ ml L-[14C]-arginine Inducible NOS (iNOS) activity was measured by omitting calcium and adding...
- 7
- 331
- 0
Báo cáo khoa hoc:" Lack of association between mutations of gene-encoding mitochondrial D310 (displacement loop) mononucleotide repeat and oxidative stress in chronic dialysis patients in Taiwan" ppsx
... result in a significant difference in levels of oxidative stress biomarkers and the mtDNA copy number in dialysis patients Discussion An increased oxidative burden is observed in chronic renal failure ... of our findings, we have proposed a possible gateway to further investigate the association between mtDNA mutations and oxidative stress in chronic renal failure References Competing interests ... susceptible region for oxidative stress, we hypothesized that the D-loop mutation exists in dialysis patients with an increased oxidative stress status In this study, we investigated that hypothesis...
- 7
- 352
- 0
Báo cáo y học: "TNF-α and IL-10 downregulation and marked oxidative stress in Neuromyelitis Optica" pptx
... apoptosis in some cells and proliferation in others Reports indicate either exacerbation or amelioration of pathological conditions in the brain during TNF- treatment, including experimentally induced ... higher than those in the active phase [27] indicating that in MS and probably in NMO, the regulatory cytokine, IL10, is impaired Regulatory mechanisms are essential in preventing autoimmune disorders ... can react with norepinephrine, dopamine and serotonin [32], to initiate their oxidation, which then continues with the production of more ROS, quinones, etc Damage to brain readily releases iron...
- 9
- 241
- 0
THE ROLE OF SURGERY IN HEART FAILURE - part 2 pps
... who have heart failure worldwide Heart failure is primarily a disease of the elderly, and the prevalence of chronic heart failure increases with advancing age Currently, chronic heart failure ... chronic shortage of donor hearts Currently, the mainstay of heart failure treatment is pharmacologic and includes angiotensin converting enzyme inhibitors, angiotensin receptor blockers, b-adrenergic ... diastolic heart failure ranges from 5% to 15%, and admission rate for recurrent heart failure is 50% within the first months [1–4] The remaining 50% to 70% of patients present with systolic heart failure...
- 2
- 302
- 0
Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008