oxidative stress in diabetes mellitus
Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
Ngày tải lên :
26/10/2012, 09:07
... synthase. The increased
activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased
and effective recycling of citrulline to arginine in anoxia, making nitric ... in brain in anoxia as observed by in-
crease in NOx concentration in this study support the
earlier findings of NO involvement in pathophysiol-
ogy of hypobaric hypoxia in brain (42-43). In this ... arginine at the site of synthesis.
Arginine is a semi essential amino acid and in CNS, its
availability depends upon: (a) uptake from the circu-
lating arginine and (b) recycling of citrulline...
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Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc
Ngày tải lên :
19/02/2014, 16:20
... oxidative stress.
Our findings show that pilocarpine induces SE,
which can produce alterations in superoxide dismutase
and catalase activities in different areas, thereby pro-
tecting the brain ... [2,19,20], immediately
after pilocarpine administration, animals persistently
show behavioral changes, including initial akinesia,
ataxic lurching, peripheral cholinergic signs (miosis,
piloerection, ... Interstrain differences in cognitive functions in
rats in relation to status epilepticus. Behav Brain Res
112, 77–83.
3 Treiman DM (1955) Electroclinical features of status
epilepticus. J Clin...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
Ngày tải lên :
07/03/2014, 12:20
... neuron. The turning point upon which
the cell looses the ability to buffer the incoming calcium
resulting in an abrupt, sustained and irreversible
increase in [Ca
2+
]
c
, probably coincides with ... functions, in addition to
having supporting functions for oxidative defences [79],
involving the thioredoxin system [40]. Aconitase acts
also as an iron-responsive element binding protein, iso-
citrate ... by proteins resi-
ding in both the inner and outer mitochondrial
membrane, that is activated by mitochondrial Ca
2+
overloading and other factors including oxidative stress
[88,89]. In neurons...
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Báo cáo khoa học: Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica pdf
Ngày tải lên :
15/03/2014, 23:20
... indicating the presence of two catalytically
independent domains, the N-terminal domain, display-
ing ALDH activity, and the C-terminal domain, con-
taining an iron-binding domain, which is involved ... against oxidative stress
damage, have not been reported.
In vivo effects on glucose-fermenting enzymes
and fluxes under oxidative stress
Recently, we reported that amebas incubated for
30 min in ... bind
close to the Fe–S clusters, blocking the access of ROS.
In this regard, a preliminary docking analysis with
coenzymes in the 3D model of EhPFOR suggested that
the CoA-binding site was, indeed,...
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Báo cáo khoa học: Fasting-induced oxidative stress in very long chain acyl-CoA dehydrogenase-deficient mice pdf
Ngày tải lên :
15/03/2014, 23:20
... mice. Fasting induced a significant increase in both
genotypes; however, this was more evident in the
VLCAD KO mice (Fig. 3A). Interestingly, the MCT
diet also induced AOX gene expression in WT mice.
After ... observed in human VLCADD [5]. In fact, in
both mice and humans, clinical symptoms become
mainly evident as a consequence of triggers such
as fasting, resulting in the accumulation of long-chain
acylcarnitines, ... quantitation of microgram quantities of protein
utilizing the principle of protein-dye binding. Anal
Biochem 72, 248–254.
S. Tucci et al. Oxidative stress in VLCAD KO mice
FEBS Journal 277 (2010)...
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Báo cáo khoa học: A nonribosomal peptide synthetase (Pes1) confers protection against oxidative stress in Aspergillus fumigatus ppt
Ngày tải lên :
30/03/2014, 10:20
... to
applied ROS. Interestingly, upregulation of pes1
expression was not observed following H
2
O
2
-induced
oxidative stress in cultures of A. fumigatus 293.1 grown
in either Sabouraud or 5% FBS in MEM ... Infect Dis
21, 161–172.
4 Denning DW (1996) Therapeutic outcome in invasive
aspergillosis. Clin Infect Dis 23, 608–615.
5 Denning DW (1998) Invasive aspergillosis. Clin Infect
Dis 26, 781–805.
6 ... this strain in subsequent gene-disruption experi-
ments.
In order to find whether pes1 was expressed during
fungal infection in G. mellonella, A. fumigatus
ATCC 26933 conidia were injected into larvae...
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Báo cáo hóa học: " Oxidative stress in NSC-741909-induced apoptosis of cancer cells" potx
Ngày tải lên :
18/06/2014, 16:20
... several LOX inhibitors, including aesculetin (a
nonselective LOX inhibitor), MK886 (an inhibitor of the
5-LOX-activating protein), zileuton (a 5-LOX inhibitor),
baicalein (a 12/15-LOX inhibitor), ... apoptosis. In fact, ROS-induced oxidative stress
and cell death play important roles in the efficacy of many
antineoplastic agents [13,14].
To investigate whether oxidative stress is involved in
the ... National Cancer Institute. Using a reverse-phase pro-
tein microarray assay, we determined molecular changes
in 77 protein biomarkers in an oncrasin-sensitive lung
cancer cell line after treatment...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
Ngày tải lên :
19/06/2014, 22:20
... brain Aβ amyloidosis model.
Previously, we have shown that a full dose of
indomethacin alone despite a significant reduction in
brain inflammation had only a marginal effect on brain
oxidative stress ... inflammation when combined with indomethacin.
In summary, our findings support the hypothesis that oxi-
dative stress and inflammation represent important but
distinct therapeutic targets in AD-like amyloidosis. ... burden in the hippocampus of these mice [16].
However, recent studies indicate that a subset of NSAIDs,
including indomethacin, also possesses a direct, COX-
independent Aβ-lowering capacity in cell...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
Ngày tải lên :
19/06/2014, 22:20
... global inhibition
of src-family tyrosine kinases or inhibition of phosphati-
dylinositol-3 kinase (PI3K) attenuates ROS production.
These findings suggest that these kinases are involved in
upstream ... has been investi-
gated with the use of specific protein kinase inhibitors
revealing that protein kinase C (PKC) [37-39], p21-acti-
vated kinase-1 (PAK1) [40], mitogen-activated protein
kinase (MAPK) ... Peroxynitrite-induced alterations in synapto-
somal membrane proteins: insight into oxidative stress in
Alzheimer's disease. J Neurochem 1999, 72:310-317.
87. Bonfoco E, Krainc D, Ankarcrona...
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Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
Ngày tải lên :
07/08/2014, 17:22
... origin, was
obtained from ATCC (Manassas, USA) and cultured Ham’s
F-12 media (Gibco) containing 2 mM L-glutamine
supplemented with 0.01 mg/ml bovine pituitary extract
(Gibco, USA), 0.005 mg/ml insulin ... study,
PM2.5 induced more MDA formation than PM10
suggesting that PM2.5 induced more oxidative stress than
PM10. In the single strand breakage assay using pBR322
DNA, the ratio of changed form II/total ... protein in the PM2.5
-
and PM10
-
t
reated rat lung epithelial cell was determined by Weste
rn
B
lotting. The lower shows the ratio of Nrf2/actin usi
ng
c
alculatging by densitometor. In the...
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Báo cáo lâm nghiệp: "Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings" pot
Ngày tải lên :
08/08/2014, 00:22
... CO
2
by PEPC increased in re-
sponse to O
3
in both groups of seedlings (Figs. 5E–5H) dur-
ing the growing season. The level of activity decreased in
the neoformed flush of the episodic seedlings when ... seedling, cut into 2 ì 2 mm pieces and
incubated in 5 mL of 100 mM phosphate buffer (pH 7.5) containing
40 mM KNO
3
and 1.5% 1-propanol. Each sample was vortexed for
2 min to help tissue in ltration ... by immersing
the tubes for 5 min in boiling water. The colorimetric determination
of NO
2
−
was done by mixing 0.25 mL of incubation medium with
0.25 mL 0.02% N-(1-Naphtyl) ethylenediamine and...
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Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
Ngày tải lên :
09/08/2014, 01:23
... production, including
hypoxic conditions and stimulation by transforming growth
factor, CD40 ligand, interleukin 1, or interleukin 6 [10]. Oxi-
dative stress also promotes angiogenesis [13]. The link
between ... previously demonstrated a sustained major decrease in
oxidative stress in response to treatment with dihydropyrid-
ine-type calcium-channel blockers [17]. The data reported
herein confirm these results ... suggest
that nifedipine can ameliorate endothelium injury in SSc
and that VEGF signalling may by impaired in this disease
without implication of the sVEGFR-1.
Endothelium injury is critical in SSc and...
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