oxidative stress hypothesis in alzheimers disease

... carriers are involved in oxidative stress during heat stress in Saccharomyces cerevisiae. Mol Cel Biol 21, 8483–8489. 17 Guo J & Lemire BD (2003) The ubiquinone-binding site of the Saccharomyces ... showing that Yap1 binding activity may be affected. It was shown that the accessibility of Yap1 to the GSH1 promoter could be repressed by Cbf1, a DNA-binding protein that binds to elements in ... in Saccharomyces cerevisiae: insights into ageing, apoptosis and diseases. Mol Aspects Med 22, 217–246. 10 Moye-Rowley WS (2002) Transcription factors regula- ting the response to oxidative stress...

Ngày tải lên: 16/03/2014, 14:20

Ngày tải lên: 23/03/2014, 15:21

Ngày tải lên: 11/08/2014, 11:21

Ngày tải lên: 19/06/2014, 22:20

... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... in brain in anoxia as observed by in- crease in NOx concentration in this study support the earlier findings of NO involvement in pathophysiol- ogy of hypobaric hypoxia in brain (42-43). In this ... arginine at the site of synthesis. Arginine is a semi essential amino acid and in CNS, its availability depends upon: (a) uptake from the circu- lating arginine and (b) recycling of citrulline...

Ngày tải lên: 26/10/2012, 09:07

... described the functioning of blood-retinal barrier in detail, how it is impacted by ROS and retinal vein occlusion induced by the inhibitor of a mitogen-activated protein kinase kinase. The section ... main aim is to show examples which mirror our knowledge on the role of oxidative stress in origin of diseases as well as its significance in disease complications. It was it that oxidative stress ... researchers in the field of basic investigations interested in the involvement of reactive oxygen species and oxidative stress in diverse pathologies, medical scientists and practical physicians wishing...

Ngày tải lên: 12/02/2014, 16:20

... Young ME, Pham M, Zhang D, Cooksey RC, McClain DA, Litwin SE et al. (2002) Insulin signaling coordinately M. F. Essop et al. Metabolic gene switching in murine female heart FEBS Journal 274 (2007) ... additional insights into this interesting question. Conclusions In summary, we have identified a novel metabolic gene switch (decrease in fatty acid utilization, increase in glucose utilization) in the ... 2007) doi:10.1111/j.1742-4658.2007.06051.x The mechanisms underlying increased cardioprotection in younger female mice are unclear. We hypothesized that serine-threonine protein kinase (protein kinase B; Akt) triggers a metabolic...

Ngày tải lên: 18/02/2014, 16:20

... oxidative stress. Our findings show that pilocarpine induces SE, which can produce alterations in superoxide dismutase and catalase activities in different areas, thereby pro- tecting the brain ... [2,19,20], immediately after pilocarpine administration, animals persistently show behavioral changes, including initial akinesia, ataxic lurching, peripheral cholinergic signs (miosis, piloerection, ... Interstrain differences in cognitive functions in rats in relation to status epilepticus. Behav Brain Res 112, 77–83. 3 Treiman DM (1955) Electroclinical features of status epilepticus. J Clin...

Ngày tải lên: 19/02/2014, 16:20

... treatment, cells were incubated in medium containing 50 lgặmL )1 neutral red at 37 C for 3 h, then xed with 1% formaldehyde containing 1% CaCl 2 for 1 min. The dye incorporated into viable cells ... Hsp105a plays an important role in protection of neuronal cells against stress- induced apoptosis [26]. In accordance with these findings, ischemia/reperfusion in the rat forebrain induces the expression ... mitogen-activated protein kinase (p38). Furthermore, oxidative stress- induced apoptosis was suppressed by SB202190, a potent inhibitor of p38, in F9 cells. These findings indicated that the activation...

Ngày tải lên: 21/02/2014, 03:20

... PM 2.5 onWATandBATspecificgenesin different adipose depots. There are several major find- ings in this study. First, exposure to PM 2.5 resulted in oxidative stress in BAT. Second, exposure to PM 2.5 induced changes ... 8 of 14 inflammatory response and IR development, were exam- ined in mice. As shown in Figure 3, PM 2.5 exposure induced a marked increase in macroph age (F4/80 + cells) infiltration in eWAT. ... reduced in both eWAT and iBAT in response to PM 2.5 exposure. Recent studies have implicated PM 2.5 in in creased adi- pose inflammation and insulin resistance [11,12], and epidemiological studies indicate...

Ngày tải lên: 06/03/2014, 19:20

... neuron. The turning point upon which the cell looses the ability to buffer the incoming calcium resulting in an abrupt, sustained and irreversible increase in [Ca 2+ ] c , probably coincides with ... functions, in addition to having supporting functions for oxidative defences [79], involving the thioredoxin system [40]. Aconitase acts also as an iron-responsive element binding protein, iso- citrate ... by proteins resi- ding in both the inner and outer mitochondrial membrane, that is activated by mitochondrial Ca 2+ overloading and other factors including oxidative stress [88,89]. In neurons...

Ngày tải lên: 07/03/2014, 12:20

... enzymatic activity involved in the oxidative stress in S. solfataricus. To detect differences in the response to various agents we induced oxidative stress with paraquat, an O 2 ã ) generating compound, ... stress conditions, are important in deter- mining the level of Bcp2 protein. Similar results are observed for genes and related proteins involved in oxidative stress in other microrganisms [24]. ... S p peroxidatic cysteine; X unidentified electron donor; S R resolving cysteine; RSH protein or domain with CXXC motif (e.g. thioredoxin). In typical 2-Cys, S p at the N terminus and S R at the C terminus belong...

Ngày tải lên: 07/03/2014, 12:20

... protein kinase and wound- induced protein kinase, two MAPKs in group A, were activated by inoculation with the tobacco mosaic virus (TMV) [10]. Their orthologs in other plant species, including ... accumulation in wild-type and transgenic plants in response to abiotic and abiotic stresses. (A) Virus infec- tion-induced H 2 O 2 accumulation detected by DAB staining. (B) Abi- otic stress- induced ... MPK6 in Arabidopsis (group A MAPKs), SIMK and SAMK in alfalfa, and LeMPK1 ⁄ 2(Lycopersicon esculentum SA-induced pro- tein kinase) and LeMPK3 (L. esculentum wound- induced protein kinase) in tomato,...

Ngày tải lên: 14/03/2014, 23:20

... indicating the presence of two catalytically independent domains, the N-terminal domain, display- ing ALDH activity, and the C-terminal domain, con- taining an iron-binding domain, which is involved ... against oxidative stress damage, have not been reported. In vivo effects on glucose-fermenting enzymes and fluxes under oxidative stress Recently, we reported that amebas incubated for 30 min in ... bind close to the Fe–S clusters, blocking the access of ROS. In this regard, a preliminary docking analysis with coenzymes in the 3D model of EhPFOR suggested that the CoA-binding site was, indeed,...

Ngày tải lên: 15/03/2014, 23:20

... gene encoding the regulatory subunit of calcineurin) under oxidative stress was tested. It was noted that CNB1 deletion resulted in an increase of tolerance to H 2 O 2 (Fig. 3B), Oxidative stress ... cells were resuspended in 0.1 m Mes ⁄ Tris buffer (pH 6.5) and transferred to the luminometer tube. A cellular luminescence baseline was determined by 1 min of recording at 1 s intervals. The exogenous ... factors regulat- ing the response to oxidative stress in yeast. Antioxid Redox Signal 4, 123–140. 25 Ikner A & Shiozaki K (2005) Yeast signaling pathways in the oxidative stress response....

Ngày tải lên: 15/03/2014, 23:20

... mice. Fasting induced a significant increase in both genotypes; however, this was more evident in the VLCAD KO mice (Fig. 3A). Interestingly, the MCT diet also induced AOX gene expression in WT mice. After ... observed in human VLCADD [5]. In fact, in both mice and humans, clinical symptoms become mainly evident as a consequence of triggers such as fasting, resulting in the accumulation of long-chain acylcarnitines, ... quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248–254. S. Tucci et al. Oxidative stress in VLCAD KO mice FEBS Journal 277 (2010)...

Ngày tải lên: 15/03/2014, 23:20

... ROS, as indicated by the lack of increase in lipid peroxidation observed in in vitro and in vivo experiments [21]. In previous studies [22,23], we observed that a single intraperitoneal administration ... the maximum increase of cysteine induced by diamide. Values indicate the increase of total Cys over levels at time zero in rat blood 75 min after the start of diamide infusion (60 min infusion, ... did not induce evident decreases in cyste- ine and GSH levels in the organs analyzed. Together, these findings prompted us to further investigate the origin of cysteine that enters blood. In theory,...

Ngày tải lên: 16/03/2014, 02:20

... 5. In uence of Ca 2+ increase in combination with H ⁄ Rand extramitochondrial NADH on respiration of brain mitochondria. Rat brain mitochondria (0.5 mgặmL )1 ) were incubated at 30 °C in incu- bation ... brain mitochon- dria by H ⁄ R and Ca 2+ . Brain mitochondria ( 0.5 mg proteinặmL )1 ) were incubated at 30 C under the conditions indicated: Ca 2+ , 15 min in incubation medium; Ca 2+ , 15 min ... sug- gests that the mitochondrial injury is caused by open- ing of the mPTP. There is evidence that ADP inhibits opening of the mPTP by occupying binding sites located in the inner and outer mitochondrial...

Ngày tải lên: 16/03/2014, 22:20

Ngày tải lên: 17/03/2014, 09:20

Ngày tải lên: 22/03/2014, 16:20