oxidative stress and parkinsons disease

... al Particle and Fibre Toxicology 2011, 8:20 http://www.particleandfibretoxicology.com/content/8/1/20 RESEARCH Open Access Ambient particulate air pollution induces oxidative stress and alterations ... resistance, oxidative stress, alteration of vasomotor tone, vascular and visceral inflammation, adiposity, and Page of 14 atherosclerosis in apolipoprotein E knockout (ApoE-/-) mice and other several ... lesions on a standard chow diet It is used for studies of hyperlipidemia and atherosclerosis, and has been used extensively in understanding the mechanisms of lipoprotein metabolism and atherosclerosis

Ngày tải lên: 06/03/2014, 19:20

... protein in Scrambleand ANT1 and ANT2 siRNA-transfected cells; the 33 kDa band corresponds to ANT proteins, the 43 kDa band corresponds to actin (E) Western blot analysis of FLAGANT1 and FLAG-ANT2 ... effects of BA, ATR and ANT1 siRNA on cell viability and glucose consumption (A,B) Cell growth curves analyzed by crystal violet assay in BA and vehicle-treated (A) and in ATR and vehicle-treated ... survival, thus indicating that ANT1 effect is mediated by oxidative stress A possible explanation for the ANT1-silencing effect on oxidative stress and cell survival could reside in the loss of the basal

Ngày tải lên: 29/03/2014, 09:20

... apoptosis protein and heat shock proteins [47,48]. Caspase-like activity and oxidative stress After the finding of caspase-like activities and a response by these enzymes to heat stress, parallel ... stud- ies and supports the occurrence of an oxidative stress period in heat stressed A. viridis [24]. We suggest that apoptosis induction could be the consequence of the previous oxidative stress ... temperatures and ultraviolet radiation cause oxidative stress and inhibit photosynthesis in symbiotic dinoflagellates Limnol Oceanogr 41, 271–283 Lesser MP (1997) Oxidative stress causes

Ngày tải lên: 30/03/2014, 10:20

... and blood urea nitrogen levels and the degree of histological abnormalities were markedly lower in group than in group (all p < 0.03) The mRNA expressions of inflammatory, oxidative stress, and ... protect the kidney against oxidative stress and inflammatory stimuli in rat during renal IR injury Methods: Adult male Sprague-Dawley (SD) rats (n = 24) were equally randomized into group (sham ... anti-inflammatory, anti -oxidative, and anti-apoptotic biomarkers were higher in group than in group (all p < 0.03) Immunofluorescent staining showed a higher number of CD31+, von Willebrand Factor+, and heme

Ngày tải lên: 18/06/2014, 19:20

... against oxidative stress [7] was verified by testing the correla- tion between levels o f 8OHdG, reflecting oxidative stress, and the reducing capacity (corresponding to a def ense against oxidative ... cardiovascular and pulmonary diseases [1]. Among the different mechanisms proposed to explain these adverse effects, the production of reactive oxygen species (ROS) and the generation of oxidative stress ... days. We collected urine samples before and after each shift, and quantified an oxidative stress biomarker (8- hydroxy-2’-deoxyguanosine), the reducing capacity and a biomarker of PAH exposure (1-hydr

Ngày tải lên: 20/06/2014, 00:20

... vitro and lung in vivo under oxidative stress Am J Physiol 1995, 269:L285-L292 Moodie FM, Marwick JA, Anderson CS, Szulakowski P, Biswas SK, Bauter MR, Kilty I, Rahman I: Oxidative stress and cigarette ... vitro and in rat lungs in vivo Am J Physiol Lung Cell and Mol Physiol 2006 (Epubmed) Rahman I, MacNee W: Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease ... smoke extract (CSE 0.5 and 1.0%) dose-dependently increased the levels of nuclear NF-κB RelA/p65 in SAEC after hr treatment (Figures 11A and 11B) Discussion Oxidative stress and inflammatory events,

Ngày tải lên: 12/08/2014, 16:20

... complex, two isoforms of α-subunit (α1 and α2 by prkaa1 and prkaa2), two of β-subunit (β1 and β2 by prkab1 and prkab2), and three of γ-subunit (γ1, γ2 and γ3 by prkag1, prkag2 and prkag3) (Chen et al., 2009; ... be removed and recycled and the targeted proteins are degraded into small peptides (Glickman and Ciechanover, 2002; Hershko and Ciechanover, 1998; Komander and Rape, 2012; Naujokat and Sarić, 2007). ... both pro-survival role and pro-death role (White and DiPaola, 2009). On the one hand, autophagy functions as a tumor suppressor maintaining cellular integrity and genomic stability (Liu and Ryan, 2012;

Ngày tải lên: 22/10/2015, 21:19

... fragmentation and Comet assay on isolated splenocytes and their prevention by resveratrol (5 and 10 μM), catechin (10 and 20 μM), curcumin (5 and 10 μM) and α-tocopherol (5, 10 and 20 μM) In ... molluscicidal and weedicidal activities and is employed for control of bacterial and fungal diseases of fruits, vegetables, nuts and field crops, algae in domestic lakes and ponds and in gardening ... concentrations of flubendiamide and copper alone, and also along with the antioxidants- resveratrol (5 and 10 μM), curcumin (5 and 10 μM), catechin (10 and 20 μM) and α-tocopherol (5, 10 and 20 μM) Solutions

Ngày tải lên: 30/05/2020, 21:22

... peroxidation and H2O2 and NO levels as a marker of oxidative and nitrosative stress were estimated in testicular tissue Previous studies authenticated the prominence of oxidative stress in the ... antioxidants and oxidative stress markers in testis Development of testicular impairment followed by CP exposure is mainly ascribed to free radical intervened oxidative distress and attenuation ... species from the genus Acacia exhibit outstanding antioxidant and chemo-preventive possessions that aid in inhibition and treatment of various oxidative stress related ailments [20–22] Acacia hydaspica

Ngày tải lên: 23/07/2020, 23:46

... context of oxidative stress and mineral imbalance and immuno regulations are equally important and remain less explored Accumulating evidence indicates a close bidirectional communication and regulation ... phagocytosis and reactive oxygen species generation) Mast cells can modulate thyroid function Therefore, evaluation of oxidative stress and mineral imbalance along with mast cell activity and neuroendocrine ... mineral profile (Iron, Zinc, Copper and Manganese), oxidative stress markers (lipid peroxidation-LPO, reduced glutathione-GSH, superoxide dismutase-SOD, CatalaseCAT and total antioxidant capacity-TAC),

Ngày tải lên: 20/09/2020, 19:30

... CPT-induced oxidative stress and not reduced DNA damage Our results also reveal the novel finding that knockdown of ATG5 protein reduces both basal oxidative stress and drug-induced oxidative stress ... CPT-induced oxidative stress Autophagy inhibition also reduced basal oxidative stress level To our knowledge, this is the first report of autophagy inhibition-mediated reduced basal oxidative stress ... autophagy [22] and we suspect that autophagy inhibition may affect levels of endogenous antioxidants With observed CPT-induced oxidative stress in this study and reports of oxidative stress induced

Ngày tải lên: 05/11/2020, 05:24

... NH2-terminal kinases (JNK), and p38 kinases, are MAPK cascades activated by cytokines, hormones, and various cellular stressors such as oxidative stress and endoplasmic reticulum stress [9, 10] As a ... role against oxidative stress- mediated diseases like diabetes, obesity, cardiovascular disease, etc [13] However, the molecular mechanism by which curcumin decreases the oxidative stress remains ... complications of metabolic diseases The modulation of redox imbalance by treatment with antioxidants can significantly alter oxidative stress resistance and the accumulation of oxidative damage In recent

Ngày tải lên: 01/11/2022, 09:55

... preserving left ventricular ejection fraction (LVEF) and attenuating inflammation, oxidative stress and LV remodeling in obese mice Methods and results: Eight-week-old C57BL/6 J mice (n=24) were ... Access Effect of obesity reduction on preservation of heart function and attenuation of left ventricular remodeling, oxidative stress and inflammation in obese mice Hui-Ting Wang1, Chu-Feng Liu1†, ... obesity (high-fat diet, 22 weeks), and obese reduction (OR) (high-fat diet, 14 weeks; then control diet, weeks) Animals were sacrificed at post 22-week high-fat diet and the LV myocardium collected

Ngày tải lên: 02/11/2022, 09:23

... of oxidative stress [6,7] To determine whether the enhanced IL-8 expression in palmitatetreated Gi HepG2 cells was due to oxidative stress, the ROS level of Sc and Gi HepG2 cells in control and ... oxidative stress Modulation of IL-8 production by glutathione peroxidase and curcumin To corroborate that oxidative stress is a causative agent of IL-8 up-regulation in palmitate-treated Sc and ... relationship between NF-κB signaling and G6PD deficiency-derived oxidative stress in inflammation Antioxidants have been shown to exert the inhibitory effect on oxidative stress and inflammatory response

Ngày tải lên: 02/11/2022, 10:43

... (ARD), traffic cops (TC) and office workers (OW) Higher levels of oxidative stress and inflammation markers in serum of ARD subjects were observed as compared to OW and TC Uni and multivariate analyses ... this study, we monitored serum oxidative stress and immunological markers and untargeted urine metabolic profiling of ARD subjects as case and office workers: OW and traffic cops: TC as controls, ... existence of exposure specific metabotypes in biofluids of ARD, OW and TC groups Monitoring serum oxidative stress and inflammation markers and urine metabolites by NMR may be useful to characterize

Ngày tải lên: 19/11/2022, 11:46

... 09 August 2016 Inhibition of Autophagy Enhances Curcumin United light irradiationinduced Oxidative Stress and Tumor Growth Suppression in Human Melanoma Cells Tianhui Niu1, Yan Tian2, Zhusong Mei1 ... apoptosis, proliferation and autophagy in human melanoma A375 cell The results showed that red united blue light irradiation efficaciously synergized with Cur to trigger oxidative stress- mediated cell ... catastrophe, senescence and especially autophagy, is necessary and fundamental to conquer this resistance25,26 Autophagy is a dynamic cellular self-digestion process and in most cells occurs

Ngày tải lên: 04/12/2022, 14:58

... pronounced susceptibility to oxidative stress and to radicals due to their low levels of anti-oxidants and radical scavangers11,12 In primary cultured OPCs, oxidative stress caused by exposure to ... expression of MBP and CNP, similar to that observed at 21% O2 These data indicate that culturing OPCs at 21% O2 negatively affects development and maturation Both enhanced oxidative stress and reduced ... (A2B5, O4, O1, MBP, CNP, arborization), oxidative stress (nitrotyrosine Western blot, NRF2 and SOD2 expression), apoptosis (TUNEL), proliferation (Ki67), and expression of transcription factors

Ngày tải lên: 04/12/2022, 15:55

... MDA, NO, DNAF, Ca2+ and XO activity, while it decreased GSH level, SOD and CAT activities as compared to the C groups; γ-radiation increased oxidative stress (OS), LPO, apoptosis and induced testes ... γ-radiation (HR and RH groups, respectively) decreased the levels of MDA, NO, DNAF and Ca2+ but increased GSH level and the activities of SOD, CAT and XO as compared to R group and this indicates ... fruits and vegetables as well as in food products and beverages derived from plant, such as tea and olive oil [9] It is the predominant flavonoid in lemons and oranges while the peel and membranous

Ngày tải lên: 04/12/2022, 16:05

... plots of proteome data in sclerotia and hyphae PCA plots compared between sclerotia and hyphae were shown in (A) (IS and IH), (B) (DS and DH) and (C) (MS and MH), and among sclerotial proteomes at ... stimulus, such as oxidative stress and environmental adaption, which are significant for sclerotia initiation and development Differentially expressed proteins in sclerotia and hyphae of P umbellatus.  ... glycerol etc) and biotic community (Armillaria mellea and companion fungus) can affect sclerotia differentiation individually or in combination Reactive oxygen species (ROS) and oxidative stress (OS)

Ngày tải lên: 19/03/2023, 15:29

... these pathways and their crosstalk with the redox system under shear stress is lacking We hypothesised that shear stress counteracts the inflammatory effects of oxidative stress and TGF-β1 on ... TGF-β​stimulation and its regulation by shear stress remain unknown The levels of oxidative stress and TGF-β​1 increase upon vascular damage4,16 However, the molecular mechanisms by which shear stress regulates ... expression of TNFA and IL1B However, the combined stimulation with oxidative stress and TGF-β​1 increased IL6 expression by 1.7-fold (see Supplementary Fig. S1A) Oxidative stress induced the

Ngày tải lên: 19/03/2023, 15:41