oxidative stress and microglial cells in parkinsons disease

... protective role in oxidative stress induced disorders [29, 30] Moreover,silymarin treatment afford protection against antineoplastic drug induced testicular toxicity by maintaining sperm count, ... Histopathological findings revealed the normal organization of germinal and Sertoli cells and active spermatogenesis in the seminiferous tubules without any histopathological injuries in control and AHE ... Somay A Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways Hum Reprod 2009;24(7):1717–25

Ngày tải lên: 23/07/2020, 23:46

... triiodothyronine, 50 μg/ml Gentamicin/Amphotericin-B (GA-1000), and 50 μg/ml fatty acid-free bovine serum albumin (BSA) Polymyxin B sulfate, an endotoxin binding agent (10 μg/ml), was also included in ... and proinflammatory cytokines (interleukin8 and interleukin-6) assays Cell lysates were prepared for GSH and 4-HNE assays Similarly, the epithelial cells were grown in 8-well chamber slides and ... NF-kB in A549 cells [9] In this study, we determined whether CSE can cause NF-kB translocation in SAEC since these cells showed a significant increase in proinflammatory cytokine (IL-8) release in

Ngày tải lên: 12/08/2014, 16:20

... of autophagy inhibition on camptothecin (CPT)-induced cytotoxicity in OS cells Camptothecin induces cell death by inhibiting topoisomerase I resulting in DNA single-strand breaks and subsequent ... CPT-induced oxidative stress and not reduced DNA damage Our results also reveal the novel finding that knockdown of ATG5 protein reduces both basal oxidative stress and drug-induced oxidative stress ... CPT-induced cell death in DLM8 cells while increasing CPT-induced cell death in K7M3 cells Autophagy inhibition reduced CPT-induced mitochondrial damage and CPT-induced caspase activation in DLM8

Ngày tải lên: 05/11/2020, 05:24

... samples with the index defined as 1.00 Cytokine profiling The cytokine profiling of Sc and Gi HepG2 cells with or without palmitate treatment was determined by using Human Cytokine Array Panel ... relationship between NF-κB signaling and G6PD deficiency-derived oxidative stress in inflammation Antioxidants have been shown to exert the inhibitory effect on oxidative stress and inflammatory response ... anti-inflammatory [52-55] activities In addition, curcumin modulates several transcription factors, including AP-1, PPAR-γ, STAT, Nrf-2 and Wnt/β-catenin, [56], protein kinases MAP kinase p38 and

Ngày tải lên: 02/11/2022, 10:43

... process and in most cells occurs at constitutive levels to maintain internal homeostasis of cytoplasm27 Recent studies presented convincing proofs that autophagy defends against various diseases, ... effects through regulating multiple signaling pathways19 For example, Cur regulates intracellular signaling pathways involving mitogen-activated protein kinases (MAP-kinases), transcription factor ... Inhibition of Autophagy Enhances Curcumin United light irradiationinduced Oxidative Stress and Tumor Growth Suppression in Human Melanoma Cells Tianhui Niu1, Yan Tian2, Zhusong Mei1 & Guangjin Guo1

Ngày tải lên: 04/12/2022, 14:58

... there was prominent formation of multinucleated giant cells through fusion of microglial cells in the spinal cord, brainstem, and red nucleus of the midbrain. Other brain regions, including substantia ... Notwithstanding these findings, more recently it was determined using chimeric animals consisting of mixtures of normal cells and cell expressing human mutant SOD1 that nonneuronal cells containing ... dramatic increase in microglial staining with OX-42 during onset (B) and its subsequent decline during end stage (C). Scale bar: 200 μm. E, morphometric quantification of microglial immunostaining

Ngày tải lên: 19/06/2014, 22:20

... to particle-induced oxida- tive stress. The observed increase of reducing species in urine would mirror an increased level in blood originat- ing from a response to oxidative stress in the body ... smoking status and time of sampling. Concentrations are expressed as μmol/mol creatinine for 1-OHP, μg/g creatinine for 8OHdG, and μW/g creatinine for the reduced species. Horizontal line in the ... against oxidative stress [7] was verified by testing the correla- tion between levels o f 8OHdG, reflecting oxidative stress, and the reducing capacity (corresponding to a def ense against oxidative

Ngày tải lên: 20/06/2014, 00:20

... local disease activity as well as to articular dam- age in RA [12,13]. Sublining macrophages, but also T cells and plasma cells, were increased in clinically involved ver- sus clinically uninvolved ... with sublining CD68 and anticitrulline staining. Globally, the correlations were weaker and less consistent in RA than in SpA. Supervised clustering in relation with disease activity in SpA On ... with disease activity in spondyloar-thropathy (SpA) (lining-layer hyperplasia, inflammatory infiltration, polymorphonuclear cells, sublining CD68, and sublining CD163)Supervised clustering analysis

Ngày tải lên: 09/08/2014, 06:22

... status in rats with lung fibrosis Oxidative stress and inflammation are related In the initial inflammation, immune cells migrate to inflammatory sites and release various proinflammatory cytokines ... has been used in research to induce pulmonary fibrosis in mice and rats and produce an oxidative injury resulting in DNA damage and the destruction of alveolar epithelial cells [11] In addition, ... inflammatory responses following BL administration were attenuated by BA administration An increased eosinophil number in BALF was reported following intratracheal BL administration, suggesting

Ngày tải lên: 13/08/2014, 14:20

... MAP kinase phosphatase-1 (MKP-1), the negative regulator of JNK and p38 MAP kinases in microglial cells. .. resulting in induction of expression of some target genes including TNF-α, ... rat microglia in vitro. International Biomedical Science Conference, Kunming, China, 2004. 4. Yan Zhou, Xiaoli Du, E A Ling and S T Dheen, Retinoic acid inhibits proliferation and inflammation ... TNF-α and iNOS positive cells are increased in the cultures treated with LPS for h (B, E). These cells appear to be increased in size and show abundant cytoplasm with numerous cytoplasmic inclusions

Ngày tải lên: 12/09/2015, 08:18

... vegetables, nuts and field crops, algae in domestic lakes and ponds and in gardening as powder and spray [13, 14] In India, copper also enters in human body through drinking water, and inhalation of ... neonicotinoid insecticides in human peripheral blood lymphocytes [52] Increase in the number of Tunel+ve cells in the present study are in agreement with increase in number of Tunel+ve germ cells in seminiferous ... Resource Section, Indian Veterinary Research Institute, Izatnagar, India and maintained under standard managemental Mandil et al BMC Pharmacology and Toxicology (2020) 21:29 conditions in the Departmental

Ngày tải lên: 30/05/2020, 21:22

... eosinophilia was observed in bubaline pediculosis according to the level of severity of infestation Remarkably increased oxidative stress and mineral imbalance were observed in sucking lice infested ... oxidative stress, mineral imbalance and inflammatory responses in dairy buffaloes Mast cell may modulate host inflammation via mineralo -oxidative mechanism in sucking lice infestation in buffaloes Introduction ... Levels of oxidative stress markers in relation to severity of sucking lice infestation in buffaloes Moreover, serum mineral profile including iron, magnesium, zinc and copper were estimated using commercial

Ngày tải lên: 20/09/2020, 19:30

... c-Jun NH2-terminal kinases (JNK), and p38 kinases, are MAPK cascades activated by cytokines, hormones, and various cellular stressors such as oxidative stress and endoplasmic reticulum stress [9, ... which curcumin decreases the oxidative stress remains unclear Hence, the present study was carried out to investigate the effect of curcumin on oxidative stress and redox-sensitive kinases in high ... syndrome and its complications are being increasingly recognised The intake of high amounts of fructose and fat is likely to lead to a constellation of abnormalities including insulin resistance,

Ngày tải lên: 01/11/2022, 09:55

... of obesity reduction on preserving left ventricular ejection fraction (LVEF) and attenuating inflammation, oxidative stress and LV remodeling in obese mice Methods and results: Eight-week-old C57BL/6 ... of left ventricular remodeling, oxidative stress and inflammation in obese mice Hui-Ting Wang1, Chu-Feng Liu1†, Tzu-Hsien Tsai2, Yung-Lung Chen2, Hsueh-Wen Chang3, Ching-Yen Tsai4, Steve Leu5, ... high-fat diet and the LV myocardium collected Heart weight, body weight, abdominal-fat weight, total cholesterol level and fasting blood glucose were higher in obesity than in control and OR (all

Ngày tải lên: 02/11/2022, 09:23

... osmotic stress and ethanol inhibition in yeast cells on process oscillation associated with continuous very-high-gravity ethanol fermentation Liang Wang1, Xin-Qing Zhao1, Chuang Xue1* and Feng-Wu ... fermentation is a promising process engineering strategy aiming at improving ethanol titer, and thus saving energy consumption for ethanol distillation and distillage treatment However, sustained process ... produced during fermentation and its inhibition in yeast cells rather than osmotic stress exerted by glucose remained within the system is one of the main reasons for triggering the process oscillation,

Ngày tải lên: 02/11/2022, 11:36

... applications in medicine, industry and agriculture; it causes changes in the chemical balance of cells by direct and indirect actions It may cause malignant changes and damage DNA leading to harmful ... of venous insufficiency and hemorrhoids [9] A deficiency of H in the diet has been linked with abnormal capillary leakiness as well as pain in the extremities causing aches, weakness and night ... DNAF, Ca2+ and XO activity, while it decreased GSH level, SOD and CAT activities as compared to the C groups; γ-radiation increased oxidative stress (OS), LPO, apoptosis and induced testes injuries

Ngày tải lên: 04/12/2022, 16:05

... depletion induced no major changes in cell cycle and in mito- chondria aspect and network, and suggest that ADF cells possess alternative mechanisms for providing mitochondria with ATP and maintaining ... reported that ANT1 levels are increased in reactive astrocytes [28] and that ANT2 levels are increased in glial cells and neurons during hypertonic- ity in the brain [29]. In the present study, we ... 1. Analysis of ANT1 and ANT2 expres- sion in nontransfected ADF cells and in ANT1- and ANT2-silenced ADF cells. (A) Number of ANT1 and ANT2 transcripts in nontransfected ADF cells. (B) Number of ANT1...

Ngày tải lên: 29/03/2014, 09:20

... researchers in the field of basic investigations interested in the involvement of reactive oxygen species and oxidative stress in diverse pathologies, medical scientists and practical physicians wishing ... States, Oxidative Stress and Cellular Damage 413 Cano-Europa, Blas-Valdivia Vanessa, Franco-Colin Margarita and Ortiz-Butron Rocio Chapter 19 Oxidative Stress in Human Autoimmune Joint Diseases ... ROS role and potential benefits of glutathione in maintaining of cell functions, which can be used to understand fundamental pathogenic mechanisms in the mammalian brain during normal aging, as...

Ngày tải lên: 12/02/2014, 16:20

... erable interest in “brown-like adi pose cells in WAT. These so c alled “brite” cells are present in WAT as evi- denced by the presence of UCP1 expressing cells in WAT. Studies in cell culture indicate ... PM 2.5 exposure induced a marked increase in macroph age (F4/80 + cells) infiltration in eWAT. Next, we analyzed the changes in uncoupling protein 1 (UCP1) in response to PM 2.5 exposure. As shown in Figure ... PM 2.5 onWATandBATspecificgenesin different adipose depots. There are several major find- ings in this study. First, exposure to PM 2.5 resulted in oxidative stress in BAT. Second, exposure to PM 2.5 induced...

Ngày tải lên: 06/03/2014, 19:20

... producing in ammatory cytokines in mouse models, although the response is apparently dependent on the prion strain used for infection [33,34]. Microglial cells can contain infectivity in vivo and ... slight increase in CpG-ODN-stimulated cells. PrP Sc accumulates intracellularly in macrophages and microglial cells before degradation To ascertain that J774 and BV-2 cells effectively inter- nalize ... obvious in uence of stimulation. By contrast, on RML infection, an increase was observed in PrP Sc in LPS-stimulated cells ( 1.4-fold) after 24 h incubation without brain homogenate, and a slight increase...

Ngày tải lên: 07/03/2014, 05:20