oxidative stress and heart failure

... OXIDATIVE STRESS AND DISEASES Edited by Volodymyr Lushchak and Dmytro V Gospodaryov Oxidative Stress and Diseases Edited by Volodymyr Lushchak and Dmytro V Gospodaryov ... 4 Oxidative Stress and Diseases Evidences for connection of oxidative stress with the stresses induced by other factors are promptly gained The potency of transition metals, some herbicides and ... pathologies and oxidative modification of proteins Most antioxidant and related enzymes are targets for oxidative modification Hence, if oxidative stress was primary event, possible oxidative modifications...

Ngày tải lên: 12/02/2014, 16:20

... oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues Particle and Fibre Toxicology 2011 8:20 Submit your next manuscript to BioMed Central and ... lesions on a standard chow diet It is used for studies of hyperlipidemia and atherosclerosis, and has been used extensively in understanding the mechanisms of lipoprotein metabolism and atherosclerosis ... insights into the roles and mechanisms of PM2.5-associated physiology and pathology In summary, our data demonstrate the important effects of PM2.5 exposure on oxidative stress and mitochondrial alterations...

Ngày tải lên: 06/03/2014, 19:20

... Giordano FJ (2005) Oxygen, oxidative stress, hypoxia, and heart failure J Clin Invest 115, 500–508 ´ ´ Lopez Farre A & Casado S (2001) Heart failure, redox alterations, and endothelial dysfunction ... Pacher P (2005) Role of oxidative- nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure Curr Vasc Pharmacol 3, 221–229 33 Narula J, Pandey P, Arbustini E, ... in mouse heart tissue and the generation of transgenic mice Protein translational levels of CYP2E1 in heart tissue from mice at embryonic age 16.5 days and at 1, 2, and weeks of age (A) and in...

Ngày tải lên: 22/03/2014, 16:20

... exposed to oxidative stress (2.5 mm and mm HA) with PARP inhibition and allowed to develop, the spores showed faster germination (32 h and 60 h) as compared to cells exposed to oxidative stress alone ... oxidative stress (Fig 4A,B) Under oxidative stress, partial inhibition of PARP activity led to altered growth, suggesting that oxidative stress could be leading to cell cycle arrest [22] and that ... 20 Oxidative stress induces PARP activation PARP activity in D discoideum was assayed at various time points (5, 10, 20 and 60 and h) after HA stress PARP activity was increased initially, and...

Ngày tải lên: 23/03/2014, 07:20

... protein in Scrambleand ANT1 and ANT2 siRNA-transfected cells; the 33 kDa band corresponds to ANT proteins, the 43 kDa band corresponds to actin (E) Western blot analysis of FLAGANT1 and FLAG-ANT2 ... effects of BA, ATR and ANT1 siRNA on cell viability and glucose consumption (A,B) Cell growth curves analyzed by crystal violet assay in BA and vehicle-treated (A) and in ATR and vehicle-treated ... survival, thus indicating that ANT1 effect is mediated by oxidative stress A possible explanation for the ANT1-silencing effect on oxidative stress and cell survival could reside in the loss of the basal...

Ngày tải lên: 29/03/2014, 09:20

... hyperthermal stress on antioxidant induction and on apoptotic markers (caspase-like activation and ⁄ or DNA degradation) in order to demonstrate the concomitant involvement of oxidative stress and apoptosis ... 6B) Effect of heat stress on antioxidant defenses and bleaching in animal tissue of A viridis The occurrence of oxidative stress in the animal tissue (ectoderm and gastroderm) and freshly isolated ... studies and supports the occurrence of an oxidative stress period in heat stressed A viridis [24] We suggest that apoptosis induction could be the consequence of the previous oxidative stress...

Ngày tải lên: 30/03/2014, 10:20

... another anti -oxidative biomarker, was remarkably lower in group than in groups and 3, and significantly lower in group than in group at 24 h and 72 h after IR injury On the other hand, this protein ... apoptosis, and suppressing oxidative stress in this experimental setting of acute kidney IR injury The cause of discrepancy between mRNA and protein expressions of HO-1 on both day and day after ... experiments, and drafted the manuscript LTC, THT, YLC, SC, PLS, and CHY were responsible for the laboratory assay and troubleshooting KCC, SL, and HKY participated in refinement of experiment protocol and...

Ngày tải lên: 18/06/2014, 19:20

... variation in oxidative stress markers in healthy and type II diabetic men Chronobiol Int 2002, 19:423-439 68 Hardeland R, Coto-Montes A, Poeggeler B: Circadian rhythms, oxidative stress and antioxidative ... against oxidative stress [7] was verified by testing the correlation between levels of 8OHdG, reflecting oxidative stress, and the reducing capacity (corresponding to a defense against oxidative stress) ... significantly influenced by OC and NO x (both with random effect modelsTable and fixed models - Additional file Table S6), and particulate copper content (only for the random effect models-Table 3)...

Ngày tải lên: 20/06/2014, 00:20

... of erythrocytes to handle the hydrogen peroxide to molecular oxygen and water [11,29] GSH-Pxs catalyze the peroxides and reduce the glutathione to form oxidized glutathione and water [30] A significant ... Press, New York, 1983 Andreyev AY, Kushnareva YE, Starkov AA Mitochondrial metabolism of reactive oxygen species Biochemistry (Mosc) 2005, 70, 200-214 Athar M Oxidative stress and experimental carcinogenesis ... Adam-Vizi V Effect of cypermethrin on oxidative stress after dermal application 259 10 11 12 13 14 15 16 17 18 19 20 21 22 Exacerbated responses to oxidative stress by an Na+ load in isolated nerve...

Ngày tải lên: 07/08/2014, 23:22

... 0.01, and §p < 0.001 compared with control group L = Live; A = Apoptosis; N = Necrosis References Kode A, Yang SR, Rahman I: Differential effects of cigarette smoke on oxidative stress and proinflammatory ... ethidium bromide and appeared red Percentage of viable (white bars), apoptotic (grey bars) and necrotic/late apoptotic (black bars) determined by counting as described in Materials and Methods Results ... cells underwent morphological changes in response to CSE and lost their characteristic spindle-shaped morphology as is evident from figs c and d SAEC were shown to be more sensitive to CSE compared...

Ngày tải lên: 12/08/2014, 15:21

... vitro and lung in vivo under oxidative stress Am J Physiol 1995, 269:L285-L292 Moodie FM, Marwick JA, Anderson CS, Szulakowski P, Biswas SK, Bauter MR, Kilty I, Rahman I: Oxidative stress and cigarette ... I: Oxidative stress in asthma and COPD: Antioxidants as a therapeutic strategy Pharmacol Ther 2006, 111:476-494 Rahman I, Biswas SK, Kode A: Oxidant and antioxidant balance in the airways and ... smoke extract (CSE 0.5 and 1.0%) dose-dependently increased the levels of nuclear NF-κB RelA/p65 in SAEC after hr treatment (Figures 11A and 11B) Discussion Oxidative stress and inflammatory events,...

Ngày tải lên: 12/08/2014, 16:20

... between oxidative stress, inflammation and angiogenesis, where increase in tpO2 and reduce oxidative stress observed in responders is associated with lower microscopic scores of T-cells (CD4 and ... oxidative stress and clinical parameters of disease activity and suggest that microscopically assessed levels of 4-HNE may closely reflect clinical scores of IA Synovial levels of oxidative stress, ... human diseases and high levels of mtDNA mutations have been also found in many tumours and cancer cells [5,6] Oxidative stress, which arises from an imbalance between ROS production and antioxidant...

Ngày tải lên: 12/08/2014, 17:22

... two isoforms of α-subunit (α1 and α2 by prkaa1 and prkaa2), two of β-subunit (β1 and β2 by prkab1 and prkab2), and three of γ-subunit (γ1, γ2 and γ3 by prkag1, prkag2 and prkag3) (Chen et al., 2009; ... be removed and recycled and the targeted proteins are degraded into small peptides (Glickman and Ciechanover, 2002; Hershko and Ciechanover, 1998; Komander and Rape, 2012; Naujokat and Sarić, ... pro-survival role and pro-death role (White and DiPaola, 2009) On the one hand, autophagy functions as a tumor suppressor maintaining cellular integrity and genomic stability (Liu and Ryan, 2012;...

Ngày tải lên: 22/10/2015, 21:19

... TBARS and decreased concentration of TAS supports the oxidative stress in anoxia and reperfusion and suggests a possible role for anti oxidants in preventing neuro- 153 degeneration in anoxia and ... direct and secondary excitotoxic neuronal injuries in vivo Excitotoxicity, oxidative stress and apoptosis comprise major routs of hypoxic-ischemic neuronal death Each route is likely activated and ... transporter-I (GLT-1), and also microglial antiporter for cystine and glutamate which may release glutamate when the demand of glutathione synthesis was increased by oxidative stress (55) From our...

Ngày tải lên: 26/10/2012, 09:07

... myocardial perfusion and of the blood volume received during diastole Since both, a reduced myocardial perfusion reserve and diastolic heart failure, are an integral part of systolic heart failure any ... patients with advanced heart failure and NYHA III functional class and may therefore not be readily generalizable to patients with a milder or a more severer degree of heart failure Furthermore, ... rest and stress in patients with heart failure Eur J Heart Fail 2007;9:644-50 Kurita T, Onishi K, Dohi K, Tanabe M, Fujimoto N, Tanigawa T, Setsuda M, Isaka N, Nobori T, Ito M Impact of heart...

Ngày tải lên: 05/11/2012, 11:32

... and Volodymyr I Lushchak Chapter Oxidative and Nitrosative Stresses: Their Role in Health and Disease in Man and Birds 47 Hillar Klandorf and Knox Van Dyke Chapter Nitric Oxide Synthase and Oxidative ... glycoxidation and carbonyl /oxidative stress 30 Oxidative Stress Molecular Mechanisms and Biological Effects The existence of a strong relation between carbonyl and oxidative stresses can be ... that oxidative stress can directly lead to pathologies, there are many evidences demonstrating a strong relationship between oxidative stress and 10 Oxidative Stress Molecular Mechanisms and...

Ngày tải lên: 12/02/2014, 16:20

... chamber To test the ability of mitochondria to withstand oxidative stress, mm ADP was added after state respiration, and the chamber was closed and sealed for a 20 period As a result, oxygen in ... strain) and heterozygous (db ⁄ +) mice Mice were obtained from Jackson Laboratory (Bar Harbor, ME) and exposed to a reverse 12 h light ⁄ 12 h dark cycle with free access to standard mouse chow and ... employed a mixture of mm malate and 25 lm palmitoyl-l-carnitine as oxidative substrates State respiration (resting) was measured after addition of oxidative substrates, and state respiration after...

Ngày tải lên: 18/02/2014, 16:20

... upregulation and apoptosis The duration of exposure to oxidative stress affects c-Fos stability and BimEL expression by changing the duration of the ERK signal Therefore, the duration of oxidative stress ... lM) or vitamin C (1 mM), and then incubated for h in the presence or absence of ATZ (20 mM) and mercaptosuccinic acid (7 mM) Cell were collected and lysed, and both firefly and Renilla luciferase ... sustained oxidative stress This idea is supported by data showing that transient oxidative stress for or h did not induce apoptosis [38] In conclusion, ERK activation resulting from sustained oxidative...

Ngày tải lên: 06/03/2014, 00:21

... Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury Cell Calcium 36, 257–264 441 Ca2+, mitochondria, ROS in neuronal disease C Chinopoulos and V Adam-Vizi 17 Andreyev AY, ... originally described in isolated heart preparations [195] and subsequently shown to be associated with tissue damage in this and other organs, including the kidney and skeletal muscle [196,197], ... proteins residing in both the inner and outer mitochondrial membrane, that is activated by mitochondrial Ca2+ overloading and other factors including oxidative stress [88,89] In neurons the presence...

Ngày tải lên: 07/03/2014, 12:20