oxidative stress and free radicals

... OXIDATIVE STRESS AND DISEASES Edited by Volodymyr Lushchak and Dmytro V Gospodaryov Oxidative Stress and Diseases Edited by Volodymyr Lushchak and Dmytro V Gospodaryov ... 4 Oxidative Stress and Diseases Evidences for connection of oxidative stress with the stresses induced by other factors are promptly gained The potency of transition metals, some herbicides and ... pathologies and oxidative modification of proteins Most antioxidant and related enzymes are targets for oxidative modification Hence, if oxidative stress was primary event, possible oxidative modifications...

Ngày tải lên: 12/02/2014, 16:20

... oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues Particle and Fibre Toxicology 2011 8:20 Submit your next manuscript to BioMed Central and ... lesions on a standard chow diet It is used for studies of hyperlipidemia and atherosclerosis, and has been used extensively in understanding the mechanisms of lipoprotein metabolism and atherosclerosis ... insights into the roles and mechanisms of PM2.5-associated physiology and pathology In summary, our data demonstrate the important effects of PM2.5 exposure on oxidative stress and mitochondrial alterations...

Ngày tải lên: 06/03/2014, 19:20

... cardiac oxidative stress, myocyte apoptosis and the DCM phenotype Materials and methods * Animals WT CYP2E1 cTnTR141W Fig Determination of the levels of cytochrome c release, cleaved caspases and ... Induction of DNA strand breaks and oxidative stress in HeLa cells by ethanol is dependent on CYP2E1 expression Mutagenesis 22, 189–194 McKillop IH & Schrum LW (2005) Alcohol and liver cancer Alcohol ... Pacher P (2005) Role of oxidative- nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure Curr Vasc Pharmacol 3, 221–229 33 Narula J, Pandey P, Arbustini E,...

Ngày tải lên: 22/03/2014, 16:20

... exposed to oxidative stress (2.5 mm and mm HA) with PARP inhibition and allowed to develop, the spores showed faster germination (32 h and 60 h) as compared to cells exposed to oxidative stress alone ... 12 and 24 h under oxidative stress (A) Developmental phenotypes of control and mM HA-treated D discoideum cells at 12 h Cells after HA treatment were starved on nutrient -free agar medium and ... oxidative stress (Fig 4A,B) Under oxidative stress, partial inhibition of PARP activity led to altered growth, suggesting that oxidative stress could be leading to cell cycle arrest [22] and that...

Ngày tải lên: 23/03/2014, 07:20

... protein in Scrambleand ANT1 and ANT2 siRNA-transfected cells; the 33 kDa band corresponds to ANT proteins, the 43 kDa band corresponds to actin (E) Western blot analysis of FLAGANT1 and FLAG-ANT2 ... effects of BA, ATR and ANT1 siRNA on cell viability and glucose consumption (A,B) Cell growth curves analyzed by crystal violet assay in BA and vehicle-treated (A) and in ATR and vehicle-treated ... survival, thus indicating that ANT1 effect is mediated by oxidative stress A possible explanation for the ANT1-silencing effect on oxidative stress and cell survival could reside in the loss of the basal...

Ngày tải lên: 29/03/2014, 09:20

... hyperthermal stress on antioxidant induction and on apoptotic markers (caspase-like activation and ⁄ or DNA degradation) in order to demonstrate the concomitant involvement of oxidative stress and apoptosis ... 6B) Effect of heat stress on antioxidant defenses and bleaching in animal tissue of A viridis The occurrence of oxidative stress in the animal tissue (ectoderm and gastroderm) and freshly isolated ... studies and supports the occurrence of an oxidative stress period in heat stressed A viridis [24] We suggest that apoptosis induction could be the consequence of the previous oxidative stress...

Ngày tải lên: 30/03/2014, 10:20

... another anti -oxidative biomarker, was remarkably lower in group than in groups and 3, and significantly lower in group than in group at 24 h and 72 h after IR injury On the other hand, this protein ... injury elicits rigorous inflammatory response and enhances generation of ROS and free radicals which, in turn, cause the damage of renal parenchyma and destroy the architectural integrity of the ... Immunofluorescent and IHC staining as well as Western blot analysis demonstrated remarkably suppressed expressions of NQO1 and HO-1, the scavengers for free radicals, in group and significant restoration...

Ngày tải lên: 18/06/2014, 19:20

... variation in oxidative stress markers in healthy and type II diabetic men Chronobiol Int 2002, 19:423-439 68 Hardeland R, Coto-Montes A, Poeggeler B: Circadian rhythms, oxidative stress and antioxidative ... against oxidative stress [7] was verified by testing the correlation between levels of 8OHdG, reflecting oxidative stress, and the reducing capacity (corresponding to a defense against oxidative stress) ... Halliwell B, Gutteridge JMC: Cellular responses to oxidative stress: adaptation, damage, repair, senescence and death In Free Radicals in Biology and Medicine edition Edited by: Halliwell B, Gutteridge...

Ngày tải lên: 20/06/2014, 00:20

... toxicant induced free radicals [33] The decrease in SOD, blood GSH and GSH-Px suggests that the dermal exposure of cypermethrin may lead to excessive free radical generation These free radicals might ... of erythrocytes to handle the hydrogen peroxide to molecular oxygen and water [11,29] GSH-Pxs catalyze the peroxides and reduce the glutathione to form oxidized glutathione and water [30] A significant ... due to over production of free radicals [24] Similarly, GST catalyzes the conjugation of the reduced glutathione to electrophiles and protects cellular components from oxidative damage [16] Increased...

Ngày tải lên: 07/08/2014, 23:22

... 0.01, and §p < 0.001 compared with control group L = Live; A = Apoptosis; N = Necrosis References Kode A, Yang SR, Rahman I: Differential effects of cigarette smoke on oxidative stress and proinflammatory ... ethidium bromide and appeared red Percentage of viable (white bars), apoptotic (grey bars) and necrotic/late apoptotic (black bars) determined by counting as described in Materials and Methods Results ... airway epithelial cells and in a variety of transformed alveolar epithelial cells Respir Res 2006, 7:132 Publish with Bio Med Central and every scientist can read your work free of charge "BioMed...

Ngày tải lên: 12/08/2014, 15:21

... vitro and lung in vivo under oxidative stress Am J Physiol 1995, 269:L285-L292 Moodie FM, Marwick JA, Anderson CS, Szulakowski P, Biswas SK, Bauter MR, Kilty I, Rahman I: Oxidative stress and cigarette ... including stress, cigarette smoke, viruses, bacteria, inflammatory stimuli, cytokines and free radicals [40-43] Previously we and others have shown that CSE caused activation of NF-κB and pro-inflammatory ... nonenal, a highly reactive and diffusible end product of lipid peroxidation, is a known marker of oxidative stress and can attack target cells far from the site of the original free radical event [3436]...

Ngày tải lên: 12/08/2014, 16:20

... between oxidative stress, inflammation and angiogenesis, where increase in tpO2 and reduce oxidative stress observed in responders is associated with lower microscopic scores of T-cells (CD4 and ... oxidative stress and clinical parameters of disease activity and suggest that microscopically assessed levels of 4-HNE may closely reflect clinical scores of IA Synovial levels of oxidative stress, ... human diseases and high levels of mtDNA mutations have been also found in many tumours and cancer cells [5,6] Oxidative stress, which arises from an imbalance between ROS production and antioxidant...

Ngày tải lên: 12/08/2014, 17:22

... antioxidants on free radicals in food and biological system Free radicals initiate oxidation of lipids in food systems and leads to the development of rancidity, protein damage, and oxidation of ... i GENERAL INTRODUCTION 12 1.1 Free radicals 12 1.2 Effect of free radicals on biological system 13 1.3 Effect of free radicals on food 13 1.4 Antioxidants ... superoxide, hydroxyl, and peroxyl radicals, and nitric oxide produced from cell or biochemical reaction systems The function of antioxidants is to intercept and react with free radicals at a rate...

Ngày tải lên: 13/09/2015, 21:10

... family for their full and endless support, especially my husband, Dr He Wei, whose constant encouragement and understanding throughout my study have made this work possible, and to my child, He ... palate, and cranial dura The mandibular nerve has both sensory and motor components The motor mandibular component innervates the muscles of mastication, the temporalis, masseter, lateral and medial ... differentiation, senescence, and apoptosis (Kolesnick and Kronke 1998; Spiegel et al 1998; Hannun and Luberto 2000; Cuvillier 2002; Hannun and Obeid 2002; Malisan and Testi 2002) Sphingolipids...

Ngày tải lên: 14/09/2015, 08:42

... two isoforms of α-subunit (α1 and α2 by prkaa1 and prkaa2), two of β-subunit (β1 and β2 by prkab1 and prkab2), and three of γ-subunit (γ1, γ2 and γ3 by prkag1, prkag2 and prkag3) (Chen et al., 2009; ... be removed and recycled and the targeted proteins are degraded into small peptides (Glickman and Ciechanover, 2002; Hershko and Ciechanover, 1998; Komander and Rape, 2012; Naujokat and Sarić, ... pro-survival role and pro-death role (White and DiPaola, 2009) On the one hand, autophagy functions as a tumor suppressor maintaining cellular integrity and genomic stability (Liu and Ryan, 2012;...

Ngày tải lên: 22/10/2015, 21:19

... TBARS and decreased concentration of TAS supports the oxidative stress in anoxia and reperfusion and suggests a possible role for anti oxidants in preventing neuro- 153 degeneration in anoxia and ... direct and secondary excitotoxic neuronal injuries in vivo Excitotoxicity, oxidative stress and apoptosis comprise major routs of hypoxic-ischemic neuronal death Each route is likely activated and ... transporter-I (GLT-1), and also microglial antiporter for cystine and glutamate which may release glutamate when the demand of glutathione synthesis was increased by oxidative stress (55) From our...

Ngày tải lên: 26/10/2012, 09:07

... Lushchak Chapter Oxidative and Nitrosative Stresses: Their Role in Health and Disease in Man and Birds 47 Hillar Klandorf and Knox Van Dyke Chapter Nitric Oxide Synthase and Oxidative Stress: Regulation ... Soha M Hamdy and Tarek M Mohamed Chapter Iron, Oxidative Stress and Health 73 Shobha Udipi, Padmini Ghugre and Chanda Gokhale Chapter Heme Proteins, Heme Oxygenase-1 and Oxidative Stress 109 Hiroshi ... glycoxidation and carbonyl /oxidative stress 30 Oxidative Stress Molecular Mechanisms and Biological Effects The existence of a strong relation between carbonyl and oxidative stresses can be...

Ngày tải lên: 12/02/2014, 16:20

... upregulation and apoptosis The duration of exposure to oxidative stress affects c-Fos stability and BimEL expression by changing the duration of the ERK signal Therefore, the duration of oxidative stress ... lM) or vitamin C (1 mM), and then incubated for h in the presence or absence of ATZ (20 mM) and mercaptosuccinic acid (7 mM) Cell were collected and lysed, and both firefly and Renilla luciferase ... sustained oxidative stress This idea is supported by data showing that transient oxidative stress for or h did not induce apoptosis [38] In conclusion, ERK activation resulting from sustained oxidative...

Ngày tải lên: 06/03/2014, 00:21

... Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury Cell Calcium 36, 257–264 441 Ca2+, mitochondria, ROS in neuronal disease C Chinopoulos and V Adam-Vizi 17 Andreyev AY, ... of nitric oxide and reactive oxygen species: implication for cell death J Neurochem 65, 2016–2021 Dykens JA (1994) Isolated cerebral and cerebellar mitochondria produce free radicals when exposed ... proteins residing in both the inner and outer mitochondrial membrane, that is activated by mitochondrial Ca2+ overloading and other factors including oxidative stress [88,89] In neurons the presence...

Ngày tải lên: 07/03/2014, 12:20