oxidative stress and antioxidant therapy in parkinson disease

... proteins fell into five subcategories In ‘Cellular Processes subcategories’, 66 proteins were involved in transport and catabolism, 44 involved in cell growth and death and 25 involved in cellular ... proteins were associated with signal transduction of ‘Environmental Information Processing’ 113 and 75 proteins were involved in translation and folding, sorting and degradation of ‘Genetic Information ... expressed differentially in DS compared with those in IS including 36 unknown proteins and 213 identified proteins, and 319 differential proteins in MS compared with those in DS Strikingly, nearly half

Ngày tải lên: 19/03/2023, 15:29

... protective role in oxidative stress induced disorders [29, 30] Moreover,silymarin treatment afford protection against antineoplastic drug induced testicular toxicity by maintaining sperm count, ... Somay A Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways Hum Reprod 2009;24(7):1717–25 ... potential against CP-induced testicular toxicity and these results are in agreement of other investigated parameters seminiferous tubules and interstitium, and decreased thickness of germinal epithelium

Ngày tải lên: 23/07/2020, 23:46

... to particle-induced oxida- tive stress. The observed increase of reducing species in urine would mirror an increased level in blood originat- ing from a response to oxidative stress in the body ... smoking status and time of sampling. Concentrations are expressed as μmol/mol creatinine for 1-OHP, μg/g creatinine for 8OHdG, and μW/g creatinine for the reduced species. Horizontal line in the ... against oxidative stress [7] was verified by testing the correla- tion between levels o f 8OHdG, reflecting oxidative stress, and the reducing capacity (corresponding to a def ense against oxidative

Ngày tải lên: 20/06/2014, 00:20

... and proinflammatory cytokines (interleukin8 and interleukin-6) assays Cell lysates were prepared for GSH and 4-HNE assays Similarly, the epithelial cells were grown in 8-well chamber slides and ... Ergothioneine inhibits oxidative stress- and TNF-alphainduced NF-kappa B activation and interleukin-8 release in alveolar epithelial cells Biochem Biophys Res Commun 2003, 302:860-864 Martin D, Leonardo ... recombinant epidermal growth factor (EGF), 0.5 μg/ml epinephrine, 10 μg/ml transferrin, μg/ml insulin, 0.1 ng/ml retinoic acid (RA), 6.5 ng/ml triiodothyronine, 50 μg/ml Gentamicin/Amphotericin-B

Ngày tải lên: 12/08/2014, 16:20

... the antioxidant status in rats with lung fibrosis Oxidative stress and inflammation are related In the initial inflammation, immune cells migrate to inflammatory sites and release various proinflammatory ... determined according to Sinha [58] Histological examination The lungs were removed, inflated at 25 cm pressure with PBS then fixed, embedded in paraffin, sectioned and stained with hematoxylin and ... inflammatory responses following BL administration were attenuated by BA administration An increased eosinophil number in BALF was reported following intratracheal BL administration, suggesting

Ngày tải lên: 13/08/2014, 14:20

... bacterial and fungal diseases of fruits, vegetables, nuts and field crops, algae in domestic lakes and ponds and in gardening as powder and spray [13, 14] In India, copper also enters in human ... through drinking water, and inhalation of copper dust and fumes [15] But it is toxic when present in the body in excess [10] Environmental pollutants increase oxidative stress [16] and dietary antioxidants ... polyphenols, including catechin, against deltamethrin-induced neurotoxicity by improving oxidative status and DNA fragmentation, and suppressing the expression of apoptotic TP53 and COX2 genes

Ngày tải lên: 30/05/2020, 21:22

... Levels of oxidative stress markers in relation to severity of sucking lice infestation in buffaloes Moreover, serum mineral profile including iron, magnesium, zinc and copper were estimated using commercial ... bubaline pediculosis according to the level of severity of infestation Remarkably increased oxidative stress and mineral imbalance were observed in sucking lice infested buffaloes Increased mast cell ... major clinical manifestations of bubaline pediculosis Severe sucking lice infestations in animals are manifested as alopecia, self-excoriation, scratching, licking and biting of their skin, erythematous

Ngày tải lên: 20/09/2020, 19:30

... reveal the novel finding that knockdown of ATG5 protein reduces both basal oxidative stress and drug-induced oxidative stress Keywords: Autophagy, Osteosarcoma, Camptothecin, Oxidative stress * Correspondence: ... study, we investigated the impact of autophagy inhibition on camptothecin (CPT)-induced cytotoxicity in OS cells Camptothecin induces cell death by inhibiting topoisomerase I resulting in DNA single-strand ... autophagy-competent and autophagy-inhibited DLM8 cells, indicating similar levels of CPT-induced DNA damage (Figure 4F) Autophagy inhibition decreases CPT-induced oxidative stress and buthionine sulfoximine

Ngày tải lên: 05/11/2020, 05:24

... c-Jun NH2-terminal kinases (JNK), and p38 kinases, are MAPK cascades activated by cytokines, hormones, and various cellular stressors such as oxidative stress and endoplasmic reticulum stress [9, ... syndrome and its complications are being increasingly recognised The intake of high amounts of fructose and fat is likely to lead to a constellation of abnormalities including insulin resistance, ... production of free radicals and depletes the antioxidant levels, thereby creating a redox imbalance which ultimately results in oxidative stress [3, 4] Oxidative stress is defined as the persistent

Ngày tải lên: 01/11/2022, 09:55

... of obesity reduction on preserving left ventricular ejection fraction (LVEF) and attenuating inflammation, oxidative stress and LV remodeling in obese mice Methods and results: Eight-week-old C57BL/6 ... of left ventricular remodeling, oxidative stress and inflammation in obese mice Hui-Ting Wang1, Chu-Feng Liu1†, Tzu-Hsien Tsai2, Yung-Lung Chen2, Hsueh-Wen Chang3, Ching-Yen Tsai4, Steve Leu5, ... high-fat diet and the LV myocardium collected Heart weight, body weight, abdominal-fat weight, total cholesterol level and fasting blood glucose were higher in obesity than in control and OR (all

Ngày tải lên: 02/11/2022, 09:23

... relationship between NF-κB signaling and G6PD deficiency-derived oxidative stress in inflammation Antioxidants have been shown to exert the inhibitory effect on oxidative stress and inflammatory response ... anti-inflammatory [52-55] activities In addition, curcumin modulates several transcription factors, including AP-1, PPAR-γ, STAT, Nrf-2 and Wnt/β-catenin, [56], protein kinases MAP kinase p38 and ... curcumin down-regulates inflammatory cytokines TNF-α, IL-8 and MIF levels in the lung, suggesting a protective role in counteracting inflammation through down-regulation of pro-inflammatory cytokines

Ngày tải lên: 02/11/2022, 10:43

... effects through regulating multiple signaling pathways19 For example, Cur regulates intracellular signaling pathways involving mitogen-activated protein kinases (MAP-kinases), transcription factor ... process and in most cells occurs at constitutive levels to maintain internal homeostasis of cytoplasm27 Recent studies presented convincing proofs that autophagy defends against various diseases, ... regulation of apoptosis, the therapy of melanoma remains a complex issue requiring a multidisciplinary approach4 So far, the combination of phototherapy and chemotherapy is considered to be an

Ngày tải lên: 04/12/2022, 14:58

... applications in medicine, industry and agriculture; it causes changes in the chemical balance of cells by direct and indirect actions It may cause malignant changes and damage DNA leading to harmful ... diosmin, is used in Europe for the treatment of venous insufficiency and hemorrhoids [9] A deficiency of H in the diet has been linked with abnormal capillary leakiness as well as pain in the ... mitochondrial matrix] and cellular antioxidant defenses as GSH and the activities of SOD and CAT were determined in testis homogenate In addition lipid profile and total protein (TP) as well as

Ngày tải lên: 04/12/2022, 16:05

... for estimating daily urine volume and measuring the ratio of urine protein to urine creatinine excretion Quantification of urine protein, BUN, and creatinine level was performed using standard laboratory ... Hematoxylin and Eosin (H & E) Staining and Histopathology Scoring Kidney specimens from all animals were fixed in 10% buffered formalin before embedding in paraffin Tissue was sectioned at mm and ... adiponectin, the anti-inflammatory indexes, were notably lower in group than in group (Table 1) These findings imply that ADMSC therapy inhibited inflammatory reaction in this experimental setting

Ngày tải lên: 18/06/2014, 19:20

... azathioprine, (hydroxy)chloroquine) with disease- modifying therapy in other rheumatological diseases when deciding on an anti-inflammatory therapy in a severe autoimmune disease such as SSc. Our findings ... clinical centers specializing in the care of SSc patients participating in the network, but also of patients who are seen only once a year in a clinical center participating in the network and ... Guidelines for clinical trials in systemic sclerosis (scleroderma). I. Disease modifying inter- ventions. The American College of Rheumatology Committee on Design and Outcomes in Clinical Trials in

Ngày tải lên: 09/08/2014, 13:22

... aggregation, and help them regain normal function following stress [41]. In this study, HSP 21 levels increased in both SA-treated and control leaves during heat stress (Fig.7). Under severe heat stress, ... improve photosynthetic capacity in spring wheat and barley under salt stress and drought stress [16,17] and Phillyrea angustifolia and wheat seedlings under drought stress [18,19]. But, relatively ... stress and pro- moted the increase in P n during recovery (Fig. 1). Under heat stress, change of C i was opposite to that of P n in the control and SA-treated leaves (Fig. 1), indicating that

Ngày tải lên: 12/08/2014, 03:21

... PM 2.5 onWATandBATspecificgenesin different adipose depots. There are several major find- ings in this study. First, exposure to PM 2.5 resulted in oxidative stress in BAT. Second, exposure to PM 2.5 induced ... analyzed. Finally, mitochondrial number was reduced in both eWAT and iBAT in response to PM 2.5 exposure. Recent studies have implicated PM 2.5 in in creased adi- pose inflammation and insulin resistance ... PM 2.5 exposure induced a marked increase in macroph age (F4/80 + cells) infiltration in eWAT. Next, we analyzed the changes in uncoupling protein 1 (UCP1) in response to PM 2.5 exposure. As shown in Figure...

Ngày tải lên: 06/03/2014, 19:20

... on both hands, mild rigidity and bradykinesia in the upper limbs, gait slowness, and mild postural instability. He cried during the interview, and worried about being unable to continue his work ... pallidotomy Indications Advanced disease with rigidity and bradykinesia, and a poor response to antiparkinsonian medications Disabling dyskinesias Severe motor Xuctuations Painful cramps and severe dystonias Serious ... the cognitive and emotional side-eVects of speciWc antiparkinsonian drugs, such as l-dopa, dopaminergic agonists, amantadine, selegiline, and anticholinergic drugs. In the eighth, and last, chapter...

Ngày tải lên: 28/03/2014, 22:21

... depletion induced no major changes in cell cycle and in mito- chondria aspect and network, and suggest that ADF cells possess alternative mechanisms for providing mitochondria with ATP and maintaining ... rup- ture and were also negative to propidium iodide stain- ing (data not shown), indicating that the plasma membrane is maintained intact, allowing us to exclude primary necrosis as the principal ... isoforms in astrocytes and astrocytic tumors. It has been reported that ANT1 levels are increased in reactive astrocytes [28] and that ANT2 levels are increased in glial cells and neurons during hypertonic- ity...

Ngày tải lên: 29/03/2014, 09:20

... harboring the zooxanthellae (Fig. 6B). Effect of heat stress on antioxidant defenses and bleaching in animal tissue of A. viridis The occurrence of oxidative stress in the animal tissue (ectoderm and ... equations for determining chlorophylls a, b, c1 and c2 in higher plants, algae and natural phytoplank- ton. Biochem Physiol Pflanzen 167, 191–194. Apoptosis and oxidative stress in bleaching S. Richier ... mitochondria and chloroplasts and can directly and ⁄ or indirectly cause caspase activa- tion (reviewed in [25,27,49]). The delay observed in our study between the antioxidant induction and the caspase-like...

Ngày tải lên: 30/03/2014, 10:20