oxidative and nitrosative stress in parkinson disease

... on both hands, mild rigidity and bradykinesia in the upper limbs, gait slowness, and mild postural instability. He cried during the interview, and worried about being unable to continue his work ... pallidotomy Indications Advanced disease with rigidity and bradykinesia, and a poor response to antiparkinsonian medications Disabling dyskinesias Severe motor Xuctuations Painful cramps and severe dystonias Serious ... the cognitive and emotional side-eVects of speciWc antiparkinsonian drugs, such as l-dopa, dopaminergic agonists, amantadine, selegiline, and anticholinergic drugs. In the eighth, and last, chapter...

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... or unfavorable, depending on the disease. As a case in point, formation of huntingtin-containing inclusion bodies in Huntington’s disease encourages cell survival, whereas monomers and small inclusion bodies ... M & Vierling E (2001) The expanding family of Arabidopsis thaliana small heat stress proteins and a new family of proteins containing a-crystallin domains (Acd proteins). Cell Stress Chap- erones ... deficient in desmin, again demonstrating inclusion body construc- tion independent of intermediate fialments [62]. Inter- estingly, inclusion body formation is slowed by aB-crystallin, Hsp27 and HspB8,...

Ngày tải lên: 19/02/2014, 18:20

... crosstalk between auxin and other plant hormones [21–24]. Our study also shows that genes involved in cytokinin (e.g. cytokinin-O- glucosyltransferase, cytokinin dehydrogenase, and response regulators), ... of growth and development in plants. Sev- eral recent discoveries in auxin biology, including the identification of F-box proteins as auxin receptors, have contributed to our understanding of the ... signaling pathways [55]. To address whether auxin-responsive genes are also involved in stress responses in rice, their expression Transcript profiling of auxin-responsive genes M. Jain and J....

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... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... arginine at the site of synthesis. Arginine is a semi essential amino acid and in CNS, its availability depends upon: (a) uptake from the circu- lating arginine and (b) recycling of citrulline ... in brain in anoxia as observed by in- crease in NOx concentration in this study support the earlier findings of NO involvement in pathophysiol- ogy of hypobaric hypoxia in brain (42-43). In this...

Ngày tải lên: 26/10/2012, 09:07

... PM 2.5 onWATandBATspecificgenesin different adipose depots. There are several major find- ings in this study. First, exposure to PM 2.5 resulted in oxidative stress in BAT. Second, exposure to PM 2.5 induced ... analyzed. Finally, mitochondrial number was reduced in both eWAT and iBAT in response to PM 2.5 exposure. Recent studies have implicated PM 2.5 in in creased adi- pose inflammation and insulin resistance ... PM 2.5 exposure induced a marked increase in macroph age (F4/80 + cells) infiltration in eWAT. Next, we analyzed the changes in uncoupling protein 1 (UCP1) in response to PM 2.5 exposure. As shown in Figure...

Ngày tải lên: 06/03/2014, 19:20

... by proteins resi- ding in both the inner and outer mitochondrial membrane, that is activated by mitochondrial Ca 2+ overloading and other factors including oxidative stress [88,89]. In neurons ... neuron. The turning point upon which the cell looses the ability to buffer the incoming calcium resulting in an abrupt, sustained and irreversible increase in [Ca 2+ ] c , probably coincides with ... calcium transients during reversible brain ischemia. Exp Brain Res 104, 462–466. 188 Silver IA & Erecinska M (1992) Ion homeostasis in rat brain in vivo: intra- and extracellular [Ca 2+ ] and [H + ]in the...

Ngày tải lên: 07/03/2014, 12:20

... protein instability caused by oxidative stress conditions, are important in deter- mining the level of Bcp2 protein. Similar results are observed for genes and related proteins involved in oxidative ... S p peroxidatic cysteine; X unidentified electron donor; S R resolving cysteine; RSH protein or domain with CXXC motif (e.g. thioredoxin). In typical 2-Cys, S p at the N terminus and S R at the C terminus belong ... resol- ving cysteine (Cys-S R ). In typical 2-Cys, S p at the N terminus and S R at the C terminus of the protein belong to different subunits and condense to form an intersubunit disulfide bond; in...

Ngày tải lên: 07/03/2014, 12:20