... properties ofthe analyst forecasts: the forecast error, the forecast dispersion and the skewness ofthe forecast distribution The earnings forecast studied hereof is the current-year forecast for the ... CAR of –12.9% from one day before to the day ofthe first financial press disclosures ofthe disputed accounting They also document a significant CAR of -6% from one day before to the day of disclosure ... numbers Besides wiping off billions of dollars of market value, these restatements also call into question the credibility ofthe firms’ accounting practices and the quality ofthe corporate oversight...
... consisting ofthe statement of a plan or of a goal, the subdialogue would be "inserted" in the task structure at the location ofthe plan described Another obvious clue is the presence of reliable ... model of what the novice user knows about the task The verbal interaction between the user and the adviser is not just one of execution of plans and recognition of plans but rather one of situated ... structure: 1) the structure ofthe sequence of utterances, 2) the structure ofthe intentions conveyed, and 3) the attentional state Distinguishing these three structures gives a better account of discourse...
... exploring some of these exciting avenues of investigation Chemotherapy We have investigated this hypothesis further by examining the timing of chemotherapy doses with respect to the LCRP immune ... investigate the timing of vaccinations with respect to the CRP cycle, while examining the clinical responses Since the periodicity ofthe L-CRP oscillatory cycle was consistent and recurrent, the results ... to produce the up-swing in CRP dom application On the basis of preliminary evidence, we hypothesise that the current random application of chemotherapy (or other immuno-cytotoxic therapy) with...
... systematic review ofthe literature After exclusion of duplicates, the abstracts of all citations were reviewed Of these, 104 citations concerning the relationship between quality of life and survival ... (BPI), and the Symptom Distress Scale (SDS) Therefore the information given in the tables was simply to reflect the variance that existed in the instruments used and neither to convey their psychometric ... better profile on the topic, and consequently aid in improving the quality of life of cancer patients Methods Using either term - 'patient-reported outcome' or 'healthrelated quality of life' - the...
... estimated The propensity score method implies a comprehensive collection of information known to be causally associated with the choice ofthe treatments, then the production of a propensity score (the ... should be given to explaining the purposes, manner ofthe management and use ofthe patients' data from questionnaires and diaries The right ofthe patient to withdraw from the studies in any time, ... To assess the quality of analgesic treatments in terms of congruence between patients' reported level of pain (intensity) and the potency ofthe prescribed analgesic drug (according to the WHO...
... guidance; this procedure allowed the completion ofthe therapeutic program for 1,930/ 1,978 (97.6%) ofthe catheters inserted The absence of pneumotorax and other major complications indicates ... at the point of insertion ofthe sternocleidomastoid muscle into the clavicular; the correct introduction ofthe needle was always confirmed by ultrasound guidance and by the easy aspiration of ... evaluate correct catheter position At the end of treatment or when required, after the removal ofthe catheter, the tip was sent to the laboratory for bacteriological examination No systemic prophylaxis...
... cells were not seen other than the reduction on POD in the hepatic resection group found On the other hand, there were also no significant differences in the percentage of CD4+IL-6+ T cells among ... interests The authors declare that they have no competing interests Authors' contributions MI was involved in the design ofthe study and writing ofthe manuscript MN and NH assembled the data ... answered; whether a shift in the Th1/Th2 balance can be used to facilitate comparisons of different surgical procedures, and the clinical significance ofthe surgery-induced shift in the Th1/ Th2...
... Figure illustration ofthe ATM gene Schematic Schematic illustration ofthe ATM gene The distribution ofthe variations detected in the studied materials along the gene is shown in the upper panel ... protective effect ofthe A allele The contradictory between our study and that of [28] may be a consequence ofthe different ethnicity ofthe populations or possibly a result ofthe limited study ... protective effect for of this variant (Table 1) Association of variance in ATM with adverse side effects of radiotherapy The impact of variation in the ATM gene on the level of radiation induced...
... The principal role ofthe antithrombotics in surgical patients is to provide effective anticoagulation over the course ofthe increased risk of VTE (during and postsurgery) with the minimum of ... cases of VTE should be initially treated with either UFH or a LMWH [18,19], or LMWH [16,17] In a recent systematic review ofthe literature, the use of LMWH over UFH for the initial treatment of ... and the potential role ofthe LMWHs as antineoplastic therapy Acknowledgements The author received editorial support in the preparation of this manuscript, funded by sanofi-aventis, NJ, USA The...
... interests The funding agencies (The Oak Foundation and The Danish Rheumatism Association) had no role in writing the report or in the decision to submit the manuscript for publication Neither ofthe ... fishy taste in the mouth might certainly cause detection bias Assessment ofthe trial reporting in terms of risk of bias, the use of random assignment, and subsequent concealment of allocation ... categorize the risk of attrition bias as being at best unclear as there is a possibility that some patients were excluded from the analyses Although the authors performed their analyses according to the...
... 76% died in the hospital [33] In the present cohort about 37% of patients received MV Whether studying the entire population or the subgroup of nonscheduled surgical patients, all ofthe general ... coworkers [14] analyzed the impact of sample size on the accuracy of MPM II models by performing computer simulations They showed that the smaller the sample size, the better the model calibration, ... appreciated in the calibration curves, which indicate significant underestimates in practically all ofthe strata of predicted mortality Nevertheless, the line of observed mortality for the SAPS II...
... Society of Clinical Oncology Chemotherapy and Radiotherapy Expert Panel: 2002 update of recommendations for the use of chemotherapy and radiotherapy protectants: clinical practice guidelines ofthe ... when the obstruction is partial [24] The relief ofthe obstruction, either by percutaneous nephrostomy or through a ureteral stent, is the cornerstone of treatment Renal recovery depends on the ... administering the bladder epithelium protectant mesna virtually eliminated haemorrhagic cystitis related to the toxicity of anticancer agents [35,39] However, several other toxic effects of these drugs...
... modifications ofthe Em/Am ratio [20,21] (Table 1) The mitral inflow velocity was recorded from the apical four-chamber view with the pulsed-wave Doppler sample volume positioned between the tips ofthe ... under the curve, 0.87; p < 0.0001) summarizes the capacity of NTproBNP as a valuable predictor of mortality of patients with septic shock In the survivors and during the first three days of ICU ... At the cutoff value of 6,624 pg/ml, NT-proBNP within the first 24 hours could permit the detection ofthe high-risk mortality population in cancer patients presenting septic shock However, the...
... ofthe manuscript 15 Authors’ information PP is coordinator ofthe Polyvalent Intensive Care Unit and president ofthe Antibiotic Commission of São Francisco Xavier Hospital PP is Professor of ... Hospital PP is Professor of Medicine ofthe Faculty of Medical Sciences from the New University of Lisbon, Portugal VCSD is assistant physician ofthe ICU ofthe Instituto Nacional de Câncer, Rio ... influenced by the presence or absence of neutropenia • CRP could be a useful biomarker of infection in cancer patients irrespective ofthe WCC and the degree of immunosuppression Page of 7 Abbreviations...
... This amount of benefit well compares with the benefits of other important therapeutic choices such as the addition of taxanes for the st line treatment of metastatic breast cancer, where the advantage ... up of 10 months [40] No significant differences in the primary objective ofthe study (the response rate), were found between the three arms, at the expense of a higher grade and incidence of ... based chemotherapy, the HR in terms fir the time to progression is 0.70 [28] In the phase III trial evaluating the addition of capecitabine to docetaxel in the same setting of patients, the HR for...
... Accordingly, the great and urgent need presently is to investigate the role of each ofthe plenitude of genes and proteins important in the progression of cancer NUCLEAR RECEPTORS The nuclear ... techniques permitted the recognition of other members ofthe family based on sequence homology especially at the DNA binding domain (Mangelsdorf et al., 1995) The identification ofthe ecdysone receptor ... characterizes the role of nuclear receptors NR4A1 and NR4A3 in drug C1 mediated apoptosis and has identified the functional relevance ofthe increase in the transcript level of NR4A1 and NR4A3 This thesis...
... oncogenic potential of loss of Rb is likely to be decided by the expression of each ofthe Rb family members and the role these family members play in the differentiation ofthe cell type involved ... complexes with E2F in the S-phase ofthe cell cycle (Dyson 1998) This might reflect the not yet fully understood specific functions of these proteins at these specific stages ofthe cell cycle 4.4 ... that in this assay loss ofthe Rb gene family is sufficient to allow oncogenic transformation On the other hand, in view ofthe lack of anchorage-independent growth of these cells, it remains...
... Goldberg R, Kiel K, Willett C, Sugarbaker D, Mayer R: Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: ... Darling G: Phase trial of preoperative irinotecan plus cisplatin and conformal radiotherapy, followed by surgery for esophageal cancer Cancer 2010, 116(17):4023-32 Burmeister BH, Smithers BM, Gebski ... Australasian Gastro-Intestinal Trials Group: Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer ofthe oesophagus: a randomised controlled phase III trial Lancet Oncol...
... any relapse in the area of surgery between the sternum and the anterior axillary line, and below the inferior clavicular fossa and above the seventh rib Any relapse involving the axillary lymph ... (42%) Five of them developed bone metastasis first and liver metastasis subsequently Two Table The distribution of recurrences and survivals in radiotherapy and no-radiotherapy group Radiotherapy ... by adjuvant chemotherapy and/or hormonotherapy alone [7-10] All patients in the RT group received systemic adjuvant therapy It was state by Truong et al., that the percentage of positive lymph...
... were used in the assay HLA-A24 level on the cell surface of T2-A24 cells is up-regulated in the presence of HLAA24-binding peptides Up-regulation of mean fluorescence intensity (MFI) of cell surface ... stimulated with either or both of these two peptides in vitro in the presence of autologous DC or PHA blasts as APCs After times stimulation over a period of four weeks, CTLs were examined for their peptide-specific ... manuscript TT and YH participated in the design ofthe study and performed the evaluation ofthe data TT helped to draft the manuscript SI contributed to the HLA-A24-binding assay and CTL induction...