overview of the stress response system

... properties of the analyst forecasts: the forecast error, the forecast dispersion and the skewness of the forecast distribution The earnings forecast studied hereof is the current-year forecast for the ... CAR of –12.9% from one day before to the day of the first financial press disclosures of the disputed accounting They also document a significant CAR of -6% from one day before to the day of disclosure ... numbers Besides wiping off billions of dollars of market value, these restatements also call into question the credibility of the firms’ accounting practices and the quality of the corporate oversight...

Ngày tải lên: 08/11/2015, 17:09

... consisting of the statement of a plan or of a goal, the subdialogue would be "inserted" in the task structure at the location of the plan described Another obvious clue is the presence of reliable ... model of what the novice user knows about the task The verbal interaction between the user and the adviser is not just one of execution of plans and recognition of plans but rather one of situated ... structure: 1) the structure of the sequence of utterances, 2) the structure of the intentions conveyed, and 3) the attentional state Distinguishing these three structures gives a better account of discourse...

Ngày tải lên: 21/02/2014, 20:20

... exploring some of these exciting avenues of investigation Chemotherapy We have investigated this hypothesis further by examining the timing of chemotherapy doses with respect to the LCRP immune ... investigate the timing of vaccinations with respect to the CRP cycle, while examining the clinical responses Since the periodicity of the L-CRP oscillatory cycle was consistent and recurrent, the results ... to produce the up-swing in CRP dom application On the basis of preliminary evidence, we hypothesise that the current random application of chemotherapy (or other immuno-cytotoxic therapy) with...

Ngày tải lên: 18/06/2014, 15:20

... systematic review of the literature After exclusion of duplicates, the abstracts of all citations were reviewed Of these, 104 citations concerning the relationship between quality of life and survival ... (BPI), and the Symptom Distress Scale (SDS) Therefore the information given in the tables was simply to reflect the variance that existed in the instruments used and neither to convey their psychometric ... better profile on the topic, and consequently aid in improving the quality of life of cancer patients Methods Using either term - 'patient-reported outcome' or 'healthrelated quality of life' - the...

Ngày tải lên: 18/06/2014, 19:20

... estimated The propensity score method implies a comprehensive collection of information known to be causally associated with the choice of the treatments, then the production of a propensity score (the ... should be given to explaining the purposes, manner of the management and use of the patients' data from questionnaires and diaries The right of the patient to withdraw from the studies in any time, ... To assess the quality of analgesic treatments in terms of congruence between patients' reported level of pain (intensity) and the potency of the prescribed analgesic drug (according to the WHO...

Ngày tải lên: 20/06/2014, 15:20

... guidance; this procedure allowed the completion of the therapeutic program for 1,930/ 1,978 (97.6%) of the catheters inserted The absence of pneumotorax and other major complications indicates ... at the point of insertion of the sternocleidomastoid muscle into the clavicular; the correct introduction of the needle was always confirmed by ultrasound guidance and by the easy aspiration of ... evaluate correct catheter position At the end of treatment or when required, after the removal of the catheter, the tip was sent to the laboratory for bacteriological examination No systemic prophylaxis...

Ngày tải lên: 09/08/2014, 03:22

... cells were not seen other than the reduction on POD in the hepatic resection group found On the other hand, there were also no significant differences in the percentage of CD4+IL-6+ T cells among ... interests The authors declare that they have no competing interests Authors' contributions MI was involved in the design of the study and writing of the manuscript MN and NH assembled the data ... answered; whether a shift in the Th1/Th2 balance can be used to facilitate comparisons of different surgical procedures, and the clinical significance of the surgery-induced shift in the Th1/ Th2...

Ngày tải lên: 09/08/2014, 04:21

... Figure illustration of the ATM gene Schematic Schematic illustration of the ATM gene The distribution of the variations detected in the studied materials along the gene is shown in the upper panel ... protective effect of the A allele The contradictory between our study and that of [28] may be a consequence of the different ethnicity of the populations or possibly a result of the limited study ... protective effect for of this variant (Table 1) Association of variance in ATM with adverse side effects of radiotherapy The impact of variation in the ATM gene on the level of radiation induced...

Ngày tải lên: 09/08/2014, 10:21

... The principal role of the antithrombotics in surgical patients is to provide effective anticoagulation over the course of the increased risk of VTE (during and postsurgery) with the minimum of ... cases of VTE should be initially treated with either UFH or a LMWH [18,19], or LMWH [16,17] In a recent systematic review of the literature, the use of LMWH over UFH for the initial treatment of ... and the potential role of the LMWHs as antineoplastic therapy Acknowledgements The author received editorial support in the preparation of this manuscript, funded by sanofi-aventis, NJ, USA The...

Ngày tải lên: 10/08/2014, 22:20

... interests The funding agencies (The Oak Foundation and The Danish Rheumatism Association) had no role in writing the report or in the decision to submit the manuscript for publication Neither of the ... fishy taste in the mouth might certainly cause detection bias Assessment of the trial reporting in terms of risk of bias, the use of random assignment, and subsequent concealment of allocation ... categorize the risk of attrition bias as being at best unclear as there is a possibility that some patients were excluded from the analyses Although the authors performed their analyses according to the...

Ngày tải lên: 12/08/2014, 11:22

... 76% died in the hospital [33] In the present cohort about 37% of patients received MV Whether studying the entire population or the subgroup of nonscheduled surgical patients, all of the general ... coworkers [14] analyzed the impact of sample size on the accuracy of MPM II models by performing computer simulations They showed that the smaller the sample size, the better the model calibration, ... appreciated in the calibration curves, which indicate significant underestimates in practically all of the strata of predicted mortality Nevertheless, the line of observed mortality for the SAPS II...

Ngày tải lên: 12/08/2014, 20:20

... Society of Clinical Oncology Chemotherapy and Radiotherapy Expert Panel: 2002 update of recommendations for the use of chemotherapy and radiotherapy protectants: clinical practice guidelines of the ... when the obstruction is partial [24] The relief of the obstruction, either by percutaneous nephrostomy or through a ureteral stent, is the cornerstone of treatment Renal recovery depends on the ... administering the bladder epithelium protectant mesna virtually eliminated haemorrhagic cystitis related to the toxicity of anticancer agents [35,39] However, several other toxic effects of these drugs...

Ngày tải lên: 12/08/2014, 23:23

... modifications of the Em/Am ratio [20,21] (Table 1) The mitral inflow velocity was recorded from the apical four-chamber view with the pulsed-wave Doppler sample volume positioned between the tips of the ... under the curve, 0.87; p < 0.0001) summarizes the capacity of NTproBNP as a valuable predictor of mortality of patients with septic shock In the survivors and during the first three days of ICU ... At the cutoff value of 6,624 pg/ml, NT-proBNP within the first 24 hours could permit the detection of the high-risk mortality population in cancer patients presenting septic shock However, the...

Ngày tải lên: 13/08/2014, 03:20

... of the manuscript 15 Authors’ information PP is coordinator of the Polyvalent Intensive Care Unit and president of the Antibiotic Commission of São Francisco Xavier Hospital PP is Professor of ... Hospital PP is Professor of Medicine of the Faculty of Medical Sciences from the New University of Lisbon, Portugal VCSD is assistant physician of the ICU of the Instituto Nacional de Câncer, Rio ... influenced by the presence or absence of neutropenia • CRP could be a useful biomarker of infection in cancer patients irrespective of the WCC and the degree of immunosuppression Page of 7 Abbreviations...

Ngày tải lên: 14/08/2014, 08:21

... This amount of benefit well compares with the benefits of other important therapeutic choices such as the addition of taxanes for the st line treatment of metastatic breast cancer, where the advantage ... up of 10 months [40] No significant differences in the primary objective of the study (the response rate), were found between the three arms, at the expense of a higher grade and incidence of ... based chemotherapy, the HR in terms fir the time to progression is 0.70 [28] In the phase III trial evaluating the addition of capecitabine to docetaxel in the same setting of patients, the HR for...

Ngày tải lên: 10/08/2014, 10:21

... Accordingly, the great and urgent need presently is to investigate the role of each of the plenitude of genes and proteins important in the progression of cancer NUCLEAR RECEPTORS The nuclear ... techniques permitted the recognition of other members of the family based on sequence homology especially at the DNA binding domain (Mangelsdorf et al., 1995) The identification of the ecdysone receptor ... characterizes the role of nuclear receptors NR4A1 and NR4A3 in drug C1 mediated apoptosis and has identified the functional relevance of the increase in the transcript level of NR4A1 and NR4A3 This thesis...

Ngày tải lên: 14/09/2015, 14:04

... oncogenic potential of loss of Rb is likely to be decided by the expression of each of the Rb family members and the role these family members play in the differentiation of the cell type involved ... complexes with E2F in the S-phase of the cell cycle (Dyson 1998) This might reflect the not yet fully understood specific functions of these proteins at these specific stages of the cell cycle 4.4 ... that in this assay loss of the Rb gene family is sufficient to allow oncogenic transformation On the other hand, in view of the lack of anchorage-independent growth of these cells, it remains...

Ngày tải lên: 25/10/2013, 21:20

... Goldberg R, Kiel K, Willett C, Sugarbaker D, Mayer R: Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: ... Darling G: Phase trial of preoperative irinotecan plus cisplatin and conformal radiotherapy, followed by surgery for esophageal cancer Cancer 2010, 116(17):4023-32 Burmeister BH, Smithers BM, Gebski ... Australasian Gastro-Intestinal Trials Group: Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial Lancet Oncol...

Ngày tải lên: 09/08/2014, 01:24

... any relapse in the area of surgery between the sternum and the anterior axillary line, and below the inferior clavicular fossa and above the seventh rib Any relapse involving the axillary lymph ... (42%) Five of them developed bone metastasis first and liver metastasis subsequently Two Table The distribution of recurrences and survivals in radiotherapy and no-radiotherapy group Radiotherapy ... by adjuvant chemotherapy and/or hormonotherapy alone [7-10] All patients in the RT group received systemic adjuvant therapy It was state by Truong et al., that the percentage of positive lymph...

Ngày tải lên: 09/08/2014, 09:20