over under connected proteins in the gene protein list of interest
Tài liệu Báo cáo khoa học: Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae docx
... the proteins of the outer membrane, we set out to determine what proportion was integral and to identify the major protein species To determine whether the major outer membrane proteins were integral ... membrane The protein profile of mitochondrial outer membranes shows at least nine major proteins (Fig 1A, asterisks), with the three most abundant of these the 45 kDa protein Om45 [18], the 29 kDa protein ... to determine the proteins present in the aqueous extract (‘Aq’), the detergent phase (‘D’) and the phospholipid-rich pellet (‘P’) Arrowheads designate the size of proteins enriched in the lipid-rich...
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Báo cáo hóa học: " Changes in the gene expression profile of Arabidopsis thaliana after infection with Tobacco etch virus" potx
... At5g59780), the ninth one (At5g59430) corresponds to the telomeric repeat-binding protein (TRP1), which also contains the typical MYB motifs [26] Eight out of these nine genes were also included in the ... tryptophan repeats found in other MYB-like proteins and, second, it has a proline rich domain at the carboxi terminal end of the protein [27] The functional categories of response to water deprivation ... metabolism are involved in several functional responses Results Differences in transcriptional profiles As a preliminary analysis, we were interested in knowing whether the overall pattern of gene expression...
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studies of pathogenesis-related proteins in the strawberry plant partial purification of a chitinase-containing protein complex and analysis of an osmotin-like protein gene
... Family: Thaumatin-Like Proteins/ Osmotin-Like Proteins Members of the PR-5 family were originally described from tobacco when induced upon TMV infection The amino acid sequences of PR-5 proteins share ... homologs of PR proteins, including a TLP The accumulation of these PR proteins in the apoplast upon exposure to cold temperature is correlated with the increase in freezing tolerance In addition, ... during the cycles of freezing and thawing, which leads to the exposure of new Ca++-binding sites Binding of Ca++ to these sites caused inhibition of the antifreeze and chitinase activities of these...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
... Bundling proteins Coactivator Supervillin NLS F-actin- and membraneassociated scaffolding protein Filamin NLS? Cross-linking proteins Filamin A NLS? Cross-linking proteins Transgelin ()) Cross-linking ... actin-binding site located in the hnRNP U C-terminus and associate with the phosphorylated C-terminal domain of Pol II [43] Injection of a peptide acting as a competitive inhibitor of protein protein ... using STARS as bait, Barrientos et al [58] identified two novel members of the actin-binding LIM protein (ABLIM) family, ABLIM-2 and -3, as STARS-interacting proteins These novel proteins contain...
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Báo cáo y học: "Novel G-protein-coupled receptor-like proteins in the plant pathogenic fungus Magnaporthe grisea" pot
... contain the CFEM domain in A nidulans These observations could represent either expansion since speciation of the CFEM-containing PTH11 relatives in M grisea, or loss of these proteins in the other ... that mark the boundaries of these domains are given The location of the domains on the membrane topology shown for the M grisea protein is the same for other proteins that share these domains For ... CFEM domain seen in a few proteins was not included), the 13 CFEM domain-containing proteins occurred together in one clade, indicating that the sequences are closely related The phylogeny also...
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Báo cáo y học: "Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data" potx
... Comparing the disordered proteins with the ordered proteins, we observe increases of 33.57% and 12.8% in the percentage of proteins possessing at least one ubiquitination site and the percentage of ... suggests that there is a reduction in the catabolism of biopolymers (such as proteins) and that the transcripts encoding highly disordered proteins and the resulting protein product remain in the cell ... novel insights into the regulation of disordered proteins This aim was achieved and we discuss our findings in the following sections Protein disorder and gene expression On consideration of the gene...
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The role of TRIP br proteins in the regulation of mammalian gene transcription and cell cycle progression
... Features PHD zinc finger protein PHD zinc finger protein Composite PHD zinc fingerbromodomain proteins PHD zinc finger protein Bromodomain protein PHD zinc finger proteins PHD zinc finger protein Composite ... Prominent examples of PHD zinc finger and/or bromodomaincontaining proteins The (*) label designates disease-associated PHD zinc finger and/or bromodomain-containing proteins Conservation of the ... So far, the physiologic roles of the TRIP-Br proteins remain elusive Nevertheless, there are several lines of indirect but compelling evidence inferring a role for the TRIP-Br proteins in regulation...
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Tài liệu Báo cáo khoa học: Electrostatic contacts in the activator protein-1 coiled coil enhance stability predominantly by decreasing the unfolding rate docx
... value into its component kinetic steps The ndings of this study are therefore of interest to the protein design eld in general, but also inform upon how to fast track the design of peptides with the ... interpretation in distinguishing interacting from noninteracting proteins One Fig Schematics of library designs The helical wheel diagram looks down the axis from the N-terminus to the C-terminus Heptad ... Previously selected pairs Proteinprotein interactions capable of sequestering oncogenic JunFos AP-1 leucine zipper proteins were previously generated using genetic libraries containing partially randomized...
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Tài liệu Báo cáo khoa học: Bone morphogenetic proteins in the early development of zebrafish pptx
... Follistatin, Chordin and Noggin [12] These proteins are antagonists of BMP and other members of the TGF-b family, binding to and inhibiting these signaling molecules from binding to their receptors in ... the extracellular space, thus inhibiting ventralizing activities Of these proteins, Chordin has a long-range effect In Xenopus, expression of the chordin gene is localized to the dorsal marginal ... sufficient to induce genes at the normal position and quantity in the embryo or cannot induce these genes at all, thus resulting in mutant phenotypes There is only one report of a mutant strain of the...
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Tài liệu Báo cáo khoa học: Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages docx
... receptor-blocking experiments The rates of uptake of both the lipid and protein components are not matched by the rate of cellular metabolism of these species, resulting in the accumulation of both ... medium during the chase period allows the turnover of preaccumulated protein to be studied in the absence of further cellular uptake In these studies, cell death was < 12% as measured by the appearance ... diagnosis of diabetes, consistent with a shared underlying pathogenesis [2] An early and persistent feature of the atherosclerotic lesion is the presence of lipid-laden (foam) cells in the intima of the...
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Tài liệu Báo cáo khoa học: Domain deletions and substitutions in the modular protein evolution doc
... six domains Each protein from a given set containing proteins of length N domains was compared with each protein from the set containing proteins of length N)1 domains For example, a protein with ... that the domain deletions are more common at either of the protein termini, and that their occurrence is slightly higher at one of the termini, depending on the number of domains in the protein ... a single domain missing anywhere in the arrangement Then we calculated the frequency of the deletion at each domain position within the group of proteins containing a given number of domains...
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Báo cáo khoa học: Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity pptx
... demonstrates the importance of each of the negatively charged residues in the C-terminal extension in maintaining the solubility of the Hsp25 oligomer Similarly, the introduction of hydrophobicity into the ... Frequency of amino acid residues in the flexible region of the C-terminal extensions of human and murine sHsps Residues present in the flexible region of the C-terminal extension of each of the eight ... that the structure of the N-terminal domain is maintained, at least in the vicinity of the tryptophan residues The increase in exposed clustered hydrophobicity observed for the mutants is therefore...
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Báo cáo khoa học: Structural and functional roles for b-strand 7 in the a-crystallin domain of p26, a polydisperse small heat shock protein from Artemia franciscana pdf
... Siddique M & Vierling E (2001) The expanding family of Arabidopsis thaliana small heat stress proteins and a new family of proteins containing a-crystallin domains (Acd proteins) Cell Stress Chaperones ... against physiological stress, was investigated by site-directed mutagenesis of a-crystallin domain residues and molecular modeling of protein structure The p26 a-crystallin domain contains nine ... within the a-crystallin domain, better understand the consequences of amino acid substitutions, and identify protein regions involved in oligomer assembly The four modified a-crystallin domain...
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Báo cáo khoa học: Structural and functional evidence for a singular repertoire of BMP receptor signal transducing proteins in the lophotrochozoan Crassostrea gigas suggests a shared ancestral BMP/activin pathway docx
... a single residue (underlined) This motif plays an important role across phyla in determining the specificity of type I receptors for Smad proteins [20] The gene and inferred protein sequence of ... of the genes encoding Cg-BMPR1 and Cg-TGFbsfR2 is shown in Fig 2C The serine ⁄ threonine kinase domain in both proteins is encoded by two exons equivalent to kinase subdomains X and XI [22] In ... underlined, and the cysteine knot is boxed Also boxed are the transmembrane domain, the ATP binding site, the L45 loop and the serine ⁄ threonine kinase domain (B) The implied amino acid sequence of CgTGFbsfR2...
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Báo cáo khoa học: Structural features in the C-terminal region of the Sinorhizobium meliloti RmInt1 group II intron-encoded protein contribute to its maturase and intron ppt
... N-terminus of the RT domain is required for protein interactions with the high-affinity binding site in subdomain DIVa of the intron, whereas other regions of the RT and domain X interact with conserved ... The mutagenic primers contained a 20 bp region of overlap and introduced a valine (V) residue in place of the moderately conserved alanine (A) in position 400 of the IEP, by changing C>T in intron ... conserved leucine residue at the N-terminus of a-helix a4, the domain X contains the conserved amino acid residues HKXRA (RmInt1 residues 388–392) carrying a stretch of basic amino acids Some of the residues...
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Báo cáo khoa học: A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion docx
... domain of p47phox binds intramolecularly to the SH3 domain in the same protein, and that this intramolecular interaction suppresses the lipid-binding activity of the PX domain in the resting state; ... ligands for the SH3 domain Thus, fad49 encodes a protein containing many protein- binding domains, suggesting that this protein may be a novel scaffold protein We next tried to isolate the full-length ... role in adipogenesis Fig Amino acid sequence and domain structure of FAD49 (A) Amino acid sequence of mouse FAD49 The PX domain is underlined by a solid line and the four SH3 domains are underlined...
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Báo cáo khoa học: Zinc-binding property of the major yolk protein in the sea urchin ) implications of its role as a zinc transporter for gametogenesis ppt
... supplies for oogenesis and spermatogenesis Results Binding of trace metals to proteins First, we investigated the binding of trace metals (manganese, iron, copper, and zinc) to proteins in the coelomic ... EGMYP, enabling it to retain zinc Indeed, 33% of the total zinc in the ovary at stage and 13% of the total zinc in the testis at stage is still bound to MYP On the basis of the results of the present ... how these domains are related to its zinc-binding properties In vertebrates, zinc-binding proteins in serum, such as albumin and vitellogenin (which circulate in the bloodstream and transport zinc...
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Báo cáo khoa học: Cellular response to unfolded proteins in the endoplasmic reticulum of plants pptx
... of proteins from the ER, and promote transport of newly synthesized proteins from the ER into ER subdomains or Golgi in yeast [167–170] Newly synthesized proteins that not fold correctly in the ... signal peptide in the 24-kDa a-zein and the 19-kDa a-zein endosperm storage proteins, respectively These mutant proteins are translocated into the lumen of the ER, but remain anchored to the membranes ... accumulation of unfolded proteins in the ER, BiP is competitively titrated from the luminal domain of IRE1 by the abundant unfolded proteins in the ER lumen, and IRE1 is activated Structural studies of the...
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Báo cáo khoa học: Identification in the yeast Pichia stipitis of the first L-rhamnose-1-dehydrogenase gene docx
... for a protein with this activity We also added a histidine-tag to the N-terminus or to the C-terminus of the protein in order to facilitate the purification However, the tagged proteins showed ... vector in the same yeast strain When testing the two modified proteins in the crude extract of S cerevisiae, we observed that the N-terminally tagged enzyme did not exhibit any activity The C-terminally ... by comparing the results of the SDS ⁄ PAGE that was done after the zymogram staining with those of the SDS ⁄ PAGE of the active fractions after the DEAE column and correlating them with the enzyme...
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Báo cáo hóa học: " Correlating novel variable and conserved motifs in the Hemagglutinin protein with significant biological functions" docx
... with the exception of block 14 which occurs in only 16 of the 17 sequences the mutation rate of each of the MEME blocks, in order to infer the evolutionary behavior of the motifs (i.e whether they ... phosphorylation domain [10] 16 of the potential phosphorylation sites are Protein kinase C (PKC) phosphorylation site encompassing different regions of the protein The clustering of the PKC phosphorylation ... co-mutating pairs suggests specific and selected base pair substitutions over the years The relatively high co-mutating pairs in this block remain unexplained Interestingly, the minimal overlap of...
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