origin metabolism action and mode of action
Báo cáo khoa học: "Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian Influenza virus (H5N1, H7N7) and swine-origin H1N1 (S-OIV)" docx
... humans and their livestock, particularly poultry and pigs, as a consequence of antigenic drift and shift, resulting frequently and unpredictably in novel mutant and re-assortant strains, some of ... barriers and become pathogenic in their new hosts [1] Prospects for the emergence of pandemic strains of swine and avian origin have been discussed in several recent reports [2,3] Some of the highly ... activity in more detail, and to elucidate possible mechanisms of action on a variety of IV strains (human and avian), with emphasis on a human isolate of the H5N1-type HPAIV, and to evaluate the potential...
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Tài liệu Báo cáo khoa học: Characterization and mode of action of an exopolygalacturonase from the hyperthermophilic bacterium Thermotoga maritima doc
... zone of the cytoplasmic fraction (not shown) No activity on PGA was observed when the corresponding medium fraction was concentrated and similarly analysed Mode of action of PelB To examine its mode ... thaliana (AAF21195.1) The mode of action (endo or exo) and the amount of GalpA cleaved off, respectively, are annotated in parentheses A question mark indicates unknown activity mode The secondary structure ... as the rst and only product on PGA and oligoGalpA On the basis of its mode of action, PelB should be classied as an exopolygalacturonase (EC 3.2.1.67) To date, no crystal structure of an exopolygalacturonase...
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Báo cáo khoa học: Peptides that bind the HIV-1 integrase and modulate its enzymatic activity – kinetic studies and mode of action pptx
... inhibitory activity of this group of peptides is attributable to their effect on the turnover number of IN, and suggest a different mode of action from that of the rst group The third group of peptides, ... resembles that of INS [56] To convert some of these peptides into efcient antiHIV drugs, it is essential to elucidate their mode of action and their effects on the kinetic parameters of the 3Â-end ... protein on the basis of the RevIN interaction [55,5863] and following the use of a Rev-derived peptide library [58] With the use of a yeast two-hybrid (Y2H) system and a random peptide library,...
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Báo cáo Y học: Isolation, enzymatic properties, and mode of action of an exo-1,3-b-glucanase from Trichoderma viride doc
... from T viride AZ36 Mode of action in the hydrolysis of laminarins The mode of action of the exo-1,3-b-glucanase was studied using laminarin from L digitata with a ratio of 1,3-b- and Exo-1,3-b-glucanase ... Km and Vmax for hydrolysis of G6G are similar to those of G3G (Tables and 4) Therefore, it may be assumed that the enzyme has a mixed mode of action towards laminarins and that it is capable of ... higher and the rate of hydrolysis is < twofold lower than for laminarin from L digitata The mode of action of the exo-1,3-b-glucanase on laminarin from L digitata was studied qualitatively by TLC and...
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HERBICIDES – MECHANISMS AND MODE OF ACTION ppt
... of biochemical mode of action can be shown for the marketed herbicides Herbicides with mode of action represent around 75% of herbicide sales (Klausener et al., 2007) Understanding the mode of ... radicals are generated and Molecular Mechanism of Action of Herbicides 19 chlorosis develops (Ahrens and Krieger-Liszkay, 2001) Stoichiometric inhibition of D1 as an herbicide mode of action has a major ... frequency range and the fitting of the Nyquist plots of impedance spectra to an equivalent circuit The use of this technique and Nyquist plots 34 Herbicides – Mechanisms and Mode of Action are a...
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Agents for hepatocellular carcinoma synthesis and mode of action
... bonds in 47 and guandinium side chain of Arg 97 and carbonyl O of Ser 263 Figure 4-10: H bonding between (A) sulfonyl O atoms of 3-12 and Arg 97, Ser 263 Phe 96; (B) Nitro O atoms of III and Ser ... Dose response curves of determination of (A) IC50 and (B) GI50 of 5-9 on HuH7 cells, 72 h incubation Figure 3-2: Dose response curves of determination of (A) IC50 and (B) GI50 of 3-12 on HuH7 cells, ... bonding of the lactam NH to amide carbonyl of Gln 167 and lactam CO to NH of imidazole in His 187 Figure 4-12 Overlap of best poses of compound 47, 8-7, 8-8 and 8-9 Figure 4-13: (A) 7-Cl of indolinone...
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Investigations into the chemopreventive potential of stilbenes, indolinones and isoindigos synthesis and mode of action studies
... POTENTIAL OF STILBENES, INDOLINONES AND ISOINDIGOS: SYNTHESIS AND MODE OF ACTION STUDIES ZHANG WEI (B.Sc., SOOCHOW UNIVERSITY) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ... elucidated A great deal more is known of the exogenous ligands of AhR, most of which are halogenated and polycyclic aromatic hydrocarbons One of its most potent ligands is 2,3,7,8tetrachlorodibenzo-p-dioxin ... the ARE enhancer regions of NQO1 and other phase II genes, and stimulate their transcription (31) 1.5 Monofunctional and Bifunctional Inducers of Phase II Enzymes Inducers of phase II enzymes may...
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Antiproliferative activity of curcumin analogs on acute promyelocytic leukemia synthesis and mode of action studies
... 5.3.3 Effects of 41, 219 and 227 on ER stress markers in NB4 cells 146 5.3.4 Effects of 41, 219 and 227 on the ER stress sensors PERK and IRE2 .148 5.3.5 Effects of 41, 219 and 227 on ... IC50 determination of curcumin and 41 on trypsin-, caspaseand chymotrypsin-like active sites of 20S proteasome 181 Appendix 4-2 Determination of substrates Km Initial rate of reaction containing ... support and guidance during the ups and downs of this PhD project Words cannot fully express the gratitude and respect I have for Prof Go, who is not only my advisor, but also a pillar of support and...
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Tài liệu Báo cáo khoa học: Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates pdf
... key features of PDH specificity and mode of inhibition of the enzyme Results and Discussion Structural analysis and model quality Crystal structures of three different complexes of LlPDH have ... 2) of the protein The mode of binding of (19.0 A PEX ⁄ PEA in the active site of LlPDH is similar to that of 6PG ⁄ RU5P, where the phosphate is recognized by interactions with Tyr192, Arg289 and ... dehydrogenase ligand complexes R Sundaramoorthy et al Fig (A) Catalytic reaction of PDH and two intermediate states (B) Structures and numbering of the inhibitors PEX (two resonance forms) and PEA deuterium...
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Báo cáo khoa học: Structures and mode of membrane interaction of a short a helical lytic peptide and its diastereomer determined by NMR, FTIR, and fluorescence spectroscopy pdf
... studies of the interaction of antimicrobial peptide and lipid bilayers Biochem Biophys Acta 1462, 185–200 Epand, R.M & Vogel, H.J (1999) Diversity of antimicrobial peptides and their mechanism of action ... Ramachandran map) Mode of interaction of lytic peptides (Eur J Biochem 269) 3875 Deviations from Idealized geometry Table Structral Statistics for the L-peptides and their diastereomers in DPCho and ... region between 1610 and 1628 cm)1 is characteristic of an aggregated b sheet structure and the region between 1640 and 1645 cm)1 corresponds to a random coil The amide I region of an a helical structure...
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Car Ownership and Mode of Transport to Work in Ireland* potx
... 25/02/2010 14:31 Page 47 CAR OWNERSHIP AND MODE OF TRANSPORT TO WORK IN IRELAND 47 and Williams and Shiels, 2000) The interactions between commuting and the housing and labour markets have been analysed ... group and industrial group; as well as variables relating to county and electoral division (ED7) of residence, county, ED and geo-code of place of work, distance travelled, time of departure and mode ... mode of transport for the journey to work Mode of transport refers to the usual mode of transport for the outward journey to work Where more than one mode of transport is used, the mode of transport...
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Báo cáo sinh học: " Number and mode of inheritance of QTL influencing backfat thickness on SSC2p in Sino-European pig pedigrees" pot
... how the presence of two QTL could affect the apparent mode of inheritance of IGF2 alleles Methods Animals and phenotypic data The French and Dutch F2 MS × European breeds crosses and the recorded ... SSC2 Mode of inheritance of the QTL Analyses of variance were performed on different subgroups of animals to investigate the effect of the IGF2 mutation Results obtained using the IGF2pat model ... cM) and S0036 (149 cM)), as previously reported [18] Genotyping of the IGF2-intron3-G3072A substitution was performed on some of the F0 and F1 animals of both pedigrees Previously, F1 boars and...
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Báo cáo khoa học: Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus doc
... for the current understanding of its mode of action The cagPAI and the Cag type IV secretion apparatus Gene arrangement and variants of the cagPAI The cagPAI, which was originally identified by ... the molecular mechanisms of effector protein secretion This minireview describes the composition of the cagPAI and the properties of both conserved and unique components of the Cag-T4SS, together ... an inversion of cagQ, a duplication of cagA and cagB associated with cagA degeneration, and a more complex rearrangement comprising all cag genes except cagA and a second inversion of several flanking...
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Báo cáo khoa học: Contribution of a central proline in model amphipathic a-helical peptides to self-association, interaction with phospholipids, and antimicrobial mode of action ppt
... & Hodges RS (1984) Synthesis of a model protein of defined secondary and quaternary structure Effect of chain length on the stabilization and formation of two-stranded alpha-helical coiled-coils ... interactions, whereas the interaction of PFPs with membranes was most affected by hydrophobic interactions These properties may lead to the selectivity of PCPs and ⁄ or the nonselectivity of PFPs ... measured, with a step resolution of 0.1 nm, scan speed of 50 nmÆmin)1, response time of 0.5 s, and bandwidth of nm CD spectra of peptides were collected and averaged over four scans at 25 °C in 50 mm...
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Báo cáo khoa học: Mode of action of the microbial metabolite GE23077, a novel potent and selective inhibitor of bacterial RNA polymerase docx
... specificity of action of GE23077 on cellular RNA synthesis and strongly suggest that its restricted antimicrobial activity is a result of its inability to cross bacterial membranes Mechanism of action of ... in the elucidation of the mechanism of action of GE23077, it is crucial to assess whether it exerts its action at the level of transcription initiation, like lipiarmycin [11] and rifampicin [16], ... potency and selectivity of GE23077, assessing its activity on different purified polymerases Second, its mode of action on whole bacteria, using permeabilized cells to confirm the specificity of RNA...
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stenersen - chemical pesticides - mode of action and toxicology (crc, 2004)
... pesticides: Mode of action and toxicology Dose and effect The law of mass action tells us that the amount of reaction products and the velocity of a chemical reaction increase with the concentrations of ... inhibit synthesis of amino acids 81 5.2.1 The mode of action of glyphosate 81 5.2.2 Degradation of glyphosate 83 5.2.3 Selectivity 84 5.2.4 Mode of action of glufosinate ... repellent, and plant activator Their mode of action is based on more new principles Most of them are listed below, together with the year of registration Chapter one: Introduction Pesticide Mode of Action...
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UPDATE ON MECHANISMS OF HORMONE ACTION – FOCUS ON METABOLISM, GROWTH AND REPRODUCTIONS pptx
... hormones and their interactions with food intake and energy expenditure, adipose tissue function and metabolism, regulation of glucose metabolism and their clinical alterations in human and animal models ... co-localization of motilin and ghrelin in the duodenum and lower intestine of suncus 6 Update on Mechanisms of Hormone Action – Focus on Metabolism, Growth and Reproductions Distributions of motilin and ... structures, distribution of motilin- and ghrelin-producing cells, distribution of their receptors, plasma profies and secretion of motilin and ghrelin, and the role of motilin and ghrelin in gastric motility...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 2 pptx
... Stenersen 2.2.2 Dose and effect The law of mass action tells us that the amount of reaction products and the velocity of a chemical reaction increase with the concentrations of the reactants This ... and resistant flies and a mixture (50:50) of susceptible and resistant flies (a) Doses and responses on linear scales (b) Doses on log scale and responses on probit scale LD50), will be large and ... between dose or concentration of the toxicant and the severity of the symptoms is fundamental in toxicology By using the law of mass action, we get the following equilibrium and mathematical expression:...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 3 pps
... butachlor, and several others) and a group of fungicides referred to as phenylamides (metalaxyl, ofurace, and oxadixyl) They have similar structure and mode of action: O C CH2R’’ N R R’ R is often ... inhibiting the formation of the microtubules Although the mode of action of the two types of compounds is different, the net result will be the same: impairment of cell division Binding of guanosine triphosphate ... fluoroglycofen-ethyl COCH3 NO2 O COCH2COCH2CH3 CF3 O OCH2CH3 NO2 Cl oxyfluorfen Bifenox, fluoroglycofen-ethyl, HC-252, lactofen, and oxyfluorfen have analogous structures and modes of action The...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 4 ppt
... from beach deserts and tundra, and may multiply in cadavers of insects and other animals Insecticidal activity does not correlate with the origin of the isolate, and many of them not seem to ... in cessation of feeding of Lepidoptera larvae and paralysis of the gut that retards the passage of food and allows the spores to germinate The larvae suffer a general paralysis and die Bt israelensis-treated ... proteins, and their function and versatility for insect control have yet to be elucidated 4.1 The mechanism of action of δ-endotoxins As mentioned, the δ-endotoxin (Cry protein) that makes up most of...
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