on chip agarose microchamber system
báo cáo khoa học: "Nanoparticles – known and unknown health risks" pot
... immunological conditions, e.g a greater uptake of particles (0.1 micron, micron and 10 micron diameter) has been demonstrated in the inflamed colonic mucosa of rats compared to non-ulcerated tissue ... has only recently been recognised Most research has concentrated on the possible consequences of particle related malfunction of the cardio-vascular system, such as arrhythmia, coagulation [46] ... extent lung inflammation modulates the extra-pulmonary translocation of particles 3.5 Fibre bio-persistence Long non-phagocytizable fibres (in humans longer than 20 micron) will not be effectively...
Ngày tải lên: 11/08/2014, 00:22
Báo cáo y học: "Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice" ppt
... receptor sIL-6-R on migration and proliferation of human pulmonary-artery smooth muscle cells Effects of IL-6 and its soluble receptor sIL-6-R on migration and proliferation of human pulmonary-artery ... overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension J Clin Invest 2001, 108(8):1141-1150 Austyn JM, Gordon S: F4/80, a monoclonal antibody ... circulation of rats exposed to chronic hypoxia J Clin Invest 1991, 87(1):155-162 Eddahibi S, Humbert M, Fadel E, Raffestin B, Darmon M, Capron F, Simonneau G, Dartevelle P, Hamon M, Adnot S: Serotonin...
Ngày tải lên: 12/08/2014, 14:20
Báo cáo y học: " Induction and effector phase of allergic lung inflammation is independent of CCL21/CCL19 and LT-beta
... Lung allergic inflammation might be considered similar in many respects to chronic inflammation, due to its accumulation of lymphocytic infiltrates and long term induction of tissue remodeling ... magnification (originally photographed at 200x) Discussion The present study was initiated to address two related questions on the mechanisms of immune effector responses First, a number of chronic ... anti-mouse CD4 antibody (Pharmingen) on a FACScan flow cytometer (Becton Dickinson, Mountain View, CA) Five million splenic CD4 T cells from donor mice were injected i.v Bronchoalveolar lavage (BAL) BAL...
Ngày tải lên: 03/11/2012, 11:24
Báo cáo y học: "The role of toll-like receptors in acute and chronic lung inflammation" pdf
... ligand stimulation Upregulation of TLR2 mRNA and protein expression was observed only in AMs from nonsmokers while no significant differences in TLR4 expression were demonstrated among these three ... concert during C pneumoniae infection [195,196] TLR2 is also upregulated in response to M pneumoniae infection, leading to increased expression of airway mucin [197,198] Allergic inflammation ... inflammation in HS-induced ALI is dependent on upregulation of TLR4 by LPS, while later inflammation is mediated by heightened TLR2 expression on AMs and endothelial cells [64] Deletion of either...
Ngày tải lên: 11/08/2014, 03:20
Báo cáo y học: "A neonate with left pulmonary artery thrombosis and left lung hypoplasia: a case report" pps
... sealed The chest tube was removed on day 17 of life His cardiac and pulmonary function gradually improved on ECMO, allowing decannulation on day 23 of life This neonate was heparinized during his ... take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color figure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus ... aortopulmonary collaterals as the primary blood supply to the left lung Pulmonary artery thrombosis was first suspected on echocardiogram evaluation Although cardiac catheterization with contrast...
Ngày tải lên: 11/08/2014, 03:21
Báo cáo y học: " A neonate with left pulmonary artery thrombosis and left lung hypoplasia: a case report" pot
... sealed The chest tube was removed on day 17 of life His cardiac and pulmonary function gradually improved on ECMO, allowing decannulation on day 23 of life This neonate was heparinized during his ... take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color figure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus ... aortopulmonary collaterals as the primary blood supply to the left lung Pulmonary artery thrombosis was first suspected on echocardiogram evaluation Although cardiac catheterization with contrast...
Ngày tải lên: 11/08/2014, 07:20
Báo cáo y học: " Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin" potx
... expression in the lung Conclusion: The present study clearly demonstrates that CD69 plays an important role in the progression of lung injury induced by BLM Keywords: cluster of differentiation 69, ... sections, which were placed on poly-L lysine-coated slides The sections were subjected to double staining with hamster anti-CD69 monoclonal antibody (Biolegend, San Diego, CA) in combination with ... Cell Biol 2008, 40 40(3):362-382 Azuma A: [Expectation of new treatments for idiopathic interstitial pneumonias] [Expectation pneumonias] Nippon Ronen Igakkai Zasshi 2005, 42 42(1):27-30 Chen J,...
Ngày tải lên: 12/08/2014, 14:20
Báo cáo y học: " Role of pulmonary intravascular macrophages in endotoxin-induced lung inflammation and mortality in a rat model" pot
... staining controls included incubation of sections with only secondary antibody, isotype matched antibodies or with only color development reagents Another control was to stain some of the sections ... Lung section stained with only secondary antibody (A) show no reaction while antivWF antibody stained vascular endothelium (arrow) Lung sections from control rats (C) contained occasional septal ... DNA contamination units of Platinum Taq DNA polymerase was substituted for the Superscript III RT/Platinum Taq mixture in the reaction A negative control reaction consisted of all the components...
Ngày tải lên: 12/08/2014, 14:20
Báo cáo y học: "An intranasal selective antisense oligonucleotide impairs lung cyclooxygenase-2 production and improves inflammation, but worsens airway function, in house dust mite sensitive mice" ppsx
... receptors antagonist (montelukast) on neurokinin a-induced bronchoconstriction J Allergy Clin Immunol 2003, 111:833-839 Weller CL, Collington SJ, Hartnell A, Conroy DM, Kaise T, Barker JE, Wilson MS, ... Sensitization protocol and antisense oligonucleotide (ASO) administration Sensitization protocol and antisense oligonucleotide (ASO) administration Oligonucleotide was administered intranasally one ... PGE2 concentration was measured using a commercially available specific ELISA (Cayman Europe, Tallin, Estonia) Pulmonary function testing To assess the effect of impaired COX-2 production on airway...
Ngày tải lên: 12/08/2014, 14:20
Báo cáo y học: "Acute lung inflammation and ventilator-induced lung injury caused by ATP via the P2Y receptors: an experimental study" pdf
... production of pro-inflammatory cytokines [7], and to the leakage of inflammatory mediators into the systemic circulation [8] Ventilation with a small tidal volume lowers the pulmonary and systemic concentrations ... http://respiratory-research.com/content/9/1/79 SYBER green detection system on an ABI 7300 Real-Time PCR system (Applied Biosystems, Foster City, CA) All samples were measured in triplicate We measured the expression levels ... Mitigation of the ventilation-induced pulmonary inflammatory response by PPADS To confirm the involvement of the purinergic system in VILI, we instilled 60 μl of 50 mM PPADS or saline before the onset...
Ngày tải lên: 12/08/2014, 14:20
Báo cáo y học: "A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice" pps
... modulation of the inflammatory response in COPD, we first assessed the effect of AON 4B/ 4D and AON 7A on PDE expression levels in NHBE cells NHBE cells were transfected with AON 4B/4D or AON 7A ... COPD: inflammation, immunity, and tissue repair and destruction Eur Respir J 2008, 31:1334-1356 Pelkonen : Smoking: relationship to chronic bronchitis, chronic obstructive pulmonary disease and ... combined AONs at 267 nM as compared to controls, and were near baseline levels seen in non-stimulated, non-transfected cells The strong inhibitory activity of combined 4B/4D and 7A AONs on IL-8...
Ngày tải lên: 12/08/2014, 14:20
Báo cáo y học: " Dietary intake, lung function and airway inflammation in Mexico City school children exposed to air pollutants" doc
... results A significant interaction was observed between FVI and ozone levels on IL-8 and lung function and between MDI and ozone levels on lung function consumption of fish (a source of omega-3 ... supplements reported on the questionnaire and were scored on a scale of to Children whose consumption was below the median value were assigned 0, while children whose consumption was at or above ... moderate alcohol consumptions component was suppressed as it was not applicable to children: ii) The high monounsaturated/saturated consumptions were eliminated because fat ratio component as it could...
Ngày tải lên: 12/08/2014, 14:20
Báo cáo y học: " CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo" ppsx
... will contribute to the induction of inflammation Recent studies have demonstrated that other TLRs and their respective ligands are also responsible for pulmonary cytokine production and pulmonary ... http://respiratory-research.com/content/8/1/72 Pulmonary TNF-α and IL-1β protein expression Pulmonary tissue was homogenized and incubated on ice for in mL of ELISA buffer containing PBS, Triton X-100 (1 μL/mL), ... contribute to an inflammatory response Further studies will be necessary to solve this issue Conclusion In summary, we demonstrate that CpG-ODN causes NFκB activation, leading to the induction...
Ngày tải lên: 12/08/2014, 15:21
Báo cáo y học: " Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice" ppt
... inflammation in the resolution of influenza infection remains controversial, with evidence for both immune-mediated amelioration [reviewed in [6]] and worsening [7-9] of the host's overall condition ... regulation is a major motivation to smoke in humans In our model there is only minor induction of systemic inflammation, as smoke did not change TNF-α transcripts in adipose tissue [16] and on smoking ... longer smoking protocol Their trend observation that prior smoke exposure increased inflammation and worsened outcomes from high dose influenza infection was similar to our general conclusions...
Ngày tải lên: 12/08/2014, 15:21
Báo cáo y học: " Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS" pot
... (combination of consolidation, ground glass opacities and reticular opacities in the presence of architectural distortion); ground-glass attenuation with traction bronchiolectasis or bronchiectasis; ... ground-glass attenuation (80.8 ± 12.2% of total abnormality on HRCT) and consolidation (13.6 ± 10.9% of total abnormality on HRCT) Honeycombing and bronchiectatic changes were found in only SARS patients ... glass opacification (hazy areas of increased attenuation without obscuration of the underlying vessels); consolidation (homogeneous opacification of the parenchyma with obscuration of the underlying...
Ngày tải lên: 12/08/2014, 18:21
Báo cáo y học: " Multiple exposures to swine barn air induce lung inflammation and airway hyper-responsiveness" pptx
... ventilation in the winter season to conserve heat Conclusion Our data show that, single and multiple exposures to endotoxin rich-swine barn air induce lung inflammation characterized by infiltration ... Larsson BM, Sundblad BM, Larsson K: Partial protection by respirators on airways responses following exposure in a swine house Am J Ind Med 2004, 46:363 Palmberg L, Larssson BM, Malmberg P, Larsson ... Predictors of longitudinal changes in pulmonary function among swine confinement workers Can Resp J 1998, 5:472-478 ANDERSEN AA: New sampler for the collection, sizing, and enumeration of viable...
Ngày tải lên: 12/08/2014, 18:21
Báo cáo y học: "Role of CD14 in lung inflammation and infection" pptx
... role in the induction and amplification of inflammatory responses evoked by a wide variety of pathogens Role of CD14 in LPS- and LTA-induced lung inflammation The contribution of CD14 to TLR ligand-induced ... response remains to be determined In contrast to rabbits, administration of LPS alone to lungs of naive mice induced severe pneumonitis, irrespective of the manner of LPS delivery (inhalation ... response against influenza A virus Conclusion CD14 plays a central role in the lung in the recognition and binding of a variety of (myco)bacterial and viral components, and in the amplification...
Ngày tải lên: 13/08/2014, 20:21
Co operation between humoral and cellular immunity in pulmonary lung inflammation
... Optimisation of OVA dosage for immunisation .38 Figure 3: Optimisation of booster injections 40 Figure 4: Determination of the best adjuvant for immunisation 41 Figure 5: Comparison ... Optimisation of PHA dose for proliferation assay 52 Figure 11: Optimisation of anti-CD3e and anti-CD28 conditions for cell proliferation assay 53 Figure 12: Optimisation of anti-CD3e ... anti-CD28 conditions for cell proliferation assay 54 Figure 13: Non-antigenic polarisation of CD4+ T cells from C57BL6 mice for one week 57 Figure 14: Non-antigenic...
Ngày tải lên: 03/10/2015, 21:57
Báo cáo y học: " High blood pressure, antihypertensive medication and lung function in a general adult population"
... no medication§ HBP and medication -0.16 0.06 0.02 HBP and medication -0.17 0.07 0.02 Only HBP -0.08 0.04 0.09 Only HBP -0.10 0.05 0.04 Only medication -0.06 0.04 0.14 Only medication -0.07 0.05 ... Thorleifsson SJ, Gudmundsson G, Olafsson I, Benediktsdottir B, Janson C, Buist AS, Gislason T: Hypertension, systemic inflammation and body weight in relation to lung function impairmentan epidemiological ... diaphragmatic contractility in chronic airway obstruction Arch Bronconeumol 2009, 45(5):230-234 24 Grimm DR, Schilero GJ, Spungen AM, Bauman WA, Lesser M: Salmeterol improves pulmonary function in persons...
Ngày tải lên: 25/10/2012, 10:45
Báo cáo y học: "Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis"
... Replication (random samples) Replication (random samples) Replication (random samples) Replication (all samples) None Replication (random samples) Replication (all samples) Replication (random ... appropriate, confounding factors should be controlled for, with particular consideration of race and ethnicity An additional major concern is the grouping of genotypes for calculation of ORs Without ... Sequencing Replication (random samples) Replication (random samples) Replication (random samples) Replication (random samples) Replication (random samples) None Caucasian 96/94 Population 0.564 (0.187)...
Ngày tải lên: 31/10/2012, 14:59