omitting radiation in patients treated with hormonal therapy

... zidovudine/didanosine/ indinavir (n = 1), stavudine/didanosine/indinavir/ nevirapine (n = 1), stavudine/didanosine/nelfinavir (n = 3), stavudine/lamivudine/nelfinavir (n = 2), abacavir/ efavirenz/nelfinavir ... patients (83%) were on stavudine, lamivudine and indinavir (n = 47) or zidovudine, lamivudine and indinavir (n = 19); the other regimens were stavudine/ didanosine/indinavir (n = 5), zidovudine/didanosine/ ... maintained in the previously IL-2 treated patients, with fewer cycles than in those newly receiving IL-2 But considering the two large randomized trials and their findings that IL-2 therapy in...

Ngày tải lên: 10/08/2014, 05:21

... Schellhammer P, Shipley WU, Sokol GH, Sandler H: Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations ... endpoint PSA levels were normalized to below ng/mL in 119 of the 133 total patients in the follow-up period Information on NAAD was available for 80 of these patients Those patients treated with ... primary therapy, to monitor responses to hormonal therapy and to detect recurrent cancer PSA can be used to determine the efficacy of primary therapy including radical prostatectomy and radiation therapy...

Ngày tải lên: 09/08/2014, 09:20

... audiological findings in 15 patients with head and neck tumors, treated with radio- and concomitant chemotherapy, using the same criteria to define ototoxicity Their results showed that 85% of patients ... the increase of the hearing thresholds, being the average and the median dose 300 mg/m2 (p = 0.393) (Tables 3) Other studies that compared patients treated only with radiotherapy and patients treated ... the use of hearing aids The three patients who reported daily auditory difficulties and interest in using hearing aids were directed and enrolled in the Hearing Aid Program of this Institution 10...

Ngày tải lên: 09/08/2014, 10:20

... Changes in PPS were assessed by using self-rated VAS for overall pain, headache, shoulder/neck pain, back pain, joint pain, thoracic pain, and abdominal pain Changes in painful and non-painful ... N=570 Patients with respective pain change after weeks Patients (%) Patients with respective pain change after weeks 50 N=3291 N=2565 N=2177 25 All patients Patients with 50% pain reduction Patients ... psychotropic/permanent pain medication • Pain symptoms at baseline • Initial dose of duloxetine • Overall pain VAS at baseline • ≥ 50% overall pain VAS reduction at weeks • ≥ 50% reduction in SSI painful symptoms...

Ngày tải lên: 11/08/2014, 15:22

... etc.) The main finding of our study is that all 134 patients with negative rPen a1 IgE before starting immunotherapy, remained tropomyosin IgE negative after completing the mite immunotherapy course ... immunotherapy Consecutive patients with ascertained respiratory allergy due to house dust mite, and prescribed with mite sublingual immunotherapy (SLIT) were evaluated at baseline (before starting ... number of patients treated with mite sublingual/oral vaccines did not result in a neosensitisation to tropomyosin, which was significantly present (as mite group 10) in the extract administered...

Ngày tải lên: 13/08/2014, 13:22

... observed Initial DNA damage levels in breast cancer patients Radiation- induced apoptosis in breast cancer patients Initial DNA damage was determined as radiationinduced double-strand breaks (DSB) in ... al.: Combined low initial DNA damage and high radiation- induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high-dose radiotherapy Radiation ... LABC patients treated with HF [18] In the other hand, determination of radiation- induced apoptosis (RIA) in PBL by flow cytometry analysis has also been proposed as an approach for predicting...

Ngày tải lên: 09/08/2014, 09:20

... prostate patients treated with SIB IMRT Methods Patient Selection, Positioning and CT scanning Twenty-two intermediate risk prostate cancer patients with the pelvic lymph node involvement that were treated ... PTVnodes with 50.4 Gy Dose-volume constraints for the critical structures were summarized in Table Intensity modulation was achieved using the sliding window technique [26] which was implemented in ... leaf-sequencing method have been described in the literature[16,25,28] During IMRT optimization, dose calculation was done using the SC algorithm available in Pinnacle3, with the intensity modulation...

Ngày tải lên: 09/08/2014, 09:22

... IIb/IIIa inhibitor (Tirofiban) was administered at the operator’s discretion All patients maintained anti-platelet therapy following the procedure (aspirin 300 mg/d for months and 100 mg/d infinitely; ... patients were pretreated with aspirin and clopidogrel A loading dose of 300 mg clopidogrel was administered before the procedure for patients who were not previously pretreated with asprin and clopidogrel ... Santa Rosa, CA) for treating single de novo lesions in patients with symptomatic coronary artery disease has been examined in the first four trials of the ongoing ENDEAVOR clinical trials program...

Ngày tải lên: 25/10/2012, 11:18

... found in patients treated with Cetuximab plus chemotherapy as second or more line with or without an increased EGFR-GCN (p = 0.03) In our population 89/101 patients were treated with combination ... 18% (10/56) in the group with 2nd or further line of therapy (p < 0.0001) Response was observed in 29/60 (48%) of patients with increased EGFR-GCN and in 6/28 (21%) in those without increased EGFR-GCN ... treatment advantage in untreated and pretreated patients This effect was maintained in the subset of k-ras evaluated patients Integration of this information with that coming from other molecular...

Ngày tải lên: 18/06/2014, 16:20

... leading to the inclusion of an adenosine instead of guanosine in positive-stranded cDNA This results in mutant viruses that contain several GA changes With cell passage, more GA mutations in ... the GA hypermutation in treated patients was decreased compared with the prevalence in untreated patients For convenience, we compared sequences in our patient populations with those of the LAV-1 ... among untreated patients, and this may be a result of spontaneous mutation In contrast, the GA hypermutation was not more prevalent in treated patients than AG transitions, and in PI -treated patients...

Ngày tải lên: 20/06/2014, 08:20

... 6-week time point An assessment at 12 weeks after commencing systemic therapy for bone metastases remains at an early enough time point to be clinically relevant in informing clinical management ... carcinoma treated with orchidectomy Eur J Nucl Med 1988, 14:203-206 Sundkvist GM, Björk T, Kjellström H, Lilja B: Quantitative bone scintigraphy in patients with prostatic carcinoma treated with ... treatment effect, with only 52% of responders showing scintigraphic improvement and 62% of non-responders showing scintigraphic deterioration at to months in one early study of patients with breast...

Ngày tải lên: 21/06/2014, 02:20

... remained low after months compared with baseline values, though not significant for etanercept In the etanercept -treated group, serum COMP decreased in 15 of the 17 patients, whereas in the infliximab ... decreased in 23 patients and remained unchanged or increased in patients (no significant difference between the groups) The reason why some of the patients were not included after months was in most ... changes (δ values) in CRP between time points correlate with those in COMP The CRP values decreased significantly in the ACR20 responders in both infliximab- and etanercepttreated patients (P < 0.001...

Ngày tải lên: 09/08/2014, 01:21

... (RA) patients treated with (TNF)-α matoid arthritis (RA) patients treated with infliximab Using this bioassay three patterns were observed and linked to the clinical response in the 20 patients with ... prolonged inhibition in circulating TNFα bioactivity, suggesting the critical contribution of systemic TNF-α in these patients In another third of the patients circulating TNF-α bioactivity was inhibited ... plasma to induce IL-6 production before infliximab therapy, followed by complete inhibition hours after the first infusion Plasma samples before the ninth infusion had low IL-6-inducing activity...

Ngày tải lên: 09/08/2014, 06:22

... Liangxi W, Guofu D, Ping L, Yongling L, Wendong P, Minghai W: Chloroquine protects mice from challenge with CpG ODN and LPS by decreasing proinflammatory cytokine release Int Immunopharmacol 2004, ... capable of reducing pro-inflammatory cytokines in vivo Considering the central role that IL-10 and TNFα cytokines play in the pathogenesis of SLE, it is possible that different cytokine production ... cytokines, this being particularly true in the case of IL-10 and TNFα, which are mutually regulated and have complex and predominantly opposing roles in systemic inflammatory responses In a previous...

Ngày tải lên: 09/08/2014, 07:20

... all patients Irradiation technique, target volume and critical normal structure definition Treatment planning and irradiation were performed with the patients in supine position (using knee and ... volume definition techniques and their influence on rectal toxicity in patients with prostate cancer treated with 3D conformal radiotherapy: a dose-volume analysis Radiat Oncol 2009, 4:14 Pinkawa ... during radiation therapy of prostate cancer J Immunol 2010, 185:1330-1339 Hurwitz MD, Kaur P, Nagaraja GM, Bausero MA, Manola J, Asea A: Radiation therapy induces circulating serum Hsp72 in patients...

Ngày tải lên: 09/08/2014, 09:20

... while maintaining a tolerance risk of normal tissue toxicity [3] Better local control outcomes with an acceptable toxicity have been obtained by using high total doses radiation administered in two ... Radiation Oncology 2009, 4:17 Introduction Radiation is an effective therapy in patients with local advanced breast cancer (LABC) [1,2] Tumor control by radiotherapy (RT) requires ... of toxicity due to RT in patients with LABC Patients and methods Twelve consecutive patients treated between 1991 and 1997 by a hyperfractionated dose-escalation radiation therapy schedule at the...

Ngày tải lên: 09/08/2014, 09:22

... number of patients (n = 3) for whom this comparison was appropriate Results Patients Baseline clinical data are presented in Table Seventy biopsies from 63 patients treated with tissue-engineered ... characteristics biopsy with hyaline characteristics taken 14 months after Hyalograft® C Autograft implantation (a) H & E and eosin staining (b) Glycosaminoglycan (safranin-O) staining (c) Collagen ... percentage of hyaline cartilage (45.4% hyaline cartilage versus 23.7% in biopsies taken within the first 18 months) Fibrocartilage was present in 55.9% of biopsies taken within 18 months after...

Ngày tải lên: 09/08/2014, 13:22

... and increase IFNα secretion [39] The authors suggested that this inhibition may explain the increase of ANA production in patients treated with TNFα blockers We confirmed their findings by showing, ... (SF) of patients with active RA is significantly increased compared with that in osteoarthritis patients Dendritic cell (DC) subsets were measured in the SF of patients with RA (n = 9) and in osteoarthritis ... are the major IFNα-producing cells in peripheral blood These data strongly suggest that infliximab maintains pDCs in an IFNα secreting state by quenching TNFα Infliximab increases plasma cell generation...

Ngày tải lên: 09/08/2014, 14:22

... undergoing CABG demonstrate the need for early intervention in the preoperative period with the goal of optimizing pulmonary function Physiotherapy, including incentive spirometry, should be continued ... measure the MIP, individuals were instructed to exhale up to the RV, inhale deeply with the manuvacuometer’s mouthpiece (Müller’s maneuver) in place and maintain the strain with their respiratory ... 4) and Patients and methods This longitudinal study included 42 subjects aged 48 to 78 years Subjects were divided into the following three groups: patients who underwent CABG, patients with coronary...

Ngày tải lên: 10/08/2014, 09:21

... be indicative of active cell injury [11] Interferon-β (IFN-β) is effective in reducing relapse rate in relapsing-remitting [6,14,17] and secondary progressive MS [3] but the mechanisms behind ... S100B at 3-month intervals in subjects with primary progressive MS (PPMS) The key questions were whether serum S100B levels correlated with disability or MRI findings in patients with PPMS, and ... washed with 0.67 M barbitone buffer containing mM calcium lactate, 0.1% BSA and 0.05% Tween and then blocked with 2% BSA and washed again Diluted serum (1:1) in 0.67 M barbitone buffer containing...

Ngày tải lên: 11/08/2014, 08:20