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... Delivoria-Papadopoulos M. Activation of p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK) during hypoxia in cerebral ... (MM-siRNA) (5’-GGCGUGUCUCUCU UACGAC-3”). SiRNAs targeting the cDNA sequence of rat TLR4 (GenBank accession NM_019178) were: 5’-CUACCAACAGAGAGGAUAU-3” (siRNA1), 5’-GUCUCAGAUAUCUAGAUCU-3’ (siRNA2), ... production of TNF-α and IL-1β in spinal cord tissues was significantly lower in the CCI group during the course of TLR4-siRNA treatment, indicating that intrathecal administration of TLR4-siRNA significantly...

Ngày tải lên: 25/10/2012, 11:48

Ngày tải lên: 13/08/2014, 18:21

... interdisciplinary health care in rural settings. J Manipulative Physiol Ther 1996, 19:82-91. 64. Shima MA: Evaluation of chest pain: back to the basics of his- tory taking and physical examination. ... pain cases presenting earlier during an episode of care-seeking, or more likely as a generalist to serve as a main source of care overall for an entire chest pain epi- sode. Along that same line, ... competencies, and standards for referrals and sharing of clinical informa- tion that may improve current and future cross-discipli- nary coordination of care for chest pain patients. Clinical and health...

Ngày tải lên: 25/10/2012, 10:06

... insertion of endotra- cheal tubes, intravenous lines and chest drains, but not after insertion of nasogastric tubes. In addition, CXRs were obtained in the case of worsening of oxygenation. As ... clinically relevant and irrelevant findings, and simply reported on all abnormalities [12]. At present, in many ICUs CXRs are still routinely obtained on a daily basis, at least in The Netherlands ... design and statistical analysis of the study. MS conceived and coordinated the study and was involved in the interpretation of the data and manuscript revi- sion. All authors read and approved...

Ngày tải lên: 25/10/2012, 10:39

... observational study of the time of activation for 2568 incidents of MET attendance. Each attendance was allocated to one of 48 half-hour intervals over the 24- hour daily cycle. Activation was related ... communicated by the switchboard operators through the hospital loudspeakers and paging system, and a detailed log of all calls is maintained. Criteria for medical emergency team activation Calling ... this to aspects of nursing and medical daily routine. Materials and methods The hospital Austin Health is a university-affiliated teaching hospital with three hospital campuses situated in Melbourne,...

Ngày tải lên: 25/10/2012, 10:45

Ngày tải lên: 05/09/2013, 17:03

... Zlatanova J, Yaneva J & Leuba SH (1998) Proteins that specifically recognize cisplatin-damaged DNA: a clue to anticancer activity of cisplatin. FASEB J 12, 791–799. 30 Kasparkova J & Brabec ... Katayama H, Sasai K, Kawai H, Yuan ZM, Bondaruk J, Suzuki F, Fujii S, Arlinghaus RB, Czerniak BA & Sen S (20 04) Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of ... DNA cis-platination when located within a 47 4 base pair fragment of the pPGM4 plasmid (not shown), in contrast to the behavior of the analogous pPGM1 fragment [31]. These data revealed a clear correlation...

Ngày tải lên: 19/02/2014, 05:20

... semantic analysis, and pragmatic analysis. Each stage has been designed to use linguistic data such as the lexicon and grammar, which are maintained separately from the engine, and can easily ... resources into our natural language understanding system. Client- server architecture was used to make a large volume of lexical information and a large knowledge base available to the system at ... Integration of Large-Scale Linguistic Resources in a Natural Language Understanding System Lewis M. Norton, Deborah A. Dahl, Li Li, and Katharine P. Beals Unisys Corporation 247 6 Swedesford Road Malvern,...

Ngày tải lên: 20/02/2014, 18:20

... signal peptide (amino acids 1–36), we retained amino acid 36, an alanine, rather than using amino acid 37, a lysine, because it is known that, after a post-translational processing of the N-terminal ... motif Arg40 Cys 84 Tyr 349 Tyr 347 Copper binding motif Trypsinisedpro-tyrosinase 332 amino acids Core domain 36–370 Copper binding motif Arg40 Cys 84 Tyr 349 Tyr 347 Lys370 Ala36 Ala36 Ala36 Val357 Phe518 B Laccase Tyrosinase β -sheet ... amino acids Core domain 37–357 C-terminal extension amino acids 358–518 Copper binding motif Arg40 Phe453 Cys 84 Tyr 349 Tyr 347 Copper binding motif Pro-tyrosinase 48 1 amino acids Core domain...

Ngày tải lên: 06/03/2014, 11:20

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Ngày tải lên: 07/03/2014, 02:20

... deuterium labelling; Calendula. The D 12 -oleate desaturase (FAD2) family of enzymes are membrane-bound nonheme iron-containing proteins that carry out a fascinating array of related oxidative transfor- mations ... linoleate and regiospecifically dideuterated isotopomers with a strain of Saccharomyces cerevisiae expressing a functional (1 ,4) -desaturase. GC-MS analysis of methyl calendate obtained in these ... Covello 1 1 Plant Biotechnology Institute, Saskatoon, SK, Canada; 2 Department of Chemistry, Carleton University, Ottawa, Ontario, Canada The mechanism by which the fatty acid (1 ,4) -desaturase of Calendula...

Ngày tải lên: 08/03/2014, 09:20

... with a safe, nutritious and sustainable food supply. For example, in Argentina, the economic gains resulting from a 140 percent increase in soybean area since 1995 are estimated to have contributed ... bioavailability. The goal of these enriched soybeans is to create an affordable, land-based, renewable source of omega-3s that can be used as an alternative to fish to create great-tasting ... consuming soy, including: alleviating menopausal symptoms 29 30 , reducing cardiovascular disease risk 31 32 , reducing risk of certain cancers 33 34 35 and increasing the bone density of...

Ngày tải lên: 13/03/2014, 21:57

... solution was rapid in the initial stages of contact and reached a maximum in the range of 35–60 min for soil minerals such as hematite and feldspar. Carbonell Barrachina et al. (1996) observed that ... soil was very acidic with pH values of about 4. 5 for a soil:water ratio of 1:1 and about 4. 7 for a soil:water ratio of 1:20. The parent material, weathering processes, and absence of carbon- ate ... were also obtained. 2. Materials and methods 2.1. Soil sample and characterization An uncontaminated reddish brown tropical soil sample was obtained from a site in the western part of Singapore...

Ngày tải lên: 16/03/2014, 00:25

... [19] catalytic activity. Interestingly, maximal activity of domain 2 was achieved only when domain 1 was functional, reinforcing, once again, the idea that catalysis at one active site is affected ... Muller A, Rognan D, Kriechbaum M & Wallimann T (1998) Mutation of cis-proline 207 in mitochondrial creatine kinase to alanine leads to increased acid stability. Protein Eng 11, 563–568. 14 Uda ... monomers that contain three apparently complete CK domains. Recently, a number of other enzymes with multiple catalytic domains have been identified – two-domain arginine kinases [19–21], a two-domain carbonic...

Ngày tải lên: 16/03/2014, 06:20

... 832–837. 4 Surolia N, RamachandraRao SR & Surolia A (2002) Paradigm shifts in malaria parasite biochemistry and anti-malarial chemotherapy. Bioessays 24, 192–196. 5 Ramya TNC, Surolia N & ... sequence of the human malaria parasite Plasmodium falciparum . Science 282, 1126–1132. 24 Sharma AK, Sharma SK, Surolia N & Sarma SP (2005) NMR assignment of the Hholo-ACP from malaria parasite ... molecular masses of apo-ACP and holo-ACP were determined with an Ultra Flex TOF ⁄ MALDI-TOF mass spectrometer. (a) Mass spectrum of refolded apo-ACP, showing a single major peak of molecular mass 942 0.639...

Ngày tải lên: 16/03/2014, 10:20

... adenoviral gene transfer. Proc Natl Acad Sci USA 103, 18 249 –182 54. 4 Singh H, Beckman K & Poulos A (19 94) Peroxisomal beta-oxidation of branched chain fatty acids in rat liver. Evidence that carnitine ... level of another aminotransferase, AGT2, in mouse liver [7], although kinetic studies [8] indicate that its alanine- glyoxylate aminotransferase activity is not favored over aminobutyrate-pyruvate, ... present in knockout mice. Acads, acyl-coenzyme A dehydrogenase, short chain; Aco1, aconitase 1; Agt ) , alanine-glyoxylate aminotransferase knockout; Aldh2, aldehyde dehydrogenase 2; Car3, carbonic anhydr- ase...

Ngày tải lên: 23/03/2014, 03:20

... Comput- ing Research Laboratory, New Mexico State University, Las Cruces NM. Yamanashi, Masa-aki. (1987). Metonymic interpretation and associative processes in natural language. In Language and ... that the main factors for treating metonymy correctly in a multil- ingual machine translation system are 1) its universality, which can be a guideline for the analysis component, 2) language ... sign said fishing was prohibited here." AN APPROACH TO TRANSLATING METONYMY An important point to realize is that actual computational treatment of metonymic expressions is determined...

Ngày tải lên: 23/03/2014, 20:20

Ngày tải lên: 29/03/2014, 03:20

Ngày tải lên: 30/03/2014, 21:20

Ngày tải lên: 18/06/2014, 16:20