obesity insulin resistance ir and the metabolic syndrome

... of obesity in Asian populations 21 1.6 The role of obesity in the pathogensis of insulin resistance and the metabolic 25 Syndrome 1.7 Obesity as a pre-requisite risk factor for defining the metabolic ... in the pathogenesis of insulin resistance and the metabolic syndrome 23    Obesity is a key feature of the metabolic syndrome, and an important determinant of insulin resistance Many studies, ... modifying the definition of central obesity in Asian 68 populations on the association between the metabolic syndrome and ischemic heart disease 4.2 The role of central obesity in the definition the metabolic...

Ngày tải lên: 12/09/2015, 10:42

... two of the components of the metabolic syndrome (high TG and hypertension), but not any of the other components (low HDL, obesity, and glucose intolerance) or the presence of the metabolic syndrome ... [9], insulin resistance [10], hypertension [11,12], and central obesity [11]: these may collectively contribute to the development of the metabolic syndrome [13,14] and atherosclerosis [15,16] The ... significantly modified their risk factors for the metabolic syndrome as a consequence of inflammation and that the addition of GC use cannot worsen these further Central obesity is associated...

Ngày tải lên: 09/08/2014, 01:22

... two of the components of the metabolic syndrome (high TG and hypertension), but not any of the other components (low HDL, obesity, and glucose intolerance) or the presence of the metabolic syndrome ... [9], insulin resistance [10], hypertension [11,12], and central obesity [11]: these may collectively contribute to the development of the metabolic syndrome [13,14] and atherosclerosis [15,16] The ... significantly modified their risk factors for the metabolic syndrome as a consequence of inflammation and that the addition of GC use cannot worsen these further Central obesity is associated...

Ngày tải lên: 09/08/2014, 13:22

... genotyping and helped to draft the manuscript AE, LK, JH and TP participated in the design of the study and performed the statistical analysis TP, STS, JL, AR and AA conceived of the study, and participated ... Obesity and metabolic syndrome in circadian Clock mutant mice Science 2005, 308:1043-5 Scott EM, Carter AM, Grant PJ: Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome ... we hypothesized that circadian clock polymorphisms contribute to the routine seasonal variations and to the metabolic syndrome Our earlier finding that seasonality was associated with the metabolic...

Ngày tải lên: 10/08/2014, 09:20

... inflammation and fibrosis independently of insulin resistance and HS and it should be a central target for future interventions in NAFLD and indeed in all the metabolic diseases [20] On the other hand, ... measure the SAAT using a 7.5 MHz probe and VAT using a 3.5 MHz probe, cm above the umbilicus The SAAT was defined as the thickness between the skin-fat interface and the linea alba, and the VAT ... presuppose the obesity as if it was the cause of IR; this fact is supported by the clear association between the inflammatory status (CPR levels and spleen volume) and the HS score Could the high...

Ngày tải lên: 11/08/2014, 08:22

... andand the presence ofmetabolic syndrome according to the definition used used * P < 0.05 EGIR The relationship between methotrexate use the presence of the the metabolic syndrome according to the ... [21] and the European Group for Study of Insulin Resistance (EGIR) [22] These share many similarities; however, they differ in some of the components, as well as their specified cutoffs and weighting ... patients The prevalence of the MetS increased with age up until the seventh decade and fell off thereafter, and was similar in males and females (P = 0.429; Table 3) Associations of the metabolic syndrome...

Ngày tải lên: 09/08/2014, 14:22

... prospective and independent of exposure levels Besides that, the levels of insulin resistance and adiponectin were not known to the surgeons and physicians treating the patients and therefore the risk ... independent of the level of insulin resistance and adiponectin and would bias the findings toward the null hypothesis Although insulin is excreted in a pulsatile fashion, and the average of three ... adding the Charlson Comorbidity Index to the model further increased the AUC to 0.86 [95% CI 0.81-0.92] There were no interactions between sex and insulin resistance or adiponectin with regard to the...

Ngày tải lên: 10/08/2014, 09:23

... definitions from the metabolic syndrome The previous work evaluated this difference and did not analyze the relative weight of each component of the metabolic syndrome The importance of the current ... OR and AS have participated in the design of the study, performed the statistical analyses and drafted the paper SB and IS conceived the study, participated in its design and coordination and ... recruited during their routine annual health check-up and gave their written consent in accordance with the guidelines of the institutional ethics committee A total of 15,605 subjects gave their informed...

Ngày tải lên: 11/08/2014, 03:20

... definitions from the metabolic syndrome The previous work evaluated this difference and did not analyze the relative weight of each component of the metabolic syndrome The importance of the current ... OR and AS have participated in the design of the study, performed the statistical analyses and drafted the paper SB and IS conceived the study, participated in its design and coordination and ... recruited during their routine annual health check-up and gave their written consent in accordance with the guidelines of the institutional ethics committee A total of 15,605 subjects gave their informed...

Ngày tải lên: 11/08/2014, 06:22

... section of the artery proximal to the carotid bulb The IMT was defined as the distance between the intimia-blood interface and the adventitia-media junction After freezing the image, the measurements ... supine with the neck extended and the probe in the antero-lateral position All measurements of IMT were made in the longitudinal plane at the point of maximum thickness on the far wall of the common ... IMT, insulin resistance and dyslipidemia Insulin resistance is a common phenomenon and plays an important role in the cardio-cerebrovascular disease in obese population [17,18] In our study, the...

Ngày tải lên: 25/10/2012, 11:40

... hyperlipidemia, and insulin resistance (features of metabolic syndrome) to the recipients suggesting that the gut microbiota mediate metabolic derangements associated with high fat diet Insulin resistance ... inflammation and insulin resistance Insulin resistance is the primary characteristic of obesity and is a risk factor for development of type-2 diabetes It has been reported that TF intake increased the ... (116 vs 83 mg/dL; P < 0.01) and serum insulin concentrations when they received either LF diet or TF diet (Figure 4A and 4B) Insulin resistance, as measured by HOMA -IR was significantly higher...

Ngày tải lên: 11/08/2014, 03:20

... hyperlipidemia, and insulin resistance (features of metabolic syndrome) to the recipients suggesting that the gut microbiota mediate metabolic derangements associated with high fat diet Insulin resistance ... inflammation and insulin resistance Insulin resistance is the primary characteristic of obesity and is a risk factor for development of type-2 diabetes It has been reported that TF intake increased the ... (116 vs 83 mg/dL; P < 0.01) and serum insulin concentrations when they received either LF diet or TF diet (Figure 4A and 4B) Insulin resistance, as measured by HOMA -IR was significantly higher...

Ngày tải lên: 11/08/2014, 06:22

... diabetes[10,14-16] Antiretroviral therapy for HIV may increase the risk of metabolic syndrome (the clustering of abdominal obesity, hyperglycaemia, dyslipidaemia and hypertension) and thus predispose ... caused, we then discuss the link between antiretroviral therapy (ART), metabolic syndrome (MS) and cardiovascular disease (CVD) We also address the potential public health importance of these relationships ... recent years there was a lack of good evidence on the strength and nature of the association between TB and DM At present recognition of the association between diabetes and TB is low The link goes...

Ngày tải lên: 11/08/2014, 14:21

... component of the syndrome The arrival of the MET brings a critical care environment to the bedside In a sense, when an MET syndrome develops, it could be argued that both the hospital and the patient ... power due to the large variance in outcome incidence and wide standard deviation and the lower-than-expected incidence of the outcome measures under investigation Given the incidence and variance ... ‘placebo’ Cluster randomisation of hospitals requires large numbers of centres Before -and- after studies lack rigour and generalisability they are In the words of the slogan of the American Society...

Ngày tải lên: 25/10/2012, 10:35

... (Buenos Aires) 2000; 60:964–972 45 Dirikolu L, Hughes C, Harkins D, et al: The toxicokinetics of cyanide and mandelonitrile in the horse and their relevance to the mare reproductive loss syndrome ... through the lung capillary beds and into the systemic circulation An obvious mechanism is movement of the material through the lungs in the same way they enter into and move through the intestine ... due to the ease of observing events occurring in the eye and the highly significant consequences of eye damage compared with limited local damage in other areas of the body and the possible therapeutic...

Ngày tải lên: 13/02/2014, 15:20

... adipose tissue in obesity and related insulin resistance [15] Here, we focus on the roles of ANGPTL2 and ANGPTL6 ⁄ AGF in obesity and related metabolic diseases, and discuss whether these ANGPTLs ... inflammation and systemic insulin resistance through the induction of vascular inflammation and monocyte migration ANGPTL6 ⁄ AGF antagonizes obesity and insulin resistance through the enhancement ... together, these findings suggest that ANGPTL6 ⁄ AGF in the circulation counteracts obesity and related insulin resistance by increasing systemic energy expenditure A recent study indicates that circulating...

Ngày tải lên: 14/02/2014, 22:20

... doctors called it syndrome X or the metabolic syndrome Solving the Mystery: Insulin Resistance Recently, researchers solved the mystery of syndrome X It’s caused by insulin resistance This discovery ... population can’t handle the starch and sugar in their diets without producing excessive insulin Although these folks usually have a genetic propensity to insulin resistance, having the tendency doesn’t ... producers, and sometimes they can obtain patents on their processing techniques so other firms can’t compete with them This allows manufacturers to sell their products at high profit margins The potential...

Ngày tải lên: 15/02/2014, 15:20

... to the phosphorylated IR at the plasma membrane and is then translocated to endosomes as a protein complex with the receptor First, as expected from insulin- induced internalization of the IR, insulin ... kinetics and dose– response studies with insulin and superactive insulin analogs, a striking correlation between the IR phosphorylation state and the content of Grb14 in the plasma membrane and ⁄ ... following insulin treatment, Grb14 was associated with the phosphorylated IR in both the plasma membrane and endosomal fractions On the other hand, although at least part of the Grb14 IR complex...

Ngày tải lên: 18/02/2014, 18:20

... ‘below’ the Q119 guanidiniums of the four domains, holding the domains together and blocking the channel Adding charges (one proton per domain) breaks the plug, the side chains separate, and the ... (–) for survivin in both the cytoplasm and the nucleus The occurrence of metastasis was higher in the N–C+ group than in the N+C– group, and the frequency of metastasis and number of cases with ... of the aromatic ring of the position and amino acid residues seem to be critical for the stimulation of the [35S] GTPcS binding and the activation of the downstream effector systems PP-76 The...

Ngày tải lên: 19/02/2014, 07:20

... at 415 and 442 nm, and for the oxidized form at 403 and 422 nm The b–band can be seen at 517 nm and the a–band at 547 nm and 603 nm The difference signals that can be observed between 400 and 700 ... c the Soret band was reported to absorb at 418 nm, the b-band at 520 nm and the a–band at 550 nm [18] The deviations of approximately nm between the signals of horse heart cytochrome c and the ... KCl) In the oxidized-minus-reduced spectra the positive signals correlate with the oxidized and the negative signals with the reduced form of the enzyme For the reduced form, the Soret band can...

Ngày tải lên: 21/02/2014, 15:20