novel therapeutic settings in the treatment of castration resistant prostate cancer

... approximately 15 minutes, the physicist then loaded the corresponding radiation plan onto the controller unit contaminating the field The catheter end was passed through a hole in the drape and a ... cavity through a small incision in the lateral breast and inflated with exactly 40 cc of saline (Figure 1) The conformity of the CED to the surrounding breast tissue was then evaluated under direct ... without Results The radiation oncologist then broke scrub, attached the XB controller to the catheter, and inserted the radiation source into the balloon The radiation therapy was then Figure and...

Ngày tải lên: 09/08/2014, 04:21

... positioning [12,13] Variables with the potential to influence prostate motion are an important aspect of clinical research in the delivery and treatment of prostate cancer The two organs receiving the ... consisted of the prostate gland and seminal vesicles with margin [20] For patients with > 10% risk of pelvic lymph node involvement, the pelvic lymph nodes were included in the initial target volume Intensity ... demonstrated to influence PVR in either treatment cohort This, however, is not surprising since the vast majority of changes in PVR occurred in the first three weeks or therapy Alpha-blockers were initiated...

Ngày tải lên: 09/08/2014, 10:20

... cells in vivo [38] The upregulation of IL-10 is in line with the induction of Tregs in vitro and in vivo in our study Moreover, in our experiments we did not find UC-MSCs in the joint of the CIA ... damage [31] The MMPs are key mediators of the invasive phenotype of FLSs [32] Therefore, we further investigated the effect of UC-MSCs on the invasive behavior of FLSs by the Cell Migration/Invasion ... UC-MSCs maintained such inhibitory effects, suggesting that the transplantation of these cells is practicable and effective for treatment of RA Interestingly, the invasive behavior of FLSs was inhibited...

Ngày tải lên: 12/08/2014, 15:22

... hrs following the post-dialysis dose There is a case report in which lithium levels were maintained in the therapeutic range by intraperitoneal administration of lithium during continuous peritoneal ... 2004, of portacaval shunting, thereby decreasing first pass metabolism; decrease in quantities and affinity of plasma proteins, thereby increasing free-drug levels; increase in volume of distribution ... syndrome), including carbamazepine, phenytoin, phenobarbital, and lamotrigine The triad of hypersensitivity includes fever, rash and internal organ involvement with onset of symptoms within to weeks of...

Ngày tải lên: 25/10/2012, 10:51

... the angles of the dural opening The most significant step involves constructing small supporting pillars on the bilateral sides of the vessels as they pass the edge of the dural window (the pillars ... and in most reports the involved patient populations are small, these experiences are valuable At present, in the absence of definite proof of the efficacy of decompressive craniectomy in the treatment ... craniectomy, which was introduced by Cushing,11 involves removing the part of the skull beneath the temporal muscle by opening the dura This was an important surgical method for the treatment of severe TBI...

Ngày tải lên: 25/10/2012, 11:40

... variations in working pressures of the main groups of muscles of the limbs whilst using compression mechanisms during exercising This is a new line of research that aims at developing facilitating devices ... technique aims at draining lymph (already in the collectors) and stimulating the formation of lymph (the flow of interstice fluid to the lymphatic capillaries) Increases in interstice pressures, ... which can be used in the control of exercising Eight devices have been developed that involve the main muscle groups with the objective of improving the mobility of joints and reducing trophic muscle...

Ngày tải lên: 26/10/2012, 09:39

... withdrawn from the study (without penalty) if, in the opinion of the treating physician, it was not in the patient’s best interest to continue For instance, if during the course of the study a patient ... unwilling to stop taking pain medication other than the study medication (for arthritis or other types of pain) or is unwilling to stop taking other medications for the treatment of OA Any other ... including glucosamine and chondroitin, one month prior to study and during the study, other than multivitamin and mineral supplements containing vitamins and minerals as the sole medicinal ingredients...

Ngày tải lên: 26/10/2012, 09:48

... reduction, the V.A.C.-system is not often used in the treatment of prosthesis – related infections Currently, there exist only four reports about the use of the V.A.C – system in the infection ... overstrain the clearance function of the V.A.C.-therapy, thus being probably the reason for the system failure in the infection treatment in case 10 One limitation of our study is that we cannot define ... of an endoprosthesis involving the local tissue and causing an immune reaction [15] The most common problem hereby is the draining sinus, prolongating and preventing wound healing The pathophysiological...

Ngày tải lên: 26/10/2012, 09:53

... by the ratio in which the antibiotics are mixed into the cement and therefore, the total dose of antibiotics should not exceed 10% of the weight of the cement in order to avoid fracture of the ... safety The most commonly used antibiotics in ALC include tobramycin, gentamicin and vanco- 254 mycin [26] The combination of vancomycin and one of the aminoglycosides provides a broad spectrum of ... salvage of the infected hip: rationale for the use of gentamicin-impregnated cement and heads The hip proceedings of the thirteenth open scientific meeting of the hip society 1985; :65-94 Ensing...

Ngày tải lên: 26/10/2012, 09:53

... remove the femoral stem For loading of the bone cement, the combination of gentamicin and vancomycin was most frequently used followed by the combination of gentamicin and teicoplanin Data about the ... http://www.medsci.org Int J Med Sci 2009, sion of the haematoma is an indispensable premise in the prevention of a wound infection Besides draining sinus, other infections during the two-stage protocol ... complications (draining sinus, pneumonia, etc.) Despite the retrospective design of our study and the limited possibility of interpreting these findings and their causes, this rate indicates that these patients...

Ngày tải lên: 26/10/2012, 09:53

Ngày tải lên: 03/11/2012, 11:01

... not localize to the same cells in the brain, suggesting that they are functionally distinct Although Signaling mediators in the treatment of obesity CPT1c is highly expressed in the hypothalamus, ... promoting an increase in proopiomelanocortin and cocaine and amphetamine regulated transcript Taken together, these findings provide a compelling argument for the role for malonyl-CoA in regulating ... needs to be explored further Other areas of the brain have also been shown to regulate feeding via AMPK [35,36] Of interest is the extensive use of fructose as a sweetener in the human diet [37]...

Ngày tải lên: 14/02/2014, 22:20

... suggesting that these cyclin-dependent kinase inhibitors are important in the regulation of adipocyte number The S-phase kinase-associated protein (Skp)1–CullinF-box protein (SCF) ubiquitin ligase ... at each phase of the cell cycle by various complexes of cell-cycle-related molecules, including cyclins, cyclin-dependent kinases, their inhibitors and the retinoblastoma protein (RB), as well ... clinical course of some types of obesity In this minireview, we focus on adipocyte hyperplasia as a novel therapeutic target for the treatment of obesity and discuss the merits of targeting recQ-mediated...

Ngày tải lên: 06/03/2014, 01:20

... risk of recurrent TB CORTICOSTEROIDS IN OTHER FORMS OF EXTRAPULMONARY TB Credible evidence from clinical trials for the use of corticosteroids in other infrequent forms of TB, such as genitourinary ... imaging of the brain was also performed in a subset of patients in this study.36 It was found that use of corticosteroids possibly reduced the risk of developing hydrocephalus and vasculitic infarcts; ... opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America...

Ngày tải lên: 06/03/2014, 04:20

... the complexity of these drug interactions, the key role of the rifamycins in the success of tuberculosis treatment mandates that the drug-drug interactions between the rifamycins and antiretroviral ... guidelines for rifabutin in the setting of antiretroviral therapy (see Table 3) In addition to their complexity, there is another potential problem of using rifabutin for tuberculosis treatment ... isozymes The rifamycins vary in their potential as CYP450 inducers, with rifampin being most potent, rifapentine intermediate, and rifabutin being much less active Rifampin also upregulates the synthesis...

Ngày tải lên: 06/03/2014, 04:20

... and, by then delivering the bound metals into the cell, it activates specific protein kinases that induce an increase in the production of Ab-degrading MMPs Neurotoxicity generated by the interaction ... in all aspects is clear In the AD affected brain, metal dyshomeostasis is evident in the form of a substantial increase in the levels of extracellular metals and a decrease in the levels of intracellular ... precursor APP both bind Cu, and over-expression of a C-terminal fragment of APP or full length APP, both containing the Ab domain, results in an overall decrease in Cu within the brain of Tg mice [81]...

Ngày tải lên: 07/03/2014, 10:20

... have been identified in those strains that are responsible for most of the steps in the biosynthesis of the oligosaccharide portions of the LPS molecules The inner core of H in uenzae LPS has been ... sequences within these bacteria A proponderance of glycoforms containing two PCho units may enhance the ability of these strains to colonize the nasopharynx Modification of LPS by addition of terminal ... members of the Finnish Otitis Media Study Group at the National Public Health Institute in Finland for the provision of NTHi strains from the nasopharynx, obtained as part of the Finnish Otitis...

Ngày tải lên: 16/03/2014, 16:20

... induces the synthesis of amino terminal consensus sequence RNA-binding domain proteins (CS-RBD) The “cold-inducible RNA-binding protein” (CIRP) is one of these proteins, and has been involved in protection ... metabolic insult Combination therapy is based in the extension of the therapeutic window of hypothermia using pharmacotherapy and establishes an interesting approach in hypothermia research 4.1 Hypothermia, ... multiple mechanisms of action in opposition to the consequences of ischemia 4 Advances in the Treatment of Ischemic Stroke Background of therapeutic hypothermia Cooling of the body for therapeutic purposes...

Ngày tải lên: 23/03/2014, 17:20

... phenylthiohydantoin amino-acid standards Tricine/SDS/PAGE The molecular mass of the sample was estimated by Tricine/ SDS/PAGE using a 16.5% separating gel, 10% spacer gel and 4% stacking gel in the presence of ... or arginine) Interestingly, the characteristic C-terminal cationic tetrapeptide, RRRH, is conserved in chrysophsins, in addition to the C-terminal amidation Secondary structure of chrysophsins ... spectroscopy of the three synthetic chrysophsin peptides in the absence or presence of 50% trifluoroethanol (Fig 8) In the absence of 50% trifluoroethanol, the spectra of all three chrysophsins are...

Ngày tải lên: 23/03/2014, 20:22

... molecules The first is the establishment of the relevance of the genetic basis of carcinogenesis Second is the determination of the specific oncogene to target Third is the determination of the specific ... Liposome Lipofection 250 GENE THERAPY IN THE TREATMENT OF CANCER now in development Such inhibition results not only in growth inhibition in vitro but also results in growth inhibition of tumors in animal ... methods, and screening for adverse 258 GENE THERAPY IN THE TREATMENT OF CANCER effects related to vaccination including the induction of autoimmunity The approach of dendritic cell vaccination has been...

Ngày tải lên: 10/04/2014, 22:11