novel techniques in the diagnosis of inflammatory bowel disease

... important role in the initiation and perpetuation of the disease( 13,14) It has been hypothesized that the intestinal inflammatory response is the result of an exaggerated intestinal host immune ... multi-item index including subjective reporting of abdominal pain, general well-being, and diarrhea and physical findings, including linear growth and laboratory parameters (hematocrit, serum albumin, ... ameliorating the disease activity in children with mildly to moderately active, stable Crohn’s disease A dose of 1010 CFU twice a day resulted in intestinal colonization in all the patients, including...

Ngày tải lên: 05/03/2014, 12:20

... weeks for maintenance of remission After 54 weeks, the initial clinical response was maintained in only 17% of patients in the single dose group compared to 43% of patients maintained on 5 mg/kg ... to normal after months of discontinuing infliximab.56 In a study of 6290 adult patients on maintenance infliximab therapy, there was no increased risk of malignancy in the infliximab group compared ... prolonged implementation of nutritional therapy They often object to the placement of these feeding tubes or the exclusivity of enteral nutritional therapy during periods of quiescent disease. 5–7 Thomsen...

Ngày tải lên: 22/03/2014, 10:20

... OPS had a linear structure Thus, the nonsubstituted Rha was estimated to be located at the nonreducing terminus of the OPS chain Taking these observations into account, the structure of the OPS ... active moiety of LPS in the induction of cytokines, including tumor necrosis factor, and the phosphate residue at the 4¢-position is a critical site for the activity [24] Therefore, the monophosphoryl ... Analysis of LPS As shown in Fig 1, a ladder-like pattern was observed in the SDS/PAGE profiles of LPS from B vulgatus IMCJ 1204, indicating that the LPS contains OPS The repeating unit of the OPS...

Ngày tải lên: 31/03/2014, 23:20

... epithelial cell and myofibroblast susceptibility to proinflammatory cytokines in the crypt region Epithelial BM molecules in the normal human intestine The epithelial BM of the human intestine ... large intestines In the mature intestine, the Alteration of the Crypt Epithelial-Stromal Interface by Proinflammatory Cytokines in Crohn's Disease epithelial renewing units consist of spatially ... conditions In the normal small intestine (left), laminins LM-322 and LM-511 are found in the BM of the villus epithelial cells while laminin LM-211, is found in the BM of crypt epithelial cells Tenascin-C...

Ngày tải lên: 27/06/2014, 16:20

... measuring the change in the daily GI (DGI) for the drug-containing vials compared with the GI for the control vials, where they report a lower MIC of 0.5–4 μg/ml, probably due to differences in the ... streptomycin the MIC range was of 0,5-2 μg/ml in both animal and human strains, for ciprofloxacin it was at 0.5–16 μg/ml, independently of the source of isolation, while rifampin produced a MIC of 0.5–1 ... Streptomycin, CPX: Ciprofloxacin, EMB: Ethambutol, DPS: Dapsone, RIF: Rifampin, RIB: Rifabutin, CLA: Clarithromycin Source of isolation of strains is also indicated Numbers represent the MIC value...

Ngày tải lên: 08/08/2014, 19:20

... long-term healing of draining fistulas was maintained over two years from the baseline of the CHARM study, while in the fistula cohort there were no differences in the rate of adverse effects in patients ... conceived of the study and participated in its design and coordination EIE participated in the design of the study, the acquisition and interpretation of the data and the drafting of the manuscript ... in the sequence alignment and the drafting of the manuscript NL participated in the design of the study and the coordination and helped to revise the manuscript VDS participated in the coordination...

Ngày tải lên: 11/08/2014, 00:23

... fistula, with surrounding inflammation and fibrosis Given the inability to repair the defect in the terminal ileum from the fistulous opening, resection of a segment of the terminal ileum and cecum ... fatigue, and painful urination, in addition to the presenting complaints He denied having a fever, but did complain of night sweats A physical examination revealed a tall, thin man in no acute distress ... achieve the diagnosis Nuclear imaging with a ‘Meckel’s scan’ was not pursued because of the complicated nature of the case Due to the lack of ectopic gastric mucosa in the resected specimen, the...

Ngày tải lên: 11/08/2014, 03:21

... fistula, with surrounding inflammation and fibrosis Given the inability to repair the defect in the terminal ileum from the fistulous opening, resection of a segment of the terminal ileum and cecum ... fatigue, and painful urination, in addition to the presenting complaints He denied having a fever, but did complain of night sweats A physical examination revealed a tall, thin man in no acute distress ... achieve the diagnosis Nuclear imaging with a ‘Meckel’s scan’ was not pursued because of the complicated nature of the case Due to the lack of ectopic gastric mucosa in the resected specimen, the...

Ngày tải lên: 11/08/2014, 07:20

... when combining rifabutin and clarithromycin leading to an increase in rifabutin levels, resulting in an increase frequency of uveitis, this could explain the acute onset of uveitis in our case[10] ... hypopyon often occurs several months after starting rifabutin In this case the presence of hypopyon, and rapid initial improvement following withdrawal of rifabutin, suggest rifabutin as the underlying ... 10 Mintz R, Feller ER, Bahr RL, Shah SA: Ocular manifestations of inflammatory bowel disease Inflammatory bowel diseases 2004, 10(2):135-139 Duker JS, Brown GC, Brooks L: Retinal vasculitis in...

Ngày tải lên: 11/08/2014, 10:22

... occurred in the terminal web of the epithelial cell and in the lateral junctions of the cells The localization of CSF1R in actin-rich areas of the cell is not surprising in view of data from in vitro ... epithelium of the terminal ileum with cytoplasmic staining of the terminal web and lateral junctions of the epithelial cells (green arrow) B Staining of the superficial epithelium of the colon C Staining ... regulation in either mononuclear cells or in intestinal epithelial cells the intestine as well as its expression pattern and pathogenic role in inflammatory bowel disease remain to be investigated further...

Ngày tải lên: 11/08/2014, 10:23

... symptoms but also in diminishment of the size of the lip swelling Another point of interest was the fact that granulomatous cheilitis was the only extraintestinal manifestation in our patient, ... manifesting as a significant swelling of the lower lip could be the first clinical sign of CD This lesion could well be correlated with the activity of the intestinal disease, being quite prominent in ... on the incidence of this lesion in patients with inflammatory bowel disease The etiology of this lesion is unknown although various factors including levels of vitamins and trace elements, other...

Ngày tải lên: 11/08/2014, 11:20

... those of the underlying disease, the recognition of cancer arising in an inflamed bowel becomes difficult Thompson et al [12] recognized the occult nature of intestinal cancer in Crohn's disease They ... suggested by the clinicopathological data obtained from over 150 case reports [6] The extent of this association has been assessed by incidence studies comparing the risk of colon cancer in patients ... 59% of all cancers and 33% of colorectal carcinomas complicating Crohn's disease were discovered only at operation Therefore, delayed diagnosis appears to be the major reason for these tumors often...

Ngày tải lên: 11/08/2014, 12:20

... minority of the variance in risk (about 10%) is explained by the sum of all 32 of these alleles, strongly suggesting that other risk alleles will be detected in the future Indeed, the sum of these ... bacteria The risk of CD or UC is the result of the interaction between the genetic hand that is drawn and the bacteria residing in the gut In this model, CD is seen as a disorder arising from both the ... JF: The epidemiology of inflammatory bowel disease in Canada: a population-based study Am J Gastroenterol 2006, 101:1559-1568 Weinstock JV, Elliott DE: Helminths and the IBD hygiene hypothesis Inflamm...

Ngày tải lên: 11/08/2014, 12:20

... colchicine Second-line agents include indomethacin, cyclosporine and dapsone Conclusion This is a case of aseptic meningitis secondary to neuroSweet disease in a patient with Crohn’s disease The ... from these lesions Histology on the specimens revealed severe papillary edema The dermis contained an infiltrate of neutrophils and nuclear dust was also present These findings supported the clinical ... from the patient for publication of this case report and accompanying images A copy of the written consent is available for review by the Editor -in- Chief of this journal Competing interests The...

Ngày tải lên: 11/08/2014, 14:20

... and therapy Competing interests The authors declare that they have no competing interests Authors' contributions NM was involved in the management of the patient while in hospital, wrote the ... literature [1] There is a higher incidence of colonic involvement and extraintestinal features in these patients The skin lesions have been observed in patients with active Crohn's disease, but ... precede the onset of intestinal symptoms It appears that the syndrome is not initiated by the underlying disease but rather shares with it a concurrent pathogenic mechanism The pathogenesis of Sweet's...

Ngày tải lên: 11/08/2014, 21:22

... inflammatory bowel diseases would show features of TA in the same age-sex pattern of the IBD Figure Abdominal CT scan: thickening of the aortic wall (arrow) Abdominal CT scan: thickening of the aortic ... small bowel follow-through were performed and showed no lesion in the oesophagus, stomach, or small intestine including the terminal ileum and cecum Abdominal CT scan showed thickening of the abdominal ... the aorta and its vasculature and may compromise intestinal vessels Therefore, it may present with gastrointestinal bleeding and exacerbate the clinical course of patients with inflammatory bowel...

Ngày tải lên: 11/08/2014, 23:21

... JR: Unexplained bronchopulmonary disease with inflammatory bowel disease Arch Intern Med 1976, 136:454-9 Black H, Mendoza M, Murin S: Thoracic manifestations of inflammatory bowel disease Chest ... manifestations of IBD are uncommon [2,3] Any part of the lung and its vasculature may be involved in association with IBD Large airways disease is the commonest site of lung involvement in IBD In a recent ... Interestingly flare up of bronchiectasis has been observed within a year following colectomy [4,5] This transfer of the inflammatory process from the gastro intestinal tract to the lungs has been...

Ngày tải lên: 13/08/2014, 10:20

... new therapies for ulcerative colitis are currently being developed in preclinical testing and clinical trials, including molecules targeting interleukin 12, interleukin 17, and endothelial integrins ... determined by asking the patient if they knew the extent of their disease Disease extent was then verified in the medical record from either a recent clinic note or colonoscopy report by the patient's ... determined each symptom domain's rating for each of the three endpoints by independently measuring the distance in millimeters from the left end of the Visual Analogue Scale (0 mm) to the point...

Ngày tải lên: 18/06/2014, 19:20

... Improvement of ileitis, healing of ulcers (after wk of the initial dose of infliximab) Improvement of ileitis, healing of ulcers (after wk of the initial dose of infliximab) However, a review of the ... Improvement of edema and healing of linear ulcers in sigmoid colon (8 weeks after the initial dose of infliximab) Improvement of edema and healing of linear ulcers in sigmoid colon (8 weeks after the initial ... hallmark findings of HPS presented to the University Hospital of Alexandropoulos in 2005 complaining of an 10-month history of recurrent episodes of abdominal pain worse with defecation and intermittent...

Ngày tải lên: 11/08/2014, 10:22