novel radiographic techniques in ibd patients

... multi-item index including subjective reporting of abdominal pain, general well-being, and diarrhea and physical findings, including linear growth and laboratory parameters (hematocrit, serum albumin, ... remained at levels below baseline Overall, the improvement in clinical activity appeared to be accompanied by a reduction in paracellular intestinal permeability In two patients, however, the clinical ... could allow luminal bacterial antigens to initiate a chronic relapsing inflammation Several studies have shown an increased intestinal permeability for various sugar molecules in patients with...

Ngày tải lên: 05/03/2014, 12:20

... and in inducing and maintaining remission in patients with active CD ACCENT I was a multicenter randomized double-blind international trial studying retreatment and remission maintenance in adult ... 43% of patients maintained on 5 mg/kg every weeks and 53% of patients maintained on 10 mg/kg every weeks In addition, successful steroid-tapering was seen in only 9% of patients in the single ... adult patients with CD treated with infliximab Patients in this study were divided into groups: patients given a single 5  mg/kg infusion, Clinical and Experimental Gastroenterology 2010:3 patients...

Ngày tải lên: 22/03/2014, 10:20

... be located at the nonreducing terminus of the OPS chain Taking these observations into account, the structure of the OPS moiety was deduced to be that shown in Fig 5C In the Bacteroides group, ... Analysis of LPS As shown in Fig 1, a ladder-like pattern was observed in the SDS/PAGE profiles of LPS from B vulgatus IMCJ 1204, indicating that the LPS contains OPS The repeating unit of the OPS was ... contaminant These results indicate that the LPS from B vulgatus mainly contains lipid A carrying four fatty acids and one phosphate Thus, the component with Rf 0.5 was further analyzed as the main...

Ngày tải lên: 31/03/2014, 23:20

... proteins on human intestinal cell function: Laminin-epithelial cell interactions, In: Gastrointestinal Functions, E.E Delvin, Lentze M.J., (Eds), 59-75,1093-4715, Vevey/Lippincott Williams & Wilkins, ... mucus gel overlying the intestinal epithelium In mice, the cysteine-rich EGF-like domains inhibit apoptosis and stimulate cell migration, implying a regulatory role in maintaining the structure ... mucins A.1 and C.1, Xenopus skin protein xp2, zona pellucida sperm-binding protein B (ZP-B), and intestinal sucrase-isomaltase TFF1 and TFF3 contain one trefoil domain, TFF2 contains two domains,...

Ngày tải lên: 27/06/2014, 16:20

... strains, for ciprofloxacin it was at 0.5–16 μg/ml, independently of the source of isolation, while rifampin produced a MIC of 0.5–1 μg/ml in human and bovine strains and of >2 μg/ml for bovine ... flare ups in Crohn's Disease These have included Ciprofloxacin and metronidazole, used either alone or in combination In recent studies, Crohn's patients were treated with antibiotics for a minimum ... paratuberculosis from intestinal mucosal biopsies of patients with and without Crohn's disease in Sardinia Am J Gastroenterol 2005, 100:1537-1538 Bull TJ, McMinn EJ, Sidi-Boumedine K, Skull A, Durkin D, Neild...

Ngày tải lên: 08/08/2014, 19:20

... for the induction and maintenance of remission in patients with moderate to severe CD, and safe and efficacious in regaining a medical response in patients intolerant or non-responsive to infliximab ... complete healing of draining fistulas in active FCD Furthermore, the long-term healing of draining fistulas was maintained over two years from the baseline of the CHARM study, while in the fistula ... of infliximab in inducing and maintaining fistula closure [8] The CHARM trial, and more recently the study by Colombel et al regarding the ADHERE study, showed that adalimumab therapy results in...

Ngày tải lên: 11/08/2014, 00:23

... small intestine Complications in patients with Meckel’s diverticulum are rare; most patients remain asymptomatic for life [3] In both adults and children, intestinal obstruction and bleeding have ... diverticulum in Amsterdam: experience in 136 patients World J Surg 1995, 19:734-737 Brown RL, Azizkhan RG: Gastrointestinal bleeding in infants and children: Meckel’s diverticulum and intestinal duplication ... weight loss in the past month, anorexia, a decrease in stool caliber, fatigue, and painful urination, in addition to the presenting complaints He denied having a fever, but did complain of night...

Ngày tải lên: 11/08/2014, 03:21

... small intestine Complications in patients with Meckel’s diverticulum are rare; most patients remain asymptomatic for life [3] In both adults and children, intestinal obstruction and bleeding have ... diverticulum in Amsterdam: experience in 136 patients World J Surg 1995, 19:734-737 Brown RL, Azizkhan RG: Gastrointestinal bleeding in infants and children: Meckel’s diverticulum and intestinal duplication ... weight loss in the past month, anorexia, a decrease in stool caliber, fatigue, and painful urination, in addition to the presenting complaints He denied having a fever, but did complain of night...

Ngày tải lên: 11/08/2014, 07:20

... reported pharmacokinetic interactions when combining rifabutin and clarithromycin leading to an increase in rifabutin levels, resulting in an increase frequency of uveitis, this could explain the acute ... several months after starting rifabutin In this case the presence of hypopyon, and rapid initial improvement following withdrawal of rifabutin, suggest rifabutin as the underlying aetiology There is ... no evidence of intra-ocular inflammation Blood tests including a full blood count, erythrocyte sedimentation rate and C-reactive protein were all within the normal range, in keeping with a state...

Ngày tải lên: 11/08/2014, 10:22

... staining most vividly (Figure 1A,1B,1C) Examination of the intracellular staining pattern revealed a characteristic staining pattern with the terminal web and the lateral junctions of intestinal ... colitis in the presence of normal intestinal bacteria [8] The MDR1 protein may also play a role in host defense against intracellular bacteria by extruding them from the cell, explaining its ... cascade of signaling events resulting in the activation of NF-kappa B and the host innate immune system [4] NOD2 is expressed in monocytes and in intestinal epithelial cells, including Paneth cells...

Ngày tải lên: 11/08/2014, 10:23

... occurring in the lips and surrounding tissues [5,8,9] It has been recognized as an early manifestation of CD following, coinciding with or preceding the onset of CD [7,8] This extraintestinal ... granulomatosis have been in adults and some in adolescents Orofacial granulomatosis in the paediatric population may be an initial manifestation of CD The interesting points regarding the clinical manifestations ... the activity of the intestinal disease, being quite prominent in periods of exacerbation of CD and retuning to almost normal appearance during periods of remission Competing interests The author(s)...

Ngày tải lên: 11/08/2014, 11:20

... Histological examination of the specimen revealing adenocarcinoma of the colon sigmoid Figure Pre-operative abdominal scan showing the sigmoid process ation or the prevalence of Crohn's disease in Morocco ... disease, the recognition of cancer arising in an inflamed bowel becomes difficult Thompson et al [12] recognized the occult nature of intestinal cancer in Crohn's disease They found that 59% ... Competing interests The authors declare that they have no competing interests Authors' contributions KM, KI and AA operated on our patient All authors participated in the followup examinations...

Ngày tải lên: 11/08/2014, 12:20

... previously reported single nucleotide polymorphism asso­ ciations were again detected, including NOD2 (nuclearbinding oligomerization domain containing 2; usually associated with structuring disease), ... residing in the gut In this model, CD is seen as a disorder arising from both the environment (including micro-organisms, smoking and ‘stress’) and one’s individual reactive genotype, including variations ... detected Only a minority of the variance in risk (about 10%) is explained by the sum of all 32 of these alleles, strongly suggesting that other risk alleles will be detected in the future Indeed, the...

Ngày tải lên: 11/08/2014, 12:20

... disease in which in addition to the skin, parts of the central nervous system (CNS) are affected by an aseptic neutrophilic inflammation Again, other organs including liver and kidneys may be involved ... Alternative first-line systemic treatments are potassium iodide and colchicine Second-line agents include indomethacin, cyclosporine and dapsone Conclusion This is a case of aseptic meningitis secondary ... bacilli) and meningococcal polymerase chain reaction negative Since these results initially suggested bacterial meningitis, g of intravenous ceftriaxone twice daily was started In addition, the...

Ngày tải lên: 11/08/2014, 14:20

... the literature [1] There is a higher incidence of colonic involvement and extraintestinal features in these patients The skin lesions have been observed in patients with active Crohn's disease, ... steroids are tapered too quickly In recurrent disease, therapy with colchicine, potassium iodide, dapsone, doxycycline, indomethacin, clofazimine, isotretinoin and cyclosporine have all been described ... data, and finalized the manuscript for submission to the journal, ML was involved in giving intellectual advice and reviewing the manuscript Consent Written informed consent was obtained from...

Ngày tải lên: 11/08/2014, 21:22

... can compromise intestinal vasculature and may present with gastrointestinal bleeding, complicating the diagnosis and perhaps exacerbating the clinical course of patients with IBD [6] Conclusion ... compromise intestinal vessels Therefore, it may present with gastrointestinal bleeding and exacerbate the clinical course of patients with inflammatory bowel disease Clinical suspicion, proper imaging, ... myalgia [7], but in people with Crohn's Disease it may be clinically silent [2] Due to the involvement of the aorta and its vasculature, TA may present with gastrointestinal bleeding [6] Since most...

Ngày tải lên: 11/08/2014, 23:21

... observed in UC, predominates in women and more common in non-smokers Interestingly flare up of bronchiectasis has been observed within a year following colectomy [4,5] This transfer of the inflammatory ... gastro intestinal tract from the primitive foregut and similarities in tissue structure suggest a patho-physiologic reason for lung involvement in IBD Clinically smaller airways disease in IBD is ... marked inflammation has been observed in CD [8] In our patient stenosis was seen in medium size airways Bronchial biopsy showed evidence of inflammation which is the most prevalent involvement in IBD...

Ngày tải lên: 13/08/2014, 10:20

... being developed in preclinical testing and clinical trials, including molecules targeting interleukin 12, interleukin 17, and endothelial integrins The efficacy of UC therapies in clinical trials ... three ratings of 28 symptom domains found in UC Sixteen of these symptom domains were from standard UC disease activity indices [7,8,10-12] The remaining 12 symptom domains were novel domains identified ... error-checking Any discrepancies in ratings for a given symptom domain endpoint were resolved by having J.C.J and T.K re-examine the original questionnaire and re-measure the distance of the VAS rating...

Ngày tải lên: 18/06/2014, 19:20

... healing of linear ulcers in sigmoid colon (8 weeks after the initial dose of infliximab) Improvement of edema and healing of linear ulcers in sigmoid colon (8 weeks after the initial dose of infliximab) ... with linear ulcers in the sigmoid colon and multiple aphthoid ulcers in the terminal ileum while pathological features were almost indistinguishable from those of Crohn's disease,, including chronic ... al in 1989 [8] and by Hazzan et al in 2006 [3] The clinical and pathologic findings described herein are most consistent with a Crohn's-like phenotype The pathogenesis of bowel involvement in...

Ngày tải lên: 11/08/2014, 10:22