... evidence forthe optimal period oftreatment and number of treatments? We found evidence forthe efficacy of shorter treatment protocols than the 4–6 months recommended by the ICS The basis ofthe ... exercise dosage is the critical factor is unclear The optimal length oftreatment and the number oftreatment episodes could be useful information forthe marketing of physical therapy for SUI Some ... effective forthetreatmentof SUI The other studies in the review were considered forthe generalisability of their findings to clinical practice by identifying the patient populations from which the...
... use The distribution ofthe medication possession ratio (MPR) for any uratelowering drug (ULD) use The distribution ofthe study population in terms of MPR for any ULD use was examined seen in the ... those high-risk subsets ofthe gout population, providers could emphasize the rationale and benefits of ULDs in thetreatmentof gout and the consequences of non-adherence Of note, post hoc analyses ... interpretation ofthe data, and critiquing of drafts of this article BB was involved in the design of this project, analysis and interpretation ofthe data, and critiquing of drafts of this article...
... cord blood support forthetreatmentofsevere aplastic anemia Journal of Hematology & Oncology 2011 4:27 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient ... significantly, the hematopoiesis recovery time did not significantly differ between the two groups (Table 1) (P > 0.05 using a ttest) There was no durable donor engraftment nor GVHD Therefore the umbilical ... patient data and samples; FKperformed the statistical analysis All authors have read and approved the final manuscript Conflict of interests The authors declare that they have no competing interests...
... solution forthetreatmentof ascending aortic aneurysms: the wrapping technique Journal of Cardiothoracic Surgery 2010 5:100 Conflicts of interest The authors declare that there are no conflicts of ... the main author ofthe manuscript and member ofthe surgical team DK coauthored the paper AB was a member ofthe surgical team MD performed linguistic control VL was a member ofthe surgical team ... surgical team DP was member ofthe anesthesiological team KS was member ofthe anesthesiological team SL performed linguistic control N T was the primary surgeon and performed the final control Submit...
... 100% relief of their pain in 86% ofthe patients with a median relief period of months The range of relief varied from zero days to up to 13 months forthe facet injection group None ofthe lumbar ... median period of pain relief being months The range of relief forthe radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure Ofthe 14 patients ... that the direct visualization ofthe joint allows better de-innervation ofthe joint and removal ofthe entire end-plate receptors that adhere to the bone and capsular tissue Limitations of the...
... allow forthe level of adherence to drug therapy regimes to be monitored Additionally, such an analysis would facilitate a more accurate assessment ofthe progression ofthe patient in terms of their ... physicians The utilisation of VL data, with knowledge ofthe presence (or lack) of drug resistant mutations, should allow clinicians to form a more accurate picture ofthe adherence levels of their ... although there is some concern over the long term efficacy when the information content is low Page of (page number not for citation purposes) AIDS Research and Therapy 2009, 6:9 The ability of patients...
... analogues 115 4.15 Methology suitable forthe radiosynthesis ofthe E isomer of CA-1 121 4.16 Radiosynthesis ofthe E isomer of CA-1 123 4.17 Scale-up synthesis of OXi8007 124 4.18 Proposed nitrogen ... among the most important of which is the formation ofthe mitotic spindle, involved in the alignment of replicated chromosomes to the equatorial plane to promote further segregation ofthe chromosomes ... based on their mode of action and the phase ofthe cell cycle in which the drug acts If the action ofthe drug is most effective at any particular phase ofthe cell cycle, the drug is called a...
... and tend to be of older age than patients with cervical or lumbar disease Also, thestenosis tends to be foraminal and not central since 66% of patients had foraminal stenosisThe lower thoracic ... and neural structures increases the risk of adverse events with invasive approaches Open surgical correction is the current standard of care for foraminal stenosisof cervical and lumbar vertebrae ... laminoforaminoplasty, should decrease the risk of major adverse events, allow for same day hospital discharge, and decrease the need for postoperative analgesia and immobility [5] [6] In the current...
... ethanol at a final concentration of 10%, then transported to the laboratory of UT at 4oCstored Then, each ofthe samples were divided into two One of them was for DNA extraction and was washed ... general, the higher concentration of primers can lead to the formation of primer dimers Also, the cost ofthe chemicals should be minimized if the same quantitativeness can be achieved The results ... Another was for FISH analysis and was stored at -80oC The extraction of DNA was performed with Fast DNA SPIN Kit for Soil (Qbuiogene, USA) according to the instruction by the manufacturer In the...
... with the increased HRT ofthe adsorption tank From an engineering application point of view, the appropriate operational parameters ofthe recycle ratio, HRT ofthe regeneration tank, HRT ofthe ... in the PO43 P removal These results revealed that the selection ofthe operational parameters ofthe CARS process had a great influence on the overall system performance Adsorptive capability of ... technical feasibility of this process was demonstrated The effects of recycle ratio, HRT ofthe regeneration tank, HRT ofthe adsorption tank and SRT ofthe system were evaluated The removal efficiency...
... from data in the RCT The survival of patients receiving ASC/BSC was calculated from the survival ofthe patients in the cetuximab monotherapy arm ofthe RCT The data from the monotherapy arm NICE ... negligible if further active treatment was not available Therefore the results seen in the single-arm cetuximab studies for these outcomes could be interpreted as an effect ofthe drug It also ... 138) The primary outcome for all studies was tumour response rate A median age of 56 years was reported in two ofthe trials and a median age of 59 years in the other two In all four studies the...
... information on barriers to the use of other therapiesfortreatmentof sickle cell disease, including the receipt of routine, scheduled care; adherence to medications; and receipt of therapies, including ... reported on the efficacy and/or effectiveness of hydroxyurea treatmentof hematologic diseases, the toxicity of hydroxyurea in thetreatmentof any disease, and the barriers to thetreatmentof sickle ... reviewer reconciled the results ofthe first two reviewers in the case ofthe randomized trials 29 Forthe other study designs, the results ofthe two reviewers were averaged The quality assessment...
... (COX) In these enzymes, the redox potential ofthe metals is harnessed to provide the enzymes with their electron transfer capabilities Paradoxically, it is the same redox potential ofthe metals ... that the interaction between Ab and these metals can promote the formation of Ab oligomers, aggregates and fibrils [48,52–55] Metal mediated oligomerization of Ab may therefore contribute to the ... within the physiological ranges that could be expected within the brain The capacity for metals to facilitate this process may therefore be a critical factor in the Ab mediated pathology of the...
... maturation with the commercialization of these pH sensors in the mid-80’s, while they were the platform forthe development of other ion-selective FETs and bio-FETs up to date When SiO2 , or other metal ... used forthe oxidation of ferrocyanide, or the reduction of methyl viologen, and the simultaneous spectroscopic monitoring ofthe products through the disc In the same year, the construction of ... technology Based on these facts it was clear that the precise control ofthe surface chemistry was mandatory forthe final optimization ofthe device performance For this reason there are some basic...
... the inclusion of lysine residues in the protein sequence ofthe A fragment but not the B fragment of PE Because only the A fragment must traffic to the cytosol for activity, the lack of lysine residues ... altering the rate of internalization ofthe receptor or influencing the intracellular trafficking The proteome ofthe target cell also influences the pathway We have observed large differences in the ... 14) of patients showed a partial response to treatment 4692 J E Weldon and I Pastan The future of PE-based RITs Many obstacles have been overcome in the development of RITs forthetreatment of...
... upon the peer review comments, the best practice statement was submitted to and approved by the PGC and the Board of Directors ofthe AUA Funding ofthe Panel and ofthe PGC was provided by the ... addressed Placement of a thermosensor to monitor the temperature ofthe external sphincter can reduce the potential of thermal injury to this muscle The thermosensor is introduced through the perineal ... Cryosurgery fortheTreatmentof Localized Prostate Cancer The supporting systematic literature review and the drafting of this document were conducted by the Cryosurgery forTreatmentof Localized...
... choice and loading ofthe NM is a compromise between the required efficiency ofthe converter and the market price ofthe NM However, the application of noble metals forthetreatmentof exhaust gas ... are formed in adsorption of reactant molecules on the semi-conducting surface; the formation of these is a function ofthe electronic properties ofthe solid, and the structure and kind of bonds ... mechanism of exhaust treatmentThe aims of this thesis will be then proposed The second chapter introduces basic principles ofthe physico-chemical methods used in the thesis, catalyst synthesis,...
... overall survival of treated animals (Figure 6D) These results confirm the anti-tumor activity of anti-VLC therapy, as observed by others, and further support the use of anti-CD52 therapy in humans ... collected at the University of Pennsylvania or the University of Michigan After obtaining informed patient consent, ascites was collected either intraoperatively or at the time of therapeutic ... intraperitoneal delivery ofthe drug Despite being a well-documented therapeutic target, the exact function of CD52 remains unknown In the ID8VEGF tumors, VLC account forthe vast majority of tumorassociated...
... to improve the effectiveness of systemic chemotherapy Thenovel strategy that I propose here to improve the effectiveness of systemic chemotherapy in thetreatmentof malignant brain tumors is ... measurement of tumor tissue MRI signal at baseline (T10) and then again following the intravenous infusion ofthe Gd-dendrimer (T1), and the in vitro measurement ofthe molar relaxivity (r1) ofthe Gd-dendrimer, ... Significance ofthe luminal glycocalyx layer ofthe BBTB of malignant brain tumor microvasculature The well-defined physiologic upper limit of pore size in the BBTB of 12 nm would be attributable to the...
... variation between the two groups of subjects caused not by thetreatment itself but by variation ofthe clinical scale at the beginning ofthe therapy To test the overall effect of adaptive training, ... compared the primary outcome measures (change in the clinical scores) between the baseline (T0) and the end ofthetreatment (T3), irrespective ofthe training mode (treatment) As regards the kinematic ... performance at the end ofthe adaptation phase as compared to the final portion ofthe wash-out phase One subject (S8) did not complete the second half ofthe trial, for reasons unrelated to the study...