novel alternative therapies for the treatment of severe aortic stenosis

... evidence for the optimal period of treatment and number of treatments? We found evidence for the efficacy of shorter treatment protocols than the 4–6 months recommended by the ICS The basis of the ... exercise dosage is the critical factor is unclear The optimal length of treatment and the number of treatment episodes could be useful information for the marketing of physical therapy for SUI Some ... effective for the treatment of SUI The other studies in the review were considered for the generalisability of their findings to clinical practice by identifying the patient populations from which the...

Ngày tải lên: 28/03/2014, 14:20

... use The distribution of the medication possession ratio (MPR) for any uratelowering drug (ULD) use The distribution of the study population in terms of MPR for any ULD use was examined seen in the ... those high-risk subsets of the gout population, providers could emphasize the rationale and benefits of ULDs in the treatment of gout and the consequences of non-adherence Of note, post hoc analyses ... interpretation of the data, and critiquing of drafts of this article BB was involved in the design of this project, analysis and interpretation of the data, and critiquing of drafts of this article...

Ngày tải lên: 09/08/2014, 14:20

... cord blood support for the treatment of severe aplastic anemia Journal of Hematology & Oncology 2011 4:27 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient ... significantly, the hematopoiesis recovery time did not significantly differ between the two groups (Table 1) (P > 0.05 using a ttest) There was no durable donor engraftment nor GVHD Therefore the umbilical ... patient data and samples; FKperformed the statistical analysis All authors have read and approved the final manuscript Conflict of interests The authors declare that they have no competing interests...

Ngày tải lên: 10/08/2014, 21:23

... solution for the treatment of ascending aortic aneurysms: the wrapping technique Journal of Cardiothoracic Surgery 2010 5:100 Conflicts of interest The authors declare that there are no conflicts of ... the main author of the manuscript and member of the surgical team DK coauthored the paper AB was a member of the surgical team MD performed linguistic control VL was a member of the surgical team ... surgical team DP was member of the anesthesiological team KS was member of the anesthesiological team SL performed linguistic control N T was the primary surgeon and performed the final control Submit...

Ngày tải lên: 10/08/2014, 09:22

... 100% relief of their pain in 86% of the patients with a median relief period of months The range of relief varied from zero days to up to 13 months for the facet injection group None of the lumbar ... median period of pain relief being months The range of relief for the radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure Of the 14 patients ... that the direct visualization of the joint allows better de-innervation of the joint and removal of the entire end-plate receptors that adhere to the bone and capsular tissue Limitations of the...

Ngày tải lên: 26/10/2012, 09:32

... allow for the level of adherence to drug therapy regimes to be monitored Additionally, such an analysis would facilitate a more accurate assessment of the progression of the patient in terms of their ... physicians The utilisation of VL data, with knowledge of the presence (or lack) of drug resistant mutations, should allow clinicians to form a more accurate picture of the adherence levels of their ... although there is some concern over the long term efficacy when the information content is low Page of (page number not for citation purposes) AIDS Research and Therapy 2009, 6:9 The ability of patients...

Ngày tải lên: 10/08/2014, 05:21

... analogues 115 4.15 Methology suitable for the radiosynthesis of the E isomer of CA-1 121 4.16 Radiosynthesis of the E isomer of CA-1 123 4.17 Scale-up synthesis of OXi8007 124 4.18 Proposed nitrogen ... among the most important of which is the formation of the mitotic spindle, involved in the alignment of replicated chromosomes to the equatorial plane to promote further segregation of the chromosomes ... based on their mode of action and the phase of the cell cycle in which the drug acts If the action of the drug is most effective at any particular phase of the cell cycle, the drug is called a...

Ngày tải lên: 14/11/2014, 11:32

... and tend to be of older age than patients with cervical or lumbar disease Also, the stenosis tends to be foraminal and not central since 66% of patients had foraminal stenosis The lower thoracic ... and neural structures increases the risk of adverse events with invasive approaches Open surgical correction is the current standard of care for foraminal stenosis of cervical and lumbar vertebrae ... laminoforaminoplasty, should decrease the risk of major adverse events, allow for same day hospital discharge, and decrease the need for postoperative analgesia and immobility [5] [6] In the current...

Ngày tải lên: 26/10/2012, 09:57

... ethanol at a final concentration of 10%, then transported to the laboratory of UT at 4oCstored Then, each of the samples were divided into two One of them was for DNA extraction and was washed ... general, the higher concentration of primers can lead to the formation of primer dimers Also, the cost of the chemicals should be minimized if the same quantitativeness can be achieved The results ... Another was for FISH analysis and was stored at -80oC The extraction of DNA was performed with Fast DNA SPIN Kit for Soil (Qbuiogene, USA) according to the instruction by the manufacturer In the...

Ngày tải lên: 05/09/2013, 09:38

... with the increased HRT of the adsorption tank From an engineering application point of view, the appropriate operational parameters of the recycle ratio, HRT of the regeneration tank, HRT of the ... in the PO43 P removal These results revealed that the selection of the operational parameters of the CARS process had a great influence on the overall system performance Adsorptive capability of ... technical feasibility of this process was demonstrated The effects of recycle ratio, HRT of the regeneration tank, HRT of the adsorption tank and SRT of the system were evaluated The removal efficiency...

Ngày tải lên: 05/09/2013, 09:38

... from data in the RCT The survival of patients receiving ASC/BSC was calculated from the survival of the patients in the cetuximab monotherapy arm of the RCT The data from the monotherapy arm NICE ... negligible if further active treatment was not available Therefore the results seen in the single-arm cetuximab studies for these outcomes could be interpreted as an effect of the drug It also ... 138) The primary outcome for all studies was tumour response rate A median age of 56 years was reported in two of the trials and a median age of 59 years in the other two In all four studies the...

Ngày tải lên: 14/02/2014, 22:20

... information on barriers to the use of other therapies for treatment of sickle cell disease, including the receipt of routine, scheduled care; adherence to medications; and receipt of therapies, including ... reported on the efficacy and/or effectiveness of hydroxyurea treatment of hematologic diseases, the toxicity of hydroxyurea in the treatment of any disease, and the barriers to the treatment of sickle ... reviewer reconciled the results of the first two reviewers in the case of the randomized trials 29 For the other study designs, the results of the two reviewers were averaged The quality assessment...

Ngày tải lên: 05/03/2014, 10:20

... (COX) In these enzymes, the redox potential of the metals is harnessed to provide the enzymes with their electron transfer capabilities Paradoxically, it is the same redox potential of the metals ... that the interaction between Ab and these metals can promote the formation of Ab oligomers, aggregates and fibrils [48,52–55] Metal mediated oligomerization of Ab may therefore contribute to the ... within the physiological ranges that could be expected within the brain The capacity for metals to facilitate this process may therefore be a critical factor in the Ab mediated pathology of the...

Ngày tải lên: 07/03/2014, 10:20

... maturation with the commercialization of these pH sensors in the mid-80’s, while they were the platform for the development of other ion-selective FETs and bio-FETs up to date When SiO2 , or other metal ... used for the oxidation of ferrocyanide, or the reduction of methyl viologen, and the simultaneous spectroscopic monitoring of the products through the disc In the same year, the construction of ... technology Based on these facts it was clear that the precise control of the surface chemistry was mandatory for the final optimization of the device performance For this reason there are some basic...

Ngày tải lên: 20/03/2014, 13:05

... the inclusion of lysine residues in the protein sequence of the A fragment but not the B fragment of PE Because only the A fragment must traffic to the cytosol for activity, the lack of lysine residues ... altering the rate of internalization of the receptor or influencing the intracellular trafficking The proteome of the target cell also influences the pathway We have observed large differences in the ... 14) of patients showed a partial response to treatment 4692 J E Weldon and I Pastan The future of PE-based RITs Many obstacles have been overcome in the development of RITs for the treatment of...

Ngày tải lên: 22/03/2014, 15:21

... upon the peer review comments, the best practice statement was submitted to and approved by the PGC and the Board of Directors of the AUA Funding of the Panel and of the PGC was provided by the ... addressed Placement of a thermosensor to monitor the temperature of the external sphincter can reduce the potential of thermal injury to this muscle The thermosensor is introduced through the perineal ... Cryosurgery for the Treatment of Localized Prostate Cancer The supporting systematic literature review and the drafting of this document were conducted by the Cryosurgery for Treatment of Localized...

Ngày tải lên: 28/03/2014, 23:20

... choice and loading of the NM is a compromise between the required efficiency of the converter and the market price of the NM However, the application of noble metals for the treatment of exhaust gas ... are formed in adsorption of reactant molecules on the semi-conducting surface; the formation of these is a function of the electronic properties of the solid, and the structure and kind of bonds ... mechanism of exhaust treatment The aims of this thesis will be then proposed The second chapter introduces basic principles of the physico-chemical methods used in the thesis, catalyst synthesis,...

Ngày tải lên: 12/05/2014, 17:14

... overall survival of treated animals (Figure 6D) These results confirm the anti-tumor activity of anti-VLC therapy, as observed by others, and further support the use of anti-CD52 therapy in humans ... collected at the University of Pennsylvania or the University of Michigan After obtaining informed patient consent, ascites was collected either intraoperatively or at the time of therapeutic ... intraperitoneal delivery of the drug Despite being a well-documented therapeutic target, the exact function of CD52 remains unknown In the ID8VEGF tumors, VLC account for the vast majority of tumorassociated...

Ngày tải lên: 18/06/2014, 15:20

... to improve the effectiveness of systemic chemotherapy The novel strategy that I propose here to improve the effectiveness of systemic chemotherapy in the treatment of malignant brain tumors is ... measurement of tumor tissue MRI signal at baseline (T10) and then again following the intravenous infusion of the Gd-dendrimer (T1), and the in vitro measurement of the molar relaxivity (r1) of the Gd-dendrimer, ... Significance of the luminal glycocalyx layer of the BBTB of malignant brain tumor microvasculature The well-defined physiologic upper limit of pore size in the BBTB of 12 nm would be attributable to the...

Ngày tải lên: 18/06/2014, 15:20

... variation between the two groups of subjects caused not by the treatment itself but by variation of the clinical scale at the beginning of the therapy To test the overall effect of adaptive training, ... compared the primary outcome measures (change in the clinical scores) between the baseline (T0) and the end of the treatment (T3), irrespective of the training mode (treatment) As regards the kinematic ... performance at the end of the adaptation phase as compared to the final portion of the wash-out phase One subject (S8) did not complete the second half of the trial, for reasons unrelated to the study...

Ngày tải lên: 19/06/2014, 08:20