non apoptotic forms of programmed cell death in metazoans
Novel mechanisms of programmed cell death in the protozoan parasite blastocystis
... Slovenia Jing Yin and Kevin S W Tan Staurosporine-induced programmed cell death in Blastocystis In 4th International Conference on Anaerobic Protists, 12 – 16 May 2008, Taoyuan, Taiwan Binhui Wu, Jing ... II cell death – autophagic cell death 16 1.2.3 Type III cell death – necrosis 21 1.3 Programmed cell death (PCD) in protozoan parasites .23 1.3.1 Occurrence of PCD in unicellular ... studies of PCD in protozoan parasites, most of the homologs of mammalian molecules involved in cell death signaling are missing in the protozoa and the molecular architecture of PCD in protozoan...
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Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc
... ANT1-silencing effect on cell viability might be a result of the onset of a programmed cell death process, we analyzed the effect of siRNA in the presence of the protein synthesis inhibitor puromycin ... requires protein synthesis ANT1-silencing induces ADF cell apoptosis and a non- apoptotic cell death modality similar to paraptosis To gain more insight regarding the observed reduction in cell viability, ... ANT1-silencing induces glioblastoma cell death A Fig Analysis of ANT1 and ANT2 expression in nontransfected ADF cells and in ANT1- and ANT2-silenced ADF cells (A) Number of ANT1 and ANT2 transcripts in...
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Báo cáo khoa học: Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics pptx
... A S Gillings et al providing a rationale for the use of combinations of MEK1 ⁄ inhibitors and PI3K–PKB pathway inhibitors Indeed, rapamycin, an inhibitor of mammalian target of rapamycin (mTOR) ... mediator of tumour cell death A S Gillings et al ERK1 ⁄ signalling contributes substantially to the increase in BIM expression In the majority of NSCLC cell lines treated with erlotinib or gefitinib, ... importance of the BCR–ABL tyrosine kinase in the survival of CML cells led to the development of the tyrosine kinase inhibitor imatinib (STI571, Gleevec), which is a potent inhibitor of BCR–ABL,...
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Báo cáo y học: " The mode of lymphoblastoid cell death in response to gas phase cigarette smoke is dose-dependent" potx
... of death of cells challenged with different doses of cigarette smoke [16-19] Taking this into consideration, there has been increasingly intense interest in the effects of GPS A common denominator ... accumulation of toxic insults, increased epithelial cell death and a decline in immune cell function Exposure of cells to CS by means of CSC or CSE does not provide a reliable simulation system of normal ... death in CCRF-CEM cells GPS induces apoptotic and necrotic cell death in CCRF-CEM cells CCRF-CEM cells were exposed to various doses of GPS (1, or puffs) and stained with Annexin V/PI, followed...
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Báo cáo khoa học: Ionizing radiation utilizes c-Jun N-terminal kinase for amplification of mitochondrial apoptotic cell death in human cervical cancer cells pptx
... analyzed induction of apoptotic cell death by fluorescence activated cell sorting (FACS) analysis with Annexin V staining Figure 1A shows that there is a time-dependent increase in apoptotic cell death, ... in the regulation of apoptotic cell death in response to various stimuli To investigate a potential involvement of MAPK in ionizing radiationinduced cell death, we employed specific chemical inhibitors ... determine the percentage of cells within a population that are actively undergoing apoptotic cell death For the cell- death assessment, the cells were plated in 60 mm dish at a density of · 105cells...
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Báo cáo sinh học: "Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells" ppt
... assessing the sub-G1 population (Figure 4B) In addition, apoptotic cells were also detected by both Annexin V/PI staining and immunofluorescent staining with Hoechst 33342 Annexin V/PI staining ... treated cells showed abnormal monopolar spindles, suggesting that the inhibition of Aurora kinase activity induced defects of mitotic spindle in VX-680 treated cells VX-680 suppresses cell growth ... proliferation of leukemic cells in AML and inhibition of activation of Akt can result in suppression of cell growth [40,41] In the present study, phosphorylation of Akt-1 and GSK3b, the downstream of Akt-1,...
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báo cáo hóa học:" Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells" ppt
... assessing the sub-G1 population (Figure 4B) In addition, apoptotic cells were also detected by both Annexin V/PI staining and immunofluorescent staining with Hoechst 33342 Annexin V/PI staining ... treated cells showed abnormal monopolar spindles, suggesting that the inhibition of Aurora kinase activity induced defects of mitotic spindle in VX-680 treated cells VX-680 suppresses cell growth ... proliferation of leukemic cells in AML and inhibition of activation of Akt can result in suppression of cell growth [40,41] In the present study, phosphorylation of Akt-1 and GSK3b, the downstream of Akt-1,...
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Báo cáo khoa học: "The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation" pot
... potency In contrast, the anti-neoplastic effects of ionizing radiation in LNCaP cells did not involve apoptosis induction implicating a role of proliferation inhibition or the induction of non- apoptotic ... despite reducing the number of viable cells in the WST-1 assay, ionizing radiation did not induce significant apoptotic nuclear fragmentation in LNCaP cells (Figure 2D) In line with these findings, ... in LNCaP and PC3 cells, whereas ionizing radiation triggered a decrease in the levels of Bcl-2 in both cell lines Moreover, ErPC3treatment decreased the levels of Mcl-1 in LNCaP cells Thus, in...
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Báo cáo khoa học: " Differential protection by wildtype vs. organelle-specific Bcl-2 suggests a combined requirement of both the ER and mitochondria in ceramide-mediated caspase-independent programmed cell death" docx
... and ciPCD [2,12,13] In fact, the ER may play a key role in certain types of ciPCD, as intracellular calcium influx caused by ER stress induces activation of calpains, a family of calcium-dependent ... Boston, USA) Cells were maintained in a mixture of Click's/RPMI 1640 (50/50% v/v) supplemented with 10% v/v FCS, mM glutamine and 50 μg/ml each of streptomycin and penicillin in a humidified incubator ... negative selection of lymphocytes, the termination of immune responses, embryonic removal of interdigital webs, regulation of bone growth, ovulation, and cellular turnover in the intestine [3] Furthermore,...
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Báo cáo y học: " Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone" pot
... replicated in flow-cytometry analyses of infected A549 cells (Fig 6a and 6b) 40 Figure growth of L pneumophila in A549 cells Intracellular Intracellular growth of L pneumophila in A549 cells A549 cells ... Results Intracellular growth and cytotoxicity of L pneumophila in A549 cells First, we verified the infection and intracellular growth of L pneumophila in A549 cells Intracellular growth of the ... Dornand J: In vitro Brucella suis infection prevents the programmed cell death of human monocytic cells Infect Immun 2000, 68:342-351 Salvesen GS, Dixit VM: Caspases: intracellular signaling by proteolysis...
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Báo cáo khoa học: Glucose oxidase prevents programmed cell death of the silkworm anterior silk gland through hydrogen peroxide production ppt
... apoptosis in cancer cells In B mori fifth instars, the ASGs notably increase in tissue size [15], and both the amount of GOD protein and GOD activity increased, indicating the involvement of GOD-produced ... These results indicated the importance of spinning to the loss of GOD activity in ASGs Finally, we examined the localization of the GOD enzyme by active staining for the silk glands of V3 larvae; ... indicating that V5 ASGs contained the inhibitor (Fig 1D) Changes of inhibitor-producing activity during the larval period We examined the inhibitor activity in the CM of ASGs from day of the...
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Báo cáo khoa học: Plant oxylipins: role of jasmonic acid during programmed cell death, defence and leaf senescence doc
... caspases Interestingly, the mycotoxin and sphingosine analogue fumonisin-B1 is a powerful inducer of singlet oxygen-dependent PCD in animals and plants [115,116] Fumonisin-1-induced PCD in plants ... homologue, dinor-OPDA, were invoked to explain cell death control [34,79] However, the induction of several enzymes involved in ethylene biosynthesis and SA action in illuminated flu plants points to ... FEBS C Reinbothe et al JA and cell death Fig Central role of JA in cell death regulation in plants Animals respond to many external factors with a plethora of different cell death pathways of which...
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Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: blebbing in programmed cell death docx
... proteins identified during reassembly of a contractile actin cortex under the membrane of blebs in filamin-deficient blebbing cells has not been examined in blebs of cells undergoing cell death ... bending the actin network Dynamic changes in the ultrastructure of the actin network due to binding and unbinding of actin-bundling proteins may also play a role, but this has not yet been examined ... can induce apoptosis by suppressing integrin-mediated cell adhesion and survival signalling [53], and can inhibit the association of talin head domain with integrin to suppress the integrin–Cdc42...
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Báo cáo hóa học: "Programmed cell death-1 (PD-1) at the heart of heterologous prime-boost vaccines and regulation of CD8+ T cell immunity" doc
... blocking PD-1/PD-1L interaction, speaking to the critical role of PD-1 in determining the fate of CD8+ T cells post-priming (summary of results in refs [42] and [48]) In this experimental setting, ... alternating the administration of a DNA vaccine with other vectors such as peptides, recombinant proteins, or viruses for the purpose of inducing and periodically replenishing low PD-1-expressing ... mechanism explaining the effectiveness of DNA priming - heterologous boosting in achieving superior immunity in immune competent organisms Alternating DNA priming with heterologous boosting (viral...
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báo cáo hóa học: " Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson''''s disease" pptx
... to dopaminergic neuronal death by oxidizing dopamine to a reactive dopamine quinone [51], by increasing DNA oxidation [7], or through increased microglial activation leading to chronic inflammation ... of oxidative and inflammatory insults The positive feed back loop may continue until the additional neuronal death (~50% of the remaining of the initial death) combined with the initial loss exceed ... conducted in attempt to fill in the gap within the literature on the effects of COX-2 inhibition in protecting SNpc dopaminergic neurons from MPTP-induced neurotoxicity We inhibited COX-2 using both...
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báo cáo khoa học: " Do mitochondria play a role in remodelling lace plant leaves during programmed cell death?" pps
... noted previously during developmental cell death in the lace plant [10], in induced cell death in lace plant protoplasts [26], and also during induced cell death by osmotic stress in tobacco suspension ... implication in victorin binding and induced cell death Plant J 2002, 29:295-312 Yu XH, Perdue TD, Helmer YM, Jones AM: Mitochondrial involvement in tracheary element programmed cell death Cell death ... following the induction of cell death, and is thought to be highly correlated with the acute change in cellular redox status, as well as the remainder of the cell death process [29,30,16] Following...
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Báo cáo y học: "Cell death in sepsis: a matter of how, when, and where" potx
... effective interventions to prevent organ failure in sepsis During sepsis, there is extensive apoptotic death of lymphocytes and gastrointestinal epithelial cells [7] The increased apoptotic death of ... activated in dying cells during sepsis [1] The simple inhibition of a particular cell death route therefore might not result in survival but rather lead to alternative pathways of cell death Indeed, ... elimination of key effector cells and, alternatively, the capacity of apoptotic cells to induce anergy and a shift to a Th2 -cell response Furthermore, apoptosis of gastrointestinal epithelial cells...
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Báo cáo y học: "A genomic approach to investigate developmental cell death in woody tissues of Populus trees" pot
... early signaling of apoptotic cell death in virus-infected animal cells [29] In plant cells, serine proteases have been implicated in pathogen-induced cell death [35,36], and serine protease activities ... in a strictly spatially and temporally coordinated and programmed fashion [1,2] The programmed cell death (PCD) of xylem has been analyzed in detail in an in vitro system of Zinnia elegans, in ... process in intact plants In addition, the Zinnia system has not allowed analysis of the different cell types of the xylem, such as the fibers Programmed cell death also occurs in plants in response...
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CHARACTERISATION OF DRUG INDUCED CELL DEATH IN MYCOBACTERIUM SMEGMATIS
... a in e d IN H h IN H h 5 1 0 5 0 0 * IC M IC IN IN H IN H IN H H /2 M M IC IC M IC l /5 IN H IN C H o n M tr o IC M IC IN IN H H M M IC IC M /2 IN IN H H C o /5 n M tr o IC l * vi iii IN H h IN ... * IC M H IN IN IN H H M IC M /2 H IN v S t a in e d v /s U n s t a in e d M IC IC /5 H IN H H M M IC IC M IC IN IN H IN H /2 M M IC IC M /5 H IN ii IC -2 -5 IN RFI % RFI IN H h S t a in e d v ... examples of some frequently applied cell- wall inhibitors β-lactams β-lactams weaken cell wall by inactivating penicillin-binding proteins involved in cell wall synthesis Transpeptidases bind to...
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Expressionsmuster des apoptoseproteins programmed cell death protein 4 (pdcd4) in urologischen tumoren
... mammalian target of rapamycin nuclear factor kappa-light-chain-enhancer of activated B cells Non muscle-invasive bladder cancer Non Small Cell Lung Cancer cyclin-dependent kinase inhibitor phosphorylierte ... Group IL Interleukin JNK N-terminal Kinases K-rasKirsten Rat Sarcoma LDH Laktatdehydrogenase MAPK = ERK Mitogen-activated protein kinase MAP4K1 Mitogen-activated protein kinase kinase kinase kinase ... immunhistochemische Fọrbungen nachzuweisen sind, klinisch effektiv verwertbar 31 1.6 Das Programmed cell death Protein Das Programmed cell death 4, kurz Pdcd4, ist ein Protein, das wọhrend der Apoptose hoch...
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