nodal and local recurrence of parotid squamous cell carcinoma

... cancer cells at all stages of cancer progression, and their production of growth factors, chemokines and extracellular matrix facilitates the angiogenic recruitment of endothelial cells and pericytes ... cell lines (TE-8 and TE-11) [24] We next examined the effects of adding growth factors to the culture medium of cancer cells and the effects of FGFR inhibitor and MET inhibitor treatment on cell ... one of the least studied and most lethal malignancies [3] Squamous- cell carcinoma accounts for 92.5% of all primary esophageal tumors in Japan and other Asian countries [4-6], while adenocarcinoma

Ngày tải lên: 30/09/2020, 13:49

... The association between serum squamous cell carcinoma antigen and recurrence and survival of patients with cervical squamous cell carcinoma: a systematic review and meta-analysis Gynecol Oncol ... radical surgery and the identification of the optimal cutoff value of SCC antigen levels are still significant for the diagnosis, prognosis and treatment of cervical squamous cell carcinoma To explore ... metastases and prognosis of patients with cervical squamous cell carcinoma Keywords: Cervical squamous cell carcinoma, Serum squamous cell carcinoma antigen, Chemosensitivity, Lymph node metastasis,

Ngày tải lên: 30/05/2020, 21:44

... Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of ... squamous cell carcinomas (SCC), adenocarcinoma, adeno -squamous carcinoma and melanoma [5, 6] In Western countries, SCC is much more common than adenocarcinoma The incidence rate of SCC is steadily ... and 95.4% of male and female patients were married (p = 0.637) When grouped by age at initial diagnosis, 41.7% of patients (n = 60) were less than Page of 13 or equal to 50 years, and 58.3% of

Ngày tải lên: 06/08/2020, 05:49

... Knockdown of SLC52A3 in ESCC cells results in inhibition of cell proliferation, colony formation and anchorage-independent growth, whereas overexpression of SLC52A3 in ESCC cells promotes cell proliferation, ... Beijing, China) Page of 11 Cell culture and dual luciferase reporter assay The human KYSE150 and KYSE180 esophageal squamous carcinoma cell lines were cultured in RPMI-1640 medium (ThermoFisher, HyClone, ... Page of 11 Table Characteristics of ESCC cases and controls Table Characteristics of ESCC cases and controls (Continued) Variables Radiotherapy after surgery SNP and ESCC risk SNP and ESCC SNP and

Ngày tải lên: 20/09/2020, 15:05

... biomarkers and therapeutic targets for esophageal squamous cell carcinoma by gene expression profiling of frozen esophageal squamous carcinoma specimens and examined the functional relevance of a newly ... second and independent cohort (n = 71) consisting of esophageal squamous cell carcinoma (n = 25), normal esophagus (n = 11), esophageal adenocarcinoma (n = 13), gastric adenocarcinoma (n = 15) and ... siRNA-mediated knockdown of WDR66 resulted in suppression of cell growth and reduced cell motility Conclusions: WDR66 might be a useful biomarker for risk stratification of esophageal squamous carcinomas WDR66

Ngày tải lên: 05/11/2020, 07:27

... Ministry of Science and Technology of China, 2006) and also had approval of the Ethics Committee of the hospital Cell lines The human immortalized oral epithelial cells (HIOEC) and three OSCC cell ... squamous cell carcinoma, Proliferation, Migration, Invasion Background Oral squamous cell carcinoma (OSCC) is the most common type of cancer in oral cavity, which accounts for more than 90% of ... inflammasome in oral squamous cell carcinoma (OSCC) Methods: NLRP3 expression in OSCC cell lines and the normal human immortalized oral epithelial cells (HIOEC) was determined by real-time PCR and western

Ngày tải lên: 24/07/2020, 02:04

... to know expression profiles for thousands of proteins and characterize the biologic behaviors of cell simultaneously, which can contribute to better understand the changes of multiple proteins ... layer and basal cell layer of OSF, and intensively staining of the cytoplasm in BSCC cell them may be explained partially by the limited dynamic range of iTRAQ [15] Moreover, the difference of races ... (2016) 16:584 Page of 11 Fig Initial validation of two candidate biomarkers a Western blot of ANXA4 and FLNA in the samples of NBM and paired BSCC and OSF, as well as their corresponding quantifications

Ngày tải lên: 20/09/2020, 15:19

... 0.04), and the postoperative radiation therapy has been a standard of care for patients with advanced resectable head and neck squamous cell carcinoma (HNSCC) Nevertheless, development of distant ... Niedobitek G, Hornung J, Rödel C, et al Squamous cell carcinoma of the oropharynx: Ki-67 and p53 can identify patients at high risk for local recurrence after surgery and postoperative radiotherapy Int ... postoperative head and neck squamous cell carcinoma is narrower than in Western countries to reduce late radiation related toxicities This strategy is at a risk of loco-regional recurrence and/ or distant

Ngày tải lên: 21/09/2020, 09:19

... of sample. Interpretation of Cut off value (RLU of specimen/mean RLU of PC) Cut-off ratio of 0 t o 0.99 is negative for HR HPV; Cut - off ratio greater than 1.0 positive for HR HPV. The cut off ... head and neck squamous cell carcinoma; (HC- II): Hybrid Capture; (OSCC): Oral squamous cell carcinoma. Acknowledgements Authors are thankful to persistent efforts of an enthusiastic group of Swaroop ... expression of the viral E6 and E7 oncoproteins, which cause deregula- tion of the cell cycle by inactivating p53 and pRb respectively [9]. Integration often disrupts the integrity and expression of the

Ngày tải lên: 12/08/2014, 01:22

... C, Carey T, et al.: Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients Clin Cancer Res ... protein and is involved in transcriptional regulation of a variety of genes [95], cell growth arrest [96,97], and apoptosis and cell death [96] Borghaei and coworkers [98] found that both ZBP-89 and ... cells Figure p53 genotype and protein expression in UM-SCC cell lines p53 genotype and protein expression in UM-SCC cell lines (a) The p53 genotype of ten University of Michigan series head and

Ngày tải lên: 14/08/2014, 07:21

... range of functions CD44+ expression has been identified as a marker for a population of cells with cancer stem cell characteristics in head and neck squamous cell carcinoma (HNSCC) The aim of this ... transition and the stem cell phenotype Cell Stem Cell 2008; 2(6):511-2 30 Mani SA, Guo W, Liao MJ, et al The epithelial-mesenchymal transition generates cells with properties of stem cells Cell 2008; ... head and neck squamous cell carcinoma Oral Oncol 2008; 44(9):823-9 41 Bajorath J Molecular organization, structural features, and ligand binding characteristics of CD44, a highly variable cell

Ngày tải lên: 02/10/2015, 17:14

... process of which is initiated by the disappearance of the basic structures of the epithelia, followed by epithelial cell degeneration, enhancement of migration capacity, and loss of cell polarity and ... adenocarcinoma (AC), lung squamous cell carcinoma (SqCC), and large cell carcinoma [2] Etiologically, tobacco smoke is the most significant risk factor that causes lung cancer development and ... in lung SqCC cell lines, i.e., SK-MES1 cells expressed the highest CLDN3 level, H1703 and H2170 cells expressed moderate levels of CLDN3, and H520 cells expressed the lowest level of CLDN3 B Western

Ngày tải lên: 15/01/2020, 11:10

... Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China Department of Oral and Maxillofacial Head Neck Oncology, School & Hospital of ... microenvironment Key words: LAMTOR5, head and neck squamous cell carcinoma, prognosis, immunohistochemistry, knockout mice Introduction Head and neck squamous cell carcinoma (HNSCC) is the seventh most ... Molinolo A, Chen W, Gutkind JS, et al Loss of TGF-beta signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation Oncogene

Ngày tải lên: 15/01/2020, 18:14

... tumorigenesis, and suggest opportunities for the future development of miRs and mRNAs as biomarkers for early detection, diagnosis, and prognosis in ESCC Keywords: Esophageal squamous cell carcinoma, ... clinicopathological factors and 260 Page of 14 miRNAs, including metastasis (no vs yes), tumor grade (grade and vs grade and 4), and tumor stage (stage I and II vs III and IV) Twenty-six miRNA expressions ... Our characterization and integrated analysis of genome-wide miRNA and gene expression in ESCC provides insights into the expression of miRNAs and their relation to regulation of RNA targets in ESCC

Ngày tải lên: 30/05/2020, 22:03

... oral and pharyngeal squamous cell carcinoma [20], cervical adenocarcinoma [21], hepatocellular carcinoma [22], and non-small cell lung carcinoma [23] In ESCC, NDRG1 abundance in carcinoma cells ... human malignancy and the sixth most common cause of cancer deaths worldwide [1] The standard treatment consists of surgical resection of locally advanced esophageal squamous cell carcinoma (ESCC) ... response of tumor cells and simultaneously reduce the effects of chemotherapy by enhancing cellular response to stress in various carcinoma cells [6] However, the correlation between the activity of

Ngày tải lên: 17/06/2020, 03:21

... Background Squamous cell carcinoma (SCC) of the hypopharynx is relatively rare and accounts for to 7% of all head and neck cancers [1–3] Notably, the hypopharyngeal SCC is a lethal disease and the ... (40/123), and 13.8% (17/123), respectively Of the cervical lymph node failure, 26 patients were isolated regional lymph node failure, were both nodal failure and local recurrence, and were both nodal ... Tianjin 300070, P.R China Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, P.R

Ngày tải lên: 17/06/2020, 11:40

... F, Teh MT Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma Oral Oncol 2010;46(7):536–42 Page of 10 20 Bustin SA, Benes V, Garson ... expressions of PLAU1 and FN1 on ovarian, lung and gastric cancers Similarly, high expression of CDCA5 were associated with poor prognosis of breast, lung and liver cancers Low expression of CRNN, ... defence and metastasis FN1 is also a downstream target of SATB1 oncogene and is up Qadir et al BMC Cancer (2019) 19:830 regulated in salivary ductal carcinoma [28], oesophageal squamous cell carcinoma

Ngày tải lên: 17/06/2020, 17:43

... correlation of cell density (positive cells/mm2) of Galectin (Gal3) positive cells and CD68, CD11c, CD163 and MRC1 expressing cells Results for the interfollicular zone (IFZ) and the sinuses of tumor-free ... The correlation of cell density (positive cells/mm2) of Galectin (Gal3) positive cells and CD68, CD11c, CD163 and MRC1 expressing cells Results for the epithelial compartment of oscc tumor resection ... Density of Gal3 positive cells in the interfollicular zone (IFZ) of lymph nodes of T2 tumors was significantly higher than in T1 carcinomas Furthermore, the ratio of Gal3 expressing cells and CD68

Ngày tải lên: 03/07/2020, 01:40

... a significant subset of head and neck tumors [10], and NRG1 expression is particularly enriched in squamous cell carcinoma of the head and neck (SCCHN) [11] Squamous cell carcinomas in general ... group and indication (FAS) Footnote: ESCC esophageal squamous cell carcinoma, PD progressive disease, Q2W once every two weeks, QW once weekly, SCCHN squamous cell carcinoma of the head and neck, ... survival [PFS], and duration of response) of LJM716, and to assess the emergence of antibodies against LJM716 Study design and treatment plan The study consisted of a dose-escalation and a doseexpansion

Ngày tải lên: 06/08/2020, 04:06

... proportion of cells with immuno-reactivity in a microscope field: 0, 0–10% of cells stained; 1, 10– 25% of cells stained; 2, 26–50% of cells stained; 3, 51– 75% of cells stained; 4, 76–100% of cells ... esophageal squamous cell carcinoma Biomed Res Int 2015; 2015:417210 Page 10 of 10 15 Song L, Wang X, Feng Z Overexpression of FOXM1 as a target for malignant progression of esophageal squamous cell carcinoma ... expression of EMT markers and EMT-related transcription factors through qRT-PCR and western blot, and also observed cell morphology changes by inverted microscope in RABL6 knockdown cells and control cells

Ngày tải lên: 06/08/2020, 05:18