nitrogen metabolism in experimental cancer

Excretory nitrogen metabolism in the chinese soft shelled turtle, pelodiscus sinensis

Ngày tải lên : 12/09/2015, 11:01

... we also aimed to determine indirectly whether increased protein degradation would occur in P sinensis during exposure to a progressive increase in ambient salinity, supplying FAAs and/or urea for ... protein to sustain protein turnover After the consumption of a protein-containing meal, free amino acids (FAAs) produced by the actions of proteases in the alimentary tract and peptidases in the intestinal ... feeding would lead to increases in FAAs, especially essential ones, in the brain of P sinensis, with special emphasis on whether a postprandial increase in glutamine content would occur Salinity...

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Nitrogen metabolism in the african lungfish, protopterus annectens, during aestivation air versus mud, and normoxia versus hypoxia

Ngày tải lên : 14/09/2015, 14:10

... Working together, GS, CPS III and OTC form citrulline in the matrix, which then exits the mitochondria Citrulline is converted to arginine via argininosuccinate synthetase and argininosuccinate ... a decrease in protein synthesis and an increase in protein degradation, resulting in muscle atrophy (Childs, 2003) However, a drastic increase in proteolysis, as in the case of fasting alone, ... first step in amino acid catabolism involves the removal of the α-amino nitrogen as ammonia For some amino acids, deamination involves specific deaminases, but many amino acids are deaminated through...

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The role of prion protein in breast cancer cell metabolism

Ngày tải lên : 12/10/2015, 17:36

... PrP in breast cancer metabolism in the study model Picture showing different lactate production in normal and cancer situation Schematic overview of the role of PrP in cancer metabolism in breast ... breast cancer cell lines (MCF7, SK-BR-3, and MDA-MB-231) Proliferation rate in breast cancer cell lines Up-regulation of p53 in breast cancer cell lines but not MCF7 Low PrP expression in breast cancer ... mTORC2 Mammalian target of rapamycin complex NAD+ Nicotinamide adenine dinucleotide II NADH Nicotinamide adenine dinucleotide (reduced) NADPH Nicotinamide adenine dinucleotide phosphate NCBI National...

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Báo cáo y học: "Effect of 1,25-dihydroxy-vitamin D3 in experimental sepss"

Ngày tải lên : 26/10/2012, 09:57

... protecting against DIC in experimental LPS-induced shock It has been argued that the experimental model of sepsis induced by infusion of LPS in high doses is unphysiological and differs from a clinical ... vitamin D3 against LPS-induced DIC but not against tissue-facter-induced DIC in rats Thromb Haemost 2001;85:287-90 Hemmingsen C, Staun M, Lewin E, Nielsen PK, Olgaard K Effects of vitamin D metabolites ... analogs on renal intestinal calbindin-D in the rat Calcified Tissue Int 1996;59:371-6 Hewison M, O`Riordan JLH Immunomodulatory and cell differentiation effects of vitamin D In: Vitamin D Feldman...

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Modeling ammonia-nitrogen degradation in a polluted stream with biofilm technique

Ngày tải lên : 05/09/2013, 09:38

... section Sampling and measuring (1) Sampling and measuring way: three times a month; (2) Sampling sections and points: sampling sections were set up in relative 0m (inlet of the contrast section), ... differentiating and counting, DO, velocity of flow, water level, temperature and pH MODELING AMMONIA -NITROGEN BIODEGRADATION Ammonia -nitrogen degradation in a created biofilm purification system Monitoring ... biofilm reacting district The degradation course of ammonia -nitrogen in biofilm can be divided into four stages: Ammonia -nitrogen diffuses to biofilm surface; Ammonia -nitrogen spread within biofilm...

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Tài liệu Clinical trials in gynecological cancer ppt

Ngày tải lên : 13/02/2014, 07:20

... utilizing erythropoietin in head and neck squamous cell carcinoma showed a decrease in local-regional 2007 IGCS and ESGO, International Journal of Gynecological Cancer 17, 547–556 Clinical trials in ... cervical cancer (ACRIN-6651)(4) While positron emission tomography (PET) scans appear promising in single-institution studies, multiinstitutional prospective studies are needed to ascertain their ... Italian Trials in Ovarian Cancer www.mito-group.it/ MRC—Medical Research Council www.mrc.ac.uk NCI—National Cancer Institute—ctep .cancer. gov NCIC-CTG—National Cancer Institute of Canada Clinical Trials...

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Tài liệu Guidance on Cancer Services Improving Outcomes in Breast Cancer pdf

Ngày tải lên : 14/02/2014, 22:20

... Clinical breast examination in primary care Each primary care team should include at least one practitioner who has had specific training in carrying out clinical breast examination (CBE) in ... overall increase in the incidence of both invasive and non-invasive breast cancer in England and Wales, the specific causes of which are unknown (Figure 1) Age-standardised incidence in the UK ... r1 Age group Source: Quinn et al1 Figure Breast cancer incidence and mortality, England and Wales, 1971-1997 Invasive incidence Non invasive incidence Mortality Screening introduced Rate per 100,000...

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Tài liệu Báo cáo khoa học: Time-dependent regulation analysis dissects shifts between metabolic and gene-expression regulation during nitrogen starvation in baker’s yeast doc

Ngày tải lên : 18/02/2014, 06:20

... proteolysis of ubiquitin-tagged proteins [41] Ubiquitination of proteins is catalysed by three enzymes: ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2) and ubiquitin protein ligase (E3) ... Table S1 C-ﬂux in mmolÆCÆmin)1ÆgÆprotein)1 during fermentative capacity assay in samples from the nitrogen- starvation experiments Table S2 C-ﬂux in mmolÆCÆmin)1ÆgÆprotein)1 during fermentative ... differences in the degradation rates of the corresponding proteins, there are two main scenarios Either, some proteins are hidden from the proteindegradation machinery or this machinery recognizes...

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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx

Ngày tải lên : 18/02/2014, 14:20

... phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase Biochemistry 46, 10170– ... glucosylceramide synthase; SMS, sphingomyelin synthase; SMse, sphingomyelinase; SPT, serine palmitoyl transferase Yellow represents enzymes directly involved in ceramide metabolism, in which mutations are ... post-lysosomal destinations Cells from NPC subjects show a decrease in acid sphingomyelinase activity, leading to the accumulation of sphingomyelin [27] Because one of the pathways for ceramide recycling is...

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Tài liệu Báo cáo khoa học: Implication of the glutamine synthetase ⁄glutamate synthase pathway in conditioning the amino acid metabolism in bundle sheath and mesophyll cells of maize leaves doc

Ngày tải lên : 18/02/2014, 18:20

... serine and glycine was reduced from 33% in the light to 25% in the dark (Fig 7A) Glutamine and asparagine were the major amino acids in the xylem sap in both the light (63% of the total amino ... hybridized in situ with the digoxigenin (DIG)-labelled antisense GLU mRNA probe Staining was found in the cytoplasmic layers of BSCs (Fig 4A) No positive staining was detected in the BSCs using the ... amino acid) were found to be the main nitrogen compounds in the phloem exudates, amounting to 51% of the total amino acids in the light and 56% in the dark (Fig 7A) The total amount of alanine,...

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Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc

Ngày tải lên : 19/02/2014, 16:20

... NADPÆmin)1Æmg protein)1 Determination of maintenance In order to calculate the amount of glucose used for maintenance, the wild-type strain A26 was used Four 100-mL aliquots of glucose minimal ... acetate to the media containing glucose and propionate, the growth rate of both strains increased and the effect of propionate became less apparent Finally, in media containing acetate and propionate ... cells), even in the mutant strain Determination of the intracellular volume In order to obtain the intracellular concentration of accumulated acyl-CoA esters, it was necessary to know the internal...

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Tài liệu Báo cáo khoa học: Elementary modes analysis of photosynthate metabolism in the chloroplast stroma ppt

Ngày tải lên : 20/02/2014, 23:20

... thioredoxin system [10,11] Thioredoxin is a small, redox active protein, capable in turn of reducing or oxidizing disulphide bonds in proteins In chloroplasts, thioredoxin is reduced by ferredoxin, ... in which the regulatory cysteines were mutated to serines, rendering the resulting product insensitive to thioredoxin (unpublished data) Such a change will impact in two ways on the system: in ... and/or measured in the complete absence of experimental error The disadvantages of kinetic modelling stem primarily from the uncertainty in the deﬁnition of the kinetics, both in terms of the...

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Radiogenomics in gynecological cancer patients doc

Ngày tải lên : 05/03/2014, 13:20

... Colorectal Cancer HPV: Human Papillomavirus HR: Homologous Recombination IARC: International Agency for Research on Cancer IFNγ: Interferon-γ IGF1: Insulin-like Growth Factor-1 IL: Interleukin IMRT: Intensity ... contributing factors Cervical cytology screening programs have led to a reduction in the incidence and mortality in the developed world Prophylactic HPV vaccines protect against persistent infection in ... identified sexual factors, particularly HPV infection, as increasing risk for vulvar cancer Smoking also increases the risk by interacting synergistically with HPV infection No apparent cause or associated...

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Trends in Childhood Cancer Incidence in the U.S. (1992–2004) pdf

Ngày tải lên : 06/03/2014, 02:21

... changed in magnitude and/or direction during the period 1992 through 2004, allowing a maximum of joinpoints and a minimum of years between consecutive joinpoints and between joinpoints and endpoints.9,14,15 ... minor changes in coding that may have impacted trends slightly beginning in 2001 The results of the current study indicate that incidence rates for pediatric cancers overall have marginally increased ... Childhood Cancer Incidence Trends/Linabery et al 429 by joinpoints were observed with respect to retinoblastoma rates in males; these patterns were not observed in females Hodgkin disease (HD) declined...

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Progress in Cervical Cancer Prevention: The CCA Report Card pot

Ngày tải lên : 06/03/2014, 02:21

... Organization Countries Using HPV Vaccines in 2010 PowerPoint slide In: CCA Webinars, HPV vaccination in developing countries October 21, 2010 • European Cervical Cancer Association Vaccination Across ... international donor provides financial resources for the scaling up of screening and treatment programs in the lowest-income countries The challenge of establishing the infrastructure, training ... persistent infection with these types of HPV indicate an important risk factor for cervical pre -cancer and cancer Increasingly available in high-income settings, current HPV DNA testing platforms...

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Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf

Ngày tải lên : 06/03/2014, 09:22

... -(CH2)3- with a terminal cationic nitrogen- containing group such as diethylamine, pyrrolidine or piperidine Structure-based drug discovery does have these few structures as starting points [42–47], ... effect in a telomere level should not be ruled out In vivo data on the recently described quadruplex-binding ﬂuoroquinolone derivative Quarﬂoxin (CX-3543) is included It is currently in clinical ... selective inhibition of cell growth, with normal human cell lines being relatively unaffected; (d) senescence; (e) inhibition of telomerase activity in cells; (f) competitive inhibition of hPOT1 binding...

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Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf

Ngày tải lên : 07/03/2014, 03:20

... maintained in RPMI-1640 containing 10% heat-inactivated newborn bovine serum (SiJiQing, Hangzhou China) at 37° C in a humidiﬁed atmosphere of 5% CO2 and 95% air Double immunoﬂuorescence staining ... of 575 nm (A) Fluorescence intensity analysis of intracellular adriamycin in gastric cancer cells (B) Adriamycin releasing index of gastric cancer cells The releasing index = (accumulation value ... PI3K/Akt signaling pathway may lead to inhibition of the MDR induced by PrPC in gastric cancer cells The mechanism underlying PI3K/Akt-mediated PrPC-induced MDR in gastric cancer was further investigated...

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Báo cáo khoa học: Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells Soumen Bera1, Theo Wallimann2, Subhankar Ray1 and Manju Ray1 potx

Ngày tải lên : 07/03/2014, 04:20

... estimation of proline and ornithine J Biol Chem 199, 91–95 45 Van Pilsum JF, Martin RP, Kito E & Hess J (1956) Determination of creatine, creatinine, arginine, guanidinoacetic acid, guanidine, and methyl-guanidine ... arginase and ornithine in malignant tumors of the human skin J Lab Clin Med 137, 340–344 23 Singh R, Pervin S, Karimi A, Cederbaum S & Chaudhuri G (2000) Arginase activity in human breast cancer ... arginase I and ODC direct ornithine towards polyamine synthesis and the mitochondrial enzymes arginase II and ornithine aminotransferase favor the channeling of ornithine to proline ⁄ glutamine...

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Báo cáo khoa học: The in vitro effects of CRE-decoy oligonucleotides in combination with conventional chemotherapy in colorectal cancer cell lines potx

Ngày tải lên : 07/03/2014, 15:20

... that CDO alone did not increase the extent of staining However, in cells that had been cocultured with CDO and a cytotoxic drug, staining was signiﬁcantly increased, indicating the presence of senescence ... provide a possible model of drug interaction in GEO cells, which involves the complex interaction of proteins involved in cell cycle regulation To recapitulate, combining CDO with cytotoxic chemotherapy ... CRE-decoy treatment reduces cyclin D1 and cyclin-dependent kinase (CDK) levels and retinoblastoma protein (Rb) phosphorylation CDO-induced growth inhibition was independent of p53 status [18,19],...

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Báo cáo khoa học: Protective effect of dietary curcumin and capsaicin on induced oxidation of low-density lipoprotein, iron-induced hepatotoxicity and carrageenan-induced inﬂammation in experimental rats ppt

Ngày tải lên : 08/03/2014, 08:20

... capsaicin (saline-injected); 6, capsaicin (Fe2+-injected); 7, curcumin + capsaicin (saline-injected); 8, curcumin + capsaicin (Fe2+-injected) 4530 on curcumin, capsaicin or curcumin + capsaicin, the anodic ... LDL in different diet groups oxidized in vivo by iron(II) 1, Control (Fe2+-injected); 2, control (saline-injected); 3, curcumin (saline-injected); 4, curcumin (Fe2+-injected); 5, capsaicin (saline-injected); ... were injected with mL saline or FeSO4 in mL saline (30 mg per kg body weight) h before death Alanine aminotransferasea Aspartate aminotransferasea Treatment Saline-injected Fe2+-injected Saline-injected...

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