nitrogen metabolism in clinical cancer
Excretory nitrogen metabolism in the chinese soft shelled turtle, pelodiscus sinensis
Ngày tải lên :
12/09/2015, 11:01
... we also aimed to determine indirectly whether increased protein degradation would occur in P sinensis during exposure to a progressive increase in ambient salinity, supplying FAAs and/or urea for ... feeding would lead to increases in FAAs, especially essential ones, in the brain of P sinensis, with special emphasis on whether a postprandial increase in glutamine content would occur Salinity ... protein to sustain protein turnover After the consumption of a protein-containing meal, free amino acids (FAAs) produced by the actions of proteases in the alimentary tract and peptidases in the intestinal...
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Nitrogen metabolism in the african lungfish, protopterus annectens, during aestivation air versus mud, and normoxia versus hypoxia
Ngày tải lên :
14/09/2015, 14:10
... Working together, GS, CPS III and OTC form citrulline in the matrix, which then exits the mitochondria Citrulline is converted to arginine via argininosuccinate synthetase and argininosuccinate ... a decrease in protein synthesis and an increase in protein degradation, resulting in muscle atrophy (Childs, 2003) However, a drastic increase in proteolysis, as in the case of fasting alone, ... first step in amino acid catabolism involves the removal of the α-amino nitrogen as ammonia For some amino acids, deamination involves specific deaminases, but many amino acids are deaminated through...
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Tài liệu Clinical trials in gynecological cancer ppt
Ngày tải lên :
13/02/2014, 07:20
... utilizing erythropoietin in head and neck squamous cell carcinoma showed a decrease in local-regional 2007 IGCS and ESGO, International Journal of Gynecological Cancer 17, 547–556 Clinical trials in ... valuable information for first-line therapy Infrastructure for clinical trials In the remainder of the article, we have set forward our thoughts on infrastructure issues to support clinical trials ... with carcinosarcoma (CS) nor what the 2007 IGCS and ESGO, International Journal of Gynecological Cancer 17, 547–556 Clinical trials in gynecological cancer optimal surgical staging should include...
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Báo cáo hóa học: " Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer" potx
Ngày tải lên :
18/06/2014, 16:20
... SQ participated in acquiring clinical samples and follow-up clinical information MSC participated in study design and coordination, data analysis and interpretation and final writing of the manuscript ... exist within the individual gene promoters for certain genes in lung cancer carcinomas MS-MLPA is only based on a single CpG site compared to an average of 4-6 CpG sites in MS-PCR assays Since only ... rearrangements and germline epimutations in Lynch syndrome Int J Cancer 2009, 124(10):2333-40 Buyru N, Altinisik J, Ozdemir F, Demokan S, Dalay N: Methylation profiles in breast cancer Cancer Invest 2009,...
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báo cáo khoa học: "Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients" pot
Ngày tải lên :
09/08/2014, 01:24
... invasion begins with inflammation around cancer cells Thus, it has been reported that serum CRP levels are higher in cases of invasive cancer than in cases of non-invasive cancer [8,9] The principal ... significance of interleukin serum levels in patients with ovarian cancer Br J Cancer 1995, 71:354-356 De Vita F, Orditura M, Auriemma A, Infusino S, Roscigno A, Catalano G: Serum levels of interleukin as ... interleukin-18 in gastric cancer patients World J Gastroenterol 2006, 12:4473-4477 21 Lin MT, Lin BR, Chang CC, Chu CY, Su HJ, Chen ST, Jeng YM, Kuo ML: IL-6 induces AGS gastric cancer cell invasion...
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Báo cáo khoa học: "Clinical efficacy and problems with CT lymphography in identifying the sentinel node in breast cancer" docx
Ngày tải lên :
09/08/2014, 07:21
... detailed investigation Our results showed that there was a single route leading to a single SN in 68% of the patients, multiple routes leading to a single SN in 4%, a single route leading to multiple ... Vries J: Lymphatic mapping with intralesional tracer administration in breast carcinoma patients Cancer 2000, 88:2546-2552 Leong SPL: Selective sentinel lymph node mapping and dissection for ... dye-guided Table 5: Number of lymph vessels leading to Sentinel nodes and the number of Sentinel nodes Single rout and Single node Multi routs and single node Single rout and multi nodes Multi routs and...
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Báo cáo khoa học: "Evaluation of clinical, laboratory and morphologic prognostic factors in colon cancer" ppsx
Ngày tải lên :
09/08/2014, 07:21
... in distinguishing T1 and T2 lesions The cancer was found in the ileocecal junction of 11 patients (11.9%), in ascending colon of 14 patients (15.2%), in transverse colon of subjects (8.7%), in ... often intriguing and conflicting [4,5] Actually, most studies investigating prognostic factors for large bowel cancers did not distinguish between the subpopulation of colon and rectal cancer, ... factors in multivariable analysis Mulcahy et al [15] found a trend for prognostic significance of vascular invasion in rectal but not in colonic cancers Accordingly, in our experience the pT staging...
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Báo cáo khoa học: "Combined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high-dose radiotherapy" pdf
Ngày tải lên :
09/08/2014, 09:20
... observed Initial DNA damage levels in breast cancer patients Radiation-induced apoptosis in breast cancer patients Initial DNA damage was determined as radiationinduced double-strand breaks (DSB) in ... performed in a FACScalibur (Becton Dickinson, San José, CA) using a 488 nm argon laser, and each sample was analyzed in a Macintosh Quadra 650 minicomputer (Apple computer Inc., Cupertino, CA) ... Annexin-V-FITC and 10 μl of propidium iodure (PI), cells were incubated during 15 minutes at room temperature in the dark Finally, 400 μl of Annexin V buffer Kit were added Every assay was made in...
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báo cáo khoa học: "Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents" ppt
Ngày tải lên :
10/08/2014, 22:20
... to have insufficient activity for further investigation in this patient population [96] Clinical trial in lung cancer exhibited minimal clinical efficacy Nineteen patients with lung cancer refractory ... with ionizing radiation and other DNA-damaging agents in pre -clinical studies [75] Recent pre -clinical data have suggested that it may act, in part, by inhibiting DNA repair resulted in a synergistic ... lymphocytic leukemia, prostate cancer, bladder cancer, head and neck squamous carcinomas and ovarian cancer cells in preclinical studies [118-126] In a phase I clinical trial, forty-six patients...
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Báo cáo y học: "Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough" potx
Ngày tải lên :
13/08/2014, 10:20
... combined with clinical experience in an attempt to provide a sensible approach to the clinician and guide practice in a field with minimal evidence 2.3 Clinical consultation of the guidelines ... of findings Lung cancer patients, N = trials from Cochrane systematic review in cancer [12]** Brachytherapy in addition to EBRT resulted in higher improvements in cough at doses of 15 Gy in fractions; ... comfortable having these guidelines applied in their hospital (= 4) The likelihood of using these guidelines in the reviewers’ own practice was explored with a singleitem scale ranging from = ‘not...
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Clinical reference of tumour infiltrating lymphocytes in colorectal cancer
Ngày tải lên :
03/10/2015, 20:57
... Genotyping SNP genotyping in clinical samples were carried out using the MassArray iPLEX genotyping platform (Sequenom, San Diego, CA) according to manufacturer‟s instructions SNPs, consisting of ... different amino acid or premature stop codon respectively For SNPs that are not in the proteincoding regions, they may still contribute to changes in gene splicing, transcription binding or affect ... The available clinical and pathological information included gender, age, tumour size, tumour stage (AJCC), histological grade, vascular invasion, perineural invasion, and lymphatic invasion Survival...
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The role of prion protein in breast cancer cell metabolism
Ngày tải lên :
12/10/2015, 17:36
... PrP in breast cancer metabolism in the study model Picture showing different lactate production in normal and cancer situation Schematic overview of the role of PrP in cancer metabolism in breast ... breast cancer cell lines (MCF7, SK-BR-3, and MDA-MB-231) Proliferation rate in breast cancer cell lines Up-regulation of p53 in breast cancer cell lines but not MCF7 Low PrP expression in breast cancer ... mTORC2 Mammalian target of rapamycin complex NAD+ Nicotinamide adenine dinucleotide II NADH Nicotinamide adenine dinucleotide (reduced) NADPH Nicotinamide adenine dinucleotide phosphate NCBI National...
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Modeling ammonia-nitrogen degradation in a polluted stream with biofilm technique
Ngày tải lên :
05/09/2013, 09:38
... section Sampling and measuring (1) Sampling and measuring way: three times a month; (2) Sampling sections and points: sampling sections were set up in relative 0m (inlet of the contrast section), ... differentiating and counting, DO, velocity of flow, water level, temperature and pH MODELING AMMONIA -NITROGEN BIODEGRADATION Ammonia -nitrogen degradation in a created biofilm purification system Monitoring ... biofilm reacting district The degradation course of ammonia -nitrogen in biofilm can be divided into four stages: Ammonia -nitrogen diffuses to biofilm surface; Ammonia -nitrogen spread within biofilm...
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The use of hypothesis-testing statistics in clinical trials
Ngày tải lên :
01/11/2013, 11:20
... often intuitively more understandable by clinicians Thus, it is typical for a clinical treatment study in psychiatry to be designed mainly 46 Chapter 8: Clinical trials to describe a change in depressive ... analyses in such a large sample The primary outcome of the study was a comparison of aspirin versus streptokinase for prevention of myocardial infarction, with a finding in favor of aspirin In subgroup ... kind of measurement, such as points on a depression rating scale This measurement can be defined in various ways; for example, it can reflect the actual change in points on a depression rating...
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Tài liệu Guidance on Cancer Services Improving Outcomes in Breast Cancer pdf
Ngày tải lên :
14/02/2014, 22:20
... age Clinical breast examination in primary care Each primary care team should include at least one practitioner who has had specific training in carrying out clinical breast examination (CBE) in ... overall increase in the incidence of both invasive and non-invasive breast cancer in England and Wales, the specific causes of which are unknown (Figure 1) Age-standardised incidence in the UK ... r1 Age group Source: Quinn et al1 Figure Breast cancer incidence and mortality, England and Wales, 1971-1997 Invasive incidence Non invasive incidence Mortality Screening introduced Rate per 100,000...
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Tài liệu INSIDER’S GUIDE TO GRADUATE PROGRAMS IN CLINICAL AND COUNSELING PSYCHOLOGY doc
Ngày tải lên :
15/02/2014, 15:20
... University of Wisconsin University of Missouri Yale University committed to research training and to the integration of such training with clinical training.” APCS includes 43 clinical psychology ... “application year” in the Time Line (Appendix A) Returning Master’s-Level Clinicians Some of you will be master’s-level clinicians interested in obtaining the doctorate in clinical or counseling psychology ... mistake of accumulating a wealth of clinical experiences at the expense of gaining research training By doing so, you may be inadvertently presenting yourself as being uninterested in research or...
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Tài liệu Báo cáo khoa học: Time-dependent regulation analysis dissects shifts between metabolic and gene-expression regulation during nitrogen starvation in baker’s yeast doc
Ngày tải lên :
18/02/2014, 06:20
... proteolysis of ubiquitin-tagged proteins [41] Ubiquitination of proteins is catalysed by three enzymes: ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2) and ubiquitin protein ligase (E3) ... Table S1 C-flux in mmolÆCÆmin)1ÆgÆprotein)1 during fermentative capacity assay in samples from the nitrogen- starvation experiments Table S2 C-flux in mmolÆCÆmin)1ÆgÆprotein)1 during fermentative ... constant during nitrogen starvation In cells shifted to glucose excess in the presence of nitrogen, the total protein in the cultures increased with time (Student’s t-test, P < 0.05) In both cultures,...
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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx
Ngày tải lên :
18/02/2014, 14:20
... phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase Biochemistry 46, 10170– ... glucosylceramide synthase; SMS, sphingomyelin synthase; SMse, sphingomyelinase; SPT, serine palmitoyl transferase Yellow represents enzymes directly involved in ceramide metabolism, in which mutations are ... post-lysosomal destinations Cells from NPC subjects show a decrease in acid sphingomyelinase activity, leading to the accumulation of sphingomyelin [27] Because one of the pathways for ceramide recycling is...
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Tài liệu Báo cáo khoa học: Implication of the glutamine synthetase ⁄glutamate synthase pathway in conditioning the amino acid metabolism in bundle sheath and mesophyll cells of maize leaves doc
Ngày tải lên :
18/02/2014, 18:20
... serine and glycine was reduced from 33% in the light to 25% in the dark (Fig 7A) Glutamine and asparagine were the major amino acids in the xylem sap in both the light (63% of the total amino ... hybridized in situ with the digoxigenin (DIG)-labelled antisense GLU mRNA probe Staining was found in the cytoplasmic layers of BSCs (Fig 4A) No positive staining was detected in the BSCs using the ... amino acid) were found to be the main nitrogen compounds in the phloem exudates, amounting to 51% of the total amino acids in the light and 56% in the dark (Fig 7A) The total amount of alanine,...
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Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc
Ngày tải lên :
19/02/2014, 16:20
... NADPÆmin)1Æmg protein)1 Determination of maintenance In order to calculate the amount of glucose used for maintenance, the wild-type strain A26 was used Four 100-mL aliquots of glucose minimal ... acetate to the media containing glucose and propionate, the growth rate of both strains increased and the effect of propionate became less apparent Finally, in media containing acetate and propionate ... cells), even in the mutant strain Determination of the intracellular volume In order to obtain the intracellular concentration of accumulated acyl-CoA esters, it was necessary to know the internal...
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