nitrite and nitrate in human breast milk implications for development
Báo cáo sinh học: "Multiplex Zymography Captures Stage-specific Activity Profiles of Cathepsins K, L, and S in Human Breast, Lung, and Cervical Cancer" potx
... Cathepsins K, L, and S in Human Breast, Lung, and Cervical Cancer Binbin Chen and Manu O Platt* Abstract Background: Cathepsins K, L, and S are cysteine proteases upregulated in cancer and proteolyze ... All human recombinant cathepsins were from Enzo Life Sciences (Plymouth Meeting, PA) Human cathepsins K and S were expressed in insect cells, human cathepsin V was expressed in NSO cells, and human ... per 10 μg breast tissue protein was determined by loading increasing doses of recombinant cathepsins K and L in the same gel as the breast cancer and normal specimens to generate a standard curve...
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The search for stem cell in human breast milk
... system in human milk by binding to cholera and other toxins (Laegreid et al 1986) 1.3.3 Proteins Human milk proteins are a source of peptides, amino acids and nitrogen for the infant, but also in ... adjustment, for instance, a slight increase in food intake or a slight increase in weight loss, is needed to compensate for the increase Chapter Introduction in metabolic needs for secretion of breast milk ... 1997) In addition to being a mitogen for T lymphocytes in culture (by induction of interleukin-2 and interleukin-2 receptors (Ellis and Picciano 1992; Grosvenor et al 1993), milk- borne prolactin...
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Báo cáo khoa học: " Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation" pps
... suspend treatment of the spine temporarily while treatment of the brain continues Since the brain and spine are in communication via the cerebrospinal fluid, holding treatment in one compartment may ... γf and γt, as described above The value for Qf, the volumetric flow rate and the spine and brain CSF volumes are taken from Bergsneider [12] The values used for the volumes of the brain and spine ... kshedNb,t,i+γfkadhNb,f,i)] where Ds and Db are the doses administered in a single fraction to the spinal and brain compartments, respectively Scenario I In this scenario (Figure 3), results following a standard course...
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Báo cáo y học: "RhoA signaling modulates cyclin D1 expression in human lung fibroblasts; implications for idiopathic pulmonary fibrosis" ppsx
... factors for hours for gene expression analysis and 24 hours for protein expression studies The chosen time points and concentrations of growth factors were determined and established in previous and ... Cyclin D1 34Kda GAPDH 36Kda Lane Figure Expression of cyclin D1 mRNA and protein in human lung fibroblasts; response to fibrogenic growth factors Expression of cyclin D1 mRNA and protein in human ... expression and induction in cyclin D1 protein, reflecting results of cyclin mRNA expression A representative blot from one of the IPF derived cell lines is shown in Fig 2c Data shown in fig 2a, 2b and...
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Effective and coordination in Lao PDR Policy Implications for power sector development.PDF
... mechanisms for streamlining aid coordination The government made institutional adjustments for aid coordination in 2004, transferring the function to the Ministry of Foreign Affairs The Department of International ... competent people working on the agenda, Laos needs to improve the local capacity Funding for training such as English language training, report writing and basic specialized trainings in order to support ... SWGs for energy and mining The review of continuous effort to improve SWGs, it continues to recommends 19 To clarify roles and responsibilities of SWGs That includes the linkages in the NGPES and...
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Tài liệu Human Breast Milk: Current Concepts of Immunology and Infectious Diseases pptx
... certain hormones in breast milk, such as erythropoietin, leptin, and melatonin, is speculative at this time.85 The list of bioactive factors contained in human breast milk is incomplete because investigators ... intake is breast milk) Breastfeeding primarily for comfort; nonnutritive, for short periods of time or infrequent Infant has never ingested any human milk breast milk will also provide the infant ... are breast milk, in combination with other nutrient foods and nonhuman milk (20–80% of nutritional intake is human breast milk) Low partial Almost no feeds are breast milk (less than 20% of intake...
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Báo cáo khoa học: "Real time PCR analyses of expression of E-cadherin, alpha-, beta- and gamma-catenin in human breast cancer for predicting clinical outcome" pps
... cut-offs for positivity and negativity We determined the expression of E-cadherin, α-, β- and γcatenin in human breast carcinomas using real time quantitative polymerase chain reaction and investigated ... relationship of E-cadherin, α-catenin, β-catenin and γ-catenin in breast tumours to Nottingham Prognostic Index (NPI) (E-cadherin p = 0.094, αcatenin p = 0.144, β-catenin p = 0.378, γ-catenin p = 0.131) ... following invasion and degradation of surrounding matrix, and migration into the vasculature and surrounding tissue, E-cadherin catenin complex is reintroduced and cells adhere to the vasculature and...
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The functional investigation of forkhead factor FOXQ1 in human breast and colon cancers
... parsed into three distinct biological settings In a 2007 meeting in Poland and a 2008 meeting in Cold Spring Harbor Laboratory, the suggestion of EMT subtypes were well discussed and divided into ... highest rates being estimated in Australia/New Zealand and Western Europe, the lowest in Africa (except Southern Africa) and South-Central Asia, and are intermediate in Latin America Incidence rates ... Kalluri and Weinberg 2009; Zeisberg and Neilson 2009) EMT not only occurs in gastrulation during early embryo development and generation of new fibrosis during wound healing and tissue inflammation,...
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Tài liệu Báo cáo khoa học: Role for nectin-1 in herpes simplex virus 1 entry and spread in human retinal pigment epithelial cells docx
... time points and stained for F-actin (red) The GFP intensity (representing virus production) increased significantly over time, as seen pictorially in Fig 3A–E and in graphical form in Fig 3F Infection ... changes in the cytoskeleton that may occur during the initial h window of infection We infected RPE cells with K26GFP [27], and stained cells for F-actin, using phalloidin at 30 and h postinfection, ... to fully understand HSV-1 infection of all target cells, including RPE cells, our study provides new starting points for understanding viral pathogenesis in the retina and advancing novel therapies...
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Tài liệu Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking pdf
... required for proper folding, trafficking and ligand-mediated signaling but not for ligand binding [37,40] The complete loss in the constitutive activity of the Ó FEBS 2003 Role of cleavage and shedding ... protein coupling, internalization, recycling) is not triggered by only one well-defined conformation, but by a continuum of independent conformations [41,45] In conclusion, cleavage and shedding ... (0–60 min) at 37 °C The concentration of the biotinylated Ig remaining on the cell surface was then quantified by measuring the binding of [125I]Streptavidin In the absence of bTSH, a very weak internalization...
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Báo cáo khoa học: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract Implications for Parkinson’s disease docx
... studies including investigations in human tissues, and that this has implications for how to interpret the role of the studied enzymes in health and disease Results The distribution and relative intensity ... Adh4 is found in the epithelial lining of upper GI tract including the tongue, esophagus and stomach, but not in the small and large intestines In the rat, Aldh1 is present higher up in the GI tract ... the villi and in the intestinal glands, while submucosal glands were empty In jejunum and ileum, Adh1 1214 mRNA showed a similar expression pattern as described for duodenum In colon and rectum,...
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Rural and Micro Finance Regulation in Ghana: Implications for Development and Performance of the Industry ppt
... ratio for deposit-taking NBFIs and 10:1 gearing ratio for non-deposit-taking NBFIs); define individual and group-based loans for microfinance and small business, with single-borrower limits for individual ... planning, financial planning and budgeting, and microenterprise development Group members make mandatory savings contributions for at least three months before qualifying for a loan Increasing ... microfinance and innovating in commercial- informal financial linkages; and a challenge to the supervisory authorities in applying the regulatory guidelines to ensure discipline as well as innovation...
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Báo cáo khoa học: Superoxide radical-scavenging effects from polymorphonuclear leukocytes and toxicity in human cell lines of newly synthesized organic selenium compounds potx
... antinociceptive, neuroprotective and anti -in ammatory properties in different experimental models [30–35] Ebselen inhibits leukocyte in ltration and activation, leading to elimination of H2O2 in ... cytotoxicity against some human cell lines, such as human keratinocytes (HaCaT cells), human embryo lung fibroblast cells (HEL cells), human nasopharyngeal carcinoma cells (HEp-2 cells) and PMNs in vitro ... excessive in ammation, leading to cell and tissue damage [13,14] In extreme instances, such as endotoxin shock, neutrophils kill the infected host [15] It is therefore important to eliminate ROS...
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Báo cáo khoa học: K4, K9 and K18 in human histone H3 are targets for biotinylation by biotinidase pdf
... allow for easier identification of biotinylated lysines in histone H3: N1)9 (including K4 and K9), N9)16 (including K9 and K14), N16)23 (including K18 and K23), and N18)25 (including K18 and K23); ... Biotinylation sites in human histone H3 K Kobza et al lysines, arginines, serines, and glutamates in the amino terminus are targets for acetylation, methylation, phosphorylation, ubiquitination, ... alanine (peptide R8A6)13) biotinylation increased considerably, suggesting that unmodified arginines interfere with biotinylation of lysines by biotinidase Substitution of arginine with ornithine...
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Báo cáo khóa học: Ouabain stimulates endothelin release and expression in human endothelial cells without inhibiting the sodium pump Robert Saunders and Georgios Scheiner-Bobis pptx
... liquid-scintillation counting The 86Rb+ activity was normalized against the amount of protein [13] per well 86 Rb+ uptake was also investigated after preincubating the cells for 15 with lM protein kinase ... ouabain treatment Ouabain was added to the cells at various concentrations in fresh ECGM0.5, and the cells incubated for an additional 12 h For counting, cells were detached and dispersed in trypsin/ ... ouabain exposure was investigated by Western blotting using an antibody against the phosphorylated form of p44/p42 MAP kinase Using this method, MAP kinase activation was clearly detectable in...
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báo cáo sinh học:" Continuity and change in human resources policies for health: lessons from Brazil" docx
... attracting and retaining health staff in remote and/ or rural areas, tackling staff mal-distribution and over-specialisation, particularly in the physician workforce, retaining and motivating health ... respond to primary care demands within SUS PROFAE 2002/2007 Aimed at expanding training of nurse technicians and nursing aides PROMED 2003/ Aimed at financing curricular reform in medical schools directed ... HRH mobility (including internationally within Mercosul and Latin America); (iii) the development of guidelines for planning and execution of the Work Management National Policy for SUS; (iv)...
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báo cáo hóa học:" Augmented inhibition of angiogenesis by combination of HER2 antibody chA21 and trastuzumab in human ovarian carcinoma xenograft" pptx
... phosphorylates downstream substrates and activates a variety of signaling cascades, including the phosphatidylinositol-3 kinase (PI3K)/serine/threoninespecific protein kinase (AKT), and it regulates various ... especially in tumor growth, and angiogenesis [15] In a previous study, we had found chA21 monotherapy could inhibit human ovarian carcinoma cell line SKOV-3 growth in vitro and in vivo [16] In this ... potency on inhibiting the AKT It may partly explain our findings that the combination of chA21 with trastuzumab could synergistically enhance the in vitro and in vivo anti-angiogenesis effects In conclusion,...
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báo cáo hóa học:" Quality of data collection in a large HIV observational clinic database in sub-Saharan Africa: implications for clinical research and audit of care" docx
... (age and CD4+ cell count) Table Number and incidence rates of opportunistic infections in the initial 24 months after ART initiation, and percent underreporting of OI events in routine clinic ... discontinuation and modification This gives a total error rate (comprising missing and incorrect items) of 67% for OIs, 52% for ART-related toxicities, and 83% and 58% for ART discontinuation ... patients in the routine clinic database who also initiated ART between April 2004 and April 2005, and who were not enrolled into the research cohort; and the 6421 patients in the routine clinic database...
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Báo cáo khoa học: "Comparison of immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) assessment for Her-2 status in breast cancer" ppsx
... of breast cancer in Guilin city of China The specimens were fixed in 10% neutral-buffered formalin (pH7.4) for 24 hours Only cases with sufficient invasive carcinoma for multiple assays were included ... methods used in clinical diagnosis, and certain kits or antibodies are approved by the FDA (U.S Food and Drug Administration) IHC is easy to perform and relatively cheap, and is predominantly used ... results, including variability in tissue fixation and processing, variable sensitivity and specificity of commercially available antibodies, and differences in scoring criteria with considerable interobserver...
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