nitrate nitrite nitric oxide pathway and the metabolic syndrome
Epidemiology of palsma lipids and the metabolic syndrome in multi ethnic population
Ngày tải lên :
12/09/2015, 10:42
... with the metabolic syndrome, these studies cast important light on some of the pathways involved in the pathophysiology of the metabolic syndrome 8 LIST OF TABLES Table Definitions of the metabolic ... increase in the risk of CVD in the Singapore population Over half of the CVD events occurring in our population are attributable to the metabolic syndrome We further show that the metabolic syndrome ... in Asian 68 populations on the association between the metabolic syndrome and ischemic heart disease 4.2 The role of central obesity in the definition the metabolic syndrome 74 4.3 Study 4: Disordered...
- 148
- 248
- 0
Báo cáo khoa học: Nitric oxide formation from the reaction of nitrite with carp and rabbit hemoglobin at intermediate oxygen saturations pdf
Ngày tải lên :
16/03/2014, 06:20
... saturation during the reaction The data revealed that the reactivity is dynamically inuenced by oxygen afnity and the allosteric equilibrium between the T and R states, and that the deoxyHb reaction ... contamination [25] or the formation of reaction intermediates other than metHb and HbNO [26] In carp and rabbit there was practically equal formation of metHb and HbNO, and the sum of metHb and HbNO concentrations ... metHb and nitrate [30] Only in the present case will the Hb oxidation be both NO-mediated and nitrite- mediated, as a result of the presence of nitrite It may also be considered that part of the...
- 13
- 462
- 0
Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
Ngày tải lên :
07/08/2014, 14:23
... D.J., Minc-Golomb, D and Schwartz, J.P Synthesis of nitric oxide in CNS glial cells T.I.N.S 1993, 16, 323-328 13 Nathan, C and Xie, Q.-W Nitric oxide synthases: Roles, tolls and controls Cell 1994, ... H., Fatzer, R., Vandevelde, M and Zurbriggen, A Comparison of inducible nitric oxide synthase expression in the brain of Listeria monocytogenes-infected cattle, sheep and goats and in macrophages ... iNOS and nNOS in the same lesion Materials and Methods Selection of cases Two cases of goats with natural listeriosis (6 months old and 2.5 years old) (Cases and 2) and two controls (1 and years...
- 4
- 437
- 0
Báo cáo y học: "Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13" docx
Ngày tải lên :
09/08/2014, 14:20
... of the morphometric analysis The superficial zone of cartilage corresponds to the superficial and the upper intermediate layers, and the deep zone to the lower intermediate and deep layers The ... Osteophytes The incidence and size of the osteophytes were similar for both groups, with a mean size of 4.77 ± 0.32 mm (mean ± standard error of the mean) for the placebo group and 5.24 ± 0.30 mm for the ... MMP-13 synthesis could explain the prevention of OA cartilage lesion development as well as the protective effect of ASU on the erosion of the calcified cartilage [19] On the other hand, ASU were...
- 9
- 547
- 0
Báo cáo y học: "Hyaluronan modulates accumulation of hypoxiainducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model" potx
Ngày tải lên :
12/08/2014, 17:21
... injection was performed on the lateral side of the tibiotarsal joint, and the transducer in the sagittal plane showed the distal end of the tibia and proximal part of the tarsus in the image plane Needle ... iNOS, and MMP3 Overexpressions of HIF-1a, iNOS, and MMP3 immunoreactivities were found within the synovial tissue in the No-tr group (Figures 4A, 5A, and 6A) and the SA group (Figures 4B, 5B, and ... conceived of the study, participated in data analysis, and drafted the manuscript JW participated in the histopathology and scored the immunohistology P-LC participated in the establishment of the animal...
- 13
- 303
- 0
Báo cáo khoa học: Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells pptx
Ngày tải lên :
07/03/2014, 12:20
... growth and differentiation On ligand binding, the insulin receptor tyrosine kinase initiates multiple signaling cascades, including activation of the phosphatidylinositol 3-kinase (PI3K) pathway and ... effectors [23] This pathway is a key signal transducer of many growth factors and cytokines and has been implicated in the regulation of cell growth, cell migration and cell survival [24] The protein ... insulin was consistent, as well as being time and concentration dependent The role of the PI3K ⁄ Akt pathway in the regulation of HO-1 has been the source of much interest lately Our data demonstrate...
- 12
- 377
- 0
Báo cáo y học: "Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study" ppsx
Ngày tải lên :
09/08/2014, 01:22
... two of the components of the metabolic syndrome (high TG and hypertension), but not any of the other components (low HDL, obesity, and glucose intolerance) or the presence of the metabolic syndrome ... hypertension [11,12], and central obesity [11]: these may collectively contribute to the development of the metabolic syndrome [13,14] and atherosclerosis [15,16] The metabolic syndrome, first described ... the draft of the manuscript GDK contributed substantially to the conception and design of the project and to the revision of the draft of the manuscript All authors read and approved the final manuscript...
- 8
- 561
- 0
Báo cáo y học: "Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production" pps
Ngày tải lên :
09/08/2014, 06:22
... role in the progression of OA pathology as they are the most effective at initiating collagen destruction during the inflammatory process and the remodelling phase of the disease [11,12] Another ... tissue and joint cartilage express the ET-1 gene and overproduce ET-1, resulting in an excessive synthesis of MMP-1 and MMP-13 in the same tissues In addition, the result goes beyond these findings ... suggests that these inhibitors are specific for the ET-1-activated pathways since they not affect the basal levels of MMP-1 and MMP-13 Another point also deserves consideration Tardif and colleagues...
- 9
- 239
- 0
Báo cáo y học: "Dynamic compression counteracts IL-1β induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs" pdf
Ngày tải lên :
09/08/2014, 10:23
... examines the interplay between mechano-sensitive and cytokine-sensitive pathways, and determines the effects of IL-1β and dynamic compression on the expression levels of iNOS and COX-2 and involvement ... 0.05) and hours (14-fold IL-1β stimulates the production of nitrite and PGE2 release The cumulative production of nitrite and PGE2 release were assessed as presented in Figure In the absence of the ... analysis and TC carried out the biochemical assays, performed the statistical analysis and drafted the manuscript DS, DB and DL participated in its design and coordination and helped to draft the...
- 13
- 261
- 0
Báo cáo y học: "Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study" pptx
Ngày tải lên :
09/08/2014, 13:22
... two of the components of the metabolic syndrome (high TG and hypertension), but not any of the other components (low HDL, obesity, and glucose intolerance) or the presence of the metabolic syndrome ... hypertension [11,12], and central obesity [11]: these may collectively contribute to the development of the metabolic syndrome [13,14] and atherosclerosis [15,16] The metabolic syndrome, first described ... the draft of the manuscript GDK contributed substantially to the conception and design of the project and to the revision of the draft of the manuscript All authors read and approved the final manuscript...
- 8
- 531
- 0
Báo cáo y học: "Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-B and JNK/p38 MAPK activation pathways" pot
Ngày tải lên :
10/08/2014, 05:21
... 2001, 13:85-94 Goodwin DC, Landino LM, Marnett LJ: Effects of nitric oxide and nitric oxide- derived species on prostaglandin endoperoxide synthase and prostaglandin biosynthesis FASEB J 1999, 13:1121-1136 ... of prostaglandin biosynthesis by nitric oxide and nitric oxide donors Pharmacol Rev 2005, 57:217-252 13 Vassalle C, Domenici C, Lubrano V, L’Abbate A: Interaction between nitric oxide and cyclooxygenase ... test compound for 48 h Then 25 μL of mg/mL MTT was added and the plate was incubated at 37°C for h The cells were then pelleted and lysed in 100 μL of dimethyl sulfoxide and the absorbance at 550...
- 11
- 294
- 0
Báo cáo y học: "NPAS2 and PER2 are linked to risk factors of the metabolic syndrome" pps
Ngày tải lên :
10/08/2014, 09:20
... drinking on the same day In the laboratory, a nurse recorded how these instructions had been followed and then took the blood samples The samples were centrifuged at the examination site and placed ... abuse and dependence, and other substance dependence and abuse As part of the assessment, the participants filled in the items of lifetime seasonal variations in mood and behavior taken and adapted ... contributions AE drafted the manuscript LK carried out the genotyping and helped to draft the manuscript AE, LK, JH and TP participated in the design of the study and performed the statistical analysis...
- 9
- 482
- 0
Báo cáo y học: "Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study" ppt
Ngày tải lên :
12/08/2014, 18:20
... Acknowledgements 18 The authors thank Dr Liliane Bodin, Dr Pierre Kalfon and Dr Pascale Poète for their contribution to the study; the nurses of the Surgical Intensive Care Unit and the technicians of the Department ... inhaled NO: (1) the anatomical remodeling of the pulmonary circulation; (2) the reduction of the lung volume accessible to gas, and (3) the presence of septic shock External compression of the pulmonary ... measured and recorded In addition, VT and FiO2 were adjusted at the ventilator level in order to maintain a constant minute ventilation and an FiO2 of 0.85 as assessed by the pneumotachograph and the...
- 16
- 569
- 0
Báo cáo y học: "Arginase attenuates inhibitory nonadrenergic noncholinergic nerve-induced nitric oxide generation and airway smooth muscle relaxation" potx
Ngày tải lên :
12/08/2014, 18:21
... the constitutive NOS (cNOS) isoforms are mainly expressed in the iNANC neurons (nNOS), the endothelium (eNOS) and the epithelium (nNOS and eNOS), whereas iNOS, which is induced by proinflammatory ... analysis and drafted the manuscript MAT assisted substantially in performing the experiments JZ participated in the design of the study, interpretation of results and final revision of the manuscript ... 2005, 6:23 Background The inhibitory nonadrenergic noncholinergic (iNANC) nervous system is the most effective bronchodilating neural pathway of the airways Inhibition of nitric oxide synthase (NOS)...
- 6
- 149
- 0
Báo cáo y học: "Nitric oxide, leukocytes and microvascular permeability: causality or bystanders" pdf
Ngày tải lên :
13/08/2014, 08:21
... 262:H611-H615 Kubes P: Nitric oxide and microvascular permeability: a continuing dilemma Eur Respir J 1997, 10:4-5 Kubes P: Nitric oxide affects microvascular permeability in the intact and inflamed vasculature ... mice and men (and rats): implications of species and stimulus differences for the interpretation of studies of nitric oxide in sepsis Br J Anaesth 2003, 90: 115-118 Dhillon SS, Mahadevan K, Bandi ... isoforms, namely eNOS and iNOS, adds to the complexity: the present data by Hollenberg et al clearly indicate a major role of iNOS, whereas other authors investigating both eNOS–/– and iNOS–/– animals...
- 2
- 202
- 0
Role of nitric oxide in wound healing facilitatory effects of nitrosoglutathione a nitric oxide donor on the extracellular matrix deposition characteristics of wound healing
Ngày tải lên :
17/09/2015, 17:19
... working with them Shirhan, Siva and Viren have been brotherly in providing all the logistic and experimental help I thank them for all the help that they have given me I wish them well The project ... in the form of a clot that plugs the defect, and over subsequent days, steps to regenerate the missing parts are initiated Inflammatory cells and then, the fibroblasts and capillaries invade the ... the scars 114 Table 4.5 Nitrite and Nitrate content of the scars 117 Table 4.6 Nitrite and Nitrate content of the plasma 119 Table 4.7 Glutathione (GSSG) content of the scars 124 xv LIST OF PUBLICATIONS...
- 258
- 672
- 0
Báo cáo y học: "Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect? A cross sectional study" pptx
Ngày tải lên :
09/08/2014, 14:22
... andand the presence ofmetabolic syndrome according to the definition used used * P < 0.05 EGIR The relationship between methotrexate use the presence of the the metabolic syndrome according to the ... patients The prevalence of the MetS increased with age up until the seventh decade and fell off thereafter, and was similar in males and females (P = 0.429; Table 3) Associations of the metabolic syndrome ... drafted the manuscript KMD acquired the data GDK made substantial contributions to the conception and design of the study and revised the draft manuscript All authors read and approved the final...
- 10
- 499
- 0
Báo cáo y học: "Waist circumference as the predominant contributor to the micro-inflammatory response in the metabolic syndrome: a cross sectional study" pptx
Ngày tải lên :
11/08/2014, 03:20
... definitions from the metabolic syndrome The previous work evaluated this difference and did not analyze the relative weight of each component of the metabolic syndrome The importance of the current ... OR and AS have participated in the design of the study, performed the statistical analyses and drafted the paper SB and IS conceived the study, participated in its design and coordination and ... to draft and review the manuscript TF, TC and OKB helped in the data organization and retrieval, English editing and final draft preparation All of the authors have read and approved the final...
- 7
- 282
- 0
Báo cáo y học: "Waist circumference as the predominant contributor to the micro-inflammatory response in the metabolic syndrome: a cross sectional study" doc
Ngày tải lên :
11/08/2014, 06:22
... definitions from the metabolic syndrome The previous work evaluated this difference and did not analyze the relative weight of each component of the metabolic syndrome The importance of the current ... OR and AS have participated in the design of the study, performed the statistical analyses and drafted the paper SB and IS conceived the study, participated in its design and coordination and ... to draft and review the manuscript TF, TC and OKB helped in the data organization and retrieval, English editing and final draft preparation All of the authors have read and approved the final...
- 7
- 323
- 0
Báo cáo y học: " The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFB signaling pathway and nitric oxide induction in macrophages" doc
Ngày tải lên :
11/08/2014, 08:22
... of the study, performed the experiments and carried out the majority of the assays, performed the statistical analysis, participated in the design and coordination of the study, and drafted the ... carried out the IL-6 ELISA, participated in the statistical analysis and in the coordination of the study MA participated in the design of the study, its coordination and drafted the manuscript ... of the study, participated in the design and coordination of the study, and drafted the manuscript All authors read and approved the final manuscript Page of 20 21 22 Competing interests The...
- 8
- 581
- 0