new shuttles for drug delivery

... purpose of drug delivery, the requirements for nanoparticulate systems can vary These aspects are discussed in Chapter for injectable delivery, Chapter for oral delivery, Chapter 10 for brain delivery, ... edited by Simon Benita 159 Nanoparticle Technology for Drug Delivery, edited by Ram B Gupta and Uday B Kompella Nanoparticle Technology for Drug Delivery edited by Ram B Gupta Auburn University ... Specialized Drug Delivery Systems: Manufacturing and Production Technology, edited by Praveen Tyle 42 Topical Drug Delivery Formulations, edited by David W Osborne and Anton H Amann 43 Drug Stability:...

Ngày tải lên: 04/06/2014, 15:15

... polypeptide -drug conjugates [PGA-Doxorubicin (Dox)] The researchers also investigated the applicability of thick-walled polymer nanocapsules for tumor therapy via drug delivery They prepared drug- loaded ... cells, and delivery of the anticancer drug into the tumor cells, leading to tumor cell death Bansal notes that it is highly desirable for antitumor applications, that the size of the delivery vehicle ... attachment of targeting ligands to the drug- conjugated capsules through established coupling protocols will further provide functional capsules for targeted drug delivery applications 267 Overall,...

Ngày tải lên: 22/06/2014, 01:20

... investigated magnetically retainable drug delivery systems, an approach as yet clinically unexploited despite the intense need for the development of novel i-a delivery modalities Thus, our aim ... per group, Page of 10 (page number not for citation purposes) was necessary for at least two reasons First, there was a need to perform these control tests for the correct evaluation of the action ... changing the material of the microparticle matrix In this respect, new formulation strategies could be found for very active compounds (for example, p38 MAPK or interleukin-1-beta inhibitors [pralnacasan]),...

Ngày tải lên: 09/08/2014, 14:20

... INTRODUCTION delivery of drug In time-controlled delivery, the drug is released in a pre-determined rate while in target-controlled delivery, the drug is delivered to a specific site The delivery ... been developed as a drug delivery system (DDS) for many peptide and protein drugs (Chan and Heng, 1998) An ideal DDS is able to control the drug concentration at the target site for a desired period ... both new opportunities and new challenges For commercial use, microspheres are formulated into pharmaceutically acceptable oral delivery systems, such as tablets, capsules and dry powder for reconstitution...

Ngày tải lên: 13/09/2015, 20:39

... Microneedles 2.1 Microneedles in Transdermal Drug Delivery Transdermal drug delivery is an alternative method for delivery of DNA/protein based drugs These drugs which have sophisticated compounds ... are designed for transdermal therapies to deliver drugs such as insulin and heparin On the other hand, microneedles can also be used for local delivery of other drugs, for example, drugs in anti-restenosis ... varying delivery of different therapeutics, which is essential for a more effective drug delivery system The direct delivery of DNA/portent based drugs into the metabolic system and the continuous delivery...

Ngày tải lên: 14/09/2015, 11:17

... Rationale for the Choice of Equipment and Method Employed 112 A1.1 Rationale for Choosing FB Hammer Mill 112 A1.2 Rationale for Choosing Laser Diffraction for Particle Sizing 113 A1.3 Rationale for ... rate of drug appearance in the blood is determined by the absorption rate of the drug whereas for Class II drugs, the rate of dissolution plays a greater role In the case of Class IV drugs, both ... B FBO Jet Mill 136 B1 Rationale for the Choice of Equipment and Method Employed 136 B1.1 Rationale for Choosing FBO Jet Mill 136 B1.2 Rationale for Choosing SEM for Particle Sizing 137 B1.3 Choice...

Ngày tải lên: 17/09/2015, 17:19

... photoluminescence, afford additional advantages for tracking and real-time monitoring of drug delivery efficacy in vivo Intracellular drug delivery To study the cellular drug delivery, in vitro ... suitable candidates for a nanoparticle-based drug delivery system to improve their pharmacological performance For this purpose, a “longboat delivery system” has been prepared for the platinum warhead ... nanohorns for the enhancement of their dispersibility This approach is also true for CNTs [72] Polymeric drug conjugates, as a new class of systems, have been envisaged for tumor tissue-specific delivery...

Ngày tải lên: 20/06/2014, 22:20

... transition metals and any drug molecule in general from a delivery are major factors that ultimately determine the success or failure of that vector when applied to targeted drug delivery One of the ... nanoparticles for therapeutic applications Nat Rev Drug Discov 2010, 9:615-627 Davis ME, Chen Z, Shin DM: Nanoparticle therapeutics: an emerging treatment modality for cancer Nat Rev Drug Discov ... Pt(IV) prodrug-PLGA-PEG nanoparticles Proc Natl Acad Sci USA 2008, 105:17356-17361 Rieter WJ, Pott KM, Taylor KML, Lin WB: Nanoscale coordination polymers for platinum-based anticancer drug delivery...

Ngày tải lên: 21/06/2014, 02:20

... the drug In order to overcome these limitations, a suitable formulation was needed to maximize the potential of DCU in vivo Several formulations strategies for SC dose have been assessed Formulations ... discovery: the potential impact of formulation on pharmacokinetic parameters Curr Op Drug Discov Devel 2002, 5(1):59-71 17 Barrett R: Nanosuspensions in drug delivery Nat Rev Drug Discov 2004, 3:785-796 ... formulation can provide for orally dosed DCU is not well understood [14] In order to understand the degree of improvement provided by an oral nanosuspension formulation, simulations were performed...

Ngày tải lên: 21/06/2014, 03:20

... experiments The CNT array owns a forest-like structure that could be exploited for the deposition of a polymeric thin film acting as drug delivery device For drug release kinetics investigation, ... can form extended neural network upon differentiation [5] In this study, we propose a combination of drug delivery system with such CNT array, exploiting a thin film of calcium alginate as drug ... be used for controlled drug delivery: any bioactive factor could be released in a spatially and temporally controlled manner The proposed approach represents an interesting solution for building...

Ngày tải lên: 22/06/2014, 00:20

... for investigating in vitro binding and internalization contained 0.1 mol% Texas red-phosphatidylethanolamine (Molecular Probes Europe) Liposomes used for studying drug delivery in vitro and for ... Diego, California, USA) For statistical analysis of CD134 expression in vivo and liposomal drug delivery in vitro, a one-way analysis of variance with Dunnett's post-hoc test was used For analysis ... internalization determined the strategy of drug delivery We here employed the mechanism of lipid-coupled drug transfer between membranes to achieve intracellular drug delivery When anti-CD134 liposomes...

Ngày tải lên: 09/08/2014, 06:22

... nanotechnology–implications for drug targeting and gene therapy Trends Biotechnol 1997, 15:217-224 11 Panyam J, Labhasetwar V: Biodegradable nanoparticles for drug and gene delivery to cells and tissue Adv Drug Deliv ... The development of novel nano-systems for pulmonary gene or drug delivery may provide a convenient, noninvasive method for the administration of gene or drugs to the lungs Such a system can also ... evaluation and selective delivery of this class of compounds for treatment of CF lung disease We evaluated the efficacy of PLGA based nano-systems for selective drug delivery A major drawback...

Ngày tải lên: 11/08/2014, 00:22

... strategies for DNA deliver and expression into eukaryotic cells, we reinforce the use of Lactococcus lactis as DNA delivery vehicle [18,26] To improve our delivery DNA strategy, we constructed a new ... Bacteria as gene delivery vectors for mammalian cells Curr Opin Biotechnol 1999, 10:477-481 Xu F, Ulmer JB: Attenuated Salmonella and Shigella as carriers for DNA vaccines J Drug Target 2003, ... of attenuated bacteria as delivery vectors for DNA vaccines Expert Rev Vaccines 2007, 6:97-110 Dietrich G, Spreng S, Gentschev I, Goebel W: Bacterial systems for the delivery of eukaryotic antigen...

Ngày tải lên: 14/08/2014, 19:22

... penetration into the inner drug- loaded core on various time scales, and therefore control the drug release from the microspheres For both microsphere formulations, the drug release profiles were ... Chapter Drug Administration (FDA) Some representative drug delivery systems which have received regulatory approval have been summarized in Table 2.1 2.1.1 Drug delivery systems Two key aims most drug ... motivation Polymeric drug delivery systems are designed to encapsulate therapeutic agents and provide their release in a predesigned manner The main purpose for controlling the drug delivery process...

Ngày tải lên: 10/09/2015, 09:05

... Integrin targeted drug and gene delivery Expert opinion on drug delivery 2010; 7(2), 159-171 Wang Z., Chui WK Ho PC Nanoparticulate delivery system targeted to tumor neovasculature for combined anticancer ... nanocapsule delivery system to investigate the capacity of temporal release of antiangiogenetic drug and anticancer drug in vitro We found that the drug release profiles of the encapsulated drugs, ... Antiangiogenesis inhibitors 10 1.3 Drug delivery system for vascular targeted antiangiogenesis or antitumor therapy 15 1.3.1 Conjugation of drug with ligand for vascular targeting 15 1.3.2...

Ngày tải lên: 11/09/2015, 09:58

... 1.2 Targeted delivery systems 1.2.1 Rationale 1.2.2 Targeting strategies 1.3 Nano-scale drug delivery systems 10 1.3.1 Rationale 10 1.3.2 Classification 11 1.4 Virus-based drug delivery systems ... could be reassembled in vitro into uniformly sized and precisely structured virus-like protein cages (PC) The PC could be an attractive platform for drug delivery as its cavity could serve as ... anticancer drug delivery systems The hypothesis for this project was that PC derived from the Hibiscus Chlorotic Ringspot virus (HCRSV) could be developed into a targeting anticancer drug delivery...

Ngày tải lên: 11/09/2015, 14:22

... physiology of normal and tumor tissues can be used for designing drug delivery systems facilitating tumor-specific delivery of the drug or prodrug and specific drug activation (1) Enhanced permeability ... Chapter the quality of life for patients Therefore, scientists focus on the research of drug delivery systems (DDS) to decrease the side effects The design of an effective drug delivery system must ... chemotherapy is the development of multidrug-resistant (MDR) tumor cells during the course of treatment To overcome MDR, a new drug formulation - PLGA-PEG-FOL formulated with d-α-tocopheryl polyethylene...

Ngày tải lên: 12/09/2015, 08:20

... 113 5.8 Performance of MEC controller for 17 patients 114 5.9 Performance of PID controller for 17 patients 115 5.10 IAE for all the 17 patients for set-point change ... interactions of the drugs This would be useful for optimizing the drug dosages while not compromising on patient’s comfort and safety during and after the surgery • Constraints on drug delivery rate ... Page 6.8 Performance of MPC and PID for sensitive and insensitive patients for the set-point changes during the maintenance period 163 6.9 Average performance of MPC and PID for the set-point...

Ngày tải lên: 14/09/2015, 08:25

... Introduction drug delivery by prompt removal of the applied formulation in the case of any adverse event Although topical drug delivery offers certain advantages over systemic delivery for selected drugs ... many dermal delivery systems (Shah, 2003) I-B Transdermal and topical drug delivery Transdermal drug delivery involves transport of drug through the skin into the systemic circulation for treatment ... topical drug delivery as this is the main focus of the present study I-B1 Advantages and limitations of topical drug delivery The principal advantage of topical drug delivery lies in targeting the drug...

Ngày tải lên: 15/09/2015, 17:10

... Human Skin Lipids and Transdermal Drug Delivery Transdermal administration of drug has been exploited extensively in the past few years In USA, out of 129 drug delivery candidate products under ... transdermal drug delivery International Journal of Pharmaceutics 311: 157-164 Kang L, Fan SK, Ho PC, Chan YW, Chan SY Improved data analysis and prediction of in vitro skin permeation study for drug ... Sawant PD, Liu XY, Chan SY 2005 US patent application for invention “Transdermal drug delivery composition comprising an organogel and process for the preparation thereof” (Pub No.: US 2005/0191338...

Ngày tải lên: 16/09/2015, 08:31