new prognostic factors and outcome prediction using gene expression signatures

... feasibility ofusing putative binding sites to identify TFs responsible for gene expression signatures of human cancer has been demonstrated [14] Our results for six human and mouse gene expression signatures ... for six human and mouse gene expression signatures are as follows First, it is feasible to identify pathways deregulated in mammalian gene expression signatures by viewing such signatures as ... Article R77 EASE and GSEA analysis We obtained six different publicly available human and mouse gene signatures Gene identifiers were mapped to UniGene clusters using ACID [42] Gene identifiers...

Ngày tải lên: 14/08/2014, 07:21

... patients, and their subsequent degeneration into malignant ulcers is limited The purpose of this study was to collect and review the various theories on Marjolin’s ulcers, the different prognostic factors, ... cutaneous immuno-surveillance against developing malignancy and also cause p53 tumor suppressor gene alterations Environmental and genetic interaction theory Attempts to explain the occurrence ... discharge and multiple sinuses that communicated with the ulcer The areas with the ulcers and the sinuses were indurated, and on digital pressure exuded discharge both from the ulcer and sinuses...

Ngày tải lên: 09/08/2014, 03:23

... addition, no study has evaluated risk factors for and impact on outcome of ICUacquired S maltophilia Identifying risk factors for S maltophilia colonisation and/ or infection could be useful for ... risk factors for, and outcome of ICU-acquired S maltophilia Materials and methods This prospective case-control study, which was a part of a cohort study, was conducted in a 30-bed medical and ... recognisable cause, new or increased sputum production, positive (≥106 colony-forming units per ml) endotracheal aspirate culture yielding a new bacteria, and no radiographic evidence of new pneumonia...

Ngày tải lên: 13/08/2014, 03:20

... http://ccforum.com/content/11/5/R115 Results Descriptive analysis and study of prognostic factors Over a 6-year period, 25 patients (14 females and 11 male, age 46 [36 to 58] years and SAPS II score 25 [19 to 51]) were ... damage early and can demonstrate (as in one of our patients) heterogeneous high intensity areas in both cortex and subcortex [12] Prognosis of severe acute insulin poisoning Prognostic factors in ... groups according to the following outcomes: 'favourable' (defined as CPC or 2) and 'unfavourable' (defined as CPC to 5) Unfavourable outcomes include death and severe neurological impairment...

Ngày tải lên: 13/08/2014, 08:20

... or IL-6 and IL-7 levels five to seven days later, may predict outcome when used in these prediction equations Increased mortality was observed as serum IL-6 and IL-10 levels increased and serum ... critically ill patients and the variety of factors affecting circulating cytokines and that serum cytokine based prediction models need to be compared to commonly applied prediction models based ... Plasma pro- and anti-inflammatory cytokine levels and outcome prediction in unselected critically ill patients Cytokine 2008, 41: 263-267 12 Holmes T: A System of Surgery, Theoretical and Practical...

Ngày tải lên: 13/08/2014, 11:22

... randomly and independently varied using their binomial, multinomial and log-normal distributions, as deducted from the respective statistical characterizations in [3,4,17] Results from [4] and ... Implications of Optimal Diagnosis and Treatment of Sepsis, Work in Progress: Marginal Penalties, Antibiotic Alterations, and Outcome Hypotheses Scandinavian Journal of Clinical and Laboratory Investigation ... adequate treatment and outcome that we imply is supported by data from an animal model of sepsis [24] and also evidenced with human data [25] N epis was left in Equation for easier understanding, but...

Ngày tải lên: 13/08/2014, 21:21

... subsequently, a gene encoding a fibrinogen-like protein, and also one for a cytokine, are strongly expressed Materials and methods Chemicals and enzymes The sources of chemicals and enzymes used ... AB024737.1 and TECL5B_TACTR; AB024738.1) (iii) Angiopoietin: angiopoietin and precursors from mouse (AGP1_MOUSE; O08538 and AGP2_MOUSE; O35608), bovine (AGP1_BOVIN; O18920 and AGP2_BOVIN; O77802), and ... increase in the expression of SDFIBI occurs Likewise, a strong expression pattern was determined for the SDEGFI-PREC gene (Fig 6) The level of expression of the housekeeping gene, tubulin, was...

Ngày tải lên: 16/03/2014, 16:20

... proposed a new approach to realize genes that play an important role in causing cancers using gene expression data A new scheme for gene selection process was also introduced The efficiency and biological ... a particular gene and then regulates the expression level of this gene (Figure 2.5) This gene regulation is often context sensitive, e.g., gene A upregulates gene C, but only if gene B is present ... measurement of each gene This means that the more number of genes a particular gene regulates, the more important this gene is In gene expression analysis, a gene is considered as a factor causing a particular...

Ngày tải lên: 01/08/2014, 17:47

... by the environment, and with expression noise [39,40], namely the extent by which a gene s expression differs among genetically identical cells [7,37] That is, genes whose expression is strongly ... diverging genes is enriched with plasma membrane genes and, in general, genes that interact with the cell environment [7] (Figure 2) These genes are needed to cope with changes in the environment and ... Variation in gene expression within and among natural populations Nat Genet 2002, 32:261-266 27 Townsend JP, Cavalieri D, Hartl DL: Population genetic variation in genome-wide gene expression Mol...

Ngày tải lên: 06/08/2014, 19:21

... protein gene expression profiles of meniscal fibrochondrocytes The x-axis refers to the passage number, and the y-axis to protein gene expression profiles of meniscal fibrochondrocytes the gene expression ... for 24 hours and then subsequently processed for RT-PCR The gene expression profiles with passage and on the different protein coatings were then determined n = was used for all gene expression ... processed and were considered to be part of a failed reaction No significant difference was observed in GAPDH expression between groups over passage Gene expression with passage The gene expression...

Ngày tải lên: 09/08/2014, 10:21

... illustrating input of subject (Gene Expression Omnibus [GEO] dataset [GDS]) and query datasets, extraction of gene expression signatures, comparison with signature database, and generation of reports ... Correspondingly, gene expression signatures are collections of significant genes determined from statistical comparisons of groups Because a microarray study can produce one or many gene expression signatures, ... identify related gene expression signatures in biologically related datasets generated using different microarray platforms For this test we utilized publicly available expression data generated from...

Ngày tải lên: 14/08/2014, 07:22

... N AND AND Model C N C AND Gene Y Gene Z reviews AND comment Model Gene W (CN independent) Gene X (CN dependent) (CN dependent/independent) (CN dependent/independent) (b) W X Y Z C 1 reports Gene ... is true for the ribosomal genes used for analysis) Another prediction is that if CN1 and CN2 regulate gene expression, biologically related genes might also contain CN1 and CN2 Interestingly, ferredoxin-dependent ... This analysis represents a first step in understanding how carbon and nitrogen signaling interact to control gene expression and has identified genes and putative cis elements that deposited research...

Ngày tải lên: 14/08/2014, 14:21

... linkage HC using the programmes Cluster and Treeview [5] (Figure 5) and clustered gene functions were investigated further using the annotation resources DAVID [25] and GeneCards [26] From GeneCards ... analyzing such clusters Recently, methods for gene- function prediction using similarities in gene- expression profiles between annotated and uncharacterized genes have been described [20] To circumvent ... the CD40L receptor gene, Bfl-1, BIRC3, EBV-induced gene (EBI3), and the genes for class I MHC-C and lymphotoxin α, as these have been previously characterized as NFκB responsive and were present...

Ngày tải lên: 14/08/2014, 14:21

... the plot represent expression ratios of individual genes over the time course Clustering patterns correspond to early upregulated genes (a), late upregulated genes (b) and genes that were downregulated ... been significant interest in using the gene expression data to classify disease subsets and predict responses to treatments In one study of MS patients, two genes (HIF2 and CKS2) were used to discriminate ... distinctly different pattern of PBMC gene expression consistent with altered immunopathogenesis for these disorders [31] The rapid and robust changes in gene expression following influenza vaccination...

Ngày tải lên: 09/08/2014, 01:23

... bradychardia, and hypotension during the test were not found to influence the outcome prediction Many studies have proposed specific TTT outcome prediction procedures In [3], a set of time and frequency ... the limited generalization because of the high dependence of samples used in validation, preventing effectively the prediction of TTT outcome Discussion and conclusions The early prediction of ... the description of our database and the results of the experiments Section has the discussion and the conclusions on the limitations of the TTT early prediction of outcome from the parameters in...

Ngày tải lên: 21/06/2014, 01:20

... therapy and have achieved complete PSA response after RP The secondary objectives are to evaluate prognostic factors related to the success of the salvage radiation therapy Materials and methods ... chi-square test KaplanMeier test was used to calculate overall and specific survival Univariate analysis was assessed using the log-ranktest and Multivariate analysis was performed by Cox regression ... 7.9) and median PSADT was 5.25 months (range 1.0 – 16.5) Univariate and multivariate analysis of selected variables are displayed on Table PSADT lower than months was an important negative prognostic...

Ngày tải lên: 09/08/2014, 10:21

... admitted to the ICU was 47.0% Prognostic factors To identify prognostic factors for death in SLE patients admitted to the ICU, univariate and multivariate analyses for these factors were conducted We ... tuberculous bacilli isolated from the cerebrospinal fluid Clinical course, treatment and outcome The clinical courses and outcomes in the 51 patients for their first admissions are summarized in Table ... bleeding, intracranial haemorrhage and septic shock are significant prognostic factors in SLE patients admitted to the ICU In contrast, the causes of ICU admission and APACHE II score are not significantly...

Ngày tải lên: 12/08/2014, 22:21

... books and teaching facility (tapes and recorder, CDs, television, computer, projector and so forth) play an important and oriented role in language teaching and learning The objectives of the new ... strengths of the new textbook are the least fully exploited Consequently, their teaching is less active and less dynamic Moreover, new teaching methods require new understandings and skills Those ... on students’ passive and dependent learning method and awareness They are confused and strange to new communicative activities such as pair work, group work, discussion, and so on Another disadvantage...

Ngày tải lên: 05/02/2014, 22:02

... levels of gene expression and probably in distinguishing target genes by mammalian HSFs In response to stress, yeast HSF bound to an HSE recruits the general transcription factors and Pol II ... Sakurai and Y Enoki SWI ⁄ SNF complexes are recruited to both the promoter and coding regions, and histones are acetylated and displaced [56–58] However, the presence of SAGA and SWI ⁄ SNF, and a ... localizes in the nucleus and binds to and regulates basal expression via HSEs of target genes [26] Deletion of the HSF gene is lethal to cells, even at physiological temperatures The genes targeted by...

Ngày tải lên: 18/02/2014, 04:20