neuronal nicotinic acetylcholinergic receptor agents

... stoichiometry of a neuronal nicotinic acetylcholine receptor Nature 350, 235–238 Conroy, W.G & Berg, D.K (1995) Neurons can maintain multiple classes of nicotinic acetylcholine receptors distinguished ... a7 nicotinic receptor by using short pulses of acetylcholine and selective blockers Proc Natl Acad Sci USA 95, 14184–14189 Lloyd, G.K & Williams, M (2000) Neuronal nicotinic acetylcholine receptors ... a-bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons J Pharmacol Exp Ther 278, 1472–1483 49 Kehoe, J & McIntosh, J.M (1998) Two distinct nicotinic receptors, one pharmacologically...

Ngày tải lên: 19/02/2014, 12:20

... receptors, e.g the a7 neuronal nAChR and the 5-HT3A homomeric receptor In these receptors, there are five identical interfaces that presumably play equivalent roles in ligand recognition and receptor ... for dTC and ACh [17,22] while the W54 of the neuronal nicotinic a7 receptor has been shown to contribute to the binding of agonists [23] In the GABAA receptor, the F64L mutation of the a1 subunit ... at a–c and a–d subunit interfaces of the nicotinic acetylcholine receptor Proc Natl Acad Sci USA 87, 2785–2789 Grutter T & Changeux JP (2001) Nicotinic receptors in wonderland Trends Biochem Sci...

Ngày tải lên: 19/02/2014, 07:20

... Reduced antinociception in mice lacking neuronal nicotinic receptor subunits Nature 398, 805–810 Lloyd, G.K & Williams, M (2000) Neuronal nicotinic acetylcholine receptors as novel drug targets J Pharmacol ... protein reveals the ligand-binding domain of nicotinic receptors Nature 411, 269–276 Dwoskin, L.P & Crooks, P.A (2001) Competitive neuronal nicotinic receptor antagonists: a new direction for drug ... a7 neuronal nicotinic acetylcholine receptors J Physiol (Paris) 92, 107–111 Sine, S.M., Bren, N & Quiram, P.A (1998) Molecular dissection of subunit interfaces in the nicotinic acetylcholine receptor...

Ngày tải lên: 19/02/2014, 12:20

... of neuronal nicotinic acetylcholine receptors in acute and chronic neurodegeneration Curr Drug Target CNS Neurol Disord 1, 399–411 Geerts, H., Finkel, L., Carr, R & Spiros, A (2002) Nicotinic receptor ... specific for neuronal nicotinic acetylcholine receptors Biochemistry 38, 3874– 3882 Ellison, M., McIntosh, J.M & Olivera, B.M (2003) Alphaconotoxins ImI and ImII Similar alpha nicotinic receptor ... block the alpha neuronal nicotinic acetylcholine receptors J Physiol Paris 92, 107–111 39 Quiram, P.A & Sine, S.M (1998) Identification of residues in the neuronal alpha7 acetylcholine receptor that...

Ngày tải lên: 19/02/2014, 12:20

... Changeux, J.P & Edelstein, S.J (1998) Allosteric receptors after 30 years Neuron 21, 959–980 Lindstrom, J (2000) The structures of neuronal nicotinic receptors In Handbook of Experimental Pharmacology ... domain of nicotinic receptors Nature 411, 269–276 13 Couturier, S., Bertrand, D., Matter, J.M., Hernandez, M.C., Bertrand, S., Millar, N., Valera, S., Barkas, T & Ballivet, M (1990) A neuronal nicotinic ... membranebound acetylcholine receptor from Torpedo californica J Mol Biol 128, 319–334 Miyazawa, A., Fujiyoshi, Y., Stowell, M & Unwin, N (1999) ˚ Nicotinic acetylcholine receptor at 4.6 A resolution:...

Ngày tải lên: 31/03/2014, 23:20

... microglial activation by alpha nicotinic receptors J Neurochem 2004, 89:337-343 Conti-Fine BM, Navaneetham D, Lei S, Maus AD: Neuronal nicotinic receptors in non -neuronal cells: new mediators ... Changeux J: Nicotinic acetylcholine receptor knockout mice as animal models for studying receptor function Eur J Pharmacol 2000, 393:113-121 Sharma G, Vijayaraghavan S: Nicotinic receptor signaling ... Tracey KJ: Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation Nature 2003, 421:384-388 Clementi F, Fornasari D, Gotti C: Neuronal nicotinic receptors, important...

Ngày tải lên: 19/06/2014, 22:20

... proposed linking the two in the lung to date Neuronal and non -neuronal nicotinic acetylcholine receptors (nAChRs) combine with glycine, GABAA, and 5HT3 receptors to form a family of ligand-gated ... pituitary Genes Dev 1996, 10:60-69 Conti-Fine BM, Navaneetham D, Lei S, Maus MD: Neuronal nicotinic receptors in non -neuronal cells: new mediators of tobacco toxicity? Eur J Pharmacol 2000, 393:279-94 ... Carlisle DL, Hopkins TM, Gaither-Davis A: Nicotine signals through muscletype and neuronal nicotinic acetylcholine receptors in both human bronchial epithelial cells and airway fibroblasts Respir...

Ngày tải lên: 12/08/2014, 13:22

... specific cell surface receptors may identify relevant receptors that contribute to transcription factor expression and ultimate lung formation Neuronal nicotinic acetylcholine receptors (nAChRs) ... Luketich JD, Christie NA, Siegfried JM: Nicotine signals through muscle-type and neuronal nicotinic acetylcholine receptors in both human bronchial epithelial cells and airway fibroblasts Respir ... Secretory Protein (CCSP, Seven Hills Bioreagents, Cincinnati, OH) was used at a dilution of 1:1600 A monoclonal antibody for Fox J1 (Seven Hills BioReagents) was used at a dilution of 1:2000 ATII...

Ngày tải lên: 12/08/2014, 13:22

... α7 nicotinic acetylcholine receptor, it was necessary to show if expression of the α7 nicotinic acetylcholine receptor protein in seen in these cell lines Using a specific antibody for the α7 nicotinic ... muscle type acetylcholine receptors may be involved in signaling responses in SCLC, our data indicates the α7 neuronal nicotinic acetylcholine receptor is a functional receptor in lung cells and ... http://respiratory-research.com/content/6/1/29 Figure showing α7 nicotinic acetylcholine receptor expression in SCLC cell lines Agarose gel Agarose gel showing α7 nicotinic acetylcholine receptor expression in SCLC cell lines...

Ngày tải lên: 12/08/2014, 18:21

... CNTF -receptor (sCNTFR) fusion protein with superagonistic activity on target cells expressing gp130 and LIF-R, but lacking membrane-bound CNTF-R In contrast to the existing cytokine–cytokine receptor ... Hyper-CNTF but not LIF induced neuronal differentiation of rat pheochromocytoma cells (PC12) These data point to a cell-specific difference in signaling via the heterodimeric receptor complex of gp130 ... Laemmli buffer and cell lysates Neuronal differentiation of PC12 cells by Hyper-CNTF In a second bioassay, we investigated the potential role of Hyper-CNTF in neuronal cell differentiation The...

Ngày tải lên: 22/02/2014, 07:20

... among neuronal nicotinic acetylcholine receptors J Biol Chem 280, 80–87 Nicke A, Wonnacott S & Lewis RJ (2004) a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic ... mammalian neuronal nicotinic acetylcholine receptor J Biol Chem 274, 36559–36564 12 Chiara DC, Xie Y & Cohen JB (1999) Structure of the agonist-binding sites of the Torpedo nicotinic acetylcholine receptor: ... become widely used tools in studies on nicotinic acetylcholine receptors (nAChRs) [6,7] because they can distinguish between different nicotinic acetylcholine receptor (nAChR) subtypes For example,...

Ngày tải lên: 16/03/2014, 13:20

... enhanced IL-1 signaling because of the loss of the IL-1 receptor' s physiological antagonist We induced AD-relevant neuroinflammation and neuronal damage by intracerebroventricular (ICV) infusion ... correlate with increased severity of AD-relevant neuroinflammation and neuronal damage To test this hypothesis, we used interleukin-1 receptor antagonist knockout At 42 days after the start of Aβ infusion, ... that has increased IL-1 signaling due to loss of the IL-1 receptor' s physiologic antagonist shows enhanced Aβinduced neuroinflammation and neuronal damage, are consistent with previous work in the...

Ngày tải lên: 19/06/2014, 22:20

... work makes a systems level analysis of contextdependent signaling by the epidermal growth factor receptor (EGFR) in the suprachiasmatic nuclei (SCN) Circadian rhythms are driven by gene regulatory ... binding predictions for CREB and three hepatocyte nuclear factor (HNF) family members in human non -neuronal cells, respectively To utilize these data in our study, we mapped the human gene data to ... Specifically, we tested reports In spite of the fact that the protein-DNA interaction data are for non -neuronal human cells, moderate enrichments were observed for HNF1-alpha and CREB in our gene groups,...

Ngày tải lên: 14/08/2014, 16:21

... of receptors (GFRs) and co-receptors The homodimeric GFLs activate downstream signaling by forming a multicomponent ligand receptor complex consisting of a preferred high-affinity GDNF family receptor ... GFLs transduce signal through a multi-component receptor complex consisting of GPI anchored GDNF family receptor alpha (GFRα) and trans-membrane co-receptors RET (RE arranged during Transformation) ... preferred receptor of GDNF and NTN respectively Mice lacking GFRα1 and GFRα2 signaling were found to suffer from deficits in various neuronal systems, supporting the physiological role of these receptors...

Ngày tải lên: 09/09/2015, 10:13

... family of receptors (GFRs), co-receptors Ret and NCAM 1.3 GDNF receptor complex in neuronal biology 1.4 GDNF receptor complex in cancer 10 1.5 Alternatively spliced isoforms of GDNF receptors ... regulation of GDNF receptor system and the profile of neuronal lineages in adherent culture in order to establish a model for the study of GDNF receptor system in neuronal differentiation and neuronal ... signal is transduced through interaction of ligand bound receptor GFRα, with transmembrane co -receptor Ret or NCAM 1.3 GDNF receptor complex in neuronal biology Since the discovery of the roles of...

Ngày tải lên: 30/09/2015, 10:11

... Practical Aspects of Agents and the Prospects of Agents in a Three Layer Model Intelligent Software Agents Theory Intelligent Software Agents Theory 2.1 Introduction Intelligent software agents are a ... being done into separate agents, such as mail agents, news agents and search agents These are the first step towards more integrated applications, where these single, basic agents are used as the ... offered There are many different kinds of software agents, ranging from Interface agents to Retrieval agents This thesis will be mainly about agents that are used for information tasks (such as...

Ngày tải lên: 08/10/2012, 15:22

... and in the absence of protein structure information (30) SiRNA targeting P2X3, δ-opioid receptor and NMDA receptor has been explored as potential means to manage pain (31-33) RNAi primarily acts ... immune response by NMDA receptors has neuropathological consequences J Neurosci 2003; 23: 11094-103 Tanga F.Y., Nutile-McMenemy N., DeLeo J.A The CNS role of Toll-like receptor in innate neuroimmunity ... Rossini C., Granucci F., Giagnoni G., Peri F., Costa B Glial TLR4 receptor as new target to treat neuropathic pain: efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice...

Ngày tải lên: 25/10/2012, 11:48

... Int J Med Sci 2009, 219 Introduction Chemotherapy, including novel antineoplastic agents, is becoming increasingly effective for cancer and is performed widely, but adverse drug ... drug reactions Among such reactions, phlebitis induced by intravenous infusion of antineoplastic agents reduces the completion of chemotherapy The causative factors of phlebitis include the pH ... may be a useful and specific index to evaluate perivascular tissue damages caused by this kind of agents [15] We have already shown that both rapid administration and dilution of the infusion solution...

Ngày tải lên: 26/10/2012, 09:57

... respectively This finding suggests that these two thioglycosides may be promising anti-diabetic agents, based on their strong inhibitory effects on hSGLT Results Inhibition of SGLT transport activity ... kidney through O-glycosides represents a different mechanism of action from other hypoglycemic agents However, until now it has not been applied to clinical practice because absorption of these ... thioglycosides exert this inhibitory effect may be different from that of other oral anti-diabetic agents Studies using rat enterocytes, where the process of glucose transport is very similar to...

Ngày tải lên: 26/10/2012, 10:04

... presence of phosphorylated BRCA1 (pBRCA1) was also performed In some cases of AD, pBRCA1 stained neuronal nuclei as well as a smaller population of NFT (Figure 5B) compared to non-phosphorylated ... or metabolic dysfunction, from which the cell cannot overcome and maintain balance, resulting in neuronal death As AD is a disease that can last ten years or more, rather than succumbing to apoptosis ... earliest event in Alzheimer disease J Neuropathol Exp Neurol 2001; 60: 759-67 Su JH, Deng G, Cotman CW Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine...

Ngày tải lên: 26/10/2012, 10:04