neuroimmune interactions and pain the role of immune and glial cells
Báo cáo khoa học: " Science review: Mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids" pdf
... artery, the renal artery and the aorta form rich plexuses in the cortex and supply the gland The plexuses are continuous with the sinuses of the medulla, which drain into the central vein of the ... superfamily It has retained the stressed native structure typical of the inhibitor members of the family, and the transition from the stressed to the relaxed conformation of the protein has been adapted ... arterial branches to the pars tuberalis and the primary plexus of the portal vessels in the median eminence are derived from the internal carotid and posterior communicating arteries The venous blood...
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MECHANISMS OF HEXOSAMINE-INDUCED CHOLESTEROL ACCUMULATION AND THERAPEUTIC ACTIONS OF CHROMIUM
... recommended by the Food and Nutrition Board of the Institute of Medicine of the National Academy of Sciences, 34 the adequate intake of chromium is set to 30 µg/d (243) Given the known absorption of chromium ... this glucose and lipid toxicity is known to promote the progressive impairment in the ability of the β cells of the pancreas to produce and secrete insulin, leading to the diagnosis of frank T2D ... 65) Another model, the repulsion model, suggests that GSVs can constantly access the PM, despite the absence of insulin (63) Rather, GSVs that arrive at the PM are repelled, and the action of insulin...
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Mixture toxicity of POPs dioxins, PCBs, PBDEs considerations from mechanisms of actions and for risk assessment
... Canton (2010) A Global Foodborne Burden of Disease? WHO-‐FERG In prep Es*ma*on of number of W-‐Europe children exceeding the TDI significantly (< 10x) in period 2005-‐2010 ... limited toxicological relevance and use for risk assessment of environmental matrices Aspects reduced bioavailability, environmental fate and transport not in present REP/TEF ... not in present REP/TEF studies evaluated Mixtures of PCDDs, PCDFs and DL-‐PCBs s*ll a health risk? One order of magnitude decline in background human exposure since...
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Báo cáo y học: "Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells"
... 43 the balance of the expression of such positive and negative regulators of apoptosis would determine apoptotic propensity In this study, we focused on the role of Bag-1 in the regulation of ... demonstrated the importance of Fas and FasL [15], and that of TNF-R1 and TNF-α[16], in preeclampsia Thus, hypoxia-induced changes in the expression of both proapoptotic and antiapoptotic proteins, and ... On the other hand, the protein expression of caspase 3, PTEN, and JNK1 in JAR cells exhibited a 4.96-fold increase, 1.92-fold increase, and in the level of phosphorylated JNK 1&2 for JAR cells...
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Study on the Photolytic Mechanisms of Red 141 Dye Wastewaters with an 185nm Vacuum-UV lamp
... requirements of the VUV photolysis of water according to Eq (1) are related to the formation of high local concentration of hydroxyl radicals (OH.) and a series of other species (Gonzalez and Braun, ... considerable disadvantage of the majority of the degradation processes introduced above is the need to add external agents into the aqueous medium In such situation, the effectiveness of the processes relies ... NaOH and H2SO4 solutions The Red 141 and H2O2 and other chemicals used were reagent grade and all experimental solutions were prepared with deionized water The solution of Red 141 was added to the...
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ISOTOPE HYDROGRAPH SEPARATION FOR MODELING OF RUNOFF MECHANISMS OF ATMOSPHERICALLY DERIVED CHEMICAL AND RADIOACTIVE POLLUTANTS
... In principle, the ratio of their content of the depositions to that of the surface soil can reflect the enrichment of the element through the atmosphere In the case of no increase, the ratio will ... to the amount-weighed mean δD of the precipitation samples (-28.1 ‰), and C2 was set to the δD of the river water just before the precipitation event (-47.9 ‰) For the main part of the runoff ... previously As a result of the calculation, and by setting C1 and C2 as mentioned above, the fraction of new water evaluated for the main part of the runoff (0000 of Oct 22 to 1600 of Oct 23, 40 h in...
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Mechanisms of Unstable Nitrite Inhibition of Aerobic Phosphate Uptake
... rate in the presence of nitrite was 13 mgP.gVSS-1.h-1 and the % activity of phosphate uptake was 39% On the other hands, in the case of AA with 1.9 mgN/gVSS of initial nitrite concentration, the ... ml of sludge was taken from the reactor at the end of anaerobic phase and was divided into two portions The one was provided with air and the other was added with nitrate anaerobically Both of ... concentration, the size of inhibition was the smallest among them The phosphate uptake rate in the presence of nitrite was 20 mgP.gVSS-1.h-1 and the % activity of phosphate uptake was 60 % These results...
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Transmission mechanisms of monetary policy the evidence
... Examines whether one variable affects another by using data to build a model that explains the channels through which the variable affects the other • Transmission mechanism – The change in the money ... not • Neither model has turned out be more accurate than the other Historical Evidence • If the decline in the growth rate of the money supply is soon followed by a decline in output in these episodes, ... component of aggregate spending (output) Reduced-Form • Examines whether one variable has an effect on another by looking directly at the relationship between the two • Analyzes the effect of changes...
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Tài liệu Women''''s attitudes towards mechanisms of action of family planning methods: survey in primary health centres in Pamplona, Spain doc
... assessment of understanding and attitudes for postfertilization effects The purpose of our study was to assess the attitudes about the mechanisms of action of FP in terms of whether these may ... hypothetical method of FP In further sections women were asked about their knowledge of the mechanism of action of specific FP methods and if doctors or providers should explain the details of ... at the conclusion of the questionnaire The Spanish and the English version of the questionnaire are available from the authors upon request The questionnaire was distributed between March and...
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Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc
... those of Sanders et al [155] On the basis of thermodynamic and kinetic data, they concluded that oligomerization of the chicken cystatin occurred in the pre-exponential phase of the fibril growth They ... of amyloid fibrils differing in the number of filaments and the helicity of their intertwining [22–24] The structure of the mature fibrils has been determined in a limited number of cases by either ... understanding of the importance of different parts of the molecule and their flexibility in the process of amyloid fibril formation often results more from a structural analysis of the amyloid endpoint...
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Tài liệu Báo cáo khoa học: Survival mechanisms of pathogenic Mycobacterium tuberculosis H37Rv ppt
... facilitated a more rational and directional approach towards the understanding of these mechanisms Therefore, it is clear that a better understanding of these mechanisms and the host–pathogen interaction ... release of the complete genome sequence of M tuberculosis, and the genomic sequence then suggested the presence of eleven putative protein kinases [48] The serine ⁄ threonine kinases of M tuberculosis ... E coli with the ability to invade HeLa cells and survive within the host macrophages [47] The intracellular survival of bacteria was impaired with the spontaneous loss of DNA from the transformants...
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Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx
... because the latter depends on (a) the structural integrity of the vascular bed of the penis; (b) the endothelium lining the cavernosal arteries and the helicine arterioles, as well as the endothelium ... production Because androgen deficiency is linked to the development of IR and T2DM, and the latter contributes profoundly to endothelium dysfunction and ED [130,131], the concept of androgen deficiency ... key role in the pathogenesis of ED Erectile function is a neurovascular process that requires the health of the central and peripheral nervous system, as well as the vascular bed of the penis, and...
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Tài liệu Báo cáo khoa học: Reaction mechanisms of thiamin diphosphate enzymes: redox reactions pdf
... Rapid depletion of the thiamin radical and reduction of all clusters is only achieved after addition of CoA What is the special role of CoA for propagation of the second electron and the associated ... deprotonation of C2a-OH of HEThDP and protonation of FAD at N5 and N1) The tight and rigid binding of both cofactors excludes a direct carbanion mechanism with covalent linkage between C2a of the HEThDP ... irreversible conversion of pyruvate, CoA and NAD+ into CO2, NADH and acetylCoA (Eqn 1) [2] The latter is utilized as a precursor for the Krebs cycle and the biosynthesis of fatty acids and steroids, whereas...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... intermediate [11] The sum of these ndings points at the involvement of more than one active oxidant in the diverse types of P450-catalyzed substrate processing [1215] The goal of the present perspective ... which small alterations in the environment can cause drastic changes in the reactivity of the active species [76] Further support in favour of the idea of the involvement of a high-valent iron-oxene ... important role in the aromatization process in concert with a histidine residue through facilitating abstraction of the 2b-hydrogen in the A-ring of the C-19 substrate and donation of a proton to the...
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Motivating Better Hygiene Behaviour: Importance for Public Health Mechanisms of Change doc
... shortage of water often goes hand in hand with a high incidence of skin and eye diseases It was not the diseases, but the scarcity of drinking water and the long distances that were the first need of ... change and how they will promote and achieve the change The hygiene educator does not direct the change but helps them to choose the key changes and organize the process of change Insight into the ... understanding of what motivates people for wanting these changes: convenience, status, the local health concepts and the means they have to implement and sustain the changes and replicate them by themselves...
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Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt
... N-acylposphatidylethanolamine-hydrolyzing phospholipase D and reduced activity and expression of FAAH Both the accumulation of anandamide (and of other N-acylethanolamines) and the protective effects of rimonabant (at mgÆkg)1) ... In another study, both CB1 and CB2 receptor agonists were able to prevent the cellular damage, the efflux of lactate dehydrogenase, the release of glutamate and tumor necrosis factor-a, and the ... phospholipase D and diacylglycerol (DAG) lipase [8] Because of their lipid solubility, AEA and 2-AG cannot be stored in vesicles and therefore they are synthesized on demand and travel, in a...
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Báo cáo khoa học: Molecular mechanisms of the phospho-dependent prolyl cis ⁄ trans isomerase Pin1 docx
... monomer and swapped dimer are mainly limited to the conformation of the Glu-Pro dipeptide in the hinge region between the last b-strand and the core of CKS The crystal structure of the complex of ... mechanisms of Pin1 G Lippens et al Fig Schematic view of the parallel between Pin1 and CKS in protein degradation Top: Model of the SCFCDC4 E3 ligase and the role of Pin1 Pin1 is brought in with the ... interact with the Pin1 WW domain (G Lippens, I Landrieu, C Smet and R Brandt, unpublished results) Further structural characterization of the complex between the Pin1 WW domain and the amyloid...
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Báo cáo khoa học: Two L-amino acid oxidase isoenzymes from Russell’s viper (Daboia russelli russelli) venom with different mechanisms of inhibition by substrate analogs pdf
... instead of FAD [36] The UVvisible absorption spectrum and RP-HPLC analysis of the dissociated cofactor from L1 and L2 indicated the presence of FAD (Fig 2) Mass spectral analysis of the cofactor and ... tively The spectral features of the dissociated cofactor were similar to those of FAD The shifting of absorption maxima of the enzyme-bound avin was due to its microenvironment The RP-HPLC proles of ... bond with the carbonyl oxygen atom of Gly464 The side chain of the ligand participated in hydrophobic interactions with the side chains Ile430, Ile374, and Phe227 [11] On the basis of the crystallographic...
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Báo cáo khoa học: Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail A comparative study of acylation systems of phospholipids in rat and the fish species Seriola quinqueradiata pot
... and sphingomyelin The fatty acid compositions of PtdCho, PtdEtn, PtdSer and PtdIns of brain, heart, spleen, kidney and ovary of yellowtail were investigated (Tables 1–4) In all the tissues, the ... significance of the enrichment of arachidonate in PtdIns can be clarified by investigating the functions of cells in which the arachidonic acid residue of PtdIns has been replaced with another fatty ... in the presence of large amounts of docosahexaenoic acid are in good agreement with the distribution patterns of arachidonic acid between PtdCho and PtdIns observed in the fatty acid analysis of...
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Báo cáo khoa học: Kinetic mechanisms of glycine oxidase fromBacillus subtilis docx
... understanding of the evolution and the mode of functioning of this class of enzymes The main goal of this project was to elucidate the structure-function relationships in glycine oxidase, with the aim of ... steric hindrance The presence of a carboxylic group and an amino group is not mandatory for binding and catalysis Furthermore, the analysis of the binding data for glycine oxidase and linear aliphatic ... and k)5 % 15– 100 M)1Æs)1 These estimated values clearly show that the release of the imino acid from the reduced glycine oxidase is slow in comparison to the rate of flavin reduction and to the...
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Tìm thêm: xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25