neurocognitive findings in bipolar disorder

... cerns, including improving inter-episode functioning and perceived quality of life Our review found that there is growing interest in characterizing QoL in bipolar disorder populations, and determining ... group in Canada, and will be dealt with in unison Following this, six other studies (one comparing QoL in patients with during different phases of the disorder, a recent study assessing QoL in bipolar ... between the two reviews due to differing inclusion criteria) The remaining 21 (75%) were published between 2000 and 2004, indicating that there is developing interest in this field of research The studies...

Ngày tải lên: 20/06/2014, 15:20

... rumination in bipolar disorder reveal that not only individuals with bipolar disorder ruminate in response to negative affect in depressed states, they ruminate in response to positive affect as well In ... executive dysfunction in bipolar disorder Research on neuropsychological functioning in bipolar disorder reveals deficits in several cognitive domains, including attention, learning and memory, and ... present in patients with bipolar disorder in euthymic states is exacerbated in mania and depression In fact, in studies using tests of executive functioning, including attentional setshifting [65,...

Ngày tải lên: 21/06/2014, 19:20

... Quetiapine, venlafaxine, lamotrigine Venlafaxine Risperidone Table 2: Working Memory Task change in the BOLD signal for each region of interest pre-post lithium The change in each region of interest ... alteration in activation in specific brain regions during a word generation task in euthymic, but not depressed, bipolar patients However, there appears to be no effect in either group in a working ... significantly increased activation compared to controls in a working memory task in several different brain regions [9] Thus, studies to date support suggestions of underlying functional changes in bipolar...

Ngày tải lên: 08/08/2014, 21:20

... evidence in bipolar disorder Expert Opin Pharmacother 2007, 8(7):1001-1009 McIntyre RS, Woldeyohannes HO, Yasgur BS, Soczynska JK, Miranda A, Konarski JZ: Maintenance treatment in bipolar disorder: ... agents in bipolar disorder J Affect Disord 2001, 65(1):85-93 Hunter J, Schmidt F: Methods of Meta-Analysis: Correcting error and bias in Research findings 2nd edition Sage Publications Inc.; 2004 ... mania, quetiapine and the olanzapine-fluoxetine combination are approved for the treatment of acute bipolar depression, and olanzapine, quetiapine and aripiprazole are approved for maintenance phase...

Ngày tải lên: 08/08/2014, 23:21

... olanzapinefluoxetine combination (OFC) [56,61-64] Quetiapine has proven efficacy against acute mania [45,65,66], including an unpublished study (NCT00309699) The data are solid also against acute bipolar ... SGAs against acute mania and SGAs in maintenance protecting from mania) Four effect cases are not adequately studied (FGAs against acute bipolar depression and in maintenance protecting from ... clinicians maintain antidepressants in some patients with acute mania? Hints from the European Mania in Bipolar Longitudinal Evaluation of Medication (EMBLEM), a large naturalistic study J Clin...

Ngày tải lên: 09/08/2014, 01:21

... studies [20,83], but is contrary to those finding higher SUD rates in bipolar I disorder compared to bipolar II disorder [1,6] Our findings of no differences in BD illness severity between patients ... study, covering both in- and outpatient units including substance abuse clinics Conclusions The current findings show that there is a significant increase in illicit substance use in BD compared ... Substance abuse in bipolar disorder Bipolar Disord 2001, 3:181-188 Pini S, Dell’Osso L, Mastrocinque C, Marcacci G, Papasogli A, Vignoli S, et al: Axis I comorbidity in bipolar disorder with psychotic...

Ngày tải lên: 11/08/2014, 16:22

... recruiting centres 132 patients fulfilling the criteria below will be included into this study by nine centres in Norway All the patients will first be included in the Bipolar Research And Innovation ... published guidelines defining objective clinical criteria for indications of treatment with ECT in bipolar depressions In the present protocol “indication for ECT” is one of the inclusion criteria ... participants in the study have taken part in mutual training-sessions in the different assessments and rating scales All participants have taken part in interrater-scorings The scorings for the...

Ngày tải lên: 11/08/2014, 16:22

... associated treatment costs in commercially insured patients with bipolar disorder newly treated with aripiprazole, ziprasidone, olanzapine, quetiapine or risperidone, alone or in combination with mood ... treating bipolar disorder in the California Medicaid (Medi-Cal) program J Affect Disord 2002, 71(1-3):131-139 Blanco C, Laje G, Olfson M, Marcus SC, Pincus HA: Trends in the treatment of bipolar disorder ... studies can provide important insights into the outcomes of clinical practice in real-world settings, where dosing, titration and concomitant medications are not constrained by trial protocols Such...

Ngày tải lên: 11/08/2014, 16:22

... influencing obesity in bipolar patients include nutrient intake and physical activity In assessing the nutrient intake of persons with bipolar disorder, Elmslie and colleagues found that they had increased ... studied primarily in patients with seizure disorders Carbamazepine-induced increase in total cholesterol is primarily due to an increase in HDL [34] This occurs during the initial weeks of therapy, ... guidelines are being formulated to aid clinicians in identifying patients at risk Screening for diabetes should include questioning patients about symptoms such as excessive thirst and urination,...

Ngày tải lên: 25/10/2012, 10:51

... compliance causes an increased work of breathing and the following clinical findings Patient identification Primarily occurs in infants of less than 34 weeks gestational age Chief complaint Respiratory ... occur in more severe cases The clinical findings associated with CF are as follows Patient identification Occurs equally in males and females; predominately in Caucasians; usually diagnosed in childhood ... serious problem in terms of airway patency and matainence Following is a list of the typical clinical findings associated with Epiglottitis Patient identification Occurs most often in children approximately...

Ngày tải lên: 29/03/2014, 11:21

... underlying cognitive domains in bipolar disorder The SCIP seems to work properly when it is administered by psychiatrists who have participated in a relatively brief training exercise In future investigations ... may be in order This would be facilitated by a more wide spread incorporation of cognitive assessments into the routine clinical examinations of bipolar patients A relative paucity of routine cognitive ... cognitive domains Also, sensitivity to change remains unexplored Conclusion: With minimal training, physicians obtained a reliable and valid estimate of cognitive impairment in approximately 15 minutes...

Ngày tải lên: 18/06/2014, 19:20

... choline concentrations, but only in limited circumstances In one study in 11 bipolar children patients were examined before and after lithium administration [14] There were no significant findings ... Cohen BM, Lafer B, Christensen JD, Renshaw PF: Choline in the treatment of rapid-cycling bipolar disorder: clinical and neurochemical findings in lithium-treated patients Biol Psychiat 1996, 40:382-8 ... better controlled in terms of the patients receiving valproate monotherapy, only including bipolar Type I patients, and in using an external choline solution to accurately quantify choline concentrations...

Ngày tải lên: 08/08/2014, 20:23

... the approval of quetiapine and the olanzapine-fluoxetine combination against acute bipolar depression and the approval of olanzapine, quetiapine and aripiprazole for the maintenance phase This ... by housing and by strain [67] Aripiprazole in bipolar disorder RCTs Acute mania Aripiprazole was studied against acute mania in five RCT studies involving a placebo arm In the first (CN138-009), ... Pharmacokinetics and tolerability of intramuscular, oral and intravenous aripiprazole in healthy subjects and in patients with schizophrenia Clin Pharmacokinet 2008, 47:475-485 Findling RL, Kauffman...

Ngày tải lên: 08/08/2014, 23:21

... schizophrenia or bipolar disorder as established by the Structured Clinical Interview for DSM-IV, being clinically stable (defined as having had no changes in severity or new treatments initiated in the ... afford greater insight in describing and grading the impact of side effects associated to antipsychotic drugs [15,16] A brief instrument is preferred for use in clinical practice and in investigations ... experts translated the original version in Swedish into Spanish Experts examined and compared these three different versions in order to reach a single one by consensus (intermediate version 1.0)...

Ngày tải lên: 09/08/2014, 01:21

... bovine serum (GIBCO) and a mixture of penicillin-streptomycinglutamine (PSG from GIBCO) Puromycin-resistant MEF lines were grown, maintained, serum shocked, and serum starved in medium containing ... of β-catenin protein, which should increase as total GSK3 levels decrease [39-41] A clear reduction in GSK3α protein levels with a concomitant increase in β-catenin levels was detected in several ... pacemaking properties of single cells, suggesting a direct modulation of the clock mechanism [15] GSK3, a serine/threonine kinase encoded in mammals by two isoforms, GSK3α and GSK3β, is a direct, in...

Ngày tải lên: 10/08/2014, 09:20

... international recognition as a clinical investigator Dr Findling is the principal investigator of a National Institute of Child Health and Human Development contract examining lithium in the treatment of ... that occur in children and adolescents with bipolar disorder, including conduct disorder, oppositional defiant disorder, anxiety disorders, and pervasive developmen- Introduction tal disorders ... 2006) In contrast to the findings in pediatric bipolar mania, mI concentrations in these prefrontal regions at weeks and were not different from those at baseline These results indicate that in...

Ngày tải lên: 11/08/2014, 04:20

... TREATMENTS terior cingulate These findings preliminarily indicate variations in neuronal activation of bipolar patients when comorbid ADHD is present Most youths with bipolar disorder in these fMRI ... explain these findings (Dager et al., 2004) Neuropharmacology 33 There are limited data evaluating the effects of psychotropic medications on GLX in bipolar disorder In one study of adults with bipolar ... exercised in translating the in vitro and animal findings to humans Lithium and Neurotransmission Preclinical studies and information from adult human studies have provided information regarding the...

Ngày tải lên: 11/08/2014, 04:20

... carbamazepine Lithium Multiple Verapamil Carbamazepine add on Lithium Lecithin Tamoxifen Nimodipine Diltiazem Diltiazem Nifedipine Nimodipine Nimodipine Nimodipine Nimodipine Nimodipine Nimodipine ... have been positive in the treatment of bipolar disorder, including treatmentresistant and rapid-cycling bipolar disorder An early case series of female inpatients with bipolar disorder showed improvement ... discontinuation of nimodipine Yingling and colleagues report the use of nimodipine in the treatment of a pregnant patient with bipolar disorder (Yingling, Utter, Vengail, & Mason, 2002) She was being...

Ngày tải lên: 11/08/2014, 04:20

... triggers, tool kit, taking charge of mad, sad, bad feelings Negative family cycles; thinking, feeling, doing Thinking, feeling, doing Problem solving for parents Problem-solving skills School services ... IFP, individual family psychoeducation; BPD, bipolar disorder; BP-I, bipolar I disorder; BP-II, bipolar II disorder; BP-NOS, bipolar disorder not otherwise specified; MDD, major depressive disorder; ... symptoms, particularly in response to the pressures of returning to school He continued to engage in biweekly individual therapy and was learning coping strategies, including mindfulness techniques,...

Ngày tải lên: 11/08/2014, 04:20

... developmental timing of SUD as it pertains to bipolar disorder in adults These research teams have found that in adults with bipolar disorder, the bipolar disorder preceded SUD in 30– 47% of cases (Winokur ... Given the prominent genetic influences in both bipolar disorder and ADHD (as individual disorders and perhaps cosegregating), it remains unclear whether SUD in youths with bipolar disorder represent ... executive functioning deficits in adolescents with bipolar disorder These findings in adolescents with bipolar disorder are of great relevance to the study of SUD given the link between academic...

Ngày tải lên: 11/08/2014, 04:20