neoadjuvant chemotherapy in malignant pleural mesothelioma

... activity in the treatment of advanced tumours, both in combined and in monotherapeutic regimes Notably, oxaliplatin has proven to be active at least in vitro against cisplatin-resistant cell lines ... clinical activity in the treatment of cisplatin/ carboplatin refractory diseases [14-16] Schütte and co-workers have previously introduced a combined chemotherapy with oxaliplatin and gemcitabine ... chemotherapy of oxaliplatin with/without gemcitabine In the majority of cases oxaliplatin and gemcitabine were administered as combination therapy (n = 25 patients vs patients with oxaliplatin...

Ngày tải lên: 20/06/2014, 00:20

... imaging for staging of limited pleural meothelioma Invest Radiol 2008, 43:737-744 International Mesothelioma Interest Group: A proposed new international TNM staging system for malignant pleural ... Volumes by CT and PET-CT in 13 Patients with Malignant Pleural Mesothelioma Volume, cc GTV Mean ± S.D Min-max CTV Mean ± S.D Min-max PTV1 Mean ± S.D Min-max PTV2 Mean ± S.D Min-max CT PET-CT P Value ... SJ: Resection margins, extrapleural nodal status and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: results in 183 patients J Thorac...

Ngày tải lên: 09/08/2014, 10:20

... not been investigated in peritoneal mesothelioma but a recent trial in pleural mesothelioma did not show any benefit [29] Interestingly in this erlotinib trial, the high EGFR expressing tumor ... one known point mutations in the EGFR-TK domain in MPM patients All mutations are clustered and reside near the ATPbinding cleft of the tyrosine kinase domain Presence of each mutation in heterozygous ... paraffin embedded tissue available to perform immunostaining and mutation analysis Institutional review board approval was obtained for this investigation Mutation analysis of EGFR in malignant mesothelioma...

Ngày tải lên: 09/08/2014, 03:22

... staining for June 2004, showing infiltration by epithelioid Original tumour cellson Calretinin (b), consistent with epiOriginal pleural biopsy on June 2004, showing infiltration by epithelioid ... with immunohistochemical staining for Calretinin (b), consistent with epithelioid mesothelioma Figure Photos of skin lesion in the right cheek Photos of skin lesion in the right cheek Page of ... prolong survival in mesothelioma Drugs with single- http://www.wjso.com/content/7/1/84 agent activity include pemetrexed, raltitrexed, vinorelbine, and vinflunine [5] The combination of pemetrexed...

Ngày tải lên: 09/08/2014, 04:21

... Response rates of neoadjuvant CT in LABC are between and 8.7% with anthracycline-based CT, taxane-containing regimens, or navelbine-containing regimens [9,37,38] In our study, using CCRTh, we found ... versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III nonsmall-cell lung cancer J Clin Oncol 1999, 17:2692-2699 Al-Sarraf M, ... were in clinical stages IIB, IIIA, and -B were 21.4, 42.9, and 35.7%, respectively (Table 1) All neoplasms were infiltrating ductal carcinoma ER-positive expression was found in 42.9%, and in 41.1%...

Ngày tải lên: 09/08/2014, 10:20

... tomography; GEM, gemcitabine; MPM, malignant pleural mesothelioma; IL-2, interleukin-2; IMIG, International Mesothelioma Interest Group; INFalpha, interferon-alpha; INF-gamma, interferon-gamma; SD, ... combined therapy showing local relapse of malignant pleural mesothelioma in the right pleural cavity, especially with tumor mass formation in the mediastino-hilar region causing airway narrowing ... staging) Then, postoperative intrathoracic chemothermotherapy using carboplatin (CBDCA, 450mg intrapleurally, one course) was administered, followed by systemic chemotherapy using gemcitabine...

Ngày tải lên: 11/08/2014, 17:21

... trials are ongoing to evaluate these drugs in the neoadjuvant setting, including Neo-ALTTO (Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimization) in phase III and CHERLOB in phase II ... FU, 5-flourouracil; adr, adriamycin; cyc, cyclophosphamide; epi, epirubicin; cis, ciplatin; doc, docetaxel; dox, doxorubicin; vinc, vincristine; vino, vinorelbine; tam, tamoxifen; pac, paclitaxel ... agents or combinations must be defined Optimal treatment algorithms also involve minimizing toxicity and maximizing quality of life And how should chemotherapy be administered in conjunction...

Ngày tải lên: 27/06/2014, 13:20

... findings of mediastinal invasion regressed upon two cures of neoadjuvant chemotherapy This shows that preoperative neoadjuvant chemotherapy is an effective method Following the diagnosis of malignant ... incisional biopsy in establishing preoperative diagnosis Neoadjuvant chemotherapy is applicable particularly in case of lesions with mediastinal invasion or lesions of extremely large sizes In ... Competing interests The authors declare that they have no competing interests Authors' contributions BK was involved in study conception and design and reviewing previous research GG was involved in...

Ngày tải lên: 09/08/2014, 07:22

... the incidence is much higher in patients receiving trastuzumab concurrently with anthracycline-containing chemotherapy regimens [21] Instead of using ECF, we decided to use docetaxel, oxaliplatin ... overexpressing HER2 The use of docetaxel, oxaliplatin and capecitabine in combination with trastuzumab in this setting remains experimental, and ideally should be considered only in the context of a clinical ... paradigm using trastuzumab in combination with chemotherapy in patients with advanced gastric cancer overexpressing HER2 MAGIC trial for investigation of perioperative chemotherapy was conducted in patients...

Ngày tải lên: 10/08/2014, 22:21

... determined by flow cytometry after surface staining or intracellular staining with anti-human-specific Abs conjugated with either phycoerythrin or fluorescein isothiocyanate These human Abs included ... Servant, R Zollinger, SI Bogiatzi, P Hupé, E Barillot, V Soumelis, A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human ... findings [14], we noted that percentages of Th17 cells represented the higher values in MPE (3.7 ± 0.4%), showing a significant increase in comparison with those in the Page of 10 corresponding...

Ngày tải lên: 12/08/2014, 13:22

... possible model of drug interaction in GEO cells, which involves the complex interaction of proteins involved in cell cycle regulation To recapitulate, combining CDO with cytotoxic chemotherapy reduced ... that CDO alone did not increase the extent of staining However, in cells that had been cocultured with CDO and a cytotoxic drug, staining was significantly increased, indicating the presence of senescence ... target for chemotherapy Indeed, it has been shown that a palindromic trioctamer of this sequence can interfere with CREB binding, and specifically inhibit PKA subunit expression, interfering with...

Ngày tải lên: 07/03/2014, 15:20

... steroids in the percentage of PBMCs displaying p-STAT-3 since patients both receiving and not receiving steroids within the same histology could not be compared due to the routine administration of intraoperative ... intraoperatively before skin incision and after the administration of 10 mg of dexamethasone, or during a routine clinic visit during a year time period (3/3/08-2/18/09) Eligible participants included any ... the CNS (n = 6; including four lung carcinomas, one bladder and one parotid gland), indicating that general anesthesia is not a contributing factor in the percent of PBMCs displaying pSTAT-3 Mean...

Ngày tải lên: 18/06/2014, 15:20

... the intrinsic chemoresistance of malignant melanoma, novel strategies are currently being investigated in order to increase tumor control, such as ASOs These agents have shown convincing in vitro ... [41] Treatment options include chemotherapy with dacarbazine, platinum analogues, chloronitrosureas, vindesine, temozolomide, taxanes, immunotherapy with interferon, interleukin and BCG [41,42] However ... fixed in 10% bufferedformalin and paraffin embedded Sections of μm were stained with haematoxylin-eosin, and haematoxylin-van Gieson For immunohistochemstry, μm sections were incubated in a microwave...

Ngày tải lên: 18/06/2014, 22:20

... shown in Figure 1A-D and the staining distribution in primary tumours vs metastases in Figure 1E-F Interestingly, and in line with previous in vitro data [20], RBM3 expression was strong in the ... [15] As RBM3, when present, was expressed in > 75% of the cells, predominantly in the nuclei and in varying intensities, only the intensity of the staining was accounted for and denoted a score ... its clinical utility in stratification of melanoma patients should be validated in future studies According to current clinical guidelines in Sweden, sentinel node biopsy is performed in melanomas...

Ngày tải lên: 20/06/2014, 04:20

... the intrinsic chemoresistance of malignant melanoma, novel strategies are currently being investigated in order to increase tumor control, such as ASOs These agents have shown convincing in vitro ... [41] Treatment options include chemotherapy with dacarbazine, platinum analogues, chloronitrosureas, vindesine, temozolomide, taxanes, immunotherapy with interferon, interleukin and BCG [41,42] However ... fixed in 10% bufferedformalin and paraffin embedded Sections of μm were stained with haematoxylin-eosin, and haematoxylin-van Gieson For immunohistochemstry, μm sections were incubated in a microwave...

Ngày tải lên: 20/06/2014, 04:20

... counterintuitive because the amount of UVB present in the terrestrial spectrum decreases with increasing latitude, suggesting something else must be increasing the incidence of CMM with increasing ... an alarming rate around the world in indoor working industrialized populations In most regions of the world, the CMM incidence decreases with increasing latitude However, in Europe the incidence ... these studies have offered insights on trends in melanoma incidence and mortality, in addition to the intrinsic and extrinsic risk factors that are increasingly important in the management and prevention...

Ngày tải lên: 27/06/2014, 19:20

... sites (single versus multiple); type of first-line chemotherapy (anthracycline- and/or taxane-containing regimen versus other); previous line of hormonotherapy administered in metastatic setting ... line chemotherapy Table Predictive factors for OS duration after a first line chemotherapy Int J Med Sci 2008, 103 Figure Progression free survival in first-line chemotherapy according to maintenance ... of chemotherapy in metastatic carcinoma of the breast Eur J Cancer 1997; 33 (13): 2194-2197 Nooi J M, de Haes J, Beex L et al Continuing chemotherapy or not after the induction treatement in...

Ngày tải lên: 08/08/2014, 17:20

... before initiation of neoadjuvant chemotherapy (NACT)that was administered in standard doses at three weekly intervals [Cyclophosphamide 500 mg/m2, Adriamycin 50 mg/m2(methotrexate in cardiotoxic patients) ... Wickerham DL, Wolmark N: Sentinel node biopsy after neo-adjuvant chemotherapy in chemotherapy in breast cancer: results from NSABP protocol B-27 J Clin Oncol 2005, 23:2694-702 Xing Y, Foy M, Cox DD: ... (30-40%) Demonstrating the accuracy of SLNB in this setting can help a proportion of initially node positive patients that have been down staged to N0 by avoiding the morbidity of routine axillary...

Ngày tải lên: 09/08/2014, 01:24

... remains to be determined Various regimens of neoadjuvant chemotherapy in gastric cancer have been shown to induce tumour responses [4] But the potential accompanied disadvantages, including increased ... regarding postoperative morbidity and mortality in patients receiving neoadjuvant chemotherapy for gastric cancer If neoadjuvant chemotherapy is to be considered as a therapeutic option in patients ... involvement as determined by physical examination, imaging and endoscopy Although clinical staging before treatment was similar in the two groups, pathologic staging (according to the AJCC system)...

Ngày tải lên: 09/08/2014, 02:21

... trastuzumabcontaining regimen in a patient with locally gastric cancer over expressing HER2 The use of oxaliplatin and capecitabine in combination with trastuzumab in this setting remains experimental, ... not retained and platinum based chemotherapy regimen including Capecitabine (2000 mg/m²/j) po bid on day1to day 14 plus oxaliplatin (130 mg/m²/j) on day were given every weeks Trastuzumab (intravenously, ... preoperative chemotherapy (infusional 5-FU 800 mg/m2 daily for five days plus cisplatin 100 mg/m2 on day or 2, every four weeks) or surgery alone In a Final report, patients undergoing neoadjuvant chemotherapy...

Ngày tải lên: 09/08/2014, 02:21