nanoscale drug delivery vehicles for solid tumors a new paradigm for localized drug delivery using temperature sensitive liposomes

nanotechnology for cancer therapy, 2007, p.810

Ngày tải lên : 04/06/2014, 14:30

... Xiaobin B Zhao, Natarajan Muthusamy, John C Byrd, and Robert J Lee Chapter 34 Nanoscale Drug Delivery Vehicles for Solid Tumors: A New Paradigm for Localized Drug Delivery Using Temperature Sensitive ... 489 Tae-il Kim and Jong-Sang Park Chapter 26 Dendritic Nanostructures for Cancer Therapy 509 Ashootosh V Ambade, Elamprakash N Savariar, and S (Thai) Thayumanavan Chapter ... Frederick, Maryland T J Miller Center for Drug Evaluation and Research Food and Drug Administration Silver Spring, Maryland Amitava Mitra Department of Pharmaceutical Sciences and Center for Nanomedicine...

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báo cáo hóa học:" Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences" doc

Ngày tải lên : 18/06/2014, 15:20

... peritoneal cavity is a common site of ovarian cancer presentation or recurrence usually accompanied by ascites [3] Massive ascites and the associated abdominal distention can cause anorexia, nausea, ... human H19 transcript was (5_-ACTGGAGACTAGGGAGGTCTCTAGCA) upstream and (5_-GCTGTGTGGGTCTGCTCTTTCAAGATG) downstream The polymerase chain reaction (PCR) was carried out for 30 cycles (98°C for 15 sec, ... profiling allows an individualized DNA-base approach to cancer therapy The therapeutic potential of the DTA-H19 vector was tested in a rat animal tumor model for colorectal liver metastases showing...

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Báo cáo hóa học: " Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences" potx

Ngày tải lên : 18/06/2014, 16:20

... activation was reported as a major mechanism for the IGF2 overexpression in a variety of tumors including bladder carcinoma, hepatocellular carcinoma, breast cancer, ovarian cancer and prostate cancer ... areas was calculated for each group The Mean and SD of bladder tumor area (A) and weight (B) are shown Amit and Hochberg Journal of Translational Medicine 2010, 8:134 http://www.translational-medicine.com/content/8/1/134 ... the RNA STAT-60TM Total RNA/mRNA isolation reagent, according to the manufacture’s instructions The RNA was treated by RNAse-free DNAse I to eliminate any contaminating DNA Total cDNA was synthesized...

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Nutraceuticals as new treatment approaches for oral cancer – i

Ngày tải lên : 01/07/2014, 13:23

... inﬂammatory pathways by nutraceuticals Cancer Metastasis Rev 2010;29(3):405–34 A Zlotogorski et al / Oral Oncology 49 (2013) 187–191 11 Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal ... Bioavailability of curcumin in clinical trials Although curcumin has multiple pathways of action that lead to enhanced therapeutic effects, the main disadvantages associated with its oral administration ... Evidence-based clinical recommendations regarding screening for oral squamous cell carcinomas J Am Dent Assoc 2010;141(5):509–20 Warnakulasuriya S Global epidemiology of oral and oropharyngeal cancer...

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IDENTIFICATION, KINETIC AND STRUCTURAL CHARACTERIZATION OF SMALL MOLECULE INHIBITORS OF ALDEHYDE DEHYDROGENASE 3A1 (ALDH3A1) AS AN ADJUVANT THERAPY FOR REVERSING CANCER CHEMO-RESISTANCE

Ngày tải lên : 24/08/2014, 09:51

... nitrogen and storing at −80°C ALDH 1A1 and ALDH2 protein was purified and kindly provided by Lanmin Zhai B Activity assays for ALDH 1A1 , ALDH2 and ALDH 3A1 The activity of ALDH 3A1 was measured using ... resistance to DNA damage (Lassen et al., 2006) ALDH 3A1 has also been identified as a potential diagnostic marker for non–small–cell lung cancer (Kim et al., 2007) and as a candidate gene in the pathogenesis ... some human tumors such as hepatoma, lung adenocarcinoma, myeloma, breast cancer as well as in stem cell populations (Sreerama et al., 1993, Sreerama et al., 1997) ALDH 3A1 is known to catalyze the...

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Delivery of proapoptotic biomolecules and drugs using amphiphilic block copolymer nanoparticles for anti cancer therapy

Ngày tải lên : 30/09/2015, 05:59

... sigmoidal curve This will provide an advantage for evaluating drugs demonstrating such a relationship This model also assumes that two drugs act through a similar mechanism, and the effect of each drug ... of orally administered Pac [49] 1.2.3.4 Combinations that lower therapeutic efficacy Some drugs work against each other and such pharmacodynamically antagonistic drug combinations are unsuitable ... the same target For example, additive drug interactions were observed in human colon cancer cell lines after treatment with 17allylamino-17-demethoxygeldanamycin (17-AAG) and oxaliplatin 17-AAG...

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Insights into the mechanism of safingol and its potential to synergize with anti cancer drugs

Ngày tải lên : 11/09/2015, 10:02

... xii List of Abbreviations 2-NBDG 3-MA 5-FU 7AAD Abs AIF ANOVA ANT AMPK APAF-1 APP Ara-C Apo2-L Atg ATP AVO BA1 Bcl-2 BH BSA CD95 Cdk Chk CI CMA 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2deoxyglucose ... such as Fas-associated death domain (FADD), which interacts with pro-caspase and 10 to form the death-inducing signaling complex (DISC) Pro-caspase and 10 are self-cleaved Activated caspase and ... membrane (phagophore) Atg activates Atg 12 and Atg 12 is transferred to Atg 10 before conjugates with Atg Then, Atg 16 conjugates to Atg12-Atg5 and attaches Atg12-Atg5-Atg16 complex to phagophore...

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nanocarriers as an emerging platform for cancer therapy

Ngày tải lên : 28/05/2014, 15:07

... REVIEW ARTICLE Box Rational design of nanocarriers for cancer therapy Nanocarriers can offer many advantages over free drugs They: For rapid and effective clinical translation, the nanocarrier ... follicular, or transformed non-Hodgkin’s lymphoma Kaposi’s sarcoma Combinational therapy of recurrent breast cancer, ovarian cancer, Kaposi’s sarcoma Refractory Kaposi’s sarcoma, recurrent breast cancer, ... suitable for nanoparticle-aptamer conjugate therapy41 For example, docetaxel (Dtxl)-encapsulated nanoparticles whose surface is modified with an aptamer that targets the antigen on the surface...

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Nutrition and cancer: A review of the evidence for an anti-cancer diet pptx

Ngày tải lên : 06/03/2014, 02:21

... who recently had a colon polyp removed, Japanese-Hawaiians, North American Caucasians, native rural Japanese, and rural native Africans Lactobacillus species and Eubacterium aerofaciens, both ... MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S: Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular ... effects for women undergoing radiation therapy for carcinomas of the uterine cervix [175], for patients undergoing radiation therapy for head and neck cancers [176], and for colorectal cancer patients...

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Báo cáo khoa học: Serum autoantibodies as biomarkers for early cancer detection docx

Ngày tải lên : 23/03/2014, 04:20

... of autoantibodies as serological biomarkers for cancers [19] In addition, proteins that are aberrantly localized during malignant transformation can also provoke a humoral response For example, ... an advantage over the natural protein microarray in that it allows TAAs to be identiﬁed readily Using a similar approach, Anderson et al [125] developed programmable protein microarrays ELISA ... First, autoantibodies can be detected in the asymptomatic stage of cancer, and in some cases, may be detectable as early as years before the onset of disease [43] Second, autoantibodies against TAAs...

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Báo cáo khoa học: Natural polyphenols as proteasome modulators and their role as anti-cancer compounds doc

Ngày tải lên : 30/03/2014, 02:20

... 44 Aki M, Shimbara N, Takashina M, Akiyama K, Kagawa S, Tamura T, Tanahashi N, Yoshimura T, Tanaka K & Ichihara A (1994) Interferon-gamma induces different subunit organizations and functional ... Bronchial dysplasia Prostate cancer High-grade prostatic intraepithelial neoplasia Breast cancer Nonmetastatic bladder cancer Prostate cancer Green tea, decaffeinated black tea II I–II I I Phase ... Phase Phase Phase Phase Phase Metastatic colon cancer Pancreatic cancer Osteosarcoma Colorectal cancer Stage IV breast cancer Gemcitabine Gemcitabine Phase II Phase II Vitamin D and soy isoﬂavones...

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báo cáo hóa học:" Randomized phase II study with two gemcitabine- and docetaxel-based combinations as first-line chemotherapy for metastatic non-small cell lung cancer" docx

Ngày tải lên : 18/06/2014, 15:20

... Georgoulias V, Papadakis E, Alexopoulos A, Tsiafaki X, Rapti A, Veslemes M, Palamidas P, Vlachonikolis I: Platinum-based and non-platinum-based chemotherapy in advanced non-small cell lung cancer: a ... gold standard of care for advanced NSCLC In a large meta-analysis published by the NSCLC Collaborative Group in 1995, cisplatin-containing therapy for advanced disease was shown to confer an absolute ... control and monitoring MDA and ON were responsible for data management and statistical analyses AP, GLF and DAM wrote the first draft of the manuscript WZ carried out the preclinical study AP, DA and...

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Báo cáo sinh học: "Use of recombinant lentivirus pseudotyped with vesicular stomatitis virus glycoprotein G for efficient generation of human anti-cancer chimeric T cells by transduction of human peripheral blood lymphocytes in vitro" pot

Ngày tải lên : 19/06/2014, 08:20

... Cancer Society.: Cancer Facts and Figures 2004 In American Cancer Society Atlanta, GA; 2004 Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ: Cancer statistics, 2003 CA Cancer J Clin 2003, ... membrane-associated Src family of protein tyrosine kinases (PTKs) such as LCK and Fyn, which leads to a cascade of downstream kinase activities that ultimately cause Ca++ fluxing, new gene transcription ... fragment (scFv) against the tumor coupled to T cell receptor signaling domains for activation effector functions A great advantage of this approach is that stimulation of a cell with a scFv-based...

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báo cáo hóa học:" Use of recombinant lentivirus pseudotyped with vesicular stomatitis virus glycoprotein G for efficient generation of human anti-cancer chimeric T cells by transduction of human peripheral blood lymphocytes in vitro" docx

Ngày tải lên : 20/06/2014, 04:20

... Cancer Society.: Cancer Facts and Figures 2004 In American Cancer Society Atlanta, GA; 2004 Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ: Cancer statistics, 2003 CA Cancer J Clin 2003, ... membrane-associated Src family of protein tyrosine kinases (PTKs) such as LCK and Fyn, which leads to a cascade of downstream kinase activities that ultimately cause Ca++ fluxing, new gene transcription ... fragment (scFv) against the tumor coupled to T cell receptor signaling domains for activation effector functions A great advantage of this approach is that stimulation of a cell with a scFv-based...

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Báo cáo hóa học: "Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol" potx

Ngày tải lên : 21/06/2014, 04:20

... light and darkness Temperature and relative humidity were maintained at 25°C and 50%, respectively All care and handling of animals were performed with the approval of Institutional Authority for ... reflex was recorded for each animal Rats were maintained in dorsal or lateral recumbency during evaluation, and the time of righting reflex return was recorded Statistical analysis All data were ... light and darkness Temperature and relative humidity were maintained at 25°C and 50%, respectively After an acclimatization period of days, the rats were fasted for 12 h but allowed free access...

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Báo cáo hóa học: " Self-Assembled Polymeric Micellar Nanoparticles as Nanocarriers for Poorly Soluble Anticancer Drug Ethaselen" pdf

Ngày tải lên : 22/06/2014, 00:20

... supplier and acclimatized for days after arrival All animals were provided with standard food and water ad libitum and were exposed to alternating 12-h periods of light and darkness Temperature and ... puriﬁcation Animals Male Kunming mice were obtained from Experimental Animal Center of Peking University and acclimatized for days after arrival New Zealand White rabbits were purchased from the same ... and relative humidity were maintained at 25 °C and 50%, respectively All care and handling of animals were performed with the approval of Institutional Authority for Laboratory Animal Care of...

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báo cáo khoa học: "Clinical relevance of "withdrawal therapy" as a form of hormonal manipulation for breast cancer" doc

Ngày tải lên : 09/08/2014, 02:21

... 3d&tabid=2341] doi:10.1186/1477-7819-9-101 Cite this article as: Agrawal et al.: Clinical relevance of “withdrawal therapy” as a form of hormonal manipulation for breast cancer World Journal of ... datasets and results of ongoing adjuvant trials are needed to provide confirmatory evidence for or against the concept and feasibility of withdrawal therapy in locally advanced and metastatic ... post-menopausal advanced breast cancer patients heavily pre-treated with endocrine agents World J Surg Oncol 2006, 4:44 Masamura S, Santner SJ, Heitjan DF, Santen RJ: Estrogen deprivation causes estradiol...

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Báo cáo y học: "tromal Vascular Fraction Transplantation as an Alternative Therapy for Ischemic Heart Failure: Anti-inflammatory Role" doc

Ngày tải lên : 10/08/2014, 09:21

... infarct area in a blinded manner in sections from each heart and averaged for statistical analysis Data Analysis All data are expressed as the mean ± SEM Comparisons of echocardiographic data among ... (REPAIR-AMI) cardiac magnetic resonance imaging substudy Am Heart J 2009, 157(3):541-547 Yamamoto N, Akamatsu H, Hasegawa S, Yamada T, Nakata S, Ohkuma M, Miyachi EI, Marunouchi T, Matsunaga K: ... Premaratne GU, Sakaguchi G, Kanemitsu N, Lin X, Nakajima H, Sakakibara Y, Kimura Y, Yamamoto M, Tabata Y, Ikeda T, Komeda M: Administration of control-released hepatocyte growth factor enhances...

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báo cáo khoa học: "Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents" ppt

Ngày tải lên : 10/08/2014, 22:20

... MDS AZA was administered at a fixed dose of 75 mg/m2 daily for days VPA was doseescalated and given orally daily for days concomitantly ATRA was given at 45 mg/m2 orally daily for days, starting ... Mohapatra A, Bali P, Mandawat A, Rao R, et al: Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation ... 110:2302-2308 Chavez-Blanco A, Segura-Pacheco B, Perez-Cardenas E, Taja-Chayeb L, Cetina L, Candelaria M, et al: Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral...

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