nano carriers of drugs and genes for the treatment of restenosis
Tài liệu Bevacizumab and cetuximab for the treatment of metastatic colorectal cancer docx
Ngày tải lên :
14/02/2014, 22:20
... from data in the RCT The survival of patients receiving ASC/BSC was calculated from the survival of the patients in the cetuximab monotherapy arm of the RCT The data from the monotherapy arm NICE ... guide for healthcare professionals Information for people with metastatic colorectal cancer and their carers (‘Understanding NICE guidance’) Details of all the evidence that was looked at and other ... evidence from the bevacizumab studies and noted that the age of the population in the largest study was lower than the age of patients normally receiving chemotherapy in England and Wales However,...
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Báo cáo y học: "Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action" pps
Ngày tải lên :
09/08/2014, 01:21
... [70] and IL-1αinduced PGE2 production [71] in a dose- and MW-dependent manner; the higher the MW and concentration, the more potent the inhibition Intra-articular injection of HA in the temporomandibular ... levels of prostaglandin F2α, 6-keto-prostaglandin F1α, and leukotriene C4 [72] In synovial fluid from the knees of patients with OA and RA, intra-articular HA reduced the levels of PGE2 [73,74] and ... In the synovium of HA-treated knees, the number and aggregation of synoviocytes decreased, and both treatments reduced the number of inflammatory cells, including macrophages, lymphocytes, and...
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Tài liệu The Acquisition of Drugs and Biologics for Chemical and Biological Warfare Defense - Department of Defense Interactions with the Food and Drug Administration doc
Ngày tải lên :
17/02/2014, 11:20
... recipients of IND drugs, medical monitoring and reporting of the use of such drugs, information about shipment and storage of drugs, disposition of unused IND drugs, and submission of annual and other ... inventory of IND drugs and vaccines for CBW defense? There are three problems First, the ease of use of licensed drugs is substantially greater than the ease of use of not-yet-approved drugs The decision ... changes in the Office of the Secretary of iii iv The Acquisition of Drugs and Biologics for CBW Defense Defense (OSD) to centralize the authority for interactions between DoD and FDA The interviews...
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Tài liệu TREES OF THE NORTHERN UNITED STATES THEIR STUDY, DESCRIPTION AND DETERMINATION FOR THE USE OF SCHOOLS AND PRIVATE STUDENTS doc
Ngày tải lên :
13/02/2014, 12:20
... The last of the four kinds of parts is found in the center of the flower, and is called the pistil It is this part which forms the fruit and incloses the seed The stamens and the pistil are the ... other time of the year The plan of branching, the position, number, size, form, color, and surface of buds, as well as the arrangement of the leaves within the bud and the peculiarities of the scales ... plants themselves This chapter therefore will be devoted mainly to the words needed for leaf description, together with their application The Leaf.—In the axil of the whole leaf the bud forms for the...
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Tài liệu Báo cáo khoa học: Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc docx
Ngày tải lên :
18/02/2014, 17:20
... prerequisite for cleavage of the bond between C20 and C22 [1,14] Another difference between the metabolism of vitamin D3 and cholesterol by P450scc is that the dissociation of intermediates occurs for the ... proliferation and differentiation of human epidermal keratinocytes cultured in vitro [10] Thus, the vitamin D3 derivatives produced by the action of P450scc are good candidates for use in the therapy of ... with the collection and interpretation of the NMR data Their spectra were recorded in CDCl3 and COSY spectra lacked fine detail HSQC and expanded COSY were not provided by Guryev et al [2] and, ...
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Cloning for reproductive purposes and cloning for the purposes of biomedical research potx
Ngày tải lên :
05/03/2014, 16:20
... process of development (such as, for example, the formation of a heap of sand from a grain of sand and the subsequent addition of further grains of sand), new qualitative stages arise and call for ... favour of restricting the exercise of this freedom These concern the legitimacy of the resources needed for cloning and the status of the cloned human embryo 3.3.1 Use and consumption of female ... However, the dignity of even the earliest forms of human life on the basis of the Christian notion of the imago Dei is unanimously upheld by the Catholic Church (although admittedly in the context of...
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Ethical Journalism A Handbook of Values and Practices for the News and Editorial Departments pdf
Ngày tải lên :
06/03/2014, 11:20
... Journalism A Handbook of Values and Practices for the News and Editorial Departments “ Reporters, editors, photographers and all members of the news staff of The New York Times share a common and essential ... protecting the integrity of the newspaper As the news, editorial and business leadership of the newspaper declared jointly in 1998: ‘Our greatest strength is the authority and reputation of The Times ... to whom the guidelines apply The Times reserves the right to modify and expand the guidelines from time to time, as appropriate (See the letter of understanding with the Newspaper Guild of New...
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Unfolding the Future of the Long War - Motivations, Prospects, and Implications for the U.S. Army docx
Ngày tải lên :
06/03/2014, 20:20
... understanding of the components of the long war, provided the basis for a set of seven strategy options for the United States in the long war xvi Unfolding the Future of the Long War Divide and ... down the components of the long war in terms of the nature of the problem, primary adversary, potential goals, and challenges and drawbacks The items refer to our thesis that the current set of ... over the coming years Therefore, the Army asked RAND Arroyo Center to explore the concept of the long war and to identify potential ways in which it might unfold and the resulting implications for...
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Báo cáo khoa học: The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts doc
Ngày tải lên :
07/03/2014, 05:20
... development of effective and safe agents for the prevention and treatment of cancer remains inefficient and costly, and falls short of the requirements for primary prevention among the high-risk ... significantly absorbed in the intestinal tract, and reach the colon mainly intact [27] They are therefore bioavailable to the epithelial cells in the intestinal wall, where procyanidins and other phenolics ... investigated the relationship of different structural factors of procyanidins, such as the mean degree of polymerization and percentage of galloylation, with their antiproliferative potential and their...
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Báo cáo khoa học: Purification, microsequencing and cloning of spinach ATP-dependent phosphofructokinase link sequence and function for the plant enzyme pdf
Ngày tải lên :
07/03/2014, 11:20
... feature of chloroplast ATP-PFK [27,28,32], and in contrast to the stimulation of the cytosolic isoenzyme observed in spinach and other plants [27] These Fig Spinach PFK activity assayed in the absence ... in the soluble fraction of transformants The heat activation treatment that was successfully used to restore highly specific ATP-dependent activity of the Entamoeba enzyme [6] also failed for the ... Cloning of PFK genes Degenerate primers were designed on the basis of peptide sequences determined from the purified protein For SoPFK1, the peptide fragments EIYFEP and GNAVLG were selected For SoPFK2,...
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Trends in the European Investment Fund Industry in the Second Quarter of 2011 and Results for the First Half of 2011 potx
Ngày tải lên :
07/03/2014, 16:20
... regarding the strength of the global economic recovery and increasing tensions in the euro area, which sparked lower demand for equity and bond funds Differences in totals between quarterly and monthly ... Equity Balanced Total Equity & Balanced Funds of funds (4) Other Total (excl Ireland & Netherlands) of w hich guaranteed funds Total (incl Ireland & Netherlands) 36,733 in No in % (3) in No (1 No full ... Quarter of 2011) Trends in the European Investment Fund Industry Net Assets by Country of Domiciliation The combined assets of the investment fund market in Europe, i.e the market for UCITS and nonUCITS,...
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Trends in the European Investment Fund Industry in the Second Quarter of 2012 and Results for the First Half of 2012 pdf
Ngày tải lên :
07/03/2014, 16:20
... Funds of funds (4) Other Total (excl Ireland & Netherlands) of w hich guaranteed funds Total (incl Ireland & Netherlands) 35,766 (1 No full data breakdo wn is available fo r Ireland and the Netherlands; ... Quarter of 2012) Trends in the European Investment Fund Industry Net Assets by Country of Domiciliation The combined assets of the investment fund market in Europe, i.e the market for UCITS and nonUCITS, ... UCITS, this segment of the business accounted for almost 71 percent of the fund market at end June 2012, with the remaining 29 percent composed of non-UCITS Table Net Assets of the European Investm...
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Ergonomic Principles and Checklists for the Selection of Office Furniture and Equipment doc
Ngày tải lên :
08/03/2014, 13:20
... (adjustable by fore -and- aft movement of the backrest) is the horizontal distance, measured from the front edge to the foremost point of the backrest on the centre line of the seat's width The minimum ... on the range of heights of the mid lumbar region (L2 - L4) of users 1.16 Armrest height is the vertical distance between the centre of the compressed seat cushion and the fore -and- aft centre of ... experience of the members of the Ergonomics Unit and consultation with other ergonomists The Australian Standard listed above had only just been published at the start of the development of the checklists...
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Why We Buy: The Science of Shopping--Updated and Revised for the Internet, the Global Consumer, and Beyond
Ngày tải lên :
15/03/2014, 15:16
... shelves and picks up a bottle of Pantene brand, reads the front label, then picks up a bottle of the store brand and reads the front label, then reads the price tag On the Pantene, then reads the ... defies the most ingrained human yearnings about the front: We all want to be there, at the front of the pack., the head of the line, the top of the class To the front-runner go the spoils In the ... in it, where they go and don't go, and by what path they go there; what they see and fail to see, or read and decline to read; and how they deal with the objects they come upon, how they shop,...
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BELMONT REPORT: ETHICAL PRINCIPLES AND GUIDELINES FOR THE PROTECTION OF HUMAN SUBJECTS OF RESEARCH ppt
Ngày tải lên :
22/03/2014, 15:21
... investigators and members of their institutions are obliged to give forethought to the maximization of benefits and the reduction of risk that might occur from the research investigation In the case of ... selected, the person responsible for the research, etc However, a simple listing of items does not answer the question of what the standard should be for judging how much and what sort of information ... patients who deliver themselves into the hand of a clinician for needed care It may be, that a standard of "the reasonable volunteer" should be proposed: the extent and nature of information should...
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Báo cáo khoa học: Structure of a trypanosomatid mitochondrial cytochrome c with heme attached via only one thioether bond and implications for the substrate recognition requirements of heme lyase potx
Ngày tải lên :
23/03/2014, 04:21
... blue) Also shown are the heme ligands (histidine and methionine in each case), the cysteines that form thioether bonds to the heme, and the methyl group of the alanine of the C fasciculata AXXCH ... methionine and histidine side chains that coordinate the heme iron, and the cysteine side chain that forms a thioether bond between heme and protein Also shown is the methyl group of the alanine of the ... identity and 72% similarity The structures are remarkably similar overall, and in the details of the heme attachment and heme position The rmsd between the structure of C fasciculata cytochrome c ˚ and...
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Pelvic floor muscle training and adjunctive therapies for the treatment of stress urinary incontinence in women: a systematic review doc
Ngày tải lên :
28/03/2014, 14:20
... evidence for the optimal period of treatment and number of treatments? We found evidence for the efficacy of shorter treatment protocols than the 4–6 months recommended by the ICS The basis of the ... the differences in outcome The expertise of health professionals may vary and also the quantity and quality of the educational information about the condition and PFM function The impact of these ... and other physical therapies for the treatment of female SUI [13] and UI [1416] has been the subject of previous systematic reviews All of these reviews limited their inclusion criteria to randomized...
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