... tissue and gastrointestinal tract, as well as other sites, are known to reach the CNS to effect changes in feeding behavior and energy expenditure Thus, insulin, leptin and ghrelin, as well as other ... closely and rapidly with reciprocal changes inthe levels ofthe orexigenic and anorectic Signaling mediators inthetreatmentof obesity neuropeptide expression inthe hypothalamus [22] Thus an increase ... explored further Other areas ofthe brain have also been shown to regulate feeding via AMPK [35,36] Of interest is the extensive use of fructose as a sweetener inthe human diet [37] Glucose and fructose...
... at each phase ofthe cell cycle by various complexes of cell-cycle-related molecules, including cyclins, cyclin-dependent kinases, their inhibitors andthe retinoblastoma protein (RB), as well ... calorie intake induces expression of RMI1 and E2Fs in adipocytes, and these changes in expression are expected to increase a positive interaction between the molecules The increased expression of ... recruitment of preadipocytes [12], suggesting that these cyclin-dependent kinase inhibitors are important inthe regulation of adipocyte number The S-phase kinase-associated protein (Skp)1–CullinF-box...
... effective inthetreatmentof psychotic major depression, andthe switch to sertraline worsened the psychotic symptoms inthe patient The mechanisms underlying the opposite effects of these two ... fluvoxamine binds to sigma-1 receptors inthe intact human brain at therapeutic doses [25], suggesting that sigma-1 receptors are involved inthe active mechanisms of fluvoxamine [19] Interestingly, ... that activation ofthe dopaminergic system by the inhibition of dopamine transporter may be involved inthe mechanism of unwanted effects (deterioration of psychosis) of sertarline in this case,...
... approved the final manuscript Competing interests The funding source had no influence on study design, inthe collection, analysis, and interpretation ofthe data, inthe writing ofthe manuscript, ... telbivudine are more widely used intreatmentof CHB In this systematic review, we focus on the comparison ofthe efficay of lamivudine and telbivudine inthe Figure Effect of telbivudine vs lamivudine ... ofthe healthcare system is not satisfactory There are limitations inthe reimbursement of anti-HBV therapy, either inthe selection of agent or the duration of dosing Therefore, lamivudine and...
... pressures and short-term survival, in comparison to the single use of epinephrine This study adds some evidence to the existing literature ofthe epinephrine-vasopressin combination benefits and further ... vasoconstrictive Page of (page number not for citation purposes) effect ofthe combination ofthe two drugs in comparison to epinephrine alone inthe first minute of CPR with an increase of CPP This increase ... interpretation ofthe clinical outcome in vasopressin studies The authors recognize several limitations inthe interpretation ofthe present findings The study was conducted on apparently healthy pigs and...
... the intervention and its effectiveness is calculated by comparing measures taken at baseline (the beginning of treatment) and comparing them to measures taken at the end oftreatment Increasingly ... improve the functioning ofthe family as a unit, or its subsystems, and/ or the functioning ofthe individual members ofthe family There are several family-oriented treatment traditions including ... interpretation in a process in which the therapist is active in creating the alliance and ensuring the time-limited focus In contrast, long-term psychodynamic psychotherapy is open-ended and intensive and...
... 2004, of portacaval shunting, thereby decreasing first pass metabolism; decrease in quantities and affinity of plasma proteins, thereby increasing free-drug levels; increase in volume of distribution ... syndrome), including carbamazepine, phenytoin, phenobarbital, and lamotrigine The triad of hypersensitivity includes fever, rash and internal organ involvement with onset of symptoms within to weeks of ... pre-dialysis and 2–3 hrs following the post-dialysis dose There is a case report in which lithium levels were maintained inthe therapeutic range by intraperitoneal administration of lithium during continuous...
... other types of pain) or is unwilling to stop taking other medications for thetreatmentof OA Any other condition that, inthe opinion ofthe investigator, would adversely affect the subject's ... Subjects inthe UC-II group were instructed to take two “sugar pills” inthe morning to protect blinding and two UC-II capsules inthe evening accounting for a daily dose of 40 mg UC-II containing ... capsules inthe morning and two inthe evening for a daily dose of 1500 mg glucosamine and 1200 mg chondroitin Removal of Patients from Therapy or Assessment The criteria for removal of patients...
... base their conclusions suffer from several shortcomings First, existing studies randomize the provision of deworming treatment within schools to treatmentand placebo groups, and then examine the ... charts, andthe training of teachers in each treatment school on worm prevention Health education stressed the importance of hand washing to avoid ingesting roundworm and whipworm larvae, wearing ... medical treatmentin 1998 This was partly because of confusion inthe field about pupil age, and partly because inthe early stages ofthe program several ofthe Kenya Ministry of Health nurses administered...
... screening including erythrocyte sedimenta- Page of tion rate and C-reactive protein was normal Plain radiographs revealed areas of periprosthetic osteolysis inthe femur andthe tibia, and a ... image ofthe left knee showing the introducing cannula and simultaneous venting ofthe medial tibial condylar cyst Discussion When dealing with massive periprosthetic osteolysis the aims of surgery ... years later In January 2005 the patient began to develop similar medial pain and swelling inthe left knee A bone scan showed increased activity inthe medial femoral condyle indicating possible...
... caspase-3 and cleaved PARP proteins in mice Increase inthe expression of caspase-3 and cleaved PARP proteins noticed inthe mice treated in vivo with GnRH-Ag also showed increase inthe number of atretic ... receptors, and steroidogenic and apoptotic factors inthe ovary was investigated following in vivo andin vitro administration of GnRH agonist inthe intact cyclic mice Methods Animals All the experiments ... http://www.ovarianresearch.com/content/3/1/26 Page of 13 Figure Effect ofin vitro treatmentof different doses of GnRH-Ag on progesterone synthesis and western blot analyses of LH-R and 3b-HSD proteins inthe ovaries of mice Progesterone...
... Annals of General Psychiatry 2009, 8:16 thetreatmentof acute mania, the approval of quetiapine andthe olanzapine-fluoxetine combination against acute bipolar depression andthe approval of olanzapine, ... dose at the end ofthe study was 15.5 mg daily The results suggest that in weeks to and then again at week there is a significant reduction inthe MADRS scores inthe aripiprazole group in comparison ... which included 66 ofthe 67 patients who completed the 26-week period Unfortunately only 12 of them (5 inthe placebo group andinthe aripiprazole group) completed the 74-week treatment period The...
... contributions All ofthe authors have been involved in drafting this paper and have read and approved the final manuscript KG conceived the idea ofthe paper, reported the case, performed the literature ... concerning radiotherapy and followed up the patient at his out-patient clinic AK was the radiologist performing the preoperative and postoperative CT and MRI scans and wrote the part ofthe paper ... radiotherapy and conventional fractionation while minimising the risks of RT-inducing brain injury like radiation necrosis and cognitive decline The optimal radiation dose has not yet been defined We...
... HT at the Tomotherapy Unit ofthe Grupo IMO inthe context of multidisciplinary national and international treatment protocols All the patients were treated with curative intent, including those ... to the Tomotherapy treatment planning system (Tomotherapy Inc., Madison, WI) to perform inverse treatment planning The planning goal was to deliver the prescription dose to at least 95% ofthe ... treatment time was composed of time required for patient set-up and anesthesia inside thetreatment room, time of MVCT acquisition, time of review/match and applying couch correction inside the...
... treatmentofthe children HB is responsible for the anaesthesia management ofthe children PH is responsible for the clinical treatmentofthe children as head ofthe division of radiation oncology in ... helical tomotherapy have the potential of selectively sparing the thyroid gland and breast tissue in craniospinal irradiation The number of children treated with IMRT andthe hard evidence for the benefit ... percent ofthe IMRT Group had grade or hearing loss, compared to 64% ofthe conventional-RT group The sparing ofthe hearing apparatus is of special importance since several modern combined chemotherapy...
... according to the actuarial method of Kaplan and Meier [24] The calculation of OS, DFS and LC was performed from the date of diagnosis to the date ofthe event Survival was measured from the date of ... sphincter-sparing surgery is nowadays the main subject of controversy One ofthe most important controversies is whether the degree of downstaging warrants this type of surgery [1] Results ofthe ... treatment was temporarily interrupted The decision of performing this weekly CT schedule instead of during the first and last week of RT course had the objective of maximize the radiation effect Adjuvant...
... cystic carcinomas ofthe head and neck are a unique kind of tumour deriving from cells ofthe major and minor salivary glands, they account for 25% of all malignant salivary gland tumours in different ... material wrapped around the head ofthe patient Serial mm CT slices oftheofthe whole treatment area plus a superior margin of cm and an adequate inferior margin to cover the neck lymph nodes ... by slice on thetreatment planning CTs using the 3D-conformal radiotherapy planning system VIRTUOS which was developed at the dkfz An image fusion ofthetreatment planning CT andthe MRI scan...
... stages III and IV) Combining the studies, there were 439 patients, and over 98% of these were late-stage Treatment efficacy The main characteristics ofthe four studies are shown in table 3, ... of those met all inclusion criteria as studies of frontline or re -treatment Two of those four met the criteria for the first analysis (frontline treatment alone) Outcome The primary goal ofthe ... (53%) or R-CHOP (63%) The international PRIMA study testing the efficacy of maintenance therapy by rituximab may provide important data inthe field ofthe best induction in patients with follicular...
... we assessed the proportion of patients receiving the service, the rate of use and rate of admissions, the time to first use ofthe service, andthe annual health care cost, in terms of total health ... antipsychotic within 14 days of discontinuation ofthe initial therapy Data on the occurrence of acute-care service use, the time to the use of such services, and total-care and acute-care service ... hospitalization/day treatment, crisis services, and any acute-care services; as well as the total duration (in days) of each of these services andthe rate of admissions to the facilities providing them Total and...
... participated inthe design ofthe study andthe analytical plan DEF participated inthe design ofthe study, the analytical plan, the interpretation ofthe results, and assisted in drafting the manuscript ... manuscript DS and ES participated inthe design ofthe study, the analytical plan, the interpretation ofthe results, and assisted in drafting the manuscript They were also involved in preparing the resource ... costing data of US-SCAP XP performed the expanded statistical analyses, participated inthe design ofthe study, the analytical plan, andthe interpretation ofthe results RRC assisted with the interpretation...